Article
Neurosciences
Guillermo L. L. Monroy, Mohsen Erfanzadeh, Michael Tao, Damon T. T. DePaoli, Ilyas Saytashev, Stephanie A. A. Nam, Harmain Rafi, Kasey C. C. Kwong, Katherine Shea, Benjamin J. J. Vakoc, Srikanth Vasudevan, Daniel X. X. Hammer
Summary: Neuromodulation devices are advancing rapidly and are used for treating neurological diseases and conditions. This study demonstrates an imaging and stimulation platform that can assess the biological effects and mechanisms of neurostimulation in the peripheral nervous system. The platform is applied to the sciatic nerve to detect excessive electrical stimulation.
Article
Chemistry, Multidisciplinary
Min Woo Lee, Namseon Jang, Nara Choi, Sungwook Yang, Jinwoo Jeong, Hyeong Soo Nam, Sang-Rok Oh, Keehoon Kim, Donghyun Hwang
Summary: The study introduces an optical coherence tomography-based imaging platform for visualizing the microstructural changes of peripheral nerves in vivo, which could potentially address chronic implantation failure and improve outcomes for amputated patients.
Article
Multidisciplinary Sciences
Thomas Pearson, Yingdi Chen, Baljean Dhillon, Siddharthan Chandran, Jano van Hemert, Tom MacGillivray
Summary: Our study investigated changes to the retina in multiple sclerosis (MS) using various modes of retinal image acquisition and analysis. The results showed that individuals with MS had a thinner retinal nerve fibre layer (RNFL) and reduced macular volume compared to healthy volunteers. Additionally, the blood vessel widths in the retinal periphery were also found to be altered in participants with MS.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Christopher A. Girkin, Akram Belghith, Christopher Bowd, Felipe A. Medeiros, Robert N. Weinreb, Jeffrey M. Liebmann, James A. Proudfoot, Linda M. Zangwill, Massimo A. Fazio
Summary: The study aimed to determine if the rate of change in the depth of the surface of the lamina cribrosa due to glaucomatous remodeling differs between glaucoma patients of African descent (AD) and European descent (ED). After adjusting for baseline characteristics, it was found that the ED group had significantly greater ALCSD posterior migration compared to the AD group.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Optics
Zunyue Zhang, Yi Wang, Jiarui Wang, Dan Yi, David Weng U. Chan, Wu Yuan, Hon Ki Tsang
Summary: In this study, a compact integrated scanning spectrometer is proposed, which utilizes a tunable micro-ring resonator and a single arrayed waveguide grating to achieve wide optical bandwidths and high spectral resolutions. The integrated spectrometer with germanium photodetectors demonstrates excellent performance.
PHOTONICS RESEARCH
(2022)
Article
Biochemical Research Methods
Ilyas Saytashev, Yong-Chul Yoon, Benjamin J. J. Vakoc, Srikanth Vasudevan, Daniel X. X. Hammer
Summary: Modern optical volumetric imaging techniques, such as OCT, provide valuable information about living tissue. This study aims to improve in vivo OCT imaging during peripheral neurosurgery in small and large animals by increasing the visualized nerve volume and suppressing motion artifacts in the imaged area. The use of mirror prisms for axially imaged volumes significantly increased the OCT signal intensity.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Optics
Jianan Fang, Kun Huang, E. Wu, Ming Yan, Heping Zeng
Summary: This article introduces an infrared 3D imaging system capable of detecting three-dimensional structure and reflectivity information. The system operates at single-photon sensitivity and femtosecond timing resolution, enabling imaging under low-light conditions. By nonlinear frequency upconversion and recording with a silicon camera, the presented system achieves high lateral and depth resolutions for 3D reconstruction. Additionally, a numerical denoiser based on spatiotemporal correlation allows the retrieval of object profile and reflectivity even with a detected flux below 0.05 photons/pixel/second. This infrared 3D imager features high detection sensitivity, precise timing resolution, and wide-field operation, offering new possibilities in life and material sciences.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Orthopedics
M. Goodwin, M. Klufts, J. Workman, A. Thambyah, F. Vanholsbeeck
Summary: This study explores the potential of polarization-sensitive optical coherence tomography (PS-OCT) to rapidly identify subtle signs of tissue degeneration in horse joints. The results show that PS-OCT can non-invasively detect sub-surface microstructural changes associated with early stages of joint tissue degeneration, which are not visible with dissection and microscopy.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Optics
Daewoon Seong, Won Ki, Pilun Kim, Jaeyul Lee, Sangyeob Han, Soojin Yi, Hong Kyun Kim, Mansik Jeon, Jeehyun Kim
Summary: This study developed a virtual intraoperative OCT angiography integrated surgical microscope, which can simultaneously visualize the morphological tissue structure and microvasculature data of the surgical region, demonstrating its potential application in in vivo imaging and simulated surgeries of small animals.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Kaveri A. Thakoor, Jiaang Yao, Darius Bordbar, Omar Moussa, Weijie Lin, Paul Sajda, Royce W. S. Chen
Summary: This study describes a deep learning approach using multimodal data to detect age-related macular degeneration (AMD) and its biomarkers. By applying Convolutional Neural Networks (CNNs), the accuracy of biomarker prediction reached up to 90.2% (with a positive predictive value of up to 75.8%), offering the potential to expedite screening of early and late-stage AMD patients.
SCIENTIFIC REPORTS
(2022)
Article
Optics
Tanbin Shao, Kecheng Yang, Min Xia, Wenping Guo
Summary: In this study, an enhanced dispersion-encoded full-range spectral interferometry technique is proposed and validated for improving measurement accuracy in samples with significant depth, inclination, and roughness. By removing the direct current and preserving data with good phase continuity, the accuracy of phase compensation is improved. The proposed technique extends the depth measurement range and achieves high axial measurement precision.
Article
Immunology
Christina Noll, Michael Hiltensperger, Lilian Aly, Rebecca Wicklein, Ali Maisam Afzali, Christian Mardin, Christiane Gasperi, Achim Berthele, Bernhard Hemmer, Thomas Korn, Benjamin Knier
Summary: This study found that rarefication of the retinal vasculature during RRMS is associated with higher frequencies of activated B cells and higher levels of pro-inflammatory cytokines in the cerebrospinal fluid. Furthermore, vessel loss in the retina is linked to future disability worsening.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Anne E. Carolus, Jens Moeller, Martin R. Hofmann, Johannes A. P. van de Nes, Hubert Welp, Kirsten Schmieder, Christopher Brenke
Summary: OCT is a useful imaging technique for visualizing human peripheral nerves and resolving nerve structures down to myelinated axons level. Tissue remodeling processes and injury-induced degeneration can result in changes in light backscattering characteristics and image appearance.
JOURNAL OF NEUROSURGERY
(2021)
Article
Optics
Qingrui Li, Tianduo Lai, Zhenyang Ding, Kuiyuan Tao, Fengyu Zhu, Hao Kuang, Peidong Hua, Yin Yu, Tiegen Liu
Summary: This paper compares polarization imaging methods based on Jones matrix and Mueller matrix, finding that Mueller matrix performs better in handling non-coaxial diattenuation. Experimental results show that Mueller matrix with incoherent averaging method has better performance in areas with low signal to noise ratio.
OPTICS AND LASER TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Min-Su Kim, Ki-Yup Nam, Young Hoon Hwang, Min-Woo Lee, Woo-Hyuk Lee, Hyung-Bin Lim, Jung-Yeul Kim
Summary: It was found that Weiss ring located near the optic disc can affect the measurement of peripapillary retinal nerve fiber layer (pRNFL) thickness, especially in the inferior quadrant and average values. Therefore, it is important to consider the presence of Weiss ring when analyzing pRNFL thickness.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Deven K. Gupta, Lily Chen, Andrew E. Heidari, Steven Chau, Brandyn Dunn, Brian J. -F. Wong
Summary: A low-cost surgical headlight using consumer-grade LED headlight and 3D-printed mount was developed, with positive results from simulation exercises and subsequent testing. The prototype showed faster operation time and wider illumination compared to the commercial headlight, but further optimization is needed.
SURGICAL INNOVATION
(2021)
Article
Biochemical Research Methods
Giriraj K. Sharma, Lily Y. Chen, Lidek Chou, Christopher Badger, Ellen Hong, Swathi Rangarajan, Theodore H. Chang, William B. Armstrong, Sunil P. Verma, Zhongping Chen, Ram Ramalingam, Brian J-F Wong
Summary: This study utilized optical coherence tomography (OCT) technology to develop quantitative methods for analyzing the anatomy and kinematics of in vivo vocal fold (VF) motion in the coronal plane. Long-range OCT imaging of awake human subjects allowed for novel kinematic analysis of VF motion, providing potential insights into human VF biomechanics and sound production.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Dermatology
Andrew E. Heidari, Ellen M. Hong, Asher Park, Tiffany T. Pham, Earl Steward, Lily Y. Chen, Yueqiao Qu, Brandyn S. Dunn, Soo H. Seo, Urja Patel, Katelyn Dilley, Amir A. Hakimi, Adeela Syed, Sehwan Kim, Michael G. Hill, Joon S. You, Brian J. F. Wong
Summary: Both V-ECLL and P-ECLL treatments induce in-vivo fat necrosis through adipocyte membrane lysis and denuclearization. However, the -1.5 V P-ECLL treatment resulted in a smaller spatial necrotic effect compared to 5 V V-ECLL. Additionally, 5 V V-ECLL produced a similar necrotic effect to that of -2.5 V and -3.5 V P-ECLL, suggesting that a low-voltage closed-loop potentiostat-based system can achieve fat necrosis to a similar extent as a higher voltage direct current system.
LASERS IN SURGERY AND MEDICINE
(2022)
Editorial Material
Surgery
Allison C. Hu, Ellen M. Hong, Brandyn S. Dunn, Jeffrey T. Gu, Brian J. F. Wong
FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
(2021)
Article
Surgery
Theodore Nguyen, Halton W. Beumer, Brian J. F. Wong
FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
(2022)
Editorial Material
Surgery
Dana M. Hutchison, Kelly Hernandez, Asher Park, Amir A. Hakimi, Natasha A. Mesinkovska, Edward C. Kuan, Wolfgang Beumer, Brian J. F. Wong
FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
(2022)
Article
Surgery
Amir A. Hakimi, Dana M. Hutchison, Asher Park, Natasha Atanaskova Mesinkovska, Sehwan Kim, Phil-Sang Chung, Brian J-F Wong
Summary: The study developed a low-cost droplet simulation model using easily accessible materials and smartphone-based cobalt blue light. The results showed that the smartphone-based cobalt blue light was comparable to the conventional UV Wood's lamp, making it a convenient alternative for fluorescence detection. This model has great potential for use in financially restricted academic centers during the COVID-19 pandemic and beyond.
SURGICAL INNOVATION
(2022)
Article
Ophthalmology
Katelyn K. Dilley, Pamela A. Borden, Yueqiao Qu, Andrew E. Heidari, Karthik R. Prasad, Yan Li, Chung Ho Sun, Zhongping Chen, Sehwan Kim, Michael G. Hill, Brian J. F. Wong
Summary: This study investigated the potential of potential-driven electrochemical treatment (P-ECT) to restore clarity after alkaline-based corneal chemical injuries (CCI). The results showed that P-ECT could restore local optical clarity after NaOH exposure. Analysis of collagen fibril orientation did not show any changes after NaOH exposure or P-ECT. This study suggests that P-ECT may be an effective and low-cost treatment for alkaline CCI.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Letter
Surgery
Elaine C. C. Martin, Amir A. A. Hakimi, Cameron McIntosh, Brian J. F. Wong
FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
(2022)
Review
Otorhinolaryngology
Cameron McIntosh, Krupa R. Patel, Garyfalia Lekakis, Brian J. F. Wong
Summary: The COVID-19 pandemic has accelerated the adoption of digital tools and virtual learning platforms in the field of rhinoplasty education. This review discusses the variety of digital software and web-based tools that rhinoplasty educators have incorporated into their teaching methods. It also highlights the advantages and potential drawbacks of virtual learning through e-content. There has been a significant shift towards digital education, with rhinoplasty surgeon-educators embracing videoconferencing, podcasts, virtual simulation, and social media to reach and teach trainees. This digital transformation is likely to have long-lasting effects even after the pandemic ends.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2022)
Article
Surgery
Konrad M. Kozlowski, Peter A. Rosston, Asher C. Park, Amir A. Hakimi, Leandro Socolovsky, Brian J-F Wong
Summary: This study aimed to identify the epidemiology and effects of facial fractures on return to play in Major League Soccer (MLS) and the English Premier League (EPL). The findings showed that most players return to play in the same season, but the recovery time can vary depending on the type of fracture, injury management, or injury severity. These findings can inform future craniofacial injury management, player safety guidelines, and fracture prevention.
FACIAL PLASTIC SURGERY
(2023)
Article
Dermatology
Asher C. C. Park, Carmen K. K. Chan, Dana M. M. Hutchison, Urja Patel, Ellen M. M. Hong, Earl Steward, Katelyn K. K. Dilley, Naya L. L. Sterritt, Sehwan Kim, Michael G. G. Hill, Joon S. S. You, Brian J. F. Wong
Summary: The aim of this study is to determine the long-lasting effects of targeted electrochemical lipolysis (ECLL) in a Yucatan pig model. The study found that ECLL led to fat reduction and contour changes, and these changes were dose-dependent.
LASERS IN SURGERY AND MEDICINE
(2023)
Proceedings Paper
Engineering, Biomedical
Asher C. Park, Zhikai Zhu, Lidek Chou, Katelyn Dilley, Akarsh Lal, Edward C. Kuan, Zhongping Chen, Brian J. F. Wong
Summary: Mucociliary clearance is essential for normal upper airway function, and measuring ciliary beat frequency is crucial. The current golden standard, phase-contrast microscopy, has limitations in displaying the variation of ciliary beat frequency across tissues. Spectrally encoded interferometric microscopy can provide insight into the changes in ciliary beat frequency on tissue surfaces, aiding in quantifying ciliary beat frequency in ex vivo upper airway tissue.
IMAGING, THERAPEUTICS, AND ADVANCED TECHNOLOGY IN HEAD AND NECK SURGERY AND OTOLARYNGOLOGY 2022
(2022)
Article
Engineering, Biomedical
Tiffany Thienthao Pham, Andrew Emon Heidari, Amir Aaron Hakimi, Yan Li, Cameron Michael Heilbronn, Ellen Minyoung Hong, Ji-Hun Mo, Edward Cheng-Lung Kuan, Zhongping Chen, Brian Jet-Fei Wong
Summary: In this study, three-dimensional optical coherence tomography (OCT) was used to analyze the substructure of olfactory mucosa in rabbits and create 3D reconstructed images of olfactory foramina. The OCT images were compared to histology to assess the accuracy of the imaging technique. The results showed that OCT can accurately depict the substructure of olfactory mucosa and visualize olfactory foramina, suggesting its potential applications in diagnosing and treating neurorhinological and neurodegenerative diseases.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Surgery
Amir A. Hakimi, Khwaja H. Ahmed, Theodore Nguyen, Edward C. Kuan, Brian J-F Wong
FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
(2021)