Article
Immunology
Hussain Albaharna, Hassan Almubiereek, Mohammed Almualim, Rehab Bukhamsin, Ahmed Abdelfattah, Lamia Buohliqah
Summary: This study validated the efficacy of chlorine dioxide wipes in disinfecting three types of airway endoscopes contaminated with COVID-19-positive patient secretions. The results showed that all the post disinfection PCR swab results were negative. Therefore, chlorine dioxide is a convenient, fast, and effective disinfection technique for COVID-19-contaminated airway endoscopes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sunghyun Nam, Doug J. Hinchliffe, Matthew B. Hillyer, Lawson Gary, Zhongqi He
Summary: In this study, a simple and effective method to produce washable antimicrobial wipes was developed using raw cotton fiber to generate silver nanoparticles. Blending the nanocomposite raw cotton fiber in the wipes reduced the viability of S. aureus and P. aeruginosa by 99.9%. The washed wipes exhibited bacterial reductions greater than 98% for both Gram-positive and Gram-negative bacteria, maintaining their antibacterial activities after 30 simulated laundering cycles.
Article
Microbiology
Jia-Feng Liu, Orit Gefen, Zi-Yin Zhang, Min-Min Liu, Maskit Bar-Meir, Nathalie Q. Balaban
Summary: The killing efficacy of antibiotic combinations is rarely measured in the clinical setting. However, this study presents a simple method to determine the killing efficacy of antibiotic combinations, which can identify combinations effective against tolerant bacteria. The findings have the potential to guide antimicrobial therapy in life-threatening infections.
Article
Microbiology
Jia-Feng Liu, Orit Gefen, Zi-Yin Zhang, Min-Min Liu, Maskit Bar-Meir, Nathalie Q. Balaban
Summary: Combination treatments are commonly used to enhance drug efficacy and prevent the evolution of resistance. The killing efficacy of antibiotic combinations is important in infections where the treatment needs to kill the infecting organism, especially when tolerant strains are involved. A visual assay, iTDtest, can be used to evaluate the survival of bacteria under antibiotic combinations and identify combinations effective against tolerant bacteria.
Article
Materials Science, Multidisciplinary
Daniel J. da Silva, Adriana Duran, Aline D. Cabral, Fernando L. A. Fonseca, Rodrigo F. Bueno, Shu Hui Wang, Derval S. Rosa
Summary: Developing cotton fibers with high self-disinfecting ability is crucial in order to prevent new pandemics caused by new variants of SARS-CoV-2. Researchers have developed cotton wipes coated with Ag, TiO2, and Ag/TiO2 hybrid nanoparticles using a sonochemical approach. These coated wipes exhibit strong antimicrobial performance against various pathogens and can effectively inactivate infectious SARS-CoV-2 (Delta variant).
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Environmental Sciences
Thomas Allison, Benjamin D. Ward, Michael Harbottle, Isabelle Durance
Summary: Consumer wet wipes sold as biodegradable and flushable have seen a threefold increase in market size in the last decade, reaching over $3 billion in 2022. However, research shows that these wipes, which consist mainly of cellulosic fibers, do not degrade as claimed and may have negative environmental impacts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Veterinary Sciences
Jacob A. Narbonne, Brian R. Radke, Derek Price, Patrick C. Hanington, Amreen Babujee, Simon J. G. Otto
Summary: Monitoring antimicrobial use in finfish aquaculture is crucial, but there is currently no standardized indicator suitable for reporting antibiotic usage in this industry. The development of suitable indicators will require industry engagement to ensure credibility and value to stakeholders.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Chemistry, Medicinal
Sanjay Prasad Selvaraj, Jyh-Yih Chen
Summary: The increasing antimicrobial resistance has led to a rise in deaths from multidrug-resistant infections. Discovery and development of novel antimicrobials are urgently needed. Antimicrobial peptides (AMPs) are a promising class of molecules with broad-spectrum activities and low resistance rates. However, issues of structural instability, degradation, and toxicity limit their clinical use. Structural modifications, such as conjugation with other biomolecules, can help overcome these limitations.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Leman Buzoglu Kurnaz, Yuanyuan Luo, Xiaoming Yang, Amjed Alabresm, Ryan Leighton, Rani Kumar, JiHyeon Hwang, Alan W. Decho, Prakash Nagarkatti, Mitzi Nagarkatti, Chuanbing Tang
Summary: Facial amphiphilicity is a unique chemical structure feature of antimicrobial peptides and polymers, and it has been extensively studied. This research introduces the Facial Amphiphilicity Index (FAI) as a quantitative measure to characterize the chemical compositions and structural features that determine antimicrobial efficacy. The study finds that larger cross-sectional areas contribute to better antimicrobial efficacy, while intermediate FAIs are more suitable for specific antimicrobial systems.
BIOACTIVE MATERIALS
(2023)
Review
Infectious Diseases
Vanessa Teixeira Marinho, Andrea Candido dos Reis, Mariana Lima da Costa Valente
Summary: The systematic review aimed to assess the effectiveness of different antimicrobial agents in reducing microorganism numbers in dentifrices for disease prevention. Chemical and herbal antimicrobial agents were commonly used in dentifrices, showing varied effectiveness in reducing microorganisms involved in oral diseases.
Article
Infectious Diseases
Katharina Rynkiewich, Kruthika Uttla, Leila Hojat
Summary: Antimicrobial stewardship programs have various impacts on medical practice, including cost reduction, antimicrobial resistance control, and adverse event prevention. However, the value of antimicrobial stewardship is perceived differently by medical practitioners, and non-physician practitioners are often excluded from antimicrobial decision-making interventions. This study highlights the limited autonomy of resident physicians and pharmacy specialists in the clinical setting and their tendency to overtreat due to pressure for safety. The perspectives and rationales of physicians in training and non-physician practitioners demonstrate the influence of individuals at all levels of medical practice on antimicrobial prescribing behavior.
Article
Materials Science, Textiles
Rim Cheriaa, Jaouachi Boubaker
Summary: The study focused on the composition and efficiency of wet wipes, determining optimal lotion stirring conditions, foamability phenomenon, and the ideal usage and moisture content of wet wipes. These findings provide valuable insights for the manufacturing and end use of wet wipes.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Multidisciplinary Sciences
Kaiyang Lim, Wei Yi Li, Afrah Dinata, En Ting Ho
Summary: In light of the COVID-19 pandemic, the use of alcohol-based sanitizers with secondary active ingredients is recommended for effective and prolonged antimicrobial protection. These sanitizers demonstrate a more rapid antimicrobial mode of action, prevent biofilm formation, and provide longer-lasting surface protection.
Review
Microbiology
Gisele Rodrigues, Lucas Souza Santos, Octavio Luiz Franco
Summary: Antimicrobial resistance (AMR) has become a global concern in recent decades due to the excessive use of antibiotics. This has led to genetic modifications in bacteria and the spread of AMR to both pathogenic and commensal bacteria. The presence of antibiotic residues in water, soil, and food has also raised concerns about public health risks. As a potential alternative to traditional antibiotics, antimicrobial peptides (AMPs) have shown promise in animal diets. However, their widespread use is hindered by issues such as in-vivo effectiveness, stability, and high production costs.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Infectious Diseases
Alexander J. Cunliffe, Peter D. Askew, Ina Stephan, Gillian Iredale, Patrick Cosemans, Lisa M. Simmons, Joanna Verran, James Redfern
Summary: This review provides a critical analysis of standardized methodology used in academia and industry, and demonstrates how many key methodological choices may impact efficacy assessment, highlighting the need to carefully consider intended antimicrobial end-use of any product.
Article
Biotechnology & Applied Microbiology
M. E. Rubiano, J. -Y. Maillard, J. R. Rubino, M. K. Ijaz
LETTERS IN APPLIED MICROBIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
R. Wesgate, C. Evangelista, R. Atkinson, A. Shepard, O. Adegoke, J. -Y. Maillard
JOURNAL OF APPLIED MICROBIOLOGY
(2020)
Article
Microbiology
Rebecca Wesgate, Florence Menard-Szczebara, Ahmad Khodr, Sylvie Cupferman, Jean-Yves Maillard
JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Laura Rushton, Ahmad Khodr, Florence Menard-Szczebara, Jean-Yves Maillard, Sylvie Cupferman, Eshwar Mahenthiralingam
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Microbiology
R. Wesgate, S. Fanning, Y. Hu, J-Y Maillard
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Microbiology
Tristan Rossignol, Sadri Znaidi, Murielle Chauvel, Rebecca Wesgate, Laurence Decourty, Florence Menard-Szczebara, Sylvie Cupferman, Maria Dalko-Sciba, Rosemary Barnes, Jean-Yves Maillard, Cosmin Saveanu, Christophe d'Enfert
Summary: HEPB demonstrates strong antifungal activity against Candida species, inhibiting their growth by promoting amino acid biosynthesis and chemical detoxification/oxidative stress response pathways. The mode of action of HEPB is distinguishable from other commonly used preservatives such as triclosan and methylparaben.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
M. J. Pascoe, J. -Y. Maillard
Summary: Cationic biocides are widely used for surface disinfection, while photosensitizers like TBO are being investigated as novel biocides. Melanin in Aspergillus brasiliensis conidia confers resistance to biocides and photosensitizers. Benzalkonium chloride, sodium dichloroisocyanurate, and TBO were highly effective against Candida albicans, but A. brasiliensis conidia showed tolerance to TBO and BZC, with NaDCC being the most effective. Inhibition of melanin biosynthesis increased sensitivity to all three biocides.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Katarzyna Ledwoch, Maddalena Magoga, Dulcie Williams, Stefania Fabbri, James Walsh, Jean-Yves Maillard
Summary: This study investigated the impact of treatments on bacterial viability, transferability, and recovery in dry-surface biofilms for the first time. The results showed that while many disinfectants were effective in killing and removing bacteria from DSBs, only a few could reduce bacterial transmission and prevent DSB recovery. Treatments without mechanical action had poorer effectiveness on DSBs.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Isabella Centeleghe, Phillip Norville, Louise Hughes, Jean-Yves Maillard
Summary: This study aimed to produce a dual species dry surface biofilm (DSB) and evaluate the efficacy of commercially available wipe products in eliminating pathogens within a dual species DSB and preventing their transfer. The results showed that some wipe products were effective in eliminating pathogens, but were not effective in preventing the transfer of Staphylococcus aureus between surfaces. This study provides important insights into the behavior of dual species DSB and the suitability of wipe products for disinfection.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jean-Yves Maillard
Summary: This review examined the impact of benzalkonium chloride (BKC), benzethonium chloride (BZT), and chloroxylenol (CHO) on antimicrobial resistance. The majority of studies used MIC to measure BKC efficacy, but the definition of "resistance" varied. In vitro studies showed that BKC exposure led to increased resistance and changes in antibiotic susceptibility profile, but the clinical significance and the correlation between BKC usage and gene dissemination remain uncertain. Limited research on BZT and CHO makes it difficult to draw conclusions about their impact on emerging resistance.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Jean-Yves Maillard, Phil Collier, Katherine Hammer
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zahraa Amer Hashim, Jean-Yves Maillard, Melanie Jay Wilson, Rachel Jane Waddington
Summary: Microbial biofilms are dominant in endodontic therapy failure, with bacterial adhesion as the first step in biofilm establishment. This study extracted and characterized a biosurfactant (Lp-BS) from Lactobacillus (L.) plantarum, revealing its anti-adhesive properties against Streptococcus (Strep.) intermedius and Strep. anginosus.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2022)
Review
Microbiology
Jean-Yves Maillard, Michael Pascoe
Summary: In this Review, the authors examine the mechanisms of action, resistance mechanisms, and implications of chemical biocides in various settings.
NATURE REVIEWS MICROBIOLOGY
(2023)
Review
Infectious Diseases
Jean-Yves Maillard, Guenter Kampf, Rose Cooper
Summary: This review discusses the challenges faced in wound care due to the emergence of antibiotic-resistant strains, the tolerance of biofilms to antibiotics, and reported resistance to non-antibiotic antimicrobials. It also highlights the lack of standardized methods for evaluating the efficacy of antimicrobial dressings, as well as the difficulties in surveillance and management. The review calls for a unified approach to developing standardized methods that will provide a better basis for practitioners to make informed choices in wound care.
JAC-ANTIMICROBIAL RESISTANCE
(2021)
Article
Materials Science, Biomaterials
Lauren Gwynne, George T. Williams, Kai-Cheng Yan, Bethany L. Patenall, Jordan E. Gardiner, Xiao-Peng He, Jean-Yves Maillard, Tony D. James, Adam. C. Sedgwick, A. Toby. A. Jenkins
Summary: Alkaline phosphatase (ALP) is an important enzyme biomarker with potential in detecting pathogenic bacteria. Research has shown that ALP has colorimetric and fluorescent responses towards Staphylococcus aureus and demonstrates selectivity over other bacteria. Encapsulation of ALP in hydrogels can be used as smart wound dressings for monitoring and treating wound infections.
BIOMATERIALS SCIENCE
(2021)