Article
Medicine, Research & Experimental
Jishang Huang, Zhixi Chen, Zhenyu Wu, Xunlu Xie, Shiwei Liu, Weihao Kong, Jianguo Zhou
Summary: The study found that geniposide can stimulate autophagy and protect against the development of osteoarthritis by activating the GLP-1R/AMPK/mTOR signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Xun-Jia Ye, Rong Xu, Si-Ying Liu, Bo Hu, Zi-Jian Shi, Fu-Li Shi, Bo Zeng, Li-Hui Xu, Yuan-Ting Huang, Ming-Ye Chen, Qing-Bing Zha, Xian-Hui He, Dong-Yun Ouyang
Summary: The study discovered that taraxasterol (TAS), an active ingredient in dandelion, can inhibit the activation and proliferation of T lymphocytes by suppressing IL-2 expression and its signaling pathway, thereby ameliorating Con A-induced acute hepatitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pathology
Yongqing Jia, Weiying Gu
Summary: The study revealed that circPVT1 is involved in the progression of T-ALL and is associated with patient prognosis, indicating it may represent a potential therapeutic target for T-ALL treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Pathology
Juan Liu, Mingyong Li, Jun Fu, Min Dong, Xiaoming Fan, Ling Zhong, Gang Xu, Yanxin Li, Qian Xi
Summary: Indolent T-lymphoblastic proliferation (iT-LBP) is a non-neoplastic T-cell proliferation in extrathymic tissues that requires no treatment. Distinguishing iT-LBP from T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) can be challenging due to overlapping features. Evaluation of TRBC1 expression patterns can serve as a simple and effective approach to differentiate between iT-LBP and T-ALL/LBL.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Qi Jin, Blanca Gutierrez Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Von Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L. Safgren, Yi-Chien Tsai, Beat Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D. Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Summary: This study reveals that in T cell acute lymphoblastic leukemia (T-ALL), ubiquitin-specific protease 11 (USP11) forms a complex with USP7 to deubiquitinate the oncogenic lymphocyte cell-specific protein-tyrosine kinase (LCK) and enhance its activity. Impairment of LCK activity leads to increased glucocorticoid receptor (GR) expression and glucocorticoids sensitivity. Additionally, the deubiquitinase activity plays a role in the transcriptional activation of GR target genes.
Article
Oncology
Giulia Veltri, Federica Lovisa, Giuliana Cortese, Marta Pillon, Elisa Carraro, Simone Cesaro, Massimo Provenzi, Salvatore Buffardi, Samuela Francescato, Alessandra Biffi, Barbara Buldini, Valentino Conter, Valentina Serafin, Lara Mussolin
Summary: T-cell lymphoblastic lymphoma (T-LBL) and lymphoblastic leukemia (T-ALL) share common features but have different phosphoproteomic profiles. A proteomic signature of six proteins can distinguish stage IV T-LBL from T-ALL, and AKT hyperphosphorylation alone can distinguish stage IV T-LBL from both T-ALL and stage III T-LBL.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiangrong Xu, Danyang Hou, Yujie Wang, Jing Zhang, Yu Hei, Bobo Wang, Shuyue Tian, Yunqing Zhang, Fenghui Wang
Summary: This study found that NF-κB activating protein (NKAP) is highly expressed in pancreatic adenocarcinoma (PAAD) cells. Inhibiting the expression of NKAP significantly suppressed the biological function of PAAD cells, promoted cell apoptosis, and increased drug sensitivity to gemcitabine. The research also discovered for the first time that the mTOR signaling pathway is involved in the oncogenic role of NKAP in PAAD.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Cell Biology
Omar Perbellini, Chiara Cavallini, Roberto Chignola, Marilisa Galasso, Maria T. Scupoli
Summary: This study reveals a high variability in signaling networks across different T-ALL cell lines and provides insight into the characterization of these differences using phospho-specific flow cytometry.
Article
Cell Biology
Shijun Yu, Qingqing Hu, Kailing Fan, Chen Yang, Yong Gao
Summary: In this study, it was found that elevated expression of CSNK2B in colorectal cancer cells promoted cell proliferation and tumorigenesis by activating the mTOR signaling pathway. These findings suggest that CSNK2B may serve as a novel oncogene contributing to the development of colorectal cancer.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Tommaso Colangelo, Patrizio Panelli, Francesco Mazzarelli, Francesco Tamiro, Valentina Melocchi, Elisabetta De Santis, Roberto Cuttano, Orazio Palumbo, Giovanni Rossi, Fabrizio Bianchi, Vincenzo Giambra
Summary: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive T-cell malignancy. Recent studies have shown that T-ALL-secreted small extracellular vesicles (sEV) contain NOTCH1-dependent microRNAs (EV-miRs), which regulate oncogenic pathways and promote the expansion and survival of highly proliferative cell subsets, thereby altering the cell heterogeneity and dynamics of leukemia.
Article
Plant Sciences
Ruli Li, He Li, Jie Lan, Dongmei Yang, Xinjing Lin, Hongling Xu, Bin Han, Ming Yang, Bo Su, Fu Liu, Wei Jiang
Summary: Damnacanthal inhibits the growth of ovarian cancer via the ERK/mTOR/autophagy signaling cascade, indicating its potential as a therapeutic candidate for ovarian cancer.
Article
Oncology
Mengping Xi, Shanshan Guo, Caicike Bayin, Lijun Peng, Florent Chuffart, Ekaterina Bourova-Flin, Sophie Rousseaux, Saadi Khochbin, Jian-Qing Mi, Jin Wang
Summary: This study found that the HDAC inhibitor chidamide has an anti-tumor effect on T-ALL cells, particularly by inhibiting the NOTCH1-MYC signaling axis. Clinical trial results support that chidamide treatment reduces minimal residual disease in patients and is well tolerated.
FRONTIERS OF MEDICINE
(2022)
Article
Oncology
Yoon Soo Chang, Joell J. Gills, Shigeru Kawabata, Masahiro Onozawa, Giusy Della Gatta, Adolfo A. Ferrando, Peter D. Aplan, Phillip A. Dennis
Summary: The study found that nelfinavir inhibits the NOTCH1 pathway and the AKT/mTOR pathway, induces endoplasmic reticulum (ER) stress, and suppresses the viability of T-ALL cells. Additionally, nelfinavir upregulates the expression of CHAC1 and SESN2, which negatively regulate the NOTCH and mTOR pathways, respectively. Nelfinavir also exhibits therapeutic efficacy against T-ALL in an SCL-LMO1 transgenic mouse model.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Hematology
Haojie Jiang, Lin Zhang, Mina Yang, Guoming Li, Chen Ding, Min Xin, Jing Dai, Xueqing Sun, Xuemei Fan, Haipeng Sun, Junling Liu, Yanyan Xu
Summary: This study reveals the important role of BCAAs in megakaryocyte differentiation and platelet production. BCAA diet can promote megakaryocyte differentiation and platelet production, while deficiency in BCAA metabolism leads to thrombocythemia. Activation of BCAA metabolism can reduce thrombocythemia.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Immunology
Yuying Liu, Nannan Zhou, Li Zhou, Jing Wang, Yabo Zhou, Tianzhen Zhang, Yi Fang, Jinwei Deng, Yunfeng Gao, Xiaoyu Liang, Jiadi Lv, Zhenfeng Wang, Jing Xie, Yuanbo Xue, Huafeng Zhang, Jingwei Ma, Ke Tang, Yiliang Fang, Feiran Cheng, Chengjuan Zhang, Bing Dong, Yuzhou Zhao, Peng Yuan, Quanli Gao, Haizeng Zhang, F. Xiao-Feng Qin, Bo Huang
Summary: IL-2 acts as an environmental cue to induce CD8(+) T cell exhaustion within tumor microenvironments by activating STAT5, inducing tryptophan hydroxylase 1, and subsequently causing T cell dysfunction.
Article
Oncology
Julie A. Hixon, Caroline Andrews, Lila Kashi, Casey L. Kohnhorst, Emilee Senkevitch, Kelli Czarra, Joao T. Barata, Wenqing Li, Joel P. Schneider, Scott T. R. Walsh, Scott K. Durum
Article
Biochemistry & Molecular Biology
Ines Pinto, Mafalda Duque, Joana Goncalves, Padma Akkapeddi, Mariana L. Oliveira, Rita Cabrita, J. Andres Yunes, Scott K. Durum, Joao T. Barata, Rita Fragoso
Article
Hematology
Renate De Smedt, Julie Morscio, Lindy Reunes, Juliette Roels, Valentina Bardelli, Beatrice Lintermans, Wouter Van Loocke, Afonso Almeida, Laurence C. Cheung, Rishi S. Kotecha, Marc R. Mansour, Anne Uyttebroeck, Peter Vandenberghe, Roberta La Starza, Cristina Mecucci, Tim Lammens, Nadine Van Roy, Barbara De Moerloose, Joao T. Barata, Tom Taghon, Steven Goossens, Pieter Van Vlierberghe
Article
Oncology
Kolja Pocha, Andreas Mock, Carmen Rapp, Steffen Dettling, Rolf Warta, Christoph Geisenberger, Christine Jungk, Leila R. Martins, Niels Grabe, David Reuss, Juergen Debus, Andreas von Deimling, Amir Abdollahi, Andreas Unterberg, Christel C. Herold-Mende
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Yasser Perera, Alice Melao, Ailyn C. Ramon, Dania Vazquez, Daniel Ribeiro, Silvio E. Perea, Joao T. Barata
Article
Oncology
E. G. Garcia, A. Veloso, M. L. Oliveira, J. R. Allen, S. Loontiens, D. Brunson, D. Do, C. Yan, R. Morris, S. Iyer, S. P. Garcia, N. Iftimia, W. Van Loocke, F. Matthijssens, K. McCarthy, J. T. Barata, F. Speleman, T. Taghon, A. Gutierrez, P. Van Vlierberghe, W. Haas, J. S. Blackburn, D. M. Langenau
Summary: The study identifies PRL3 as a collaborating oncogenic driver in T-ALL, which synergizes with MYC to promote leukemia development and suppress apoptosis in cells. By suppressing downstream phosphorylation signaling pathways, PRL3's role in T-ALL is elucidated.
Article
Oncology
Sara Rocha, Afonso P. Basto, Marieke E. Ijsselsteijn, Sara P. Teles, Maria M. Azevedo, Gilza Goncalves, Irene Gullo, Gabriela M. Almeida, Joaquin J. Maqueda, Marta Oliveira, Fatima Carneiro, Joao T. Barata, Luis Graca, Noel F. C. C. de Miranda, Joana Carvalho, Carla Oliveira
Summary: The role of regulatory T cells (Tregs) in gastric cancer (GC) remains controversial. Tregs may have a non-immunosuppressive effect on intestinal-type GC by inducing membrane expression of IL2R alpha and activating the MAPK signaling pathway, promoting spheroid growth in early stages of tumor development. This finding could lead to novel therapeutic strategies for intestinal-type GC and other tumors with similar immune context.
Article
Hematology
Ana Silva, Afonso R. M. Almeida, Ana Cachucho, Joao L. Neto, Scifie Demeyer, Mafalda de Matos, Thea Hogan, Yunlei Li, Jules Meijerink, Jan Cools, Ana Rita Grosso, Benedict Seddon, Joao T. Barata
Summary: Overexpression of IL-7R alpha can promote T-cell tumorigenesis and lead to malignancies in various organs, involving activation of multiple signaling pathways and sensitivity to inhibitors of IL-7R-mediated signaling. Established tumors may no longer require high levels of IL-7R expression upon secondary transplantation, highlighting potential therapeutic implications.
Article
Multidisciplinary Sciences
Ifat Geron, Angela Maria Savino, Hila Fishman, Noa Tal, John Brown, Virginia A. Turati, Chela James, Jolanda Sarno, Michal Hameiri-Grossman, Yu Nee Lee, Avigail Rein, Hillary Maniriho, Yehudit Birger, Anna Zemlyansky, Inna Muler, Kara L. Davis, Victoria Marcu-Malina, Nicole Mattson, Oren Parnas, Rabea Wagener, Ute Fischer, Joao T. Barata, Catriona H. M. Jamieson, Markus Muschen, Chun-Wei Chen, Arndt Borkhardt, Ilan Richard Kirsch, Arnon Nagler, Tariq Enver, Shai Izraeli
Summary: This study reveals that activating mutations in Interleukin-7 receptor alpha can initiate preleukemia in primary human hematopoietic progenitors and cooperate with CDKN2A silencing in the progression into acute lymphoblastic leukemia (BCP-ALL).
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Afonso R. M. Almeida, Joao L. Neto, Ana Cachucho, Mayara Euzebio, Xiangyu Meng, Rathana Kim, Marta B. Fernandes, Beatriz Raposo, Mariana L. Oliveira, Daniel Ribeiro, Rita Fragoso, Priscila P. Zenatti, Tiago Soares, Mafalda R. de Matos, Juliana Ronchi Correa, Mafalda Duque, Kathryn G. Roberts, Zhaohui Gu, Chunxu Qu, Clara Pereira, Susan Pyne, Nigel J. Pyne, Vasco M. Barreto, Isabelle Bernard-Pierrot, Emannuelle Clappier, Charles G. Mullighan, Ana R. Grosso, J. Andres Yunes, Joao T. Barata
Summary: The study shows that activating mutations in IL7Ra can initiate precursor B-cell acute lymphoblastic leukemia, and the mechanism is elucidated through research on a knock-in mouse model, providing new directions for the treatment of this type of leukemia.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Helena Nunes-Cabaco, Andreia Ramalho-dos-Santos, Ana R. Pires, Leila R. Martins, Joao T. Barata, Ana E. Sousa
Summary: IL-4 plays a role in the regulation of human thymocyte plasticity and is involved in the generation of CD8+ T cells in the thymus. IL-4 also has implications in neonatal immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Mariana L. Oliveira, Alexandra Veloso, Elaine G. Garcia, Sowmya Iyer, Clara Pereira, Vasco M. Barreto, David M. Langenau, Joao T. Barata
Summary: This study demonstrates the collaboration between mutant IL7R and Myc in inducing T-ALL and shows that mutant IL7R enriches for leukemia propagating potential.
Article
Oncology
Nan Qin, Eunice Paisana, Maike Langini, Daniel Picard, Bastian Malzkorn, Carlos Custodia, Rita Cascao, Frauke-Dorothee Meyer, Lena Bluemel, Sarah Goebbels, Kuebra Taban, Jasmin Bartl, Nicole Bechmann, Catleen Conrad, Jan Gravemeyer, Juergen C. Becker, Anja Stefanski, Stephanie Puget, Joao T. Barata, Kai Stuehler, Ute Fischer, Joerg Felsberg, Olivier Ayrault, Guido Reifenberger, Arndt Borkhardt, Graeme Eisenhofer, Claudia C. Faria, Marc Remke
Summary: The study highlights the importance of interclonal cross-talk between MYC-driven and non-MYC-driven cells in medulloblastoma, showing how their interactions influence metastasis, angiogenesis, and tumor progression. Targeting the secretome can effectively suppress this communication between subclones.
Article
Cell Biology
Lena Bluemel, Nan Qin, Johannes Berlandi, Eunice Paisana, Rita Cascao, Carlos Custodia, David Pauck, Daniel Picard, Maike Langini, Kai Stuehler, Frauke-Dorothee Meyer, Sarah Goebbels, Bastian Malzkorn, Max C. Liebau, Joao T. Barata, Astrid Jeibmann, Kornelius Kerl, Serap Erkek, Marcel Kool, Stefan M. Pfister, Pascal D. Johann, Michael C. Fruehwald, Arndt Borkhardt, Guido Reifenberger, Claudia C. Faria, Ute Fischer, Martin Hasselblatt, Jasmin Bartl, Marc Remke
Summary: Primary ciliogenesis plays an important role in the biology of Atypical teratoid/rhabdoid tumor (AT/RT) and its downstream signaling pathway may serve as a novel therapeutic target.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Claudia C. Faria, Rita Casca, Carlos Custodia, Eunice Paisana, Tania Carvalho, Pedro Pereira, Rafael Roque, Jose Pimentel, Jose Miguens, Isidro Cortes-Ciriano, Joao T. Barata
Summary: This study established a library of patient-derived xenografts of brain metastases and demonstrated their similarity to human metastatic disease. The efficacy of two drugs was tested, and RNA sequencing revealed similar transcriptional profiles between human brain metastases and the xenografts.
CELL REPORTS MEDICINE
(2022)
