Life after death: the critical role of extracellular DNA in microbial biofilms

Extracellular DNA Shields against Aminoglycosides in Pseudomonas aeruginosa Biofilms

(2013) Wen-Chi Chiang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Extracellular DNA Release Acts as an Antifungal Resistance Mechanism in Mature Aspergillus fumigatus Biofilms

(2013) Ranjith Rajendran et al.   EUKARYOTIC CELL

Efficacy of a Marine Bacterial Nuclease against Biofilm Forming Microorganisms Isolated from Chronic Rhinosinusitis

(2013) Robert C. Shields et al.   PLoS One

Extracellular DNA-induced antimicrobial peptide resistance mechanisms in Pseudomonas aeruginosa

(2013) Shawn Lewenza   Frontiers in Microbiology

Functional Specificity of Extracellular Nucleases of Shewanella oneidensis MR-1

(2012) Magnus Heun et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Membrane Vesicle Formation as a Multiple-Stress Response Mechanism Enhances Pseudomonas putida DOT-T1E Cell Surface Hydrophobicity and Biofilm Formation

(2012) Thomas Baumgarten et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

CodY-mediated regulation of Streptococcus pyogenes exoproteins

(2012) Emily J McDowell et al.   BMC MICROBIOLOGY

Chemical Rescue of Active Site Mutants of S. pneumoniae Surface Endonuclease EndA and Other Nucleases of the HNH Family by Imidazole

(2012) Marika Midon et al.   CHEMBIOCHEM

Insight into the composition of the intercellular matrix ofStreptococcus pneumoniaebiofilms

(2012) Mirian Domenech et al.   ENVIRONMENTAL MICROBIOLOGY

Impact of Extracellular Nuclease Production on the Biofilm Phenotype of Staphylococcus aureus underIn VitroandIn VivoConditions

(2012) Karen E. Beenken et al.   INFECTION AND IMMUNITY

Characterization and Functional Analysis of atl, a Novel Gene Encoding Autolysin in Streptococcus suis

(2012) C.-X. Ju et al.   JOURNAL OF BACTERIOLOGY

sarAnegatively regulatesStaphylococcus epidermidisbiofilm formation by modulating expression of 1 MDa extracellular matrix binding protein and autolysis-dependent release of eDNA

(2012) Martin Christner et al.   MOLECULAR MICROBIOLOGY

Involvement of three meningococcal surface-exposed proteins, the heparin-binding protein NhbA, the α-peptide of IgA protease and the autotransporter protease NalP, in initiation of biofilm formation

(2012) Jesús Arenas et al.   MOLECULAR MICROBIOLOGY

Removal of Biofilms from Tracheoesophageal Speech Valves Using a Novel Marine Microbial Deoxyribonuclease

(2012) Adam Shakir et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Contribution of the Staphylococcus aureus Atl AM and GL Murein Hydrolase Activities in Cell Division, Autolysis, and Biofilm Formation

(2012) Jeffrey L. Bose et al.   PLoS One

DNA Builds and Strengthens the Extracellular Matrix in Myxococcus xanthus Biofilms by Interacting with Exopolysaccharides

(2012) Wei Hu et al.   PLoS One

Extracellular DNA Release by Undomesticated Bacillus subtilis Is Regulated by Early Competence

(2012) Olga Zafra et al.   PLoS One

Enterococcus faecalis Produces Abundant Extracellular Structures Containing DNA in the Absence of Cell Lysis during Early Biofilm Formation

(2012) A. M. T. Barnes et al.   mBio

Roles of Two Shewanella oneidensis MR-1 Extracellular Endonucleases

(2011) Julia Gödeke et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Vancomycin promotes the bacterial autolysis, release of extracellular DNA, and biofilm formation in vancomycin-non-susceptible Staphylococcus aureus

(2011) Chi-Yu Hsu et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Pattern differentiation in co-culture biofilms formed byStaphylococcus aureusandPseudomonas aeruginosa

(2011) Liang Yang et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

TheNeisseria gonorrhoeaeBiofilm Matrix Contains DNA, and an Endogenous Nuclease Controls Its Incorporation

(2011) Christopher T. Steichen et al.   INFECTION AND IMMUNITY

Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci

(2011) Jeffrey B Kaplan et al.   JOURNAL OF ANTIBIOTICS

Deletion of  54 (rpoN) Alters the Rate of Autolysis and Biofilm Formation in Enterococcus faecalis

(2011) V. S. Iyer et al.   JOURNAL OF BACTERIOLOGY

The  B-Dependent yabJ-spoVG Operon Is Involved in the Regulation of Extracellular Nuclease, Lipase, and Protease Expression in Staphylococcus aureus

(2011) B. Schulthess et al.   JOURNAL OF BACTERIOLOGY

The Major Autolysin of Streptococcus gordonii Is Subject to Complex Regulation and Modulates Stress Tolerance, Biofilm Formation, and Extracellular-DNA Release

(2011) Y. Liu et al.   JOURNAL OF BACTERIOLOGY

Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy

(2011) Reinhard Manzenreiter et al.   Journal of Cystic Fibrosis

Role of eDNA on the Adhesion Forces betweenStreptococcus mutansand Substratum Surfaces: Influence of Ionic Strength and Substratum Hydrophobicity

(2011) Theerthankar Das et al.   LANGMUIR

Differential Secretomics of Streptococcus pyogenesReveals a Novel Peroxide Regulator (PerR)-regulated Extracellular Virulence Factor Mitogen Factor3 (MF3)

(2011) Yao-Tseng Wen et al.   MOLECULAR & CELLULAR PROTEOMICS

Extracellular nucleases and extracellular DNA play important roles in Vibrio cholerae biofilm formation

(2011) Andrea Seper et al.   MOLECULAR MICROBIOLOGY

Addition of DNase improves the in vitro activity of antifungal drugs against Candida albicans biofilms

(2011) Margarida Martins et al.   MYCOSES

Extracellular DNA Is Essential for Maintaining Bordetella Biofilm Integrity on Abiotic Surfaces and in the Upper Respiratory Tract of Mice

(2011) Matt S. Conover et al.   PLoS One

Nuclease Modulates Biofilm Formation in Community-Associated Methicillin-Resistant Staphylococcus aureus

(2011) Megan R. Kiedrowski et al.   PLoS One

Role of Extracellular DNA during Biofilm Formation by Listeria monocytogenes

(2010) M. Harmsen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effect of Extracellular DNA Destruction by DNase I on Characteristics of Forming Biofilms

(2010) Victor V. Tetz et al.   DNA AND CELL BIOLOGY

Extracellular DNA in Helicobacter pylori biofilm: a backstairs rumour

(2010) R. Grande et al.   JOURNAL OF APPLIED MICROBIOLOGY

Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps

(2010) Evelien T.M. Berends et al.   Journal of Innate Immunity

A dual role of extracellular DNA during biofilm formation ofNeisseria meningitidis

(2010) Martin Lappann et al.   MOLECULAR MICROBIOLOGY

Dispersal of Biofilms by Secreted, Matrix Degrading, Bacterial DNase

(2010) Reindert Nijland et al.   PLoS One

Beta toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms

(2010) M. J. Huseby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions of DNA with Biofilm-Derived Membrane Vesicles

(2009) S. R. Schooling et al.   JOURNAL OF BACTERIOLOGY

A fratricidal mechanism is responsible for eDNA release and contributes to biofilm development ofEnterococcus faecalis

(2009) Vinai Chittezham Thomas et al.   MOLECULAR MICROBIOLOGY

Presence of Extracellular DNA in the Candida albicans Biofilm Matrix and its Contribution to Biofilms

(2009) Margarida Martins et al.   MYCOPATHOLOGIA

Effect of DNase and Antibiotics on Biofilm Characteristics

(2008) G. V. Tetz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Two N-Linked Glycosylation Sites (Asn18 and Asn106) Are Both Required for Full Enzymatic Activity, Thermal Stability, and Resistance to Proteolysis in Mammalian Deoxyribonuclease I

(2008) Junko FUJIHARA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates

(2008) Luanne Hall-Stoodley et al.   BMC MICROBIOLOGY

Identification and characterization of an autolysin gene,atlg, fromStreptococcus sobrinus

(2008) Arisa Yamada et al.   FEMS MICROBIOLOGY LETTERS

The Extracellular Nuclease Dns and Its Role in Natural Transformation of Vibrio cholerae

(2008) M. Blokesch et al.   JOURNAL OF BACTERIOLOGY

Regulation of Autolysis-Dependent Extracellular DNA Release by Enterococcus faecalis Extracellular Proteases Influences Biofilm Development

(2008) V. C. Thomas et al.   JOURNAL OF BACTERIOLOGY

Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

(2008) Heidi Mulcahy et al.   PLoS Pathogens