Article
Pharmacology & Pharmacy
Roberto Rosales-Rojas, Matias Zuniga-Bustos, Francisca Salas-Sepulveda, Constanza Galaz-Araya, Ricardo A. Zamora, Horacio Poblete
Summary: This study focuses on the computational investigation of the structural micro-organization of hydrogels based on collagen-like peptides (CLPs) in complex with Rose Bengal (RB). The results suggest that RB can stabilize ordered three-dimensional structures and provide a basis for the development of improved synthetic peptides for photochemical tissue bonding therapies.
Article
Biochemistry & Molecular Biology
Anastasia S. Kuryanova, Marina A. Savko, Vladislav S. Kaplin, Nadezhda A. Aksenova, Victoria A. Timofeeva, Aleksandr Chernyak, Nicolay N. Glagolev, Petr S. Timashev, Anna B. Solovieva
Summary: The influence of chitosan and amphiphilic polymers on the photocatalytic activity of rose bengal was studied. It was shown that the presence of chitosan decreases the effective rate constant of tryptophan photo-oxidation catalyzed by rose bengal. The introduction of amphiphilic polymers into the solution prevents direct interaction between rose bengal and chitosan, leading to the preservation of dye's photocatalytic activity.
Article
Biochemistry & Molecular Biology
Alina Bekmukhametova, Anu Antony, Catriona Halliday, Sharon Chen, Chun-Hoong Ho, Mir Muhammad Nasir Uddin, Leonardo Longo, Christian Pedrinazzi, Laurel George, Richard Wuhrer, Simon Myers, Damia Mawad, Jessica Houang, Antonio Lauto
Summary: Rose bengal (RB) solutions combined with a green laser have been effective in treating stubborn nail infections caused by Trichophyton rubrum. However, the RB solution can be diluted or dispersed, making it difficult to reach the infected area. To overcome this issue, RB-encapsulated chitosan nanoparticles have been synthesized, which can effectively penetrate the nail and kill the common pathogens in onychomycosis. These nanoparticles are safe for human cells, making them suitable for clinical use.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Medicine, General & Internal
Kai-Ying Lin, Yeou-Guang Tsay, C. Allen Chang
Summary: Experimental evidence indicates that the outer polyallylamine (PAH) coat plays a key role in enhancing the biological activities of photosensitizer delivered via nanoparticles (NPs), including an increase in singlet oxygen production and photocytotoxic effects.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Surgery
Nicholas C. King, Kalyn R. McGuire, Maria Bejar-Chapa, Yannick A. J. Hoftiezer, Mark A. Randolph, Jonathan M. Winograd
Summary: This study investigated the biomechanical properties of different collagen membranes used for peripheral nerve repair. The results showed that commercial noncrosslinked amnion allograft membranes can withstand physiological strain and have comparable performance to repairs with human amnion.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Constanza Alvarez-Lopez, Daniela Cavazos-Elizondo, Belinda Heyne, Irene E. Kochevar, Alan Aguirre-Soto
Summary: Photosensitized crosslinking of proteins in tissues has various medical applications. Rose Bengal (RB), commonly used as a photosensitizer, is not as efficient as desired. Nanocages, specifically hydroxypropyl-functionalized cyclodextrins, can inhibit RB aggregation and enhance photo-bleaching and oxygen consumption rates. These results suggest that nanocages have the potential to improve the efficiency of photo-medical therapies.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Review
Chemistry, Applied
Sara Demartis, Antonella Obinu, Elisabetta Gavini, Paolo Giunchedi, Giovanna Rassu
Summary: Rose Bengal, an anionic xanthene dye derived from fluorescein, originally used as a textile dye, is now primarily known in ophthalmology and biomedical field. It exhibits intrinsic cytotoxicity against tumor and microbial cells, making it suitable for sono-photodynamic therapy. However, due to its disadvantageous bio-pharmaceutical profile, it is currently approved only for ocular diagnostics.
Article
Chemistry, Organic
Goutam Brahmachari, Anindita Bhowmick, Indrajit Karmakar
Summary: A new series of biologically interesting 3-(alkyl/benzylthio)-4-hydroxy-2H-chromen-2-ones have been synthesized through a photochemical method driven by visible light, such as white light-emitting diodes or direct sunlight. The notable features of this newly developed method include mild reaction conditions, high energy efficiency, metal-free synthesis, good to excellent yields, and the use of low-cost materials, making it eco-friendly.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Nanako Sumi, Shota Nagahiro, Eiji Nakata, Kazunori Watanabe, Takashi Ohtsuki
Summary: TatU1A-RB, an ultrasound-sensitive RNA carrier molecule, delivers RNA through endocytosis and achieves endosomal escape and cytosolic dispersion by ultrasound. This ultrasound-dependent RNA delivery method serves as the foundation for novel nucleic acid therapeutics.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Endocrinology & Metabolism
Patrick Delafontaine-Martel, Cong Zhang, Xuecong Lu, Rafat Damseh, Frederic Lesage, Paul J. Marchand
Summary: Microvascular stalling, a temporary loss of perfusion in capillaries, has gained attention in various neuropathologies. A new methodology using multiphoton excitation of Rose Bengal is presented to enable transient occlusions of targeted microvascular segments. The experiments demonstrate reversible blockages in mice, activated by a femtosecond laser, and the occlusion duration is examined using Optical Coherence Microscopy. It is concluded that blood flow cessation is caused by the photothrombotic agent and attributed to neutrophil adherence in the vascular lumen.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biophysics
Catia Correia, Rita O. Sousa, A. Catarina Vale, Daniela Peixoto, Tiago H. Silva, Rui L. Reis, Iva Pashkuleva, Natalia M. Alves
Summary: This study describes the development of bioadhesive membranes using marine renewable biomaterials, chitosan and collagen extracted from fish skins. The functionalization of collagen with catechol groups enhances the adhesive and mechanical properties of the membranes, leading to improved cell attachment and proliferation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Yanna Gurianov, Michael Meistelman, Yael Albo, Marina Nisnevitch, Faina Nakonechny
Summary: This study reports the incorporation of Rose Bengal into organically modified silica matrices using the sol-gel technique. The addition of solidifier to the matrix was found to affect the antibacterial activity of Rose Bengal. The RB6@ORMOSIL matrix immobilized on a linear low-density polyethylene surface exhibited the highest antibacterial activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Anupam Das, K. R. Justin Thomas
Summary: This report presents a sustainable and greener method for Knoevenagel condensation reaction using rose bengal as a photosensitizer in an aqueous medium. The protocol works smoothly for aromatic aldehydes and ketones containing both electron-donating and electron-withdrawing substituents.
Article
Biochemical Research Methods
Jessica Houang, Catriona Halliday, Sharon Chen, Chun-Hoong Ho, Alina Bekmukhametova, Antonio Lauto
Summary: The study demonstrated that photodynamic therapy using Rose Bengal can act against a broader spectrum of fungal pathogens, potentially expanding its clinical antifungal applications.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Chemistry, Physical
P. O. Maksimchuk, K. O. Hubenko, I. I. Bespalova, A. Sorokin, I. A. Borovoy, S. L. Yefimova
Summary: The study presents the creation of nanocomplexes based on scintillation nanoparticles and organic photosensitizers for efficient energy transfer and singlet oxygen generation under UV and X-ray irradiation, suitable for X-ray activated photodynamic therapy. It is shown for the first time that LaF3:Tb3+ SNPs can produce hydroxyl radicals under X-ray irradiation, addressing the low efficiency issue of conventional PDT in hypoxic areas of tumors.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Lorenzo Travaglini, Adam P. Micolich, Claudio Cazorla, Erica Zeglio, Antonio Lauto, Damia Mawad
Summary: The organic electrochemical transistor (OECT) with a conjugated polymer as the active material serves as the elementary unit of organic bioelectronic devices. By utilizing a complementary circuit with PANI as the channel material in both transistors, low power consumption and excellent performance can be achieved. This PANI-based circuit demonstrates a gain of approximately 7 and operates effectively in aqueous electrolyte on a flexible biocompatible chitosan substrate.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemical Research Methods
Jessica Houang, Catriona Halliday, Sharon Chen, Chun-Hoong Ho, Alina Bekmukhametova, Antonio Lauto
Summary: The study demonstrated that photodynamic therapy using Rose Bengal can act against a broader spectrum of fungal pathogens, potentially expanding its clinical antifungal applications.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Materials Science, Biomaterials
Md Lutful Amin, Damia Mawad, Socrates Dokos, Pramod Koshy, Penny Jo Martens, Charles C. Sorrell
Summary: The study demonstrated that highly crosslinked PVA-fucoidan and PVA-carrageenan hydrogels can control the permeation of inflammatory cytokines while allowing the passage of globular proteins. Physicochemical characterization and release studies showed the stability of the hydrogels and minimal cytokine permeation, making them potential candidates for cytokine-protective implantable devices in clinical applications.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Neurosciences
Rustam Asgarov, Monokesh K. Sen, Meena Mikhael, Tim Karl, Erika Gyengesi, David A. Mahns, Chandra S. Malladi, Gerald W. Munch
Summary: The study investigated the cerebellum proteome of GFAP-IL6 transgenic mice and found that changes in protein form levels associated with IL-6 overexpression may contribute to motor function deficits. Analysis revealed differentially expressed proteoforms in three classes related to metabolism, neurodegenerative processes, and protein aggregation in the cerebellum. Additionally, impaired motor skills in transgenic mice were correlated with specific proteoform expression levels.
Article
Chemistry, Multidisciplinary
Yazhou Wang, Erica Zeglio, Lewen Wang, Shengyu Cong, Genming Zhu, Hailiang Liao, Jiayao Duan, Yecheng Zhou, Zhengke Li, Damia Mawad, Anna Herland, Wan Yue, Iain McCulloch
Summary: This study reports a series of novel donor-acceptor-conjugated polymers for n-type organic electrochemical transistors (OECTs) synthesized through an economic and environmentally friendly method. The polymers exhibit high electron mobility and ionic conductivity, resulting in high-performance OECTs. Analysis of the microstructure of the devices reveals the reasons behind their superior performance. The design strategy provides a metal-free and inexpensive route for synthesizing n-type OECTs.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Jonathan Hopkins, Kristina Fidanovski, Lorenzo Travaglini, Daniel Ta, James Hook, Pawel Wagner, Klaudia Wagner, Antonio Lauto, Claudio Cazorla, David Officer, Damia Mawad
Summary: PEDOT-Phos, a new conjugated polymer, shows great promise as a channel material for energy-efficient, bioelectronic devices. It combines a PEDOT backbone with alkyl-protected phosphonate groups, exhibiting efficient operation in aqueous OECTs, long-term stability, and good performance comparable to other PEDOT-based materials.
CHEMISTRY OF MATERIALS
(2022)
Review
Neurosciences
Monokesh K. Sen, David A. Mahns, Jens R. Coorssen, Peter J. Shortland
Summary: Microglia and astrocytes play important roles in the clearance of myelin debris and remyelination in human demyelinating diseases. Recent studies have shown that up-regulation of signaling proteins in microglia facilitates effective phagocytosis of myelin debris and the release of protective mediators accelerates remyelination. However, inadequate activation or recruitment of microglia, as well as the production of toxic mediators, impairs remyelination and leads to progressive demyelination.
Article
Dermatology
Alina Bekmukhametova, Mir Muhammad Nasir Uddin, Jessica Houang, Chandra Malladi, Laurel George, Richard Wuhrer, Shital K. Barman, Ming J. Wu, Damia Mawad, Antonio Lauto
Summary: A simple protocol was established to prepare and purify biocompatible chitosan nanoparticles with a peak size of approximately 200 nm. These nanoparticles can be coupled with photodynamic treatment and exhibit remarkable antitumor activity.
LASERS IN SURGERY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mohammed S. M. Almuslehi, Monokesh K. Sen, Peter J. Shortland, David A. Mahns, Jens R. Coorssen
Summary: A study using histology and proteomics found that a change in visual perception is an early symptom of multiple sclerosis (MS). Although histological investigation did not detect clear pathological changes, proteomic analysis revealed significant alterations in protein forms in the optic nerve, suggesting that these proteoforms could serve as potential early markers for degenerative demyelinating conditions.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Muhammad Sana Ullah Sahar, Tamer Mettyas, Megha Shah, Randy Bindra, Matthew Barton
Summary: This study presents a technique to translate ex-vivo axonal stretch growth to in-vivo nerve stretch growth. By examining the regrowth rate of a transected sciatic nerve in a rat model, the authors found that applying a controlled amount of negative pressure to the resected ends of the nerve resulted in enhanced growth rate of regenerating nerve fibers.
NEUROSCIENCE LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Modi Gu, Lorenzo Travaglini, Jonathan Hopkins, Daniel Ta, Antonio Lauto, Pawel Wagner, Klaudia Wagner, Erica Zeglio, Lilli Jephcott, David L. Officer, Damia Mawad
Summary: In this study, a random copolymer P(EDOTCOOH-co-EDOTS) was designed and synthesized based on functionalized EDOT monomers. The copolymer exhibited high hydrophilicity and enhanced volumetric capacitance, leading to improved performance as an active channel in an organic electrochemical transistor.
Article
Multidisciplinary Sciences
Tuan-Khoa Nguyen, Matthew Barton, Aditya Ashok, Thanh-An Truong, Sharda Yadav, Michael Leitch, Thanh-Vinh Nguyen, Navid Kashaninejad, Toan Dinh, Leonie Hold, Yusuke Yamauchi, Nam-Trung Nguyen, Hoang-Phuong Phan
Summary: Electrical neuron stimulation using flexible electrodes is a promising solution for treating neurological disorders. This article presents a concept of long-lived flexible neural electrodes using silicon carbide (SiC) nanomembranes and thermal oxide thin films. The proposed material system offers excellent stability and scalability, and has been demonstrated to be effective in an animal model.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Biochemistry & Molecular Biology
Emily Lowe-Calverley, Matthew Barton, Michael Todorovic
Summary: With universities transitioning to online education, the focus has shifted towards identifying best practices and considering nontraditional platforms. In this article, we explore how social media can offer accessible and high-quality medical education experiences.
TRENDS IN MOLECULAR MEDICINE
(2022)
Review
Engineering, Biomedical
Kristina Fidanovski, Modi Gu, Lorenzo Travaglini, Antonio Lauto, Damia Mawad
Summary: Conjugated polymers play a crucial role in flexible bioelectronics due to their organic nature that allows for modification and tuning. The use of dopants in organic semiconductors can result in deterioration of electronic properties, leading to the development of self-doped and self-acid-doped polymers. While the terms are often used interchangeably, their doping mechanisms differ, with self-doped polymers requiring an external dopant for charge transfer and self-acid-doped polymers being inherently doped. Drawing a distinction between the two categories is important to understand their unique properties and potential applications. Examples of self-acid-doping in bioelectronics highlight the stability of these polymers under physiological conditions. However, a lack of clarity in terminology in the literature limits the understanding and development of these important bioelectronic components.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Engineering, Biomedical
Reem M. Almasri, Francois Ladouceur, Damia Mawad, Dorna Esrafilzadeh, Josiah Firth, Torsten Lehmann, Laura A. Poole-Warren, Nigel H. Lovell, Amr Al Abed
Summary: Optrode arrays utilize light to modulate biological tissues and transduce bioelectrical signals into the optical domain. This review provides an overview of devices and material systems that use light for electrophysiology recording and stimulation.
APL BIOENGINEERING
(2023)
