Article
Biochemical Research Methods
Iris Schmidt, Wouter B. Nagengast, Dominic J. Robinson
Summary: The study investigated factors influencing device calibration and tissue optical property determination, validating findings through phantom and clinical studies. Results showed that the quality of intralipid phantom and fiber tree performance were the main factors affecting calibration quality.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Physics, Multidisciplinary
Alice Dal Fovo, George J. Tserevelakis, Evgenia Klironomou, Giannis Zacharakis, Raffaella Fontana
Summary: The study explores the application of photoacoustic methods in paintings analysis, overcoming the detection limits of optical techniques and providing promising results from a real case study. The multi-modal approach has been proven effective in revealing hidden features and providing cross-sectional measurements.
EUROPEAN PHYSICAL JOURNAL PLUS
(2021)
Article
Chemistry, Analytical
Tatevik Chalyan, Indy Magnus, Maria Konstantaki, Stavros Pissadakis, Zacharias Diamantakis, Hugo Thienpont, Heidi Ottevaere
Summary: This study examines noninvasive optical biosensing techniques for characterizing oak barrels used in wine aging, with the goal of developing a model to predict their lifespan without causing structural damage. Spectroscopic diagnostic techniques are used to assess chemical composition changes in the oakwood barrel and their relationship to repeated refills. Reflectance spectroscopy is found to be a valuable tool for characterizing oak barrels, with the most accurate classification performance achieved using a Partial Least Squares Discriminant Analysis model. These preliminary results show the potential for cost-effective and non-invasive biosensing techniques based on reflectance spectroscopy in assessing oak barrel quality.
Article
Physics, Multidisciplinary
Guo-Sheng Lin, Shih-Cheng Tu, Chong-Ian Mok, Tsan-Hsueh Huang, Chi-Hau Chen, Lin-Hung Wei, Kung-Bin Sung
Summary: This study used two-layer forward Monte Carlo models to predict diffuse reflectance and fluorescence intensities of cervical mucosa. The models showed improved accuracy in estimating tissue properties and detecting precancerous changes compared to conventional models. It suggests the potential of fluorescence spectroscopy for detecting precancers in the cervix.
FRONTIERS IN PHYSICS
(2022)
Review
Medicine, General & Internal
Siddra Maryam, Marcelo Saito Nogueira, Rekha Gautam, Shree Krishnamoorthy, Sanathana Konugolu Venkata Sekar, Kiang Wei Kho, Huihui Lu, Richeal Ni Riordain, Linda Feeley, Patrick Sheahan, Ray Burke, Stefan Andersson-Engels
Summary: Oral cancer is the 16th most common cancer worldwide, and early diagnosis is challenging. Optical spectroscopy could be a non-invasive and cost-effective diagnostic technique with advantages such as cost, speed, objectivity, sensitivity, painlessness, and ease-of-use. This review provides a comprehensive overview and recent developments in optical spectroscopy for oral cancer diagnosis, emphasizing the importance of saliva-based potential biomarkers for early-stage diagnosis.
Article
Chemistry, Multidisciplinary
Xuemei Dong, Ziwen Zhang, Rongchen Wang, Jie Sun, Chengjun Dong, Lixin Sun, Cai Jia, Xianfeng Gu, Chunchang Zhao
Summary: A RSS and ROS sequentially activated CO delivery system has been developed for boosting NIR imaging-guided on-demand photodynamic therapy. The system utilizes a CO releaser (BOD-CO) and a photosensitizer (BOD-I) to achieve precise CO release and identification of tumors through H2S activation. The system also utilizes long-wavelength light irradiation to generate O-1(2) for both PDT and precise local release of CO. The results demonstrate the ideal anticancer effects achieved through the release of CO combined with the depletion of endogenous H2S.
Article
Chemistry, Analytical
Marco Gargano, Margherita Longoni, Valeria Pesce, Maria Chiara Palandri, Aurora Canepari, Nicola Ludwig, Silvia Bruni
Summary: In this study, a comprehensive non-invasive investigation was conducted on six woodblock prints by Utagawa Kunisada, using various techniques to analyze the printing materials and support. The results provide valuable information for historians, conservators, and curators, shedding light on these previously unstudied works of art.
Article
Biochemistry & Molecular Biology
Carolina Diaz-Norambuena, Edurne Avellanal-Zaballa, Alejandro Prieto-Castaneda, Jorge Banuelos, Santiago de la Moya, Antonia R. Agarrabeitia, Maria J. Ortiz
Summary: Heavy-atom-free photosensitizers, such as BODIPY-based orthogonal dimers with proper formyl functionalization, have the potential to visualize and kill tumor cells through fluorescence signaling and photodynamic therapy. The photophysical properties of formyl-functionalized BODIPY dimers were analyzed, indicating that their dual performance of fluorescence and singlet oxygen generation can be modulated by the formyl functionalization at specific positions. Regioselective formylation was proposed as an effective tool to balance fluorescence, singlet oxygen generation, and intramolecular charge transfer for photo-theragnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Anouk L. Post, Dirk J. Faber, Henricus J. C. M. Sterenborg, Ton G. van Leeuwen
Summary: The study developed a model for spectral measurements and validated it through simulations. Experimental validation was conducted to assess the model's feasibility, and a parameterization method was proposed to prevent overfitting. The parameterization improved fitting speed and enabled single fiber measurements.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Soil Science
Zefang Shen, Haylee D'Agui, Lewis Walden, Mingxi Zhang, Tsoek Man Yiu, Kingsley Dixon, Paul Nevill, Adam Cross, Mohana Matangulu, Yang Hu, Raphael A. Viscarra Rossel
Summary: Mining can cause disturbances to the soil, but miniaturised spectrometers can accurately estimate soil properties for rehabilitation at a lower cost.
Article
Chemistry, Applied
Said Abou El Karam, Maxime Ferrand, Mohammed El Jabri, Antoine Vautier, Martine Carlier, Arnaud Germond, Thierry Astruc
Summary: Salted and tumbled pork teres major muscles with different levels of sodium chloride (1.1% to 1.9%) were analyzed using UV fluorescence spectroscopy. The results showed that muscle fluorescence changed due to protein denaturation, and the threshold for significant fluorescence properties alteration was 1.5% NaCl. The changes in muscle fluorescence were not linearly related to salt levels, indicating potential influences from carcass characteristics and muscle physicochemical changes.
Article
Optics
Mahmoud Al-Salihi, Rongxing Yi, Shiqi Wang, Qiang Wu, Fangrui Lin, Junle Qu, Liwei Liu
Summary: This paper introduces a method to distinguish neoplastic tissues from non-neoplastic tissues using calibration-free laser-induced breakdown spectroscopy (CF-LIBS). By analyzing the plasma emission lines of different elements, the study identified higher concentrations of major and trace elements in neoplastic tissues, especially in the early temporal observation windows. The results obtained from the CF-LIBS method were in good agreement with that of Inductive coupled plasma-optical emission spectroscopy (ICP-OES).
Article
Chemistry, Analytical
Yunhe Zhang, Yixin Lu, Zhanqin Zhang, Zhuowen Liang, Qianqian Xiao, Kaijian Shao, Yu Wang, Jiawei Zhang, Shuang Wang
Summary: Accurate assessment of blood content in biological tissues is crucial for diagnosing and monitoring various diseases. A multispectral endoscopic imaging system was developed to capture tissue reflection optical images and evaluate blood content and tissue composition using spectral analysis algorithm.
ANALYTICAL METHODS
(2023)
Article
Biochemical Research Methods
Erica Dao, Gabriella Gohla, Phillip Williams, Peter Lovrics, Fares Badr, Qiyin Fang, Thomas J. Farrell, Michael J. Farquharson
Summary: A system combining time-resolved fluorescence and diffuse reflectance was developed to detect the optical properties of breast tissue. Using a dataset that combines both techniques, the sensitivity and specificity of tissue classification were significantly improved. Further research on fibroglandular tissue could enhance the system for intraoperative tumor margin detection.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Environmental Sciences
Joshua P. Harringmeyer, Karl Kaiser, David R. Thompson, Michelle M. Gierach, Curtis L. Cash, Cedric G. Fichot
Summary: UV-visible imaging spectroscopy is expected to enhance remote sensing capabilities of coastal waters, particularly in monitoring CDOM, yet further research is needed to demonstrate its effectiveness.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2021)
Article
Oncology
Esther Kho, Lisanne L. de Boer, Koen K. Van de Vijver, Frederieke van Duijnhoven, Marie-Jeanne T. F. D. Vrancken Peeters, Henricus J. C. M. Sterenborg, Theo J. M. Ruers
CLINICAL CANCER RESEARCH
(2019)
Article
Biochemical Research Methods
Elisabeth J. M. Baltussen, Esther N. D. Kok, Susan G. Brouwer de Koning, Joyce Sanders, Arend G. J. Aalbers, Niels F. M. Kok, Geerard L. Beets, Claudie C. Flohil, Sjoerd C. Bruin, Koert F. D. Kuhlmann, Henricus J. C. M. Sterenborg, Theo J. M. Ruers
JOURNAL OF BIOMEDICAL OPTICS
(2019)
Article
Biochemical Research Methods
Xu U. Zhang, Dirk J. Faber, Anouk L. Post, Ton G. van Leeuwen, Henricus J. C. M. Sterenborg
JOURNAL OF BIOPHOTONICS
(2019)
Article
Dermatology
Susan G. Brouwer de Koning, Pim Weijtmans, M. Baris Karakullukcu, Caifeng Shan, Elisabeth J. M. Baltussen, Laura A. Smit, Robert L. P. van Veen, Benno H. W. Hendriks, Henricus J. C. M. Sterenborg, Theo J. M. Ruers
LASERS IN SURGERY AND MEDICINE
(2020)
Article
Biochemical Research Methods
Elisabeth J. M. Baltussen, Henricus J. C. M. Sterenborg, Theo J. M. Ruers, Behdad Dashtbozorg
BIOMEDICAL OPTICS EXPRESS
(2019)
Article
Biochemical Research Methods
Xu U. Zhang, Piet van der Zee, Isabella Atzeni, Dirk J. Faber, Ton G. van Leeuwen, Henricus J. C. M. Sterenborg
JOURNAL OF BIOMEDICAL OPTICS
(2019)
Article
Biochemical Research Methods
Anouk L. Post, Henricus J. C. M. Sterenborg, Fransien G. Woltjer, Ton G. van Leeuwen, Dirk J. Faber
JOURNAL OF BIOMEDICAL OPTICS
(2020)
Article
Dermatology
Elisabeth J. M. Baltussen, Susan G. Brouwer de Koning, Joyce Sanders, Arend G. J. Aalbers, Niels F. M. Kok, Geerard L. Beets, Benno H. W. Hendriks, Henricus J. C. M. Sterenborg, Koert F. D. Kuhlmann, Theo J. M. Ruers
LASERS IN SURGERY AND MEDICINE
(2020)
Article
Optics
Dirk J. Faber, Anouk L. Post, Henricus J. C. M. Sterenborg, Ton G. Van Leeuwen
Article
Biochemical Research Methods
Anouk L. Post, Dirk J. Faber, Henricus J. C. M. Sterenborg, Fransien G. Woltjer, Ton G. van Leeuwen
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Biochemical Research Methods
Anouk L. Post, Albert J. de Groof, Xu U. Zhang, Anne-Fre Swager, Kiki N. Fockens, Roos E. Pouw, Bas L. A. M. Weusten, Dirk J. Faber, Daniel M. de Bruin, Jacques J. G. H. M. Bergman, Ton G. van Leeuwen, Henricus J. C. M. Sterenborg, Wouter L. Curvers
Summary: This study utilized multidiameter single fiber reflectance spectroscopy (MDSFR) to improve surveillance of Barrett's esophagus, developing a classifier based on logistic regression analysis to predict the presence of neoplasia in other parts of the Barrett's segment with high sensitivity and specificity.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Biochemical Research Methods
Anouk L. Post, Dirk J. Faber, Henricus J. C. M. Sterenborg, Ton G. van Leeuwen
Summary: The study developed a model for spectral measurements and validated it through simulations. Experimental validation was conducted to assess the model's feasibility, and a parameterization method was proposed to prevent overfitting. The parameterization improved fitting speed and enabled single fiber measurements.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Chemistry, Multidisciplinary
Esther Kho, Behdad Dashtbozorg, Joyce Sanders, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke van Duijnhoven, Henricus J. C. M. Sterenborg, Theo J. M. Ruers
Summary: Developing algorithms for analyzing hyperspectral images as an intraoperative tool for margin assessment during breast-conserving surgery requires a dataset with reliable histopathologic labels. By comparing tissue slices and lumpectomy datasets, using wavelengths with appropriate penetration depth to develop tissue classification algorithms was explored. Spectral differences between tissue slices and lumpectomy datasets were observed, affecting the discrimination of different tissue types.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Lisanne L. de Boer, Esther Kho, Koen K. van de Vijver, Marie-Jeanne T. F. D. Vranken Peeters, Frederieke van Duijnhoven, Benno H. W. Hendriks, Henricus J. C. M. Sterenborg, Theo J. M. Ruers
Summary: DRS has the potential to guide surgeons intraoperatively by characterizing tissue and discriminating between healthy and malignant tissues, including diseases like ductal carcinoma in situ. However, further research is needed to fully understand its optical characteristics and capabilities in characterizing mixed tissue types.
BREAST CANCER RESEARCH
(2021)
Article
Optics
Xu U. Zhang, Dirk J. Faber, Ton G. Van Leeuwen, Henricus J. C. M. Sterenborg
JOURNAL OF PHYSICS-PHOTONICS
(2020)