Article
Public, Environmental & Occupational Health
Rebecca Simmonds -Cavanagh
Summary: This study aimed to determine the duration of pathogenic bacteria's viability on mobile phones. The results showed that the bacteria could survive for an extended period, indicating the potential for cross-transmission within and outside the hospital. Mobile phone decontamination should be combined with hand hygiene to prevent infection.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Microbiology
Menghuan Yu, Haimei Shi, Hao Shen, Xueqin Chen, Li Zhang, Jianhua Zhu, Guoqing Qian, Bin Feng, Shaoning Yu
Summary: Oxacillin sodium salt combined with Gram staining and machine vision (MV) analysis is a new, simple and rapid method for identification of MRSA, which significantly reduces the time to detect resistance.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pediatrics
Cortney Foster, Dayanand Bagdure, Jason Custer, Adrian Holloway, Peter Rycus, Jenni Day, Adnan Bhutta
Summary: In this study of 308 patients, there were no significant differences in outcomes for children receiving ECMO support with Staphylococcus aureus sepsis according to microbial methicillin sensitivity, with no increase in survival among patients with MRSA and MSSA infections.
FRONTIERS IN PEDIATRICS
(2021)
Article
Infectious Diseases
Beatriz Muller Nunes Souza, Juliana Guerra Pinto, Andre Henrique Correia Pereira, Alejandro Guillermo Minan, Juliana Ferreira-Strixino
Summary: The study found that the use of PDZ for antimicrobial photodynamic therapy has a significant bactericidal effect on Staphylococcus aureus, including complete inactivation of MRSA strains.
Article
Veterinary Sciences
Ting Gan, Gang Shu, Hualin Fu, Qigui Yan, Wei Zhang, Huaqiao Tang, Lizi Yin, Ling Zhao, Juchun Lin
Summary: S. aureus isolates from food animals in Sichuan province of China demonstrate severe antimicrobial resistance with various resistance genes, especially MRSA isolates. The genetic pool of MRSA isolates is diverse and complex, indicating the need for further investigation.
BMC VETERINARY RESEARCH
(2021)
Article
Microbiology
Aya Abd El Rahman, Yasmine El Kholy, Rania Y. Shash
Summary: The study revealed that methicillin-resistant Staphylococcus aureus (MRSA) is more proficient in biofilm-formation compared to methicillin-sensitive Staphylococcus aureus (MSSA). Furthermore, the expression of mazEF was significantly correlated to methicillin resistance in Staphylococcus aureus.
Article
Biochemistry & Molecular Biology
Fabien Lamret, Jennifer Varin-Simon, Melodie Six, Lea Thoraval, Julie Chevrier, Cloe Adam, Christine Guillaume, Frederic Velard, Sophie C. Gangloff, Fany Reffuveille
Summary: Osteoblasts and Staphylococcus aureus interactions can lead to impaired bone homeostasis. This study found that human osteoblast culture supernatant has a moderate effect on S. aureus biofilm formation, but does not significantly change the biofilm matrix or regulation of biofilm-related genes. Additionally, the sensitivity of S. aureus to bone cell secretions is strain-dependent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Arianna Pani, Valeria Lucini, Silvana Dugnani, Francesco Scaglione
Summary: This study evaluated the effects of erdosteine in combination with different antibiotics against Staphylococcus aureus biofilms. The results showed that erdosteine enhanced the activity of antibiotics and reduced biofilm mass and bacterial viability. This suggests that erdosteine has potential clinical value in treating biofilm-related infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Infectious Diseases
Daniele Roberto Giacobbe, Silvia Dettori, Silvia Corcione, Antonio Vena, Chiara Sepulcri, Alberto Enrico Maraolo, Francesco Giuseppe De Rosa, Matteo Bassetti
Summary: Staphylococcus aureus is an important human pathogen with a high mortality rate, and distinguishing between methicillin-susceptible and methicillin-resistant strains is crucial for treatment choices. The availability of approved agents with anti-MRSA activity allows for personalized treatment based on patient characteristics and evidence from controlled trials. In the treatment of S. aureus bloodstream infections, the development of new agents and the need for evidence on combination therapy are important considerations.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Clinical Neurology
Rodrigo Saad Berreta, Helen Zhang, Daniel Alsoof, Christopher L. McDonald, Bassel G. Diebo, Eren Kuris, Alan H. Daniels
Summary: This study investigated the epidemiological and microbiological landscape of spinal osteomyelitis and spondylodiscitis (SD), as well as the medical and surgical challenges in treating these infections. It found that more than 50% of SD cases were associated with Staphylococcus aureus, and there was an increasing prevalence of methicillin-resistant S. aureus (MRSA) in these infections. Substance abuse, such as alcohol, tobacco, and drug use, was a strong predictor for surgical intervention in SD cases.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Article
Immunology
Mehmet Demirci, Akin Yigin, Cemil Demir
Summary: This study investigated the antimicrobial and biofilm efficacy of the antimicrobial peptide LL-37 against biofilm-positive methicillin-susceptible S. aureus (MSSA) strains and biofilm-positive methicillin-resistant S. aureus (MRSA) strains, as well as its effects on gene expression levels. The results showed that LL-37 had inhibitory effects on biofilm formation in both MRSA and MSSA strains, and significantly affected gene expression levels in MRSA strains. The required antimicrobial concentration of LL-37 was high, but the antibiofilm concentration may be acceptable for use in humans.
MICROBIAL PATHOGENESIS
(2022)
Article
Microbiology
Fabien Lamret, Jennifer Varin-Simon, Frederic Velard, Christine Terryn, Celine Mongaret, Marius Colin, Sophie C. Gangloff, Fany Reffuveille
Summary: Staphylococcus aureus poses a significant threat in hospital healthcare, often forming biofilms on medical devices like bone and joint prostheses leading to treatment failure. Different strains of S. aureus exhibit varying responses in a bone-like environment, but share common traits of producing extracellular DNA and engaging in the SOS response. This study sheds light on potential common targets for antibiofilm strategies against S. aureus.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Ameni Arfaoui, Rym Ben Sallem, Rosa Fernandez-Fernandez, Paula Eguizabal, Raoudha Dziri, Idris Nasir Abdullahi, Noureddine Sayem, Salma Ben Khelifa Melki, Hadda-Imen Ouzari, Carmen Torres, Naouel Klibi
Summary: This study analyzed the antimicrobial resistant phenotypes and genotypes, as well as the virulence content, of S. aureus isolates from patients with diabetic foot infections in a Tunisian hospital. The study found a high prevalence of S. aureus in DFIs, with genetic diversity among the MSSA and MRSA isolates. This is the first report on the prevalence and molecular characterization of S. aureus from DFIs in Tunisia.
Article
Infectious Diseases
Fred C. Tenover, Isabella A. Tickler
Summary: The application of molecular detection methods has greatly improved the outcomes of septic patients with MRSA infections. However, the accuracy of molecular tests may be affected by the presence of other staphylococcal species and genetic mutations. Phenotypic methods should be considered when resolving discrepancies between genotypic and phenotypic results.
Article
Veterinary Sciences
Lijiao Yan, Yuze Yang, Xiaojun Ma, Lianhua Wei, Xuerui Wan, Zhao Zhang, Jucai Ding, Jie Peng, Guo Liu, Huitian Gou, Chuan Wang, Xiaoli Zhang
Summary: This study investigated the effects of different drug-resistant S. aureus on dairy cow mammary epithelial cells. The adhesion, invasion, and apoptosis ability of MRSA-infected and MSSA-infected MAC-T cells were assessed over time. RNA sequencing revealed differentially expressed mRNAs in both groups compared to uninfected cells, with these genes being involved in immune response, inflammation, apoptosis, and other processes. Overall, the study provides valuable insights into the prevention of mastitis in the dairy industry.
FRONTIERS IN VETERINARY SCIENCE
(2022)