Article
Biochemical Research Methods
Peiya Lin, Hiromi Niimi, Tomomitsu Hirota, Yujin Ohsugi, Tsuyoshi Shimohira, Keita Toyoshima, Sayaka Katagiri, Takanori Iwata, Akira Aoki
Summary: This study investigated the effects of low-level Er:YAG laser irradiation on gingival fibroblast proliferation and gene expression. The results showed that irradiation at 3.9 J/cm(2) promoted cell proliferation and increased the expression of Fn1 gene. RNA-seq analysis identified differentially expressed genes between irradiated and non-irradiated cells, with enhancement of the MAPK pathway and enrichment in the TGF-beta signaling gene set. Inhibition of Dusp4, Dusp5, and Tgfr1 expression eliminated the enhanced proliferation effect of low-level Er:YAG laser irradiation.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Medicine, General & Internal
Taichen Lin, Cheng-Chia Yu, Chia-Ming Liu, Pei-Ling Hsieh, Yi-Wen Liao, Chuan-Hang Yu, Chun-Jung Chen
Summary: The study revealed that Er:YAG laser can enhance the proliferation and mobility of periodontal ligament fibroblasts, with galectin-7 playing a crucial role in this process.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Medicine, General & Internal
Yuki Wada, Asami Suzuki, Hitomi Ishiguro, Etsuko Murakashi, Yukihiro Numabe
Summary: This study examined the molecular processes of human immortalized gingival fibroblasts (HGF) by Low reactive Level Laser Therapy (LLLT) at different time points, identifying key genes involved in the defense response. Genes such as CXCL8 and NFKB1 were upregulated, while NFKBIA and STAT1 were downregulated after LLLT treatment, suggesting their importance in the defense response.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ricardo Roberto de Souza Fonseca, Camila Pantoja Silva, Beatriz Leal de Senna Sastre, Erich Brito Tanaka, Tabata Resque Beckmann Carvalho, Paula Gabriela Faciola Pessoa de Oliveira, Silvio Augusto Fernandes de Menezes, Rogerio Valois Laurentino, Renata Pimentel de Oliveira, Roberta Pimentel de Oliveira, Andrea Dias Neves Lago, Luiz Fernando Almeida Machado
Summary: This study aimed to evaluate the clinical results of a bilateral root coverage (RC) of gingival recession (GR) associated with an autogenous connective tissue graft (aCTG) alone or combined with low-level laser therapy (aCTG + LLLT). The results indicated that aCTG + LLLT might have an additional benefit to GR root coverage within the evaluated time.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Nursakinah Suardi, Pegah Moradi Khaniabadi, Aijesta Taggo, Siti Farrah Mursyida Zulbaharin, Daruliza Kernain Mohd Azman, Sylvester Jande Gemanam
Summary: Breast cancer is a leading cause of cancer deaths among women, with radiotherapy being linked to toxic risks. Low-level laser therapy shows promise in alleviating side effects of radiotherapy, and fractionated irradiation appears to be more successful than single irradiation in killing tumor cells.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Chen-Ying Wang, Bor-Shiunn Lee, Ya-Ting Jhang, Kevin Sheng-Kai Ma, Chen-Pang Huang, Kuan-Lun Fu, Chern-Hsiung Lai, Wan-Yu Tseng, Mark Yen-Ping Kuo, Yi-Wen Chen
Summary: The study showed that curettage plus Er:YAG laser irradiation was the most effective method for removing bacteria and lipopolysaccharide. There was no significant difference in fibroblast adhesion between the control group and the group receiving combined treatment. The use of Er:YAG laser irradiation in conjunction with curettage optimized lipopolysaccharide clearance and fibroblast adhesion on titanium discs.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Agnieszka Nowak-Terpilowska, Joanna Zeyland, Magdalena Hryhorowicz, Pawel Sledzinski, Marzena Wyganowska
Summary: Phototherapy, particularly using lasers, can be an effective and minimally invasive treatment option for periodontal and peri-implant diseases. This study examined the effects of different laser wavelengths, power densities, and energy densities on in vitro cultured human gingival fibroblasts. The findings suggest that laser irradiation at a wavelength of 1064nm resulted in the highest increase in cell viability after 48 and 72 hours.
Article
Multidisciplinary Sciences
Raquel Roldan-Montero, Juan M. Perez-Saez, Isabel Cerro-Pardo, Jorge Oller, Diego Martinez-Lopez, Estefania Nunez, Sebastian M. Maller, Carmen Gutierrez-Munoz, Nerea Mendez-Barbero, Joan C. Escola-Gil, Jean-Baptiste Michel, Maria Mittelbrunn, Jesus Vazquez, Luis M. Blanco-Colio, Gabriel A. Rabinovich, Jose L. Martin-Ventura
Summary: Galectin-1 (Gal-1) plays a significant role as a therapeutic target for atherosclerosis and abdominal aortic aneurysm (AAA). Lack of Gal-1 leads to severe atherosclerosis and VSMC phenotypic switch, while treatment with recombinant Gal-1 prevents these effects and alleviates the conditions of atherosclerosis and AAA.
Article
Biochemistry & Molecular Biology
Kimia Hafezi Motlagh, Arash Azizi, Nahid Moezzi Ghadim
Summary: This study investigated the effect of 445 nm blue laser and 660 nm low-power laser on the quantity and quality of human gingival fibroblasts. The results showed that the 660 nm laser had a positive effect on fibroblast proliferation, while the 445 nm laser had a negative effect on cell viability.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Husna Azdiyah Habita Habit, Nursakinah Suardi, Shahrom Mahmud, Rabiatul Basria S. M. N. Mydin, Siti Khadijah Mohd Bakhori, Elham Mzwd
Summary: Low-level laser therapy (LLLT) has been used in cancer therapy through photodynamic treatment (PDT) or photothermal therapy (PTT). Gold nanoparticles (AuNPs) can improve the effectiveness of LLLT by serving as photo-absorbing agents. This study evaluated the combined inhibitory effect of 532 nm green laser irradiation and AuNPs on MCF-7 cells. The presence of AuNPs significantly enhanced the cell inhibition effect of low-level laser therapy.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Health Care Sciences & Services
Rada Kazakova, Angelina Vlahova, Georgi Tomov, Mariya Dimitrova, Stoyan Kazakov, Stefan Zlatev, Marta Forte, Giuseppe Barile, Massimo Corsalini, Saverio Capodiferro
Summary: The aim of this study was to analyze and compare the effects of six different gingival-displacement methods on post-retraction gingival height changes. The study involved 23 patients and analyzed 263 teeth. Three conventional retraction methods and three surgical techniques were used. The results showed that most of the methods resulted in minimal or negligible gingival recession post-retraction, except for one surgical technique.
Article
Chemistry, Multidisciplinary
Yaser A. Alhazmi, Mohammed Y. Aljabri, Shereen N. Raafat, Shaimaa M. Gomaa, Mohamed Shamel
Summary: This study aimed to examine the impact of low-level laser therapy (LLLT) on the viability and osteo/odontogenic potential of gingival-derived mesenchymal stem cells (GMSCs). The results showed that LLLT of both energy densities had no cytotoxic effect on GMSC viability. LLLT of 1.5 J/cm(2) demonstrated better viability and promoted osteo/odontogenic differentiation potential of GMSCs.
APPLIED SCIENCES-BASEL
(2023)
Article
Optics
Kammam Amitha, Rashmi Paramashivaiah, Munivenkatappa Laxmaiah Venkatesh Prabhuji, Ashwin Parakkaje Subramanya, Ali A. Assiry, Syed Wali Peeran, Hytham Fageeh, Shaeesta Khaleelahmed Bhavikatti, Giuseppe Alessandro Scardina
Summary: This study assessed the effect of low-level laser therapy (LLLT) on wound healing after a modified coronally advanced flap (MCAF) procedure for treatment of recession-type defects. The results showed that LLLT significantly reduced the mean recession depth and width, and patients had high acceptability.
Article
Biochemistry & Molecular Biology
Seok-Rae Park, Younghwan Han, Su Jeong Lee, Ki-Il Lee
Summary: This study aimed to evaluate the efficacy of low-level laser therapy (LLLT) for rhinosinusitis. The results showed that LLLT significantly improved tissue inflammation, sinus opacification, and cytokine expression, indicating that LLLT is an effective treatment option for rhinosinusitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Aqsa Kamal, Basheer Salman, A. R. Noor Hayatie, A. R. Samsudin
Summary: The study investigated the efficacy of low-level laser therapy (LLLT) for dry socket management. Results showed that LLLT treatment led to lower pain scores and faster healing compared to conventional treatment, indicating its clinical effectiveness in promoting dry socket healing.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Otofumi Chigasaki, Yasuo Takeuchi, Akira Aoki, Yoshiyuki Sasaki, Koji Mizutani, Norio Aoyama, Yuichi Ikeda, Misa Gokyu, Makoto Umeda, Isao Ishikawa, Yuichi Izumi
JOURNAL OF ORAL SCIENCE
(2018)
Article
Medicine, Legal
Kana Unuma, Yohsuke Makino, Yoshiyuki Sasaki, Hirotaro Iwase, Koichi Uemura
FORENSIC SCIENCE INTERNATIONAL
(2019)
Correction
Multidisciplinary Sciences
Kohei Takeda, Koji Mizutani, Takanori Matsuura, Daisuke Kido, Risako Mikami, Masahiro Noda, Prima Buranasin, Yoshiyuki Sasaki, Yuichi Izumi
Review
Multidisciplinary Sciences
Risako Mikami, Koji Mizutani, Yoshiyuki Sasaki, Takanori Iwata, Akira Aoki
Article
Multidisciplinary Sciences
Koji Mizutani, Risako Mikami, Tomohito Gohda, Hiromichi Gotoh, Norio Aoyama, Takanori Matsuura, Daisuke Kido, Kohei Takeda, Yuichi Izumi, Yoshiyuki Sasaki, Takanori Iwata
SCIENTIFIC REPORTS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Otofumi Chigasaki, Norio Aoyama, Yoshiyuki Sasaki, Yasuo Takeuchi, Koji Mizutani, Yuichi Ikeda, Misa Gokyu, Makoto Umeda, Yuichi Izumi, Takanori Iwata, Akira Aoki
Summary: The study in a Japanese population found that the amount of P. gingivalis is strongly associated with the severity of periodontal condition, and the co-occurrence of P. gingivalis with other bacteria can exacerbate the progression of periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Pharmacology & Pharmacy
Aya Enomoto, Yasunari Mano, Yohei Kawano, Tomoki Nishikawa, Takao Aoyama, Yoshiyuki Sasaki, Masashi Nagata, Hiromitsu Takahashi
Summary: This study compared the safety and effectiveness of four direct oral anticoagulants in Japanese patients. The findings indicate that dabigatran had a significantly lower risk of major bleeding compared to apixaban, but there was no significant difference in effectiveness among the four drugs.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yosuke Harazono, Kou Kayamori, Junichiro Sakamoto, Yu Akaike, Yasuhiro Kurasawa, Fumihiko Tsushima, Yoshiyuki Sasaki, Hiroyuki Harada, Tetsuya Yoda
Summary: This study reviews the clinicopathological characteristics and specific pathology of ancient change in 40 cases of Schwannoma in the oral and maxillofacial region. The tongue was the most commonly affected site, and the average tumor size was 13.2 mm. The study found significant associations between ancient change and tumor size, as well as the apparent diffusion coefficient (ADC) value derived from diffusion-weighted magnetic resonance imaging (MRI).
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Article
Environmental Sciences
Takuma Okumura, Koji Hara, Ayako Nakane, Chizuru Namiki, Kazuharu Nakagawa, Kohei Yamaguchi, Kanako Yoshimi, Mizue Toyoshima, Yoshiyuki Sasaki, Haruka Tohara
Summary: This study identified predictive factors for the removal of nasogastric tubes and oral intake recovery in oral cancer patients post-surgery, with upper esophageal sphincter opening being the most significant factor. After oral cancer surgery, videofluoroscopic swallowing studies should be conducted to assess safe eating methods and predict recovery of oral intake and NGT removal.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mari Shibata, Namiaki Takahara, Nobuyoshi Tomomatsu, Yasuhiro Kurasawa, Yoshiyuki Sasaki, Tetsuya Yoda
Summary: This study aimed to investigate the morphologic and surgical risk factors causing neurosensory disturbances (NSDs) after bilateral sagittal split osteotomy (BSSO). It was found that advanced age, close distance between mandibular canal and inner surface of the cortical bone, and intraoperative exposure of the inferior alveolar nerve (IAN) were risk factors for NSD one year postoperatively.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Akira Aoki, Koji Mizutani, Risako Mikami, Yujin Ohsugi, Hiroaki Kobayashi, Tatsuya Akizuki, Yoichi Taniguchi, Yasuo Takeuchi, Sayaka Katagiri, Yoshiyuki Sasaki, Motohiro Komaki, Walter Meinzer, Yuichi Izumi, Takanori Iwata
Summary: This study compared the effectiveness of a novel pocket therapy (Er:YAG laser-assisted comprehensive periodontal pocket therapy [Er-LCPT]) with conventional mechanical treatment alone in treating residual pockets. The results indicated that Er-LCPT was more effective in thoroughly and safely debriding the pockets, resulting in significant reduction in probing pocket depth and improvement in clinical attachment.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mari Shibata, Namiaki Takahara, Toma Kaneko, Meiko Oki, Yoshiyuki Sasaki, Nobuyoshi Tomomatsu, Yasuhiro Kurasawa, Koichi Nakakuki, Tetsuya Yoda
Summary: This study aimed to quantify facial swelling in Class III patients 1 week after Le Fort I osteotomy and bilateral sagittal splitting ramus osteotomy and identify the factors contributing to the swelling. Retrospective analysis of data from 63 patients was conducted, and facial swelling was quantitatively measured using computed tomography data. Multiple regression analysis revealed that the use of postoperative facial bandages, masseter muscle thickness, and horizontal mandibular movement were significantly associated with facial swelling.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Health Care Sciences & Services
Yuichi Ikeda, Otofumi Chigasaki, Koji Mizutani, Yoshiyuki Sasaki, Norio Aoyama, Risako Mikami, Misa Gokyu, Makoto Umeda, Yuichi Izumi, Akira Aoki, Yasuo Takeuchi
Summary: Oral health screening is crucial for maintaining and improving one's quality of life. This study aimed to assess the possibility of using salivary bacterial testing and background information to screen patients with a certain level of alveolar bone resorption. The results showed that the count of Porphyromonas gingivalis bacteria and patients' background information were significantly associated with the presence of bone resorption, suggesting that it may be possible to screen for bone resorption without the need for radiography or oral examination.
Article
Oncology
Kohei Nojima, Masahiro Hayashi, Atsushi Tanemura, Hind Al-Busani, Toru Saito, Tamio Suzuki, Masashi Ishikawa, Taisuke Mori, Shogo Wada, Naoya Yamazaki, Ichiro Katayama, Hiroki Mori, Hiroo Yokozeki, Naoko Okiyama, Yoshiyuki Sasaki, Takeshi Namiki
Summary: A deficiency in PTEN activates phospho-Akt at serine 473 (p-Akt) and promotes melanoma development by coupling with NUAK2 amplification. This study investigated the prognostic impact of p-Akt and/or NUAK2 expression in melanoma patients. Immunohistochemistry was used to analyze primary tumors from acral melanomas, Low-cumulative sun damage (CSD) melanomas, and High-CSD melanomas. The expression of p-Akt and NUAK2 was inversely correlated with relapse-free survival (RFS) in primary melanoma patients and acral melanoma patients. Multivariate analyses revealed that p-Akt had a significant impact on RFS, while NUAK2 did not. Subset analyses showed that p-Akt expression predicted poorer RFS in patients with acral melanomas. In conclusion, the expression of p-Akt has a significant impact on RFS and can predict relapse in patients with primary melanomas, particularly acral melanomas.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Article
Dermatology
Tadatsune Iida, Michiko Nakamura, Minako Inazawa, Takichi Munetsugu, Makiko Nishida, Tomoko Fujimoto, Yoshiyuki Sasaki, Yuichiro Ohshima, Yoshihiko Nakazato, Takeshi Namiki, Hiroo Yokozeki
Summary: Acquired idiopathic generalized anhidrosis is a rare disease with unknown etiology, for which systemic corticosteroid therapy is the main treatment. The study found a treatment response rate of 73% and a recurrence rate of 48%, suggesting prompt treatment initiation and considering seasonal effects in treatment planning.
JOURNAL OF DERMATOLOGY
(2021)
