Journal
LETTERS IN APPLIED MICROBIOLOGY
Volume 60, Issue 1, Pages 66-71Publisher
WILEY-BLACKWELL
DOI: 10.1111/lam.12338
Keywords
antibiofilm; antibiotic lock therapy; antifungal agent; Candida tropicalis; candidiasis; imidazolium salt; ionic liquid
Categories
Funding
- CAPES
- CNPq (Including the Public Notice Universal MCTI/CNPq) [14/2013]
- FAPERGS
- FAPERGS-CAPES
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The in vitro activity of the imidazolium salt C(16)MImCl against planktonic and biofilm cells of multidrug-resistant isolates of Candida tropicalis was evaluated, both in solution and applied on a commercial catheter surface. This was determined by inhibition and susceptibility assays of biofilm and planktonic cells. In both cases, C(16)MImCl prevented in vitro biofilm formation of C.tropicalis strains, including multidrug-resistant ones. Outstanding performances were observed, even at extremely low concentrations. Furthermore, this is the first report of the antifungal lock property of C(16)MImCl, using a tracheal catheter as the test specimen to mimic a clinical in vivo condition. As such, C(16)MImCl has been identified as a promising antimicotic pharmaceutical candidate for the treatment of candidiasis infections. Significance and Impact of the StudyThe imidazolium salt 1-n-hexadecyl-3-methylimidazolium chloride (C(16)MImCl) strongly prevents, in concentrations as low as 0028gml(-1), the biofilm formation of multidrug-resistant Candida tropicalis isolates, either in solution or applied on the surface of commercial catheters. This presents an effective antimicotic candidate and alternative for invasive clinical procedure toolset asepsis.
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