Review
Oncology
Clifton P. Thornton, Mengchi Li, Chakra Budhathoki, Chao Hsing Yeh, Kathy Ruble
Summary: Anti-inflammatory mouthwashes are a potentially effective means to prevent or reduce mucositis associated with cancer therapy, reducing the incidence of symptomatic mucositis and dose-limiting mucositis. Limited adverse effects and high adherence indicate the safety and feasibility of using these mouthwashes. They should be considered for supportive care in individuals at risk for mucositis and further evaluated for efficacy across various chemotherapy agents, adverse effects, and impacts on symptoms, pain, and quality of life.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata, Senji Kasahara, Takaaki Ono, Michio Sawada, Koichi Ohata, Hiroko Kato-Hayashi, Hideki Hayashi, Masahito Shimizu, Yoshinori Itoh, Hisashi Tsurumi, Akio Suzuki
Summary: This multi-center prospective study demonstrates that in patients undergoing HSCT, PZ lozenge is effective in reducing the incidence of grade >= 2 oral mucositis associated with chemotherapy without affecting the outcomes of HSCT or incidence rates of other adverse events.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biophysics
Jana Jabbour, Batoul Manana, Ammar Zahreddine, Laila Al-Shaar, Ali Bazarbachi, Didier Blaise, Jean El-Cheikh
Summary: This study found that individualized nutritional counseling for patients with hematological malignancies receiving hematopoietic stem cell transplant (HSCT) was associated with improved intake of certain micronutrients, but vitamin D intake remained low regardless of counseling.
BONE MARROW TRANSPLANTATION
(2021)
Article
Oncology
Shu Ping Wong, Sen Mui Tan, Cheng-Siang Lee, Kian Boon Law, Yvonne Ai Lian Lim, Reena Rajasuriar
Summary: The study aimed to characterize the incidence of oral and gastrointestinal (GI) mucositis, the temporal changes in pro-inflammatory cytokines, and factors associated with their occurrences in hematopoietic stem cell transplant (HSCT). Autologous HSCT patients were recruited and mucositis assessments were conducted daily. The results showed that oral mucositis and diarrhea were reported in a high percentage of patients. Predictive factors for moderate-severe mucositis and the predictive value of cytokines were identified.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Engineering, Biomedical
Fernanda Vieira Heimlich, Jose Alcides Almeida de Arruda, Nickolas Mendes Pereira, Larissa dos Santos Faria, Lucas Guimaraes Abreu, Marcus Vinicius Lucas Ferreira, Fabiana Maria Kakehasi, Denise Vieira Travassos, Tarcilia Aparecida Silva, Ricardo Alves Mesquita
Summary: This study analyzed three protocols of photobiomodulation therapy (PBMT) for preventing oral and oropharyngeal mucositis in patients undergoing chemotherapy and/or hematopoietic stem cell transplantation. The results showed that PBMT is a safe and effective approach for preventing mucositis.
LASERS IN MEDICAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Dasa Hafner, Petra Hrast, Tanja Tomazevic, Janez Jazbec, Marko Kavcic
Summary: Oral mucositis (OM) is a common side effect of chemotherapy, particularly in children. Photobiomodulation (PMB) with low-level laser therapy (LLLT) has shown promising results in relieving pain and promoting healing. This review analyzed 15 clinical trials and identified inconsistencies in laser parameters and a lack of standardized protocols for pediatric patients.
Article
Medicine, General & Internal
Vladimira Radochova, Martin Sembera, Radovan Slezak, Ondrej Heneberk, Jakub Radocha
Summary: This study found that the prevalence of oral mucositis (OM) is high in patients undergoing hematopoietic stem cell transplantation, especially in autologous and myeloablative allogeneic groups. However, there was no significant association between oral hygiene and periodontal disease before HSCT and the occurrence of OM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Tzu-Rong Peng, Hung-Hong Lin, Li-Jou Yang, Ta-Wei Wu
Summary: This meta-analysis showed that compared with placebo, glutamine significantly reduced the incidence of grade 3 and 4 oral mucositis induced by chemotherapy or radiation therapy. Oral administration of glutamine and the use of medium or low doses can decrease the risk. Glutamine also had a significant effect in reducing the risk of grade 3 and 4 oral mucositis induced by radiotherapy, especially in prevention.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Veterinary Sciences
Alexandra Gareau, Alexandra Z. Ripoll, Steven E. Suter
Summary: Combining CHOP chemotherapy, autoPBHSCT, and ACT for the treatment of dogs with B-cell LSA can potentially lead to better outcomes compared to dogs treated with chemotherapy and autoPBHSCT alone, although further studies are needed to confirm the potential benefits of this aggressive treatment protocol.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Oncology
Sharon Elad, Noam Yarom, Yehuda Zadik, Michal Kuten-Shorrer, Stephen T. Sonis
Summary: Oral mucositis is a common and highly symptomatic complication of cancer therapy, affecting patients' quality of life and treatment tolerance. Research on managing oral mucositis is ongoing, with reports of oral mucosal toxicities in other therapies as well.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Oncology
Saori Oku, Toshiko Futatsuki, Yoshiko Imamura, Haruna Hikita, Akemi Inada, Shinsuke Mizutani, Yasuo Mori, Haruhiko Kashiwazaki
Summary: This study found that cryotherapy can effectively prevent oral mucositis (OM) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, especially in cases without methotrexate (MTX) for graft-versus-host disease (GVHD) prophylaxis.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Medicine, General & Internal
Rocco Franco, Ettore Lupi, Enzo Iacomino, Angela Galeotti, Mario Capogreco, Joao Miguel Marques Santos, Maurizio D'Amario
Summary: Oral mucositis is a common side effect of stem cell transplantation in cancer patients, leading to inflammation, ulcers, and various difficulties. This scientific article reviews the efficacy of laser therapy in treating post-transplant mucositis and concludes that it reduces the severity of symptoms.
MEDICINA-LITHUANIA
(2023)
Article
Immunology
Rebeca Bailen, Jose Luis Vicario, Laura Solan, Irene Sanchez-Vadillo, Pilar Herrera, Maria Calbacho, Raquel Alenda, Jose Luis Lopez-Lorenzo, Karem Humala, Anabelle Chinea, Jose Sanchez-Pina, Antonio Balas, Miguel Angel Moreno, Javier Arzuaga, Virginia Pradillo, Nieves Dorado, Gillen Oarbeascoa, Javier Anguita, Jose Luis Diez-Martin, Mi Kwon
Summary: This study reports the experience of using desensitization treatments for patients with DSAs undergoing haplo-HSCT. The results show that utilizing desensitization strategies guided by DSAs intensity kinetics can effectively decrease DSA intensity and improve engraftment rates.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
S. S. Alqahtani, D. A. A. Siraj Khan
Summary: This systematic review found that good oral care, glutamine, certain biological agents, and laser therapy have a significant impact in reducing the pain sensation and occurrence of oral mucositis in children.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Oncology
Ourania Nicolatou-Galitis, Paolo Bossi, Ester Orlandi, Rene-Jean Bensadoun
Summary: This document discusses the role of benzydamine in preventing and treating radiation-induced oral mucositis in head and neck cancer patients. Benzydamine is a local anti-inflammatory drug with analgesic properties that has been shown to effectively prevent and reduce the severity of oral mucositis in this patient population. While international guidelines recommend benzydamine for OM prevention and treatment in H&N cancer patients, further real world trials are needed to confirm its efficacy.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Dermatology
Sarah Campos de Sales, Sicilia Rezende Oliveira, Erika Soares Pantuzzo, Fernanda Pereira Delgado Costa, Marcus Henrique Xavier, Ricardo Alves de Mesquita, Lucas Guimaraes Abreu, Felipe Eduardo Baires Campos, Wagner Henriques de Castro, Tarcilia Aparecida Silva
Summary: Cheilitis glandularis (CG) is a rare inflammatory disease that mainly affects the minor salivary glands in the lower lip. This article presents a case of deep suppurative CG in an 18-year-old black woman. A systematic literature review identified a total of 40 articles reporting CG cases, with varied clinical manifestations and treatment modalities.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Rafaela da Silveira Pinto, Mario Vianna Vettore, Mauro Henrique Guimaraes Nogueira de Abreu, Andrea Clemente Palmier, Rosa Nubia Vieira de Moura, Angelo Giuseppe Roncalli
Summary: This study evaluates the reliability of examiners in reproducing dental indices using in-lux examination method. The results show that the in-lux examination method can replace the in vivo examination method and is more feasible when clinical calibration is unrealistic and involving a large number of examiners.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vivian Louise Soares de Oliveira, Emilie Pollenus, Nele Berghmans, Celso Martins Queiroz-Junior, Marfa Blanter, Matheus Silverio Mattos, Mauro Martins Teixeira, Paul Proost, Philippe E. Van den Steen, Flavio Almeida Amaral, Sofie Struyf
Summary: In a murine model of ARDS, the absence of CCR2 leads to increased pulmonary leukocytes, enhanced neutrophil influx, and decreased monocyte and interstitial macrophage numbers. However, the time needed to control inflammation was comparable between CCR2(+/+) and CCR2(-/-) mice. Interestingly, CCR2(-/-) mice showed higher numbers and increased proliferation of alveolar macrophages, which had a more pronounced M2 profile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Jose Alcides Almeida de Arruda, Fernanda Vieira Heimlich, Victor Zanetti Drumond, Lauren Frenzel Schuch, Manoela Domingues Martins, Lucas Guimaraes Abreu, Antonio Lucio Teixeira, Ricardo Alves Mesquita, Tarcilia Aparecida Silva
Summary: This systematic review examined the potential association between anxiety and depression and chemo/radiotherapy-induced oral mucositis. The results showed that there is a connection between anxiety and depression and the severity of oral mucositis in a significant number of participants. However, the limited number of cases and heterogeneity in the data hindered a conclusive conclusion about this association.
Article
Food Science & Technology
Marina C. Zicker, Carina C. Montalvany-Antonucci, Debora R. Lacerda, Marina C. Oliveira, Tarcilia A. Silva, Soraia Macari, Mila F. M. Madeira, Adaliene V. M. Ferreira
Summary: This study found that supplementation of virgin coconut oil (VCO) can attenuate the osteopenic effects induced by obesity. VCO supplementation increases trabecular bone and improves the microarchitecture of the femur and alveolar bone.
Article
Dentistry, Oral Surgery & Medicine
Ana Carolina Velasco Ponde de Sena, Jose Alcides Almeida de Arruda, Larissa Marques Bemquerer, Erika Soares Pantuzzo, Fabiana Maria Kakehasi, Felipe Paiva Fonseca, Benjamin P. J. Fournier, Lucas Guimaraes Abreu, Denise Vieira Travassos, Tarcilia Aparecida Silva
Summary: This study analyzed the oral health status and occurrence of oral malignant infiltrations (OMI) in individuals with leukemia/lymphoma. The results showed that OMI occurred in a small percentage of cases, but was more common in adults with AML and was associated with increased risk of death and worse periodontal condition.
Article
Biology
Ricardo Luiz de Barreto Aranha, Renata de Castro Martins, Ligia Cristelli Paixao, Mauro Henrique Nogueira Guimaraes de Abreu
Summary: This study aimed to identify professional factors associated with case resolution without a referral of orofacial pain to secondary health care. A cross-sectional study was conducted from January 2019 to December 2020 using secondary databases from asynchronous teleconsulting Telehealth Brazil Networks. The results showed that in 2019, nurses and other professionals had a lower frequency of case resolution without a referral compared to general dentists. In 2020, oral-cavity-related doubts and temporomandibular disorders surpassed other causes of orofacial pain in case resolution without a referral, and female professionals avoided referrals more frequently than men.
Article
Pathology
Ana Carolina Velasco Ponde de Sena, Jose Alcides Almeida de Arruda, Sicilia Rezende Oliveira, Nickolas Mendes Pereira, Larissa dos Santos Faria, Denise Vieira Travassos, Tarcilia Aparecida Silva
Summary: Cryptococcosis is a neglected fungal disease, especially in Brazil. We present a case of orofacial cryptococcosis in a 57-year-old man after heart transplantation, with multiple ulcers and erosions in the oral cavity. Computed tomography revealed lung abnormalities. Histopathological features confirmed Cryptococcus spp. Treatment with amphotericin B and fluconazole was successful, and the patient remained disease-free during 6 months of follow up. A review of oral cryptococcosis literature showed male predilection, with ulcers mostly affecting the palate and tongue. Amphotericin B was the primary therapy and 65% of patients survived.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alex Junio Silva Cruz, Maria Auxiliadora Parreiras Martins, Diego Rodrigues de Aguilar, Jacqueline Silva Santos, Woosung Sohn, Lia Silva de Castilho, Mauro Henrique Nogueira Guimaraes Abreu
Summary: This study aimed to investigate the prevalence of potential drug-drug interactions involving psychotropics prescribed by dentists and dispensed by the public healthcare system in the state of Minas Gerais, Brazil. The results showed that the prevalence of potential drug-drug interactions among dental patients receiving psychotropic drugs was 24.8%, and most of these interactions were of major severity. These interactions may pose potential risks and life-threatening effects to the patients.
Article
Medicine, Research & Experimental
Juliana P. Vago, Isabella Zaidan, Luiza O. Perucci, Larissa Froede Brito, Livia C. R. Teixeira, Camila Meirelles Souza Silva, Thais C. Miranda, Eliza M. Melo, Alexandre S. Bruno, Celso Martins Queiroz-Junior, Michelle A. Sugimoto, Luciana P. Tavares, Lais C. Grossi, Isabela N. Borges, Ayda Henriques Schneider, Nagyung Baik, Ayda H. Schneider, Andre Talvani, Raphael G. Ferreira, Jose C. Alves-Filho, Vandack Nobre, Mauro M. Teixeira, Robert J. Parmer, Lindsey A. Miles, Lirlandia P. Sousa
Summary: In this study, we investigated the role of the plasminogen/plasmin system during sepsis. Plasminogen levels were negatively correlated with IL-6, while plasminogen activator inhibitor-1 levels were positively correlated with IL-6. Plasminogen deficiency increased susceptibility to sepsis and resulted in increased inflammation, organ damage, and neutrophil extracellular trap release. Conversely, exogenous plasminogen protected against sepsis-induced lethality and reduced inflammation and organ damage.
Article
Cell Biology
Mariana de S. Santos, Virginia T. M. Lima, Breno R. Barrioni, Juliana P. Vago, Jose Alcides A. de Arruda, Pedro D. Prazeres, Flavio A. Amaral, Tarcilia A. Silva, Soraia Macari
Summary: This study investigated the role of PI3K gamma in tooth movement and bone remodeling. The results showed that the deficiency or inhibition of PI3K gamma can reduce bone resorption and improve bone quality by increasing osteoblasts and decreasing osteoclasts. The PI3K gamma/Akt axis plays a crucial role in bone remodeling.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Letter
Dentistry, Oral Surgery & Medicine
Fernanda Aragao Felix, Lucas Tadeu Ferreira Gomes, Flavia Martins Vasconcellos Filliu, Stanley de Almeida Araujo, Tarcilia Aparecida da Silva, Marina Goncalves Diniz, Ricardo Santiago Gomez, Roberta Rayra Martins-Chaves, Silvia Ferreira de Sousa
Letter
Dentistry, Oral Surgery & Medicine
Tatiana F. A. Almeida, Sicilia R. Oliveira, Mariana S. de Noronha, Amalia Moreno, Ricardo A. Mesquita, Lucas G. Abreu, Tarcilia A. da Silva
JOURNAL OF PROSTHETIC DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ana Carolina Marques-Medeiros, Renata Castro Martins, Leandro Napier de Souza, Ricardo Santiago Gomez, Maria Elisa de Souza e Silva, Maria Auxiliadora Parreiras Martins, Mauro Henrique Nogueira Guimaraes de Abreu
Summary: The aim of this study was to evaluate the effectiveness of e-learning in compliance with new biosafety recommendations in dentistry among clinical staff in a dental school in Brazil during the COVID-19 pandemic. A quasi-experimental epidemiological study using a pre-tested online questionnaire was conducted, with an educational intervention in the form of e-learning. Statistical tests were performed after data collection. The study involved 549 clinical staff members in two phases, with a return rate of 26.9%. The use of disposable gloves, protective goggles, and surgical masks decreased after the e-learning intervention. The study found no impact on the staff's knowledge of the proper sequence for donning personal protective equipment (PPE), but showed 100% effectiveness in the proper PPE doffing sequence. Knowledge about avoiding aerosol-generating procedures in the clinical setting improved. It was concluded that online intervention alone was ineffective in significantly enhancing learning about the new clinical biosafety guidelines, and hybrid teaching and repetitive training were recommended.
BRAZILIAN ORAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Daiana Cristina Pereira Santana, Larissa Abbehusen Couto, Johelle de Santana Passos-Soares, Flavia Calo de Aquino Xavier, Ricardo Alves Mesquita, Fernanda Aragao Felix, Tarcilia Aparecida da Silva, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Christany Rodrigues Ferreira, Tatiana Nayara Liborio-Kimura, Lucileide Castro de Oliveira Moreira, Jeconias Camara, Caroline Alfaia Silva, Elismauro Francisco de Mendonca, Nadia do Lago Costa, Helder Antonio Rebelo Pontes, Lucas Lacerda de Souza, Jurema Freire de Castro Lisboa, Gustavo Pina Godoy, Lais Azevedo Lins de Holanda, Manoela Domingues Martins, Pantelis Varvaki Rados, Tuany Rafaeli Schmidt, Roseana de Almeida Freitas, Lelia Batista de Souza, Everton Freitas de Morais, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Gabriella Alves Quixabeira Oliveira, Jean Nunes dos Santos, aguida Cristina Gomes Henriques
Summary: This multicenter study aimed to evaluate cases of non-syndrome and syndromic odontogenic keratocysts. The study found that non-syndromic keratocysts were more common in the population. Clinicopathological features, age, and recurrence may differ between syndromic and non-syndromic cases. Additionally, there was an association between lesion size and clinical features, as well as between recurrence time interval and the syndromic spectrum.
CLINICAL ORAL INVESTIGATIONS
(2023)
