Review
Engineering, Biomedical
Paola Caroline da Silva Mira, Larissa Dias Vilela, Silmara Aparecida Milori Corona, Maria Cristina Borsatto
Summary: This systematic review examined the use of low-level laser therapy (LLLT) at acupuncture points in pediatric dental patients. Four studies revealed that LLLT effectively reduced the gag reflex during radiographic examinations and impression taking, alleviated preanesthetic pain, and improved symptoms of sleep bruxism in pediatric dental patients. Standardization of study design and analysis methods should be prioritized in future research.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Chemistry, Medicinal
M. E. Gonzalez-Trujano, N. Paez-Martinez, F. Krengel, D. Martinez-Vargas, M. Leon-Santiago, B. Cruz-Lopez, J. M. Puentes-Guerrero, J. K. Diaz-Canton, R. Reyes-Chilpa, S. L. Guzman-Gutierrez
Summary: This study examined the effects of an alkaloid extract obtained from the root bark of Tabernaemontana arborea on central nervous system-related activities. The extract, which mainly contained monoterpenoid indole alkaloids, exhibited antidepressant and antinociceptive effects without altering motor coordination, ambulatory activity, and memory. This suggests that the alkaloids from T. arborea may have therapeutic value in pain relief and the treatment of psychiatric diseases without causing neurotoxicity at effective doses.
Article
Computer Science, Information Systems
Duc Tri Phan, Quoc Bao Ta, Cao Duong Ly, Cong Hoan Nguyen, Sumin Park, Jaeyeop Choi, Hwi O. Se, Junghwan Oh
Summary: In this study, a low-level laser therapy (LLLT) system with a deep neural network and medical internet of things (MIoT) assistance is proposed for computer-aided diagnosis using dermoscopy images. The main contributions of this study include a comprehensive hardware and software design for an automatic phototherapy system, a modified-U(2)Net deep learning model for facial dermatological disorder segmentation, and the development of a synthetic data generation process to address the issue of the limited and imbalanced dataset.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Integrative & Complementary Medicine
JeongIn Kang, MiJu Son, YoungEun Kim, EunHee Lee, NamHun Heo, NamKwen Kim, SuRan Kim, DongHyo Lee
Summary: The study showed that intranasal LLLT is noninferior compared to acupuncture in terms of treating allergic rhinitis, suggesting it as an alternative or adjunctive treatment for relieving AR symptoms.
EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
(2022)
Article
Biochemistry & Molecular Biology
Seok-Rae Park, Younghwan Han, Su Jeong Lee, Ki-Il Lee
Summary: This study aimed to evaluate the efficacy of low-level laser therapy (LLLT) for rhinosinusitis. The results showed that LLLT significantly improved tissue inflammation, sinus opacification, and cytokine expression, indicating that LLLT is an effective treatment option for rhinosinusitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Tian Li, Siyao Wang, Ke Cheng, Lu Sun, Daopeng Jin, Shen Zhang, Zhen Yang, Zouqin Huang
Summary: This study compared the efficacy of stronger and weaker heat stimulation in warm acupuncture for patients with acute low back pain. The results showed that warm acupuncture with silver needle significantly relieved disability and pain intensity in both the short and long term compared to warm acupuncture with stainless steel needle.
INTEGRATIVE MEDICINE RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Aqsa Kamal, Basheer Salman, A. R. Noor Hayatie, A. R. Samsudin
Summary: The study investigated the efficacy of low-level laser therapy (LLLT) for dry socket management. Results showed that LLLT treatment led to lower pain scores and faster healing compared to conventional treatment, indicating its clinical effectiveness in promoting dry socket healing.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Pharmacology & Pharmacy
Isaac Tabiri Henneh, Francis Ackah Armah, Elvis Ofori Ameyaw, Robert Peter Biney, Ernest Obese, Eric Boakye-Gyasi, Emmanuel Awintiig Adakudugu, Martins Ekor
Summary: The study demonstrated that the hydro-ethanolic root bark extract of Ziziphus abyssinica possesses significant analgesic properties, alleviating both acute and chronic musculoskeletal pain and reversing pain sensitization induced by pro-inflammatory mediators. The analgesic effect of the extract may be mediated through various pathways, including opioidergic, ATP-sensitive K+ channels, and NO-cGMP pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jae-Hong Kim, Chang-Su Na, Myoung-Rae Cho, Gwang-Cheon Park, Jeong-Soon Lee
Summary: This study aimed to investigate the efficacy of invasive laser acupuncture for chronic non-specific low back pain. The results showed that both 650 nm-wavelength and 830 nm-wavelength ILA significantly reduced pain intensity and improved functional disability.
Article
Biochemistry & Molecular Biology
Nazli Turan Yucel, Ummuhan Kandemir, Umide Demir Ozkay, Ozgur Devrim Can
Summary: Vortioxetine, a multimodal antidepressant drug, exhibits analgesic effects by affecting central pathways carrying acute thermal and mechanical nociceptive stimuli, mediated by 5-HT1A serotonergic, alpha-adrenergic, and opioidergic receptors. The contributions of central serotonergic and catecholaminergic neurotransmissions are critical for this analgesic effect.
Article
Biology
Yi-Yuan Lin, Shin-Yi Lee, Yu-Jung Cheng
Summary: The effects of low-level laser therapy (LLLT) on tumor growth and angiogenesis in melanoma were investigated. It was found that LLLT promotes melanoma tumor growth by inducing angiogenesis.
Review
Biochemistry & Molecular Biology
Micaela Berni, Alice Maria Brancato, Camilla Torriani, Valentina Bina, Salvatore Annunziata, Elena Cornella, Michelangelo Trucchi, Eugenio Jannelli, Mario Mosconi, Giulia Gastaldi, Laura Caliogna, Federico Alberto Grassi, Gianluigi Pasta
Summary: Low-level laser therapy (LLLT) is increasingly used in orthopedics practices to promote angiogenesis, fracture healing, and osteogenic differentiation of stem cells. However, the cellular mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation, and frequency of LLLT influence the cellular mechanisms, and the effects of LLLT vary according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process to improve its clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Jie Bai, Lijun Li, Ni Kou, Yuwen Bai, Yaoyang Zhang, Yun Lu, Lu Gao, Fu Wang
Summary: LLLT enhances vascularized bone regeneration by coupling angiogenesis and osteogenesis. ROS/HIF-1 alpha is necessary for these effects of LLLT, and there may be a positive feedback loop between ROS and HIF-1 alpha, further amplifying HIF-1 alpha induction.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Optics
Renata Goncalves Rando, Daniela Vieira Buchaim, Paula Cristina Cola, Rogerio Leone Buchaim
Summary: Alveolar bone repair is a vital and intricate process for restoring functions such as mastication, occlusion, and implant osseointegration. Various methods including biomaterial grafting, platelet-rich fibrin (PRF), and low-level laser therapy (LLLT) have been investigated to optimize this process. This review analyzed the use of LLLT as an auxiliary tool in alveolar bone repair, and found that it promotes repair by enhancing ATP production, activating growth factors, reducing inflammation, and inducing angiogenesis. The Gallium Aluminum Arsenide-GaAlAs laser with a wavelength of 830 nm was found to be the most effective. Overall, PBM with LLLT has beneficial effects on alveolar bone repair, accelerating the formation of new bone matrix and preserving or increasing the height and/or thickness of the alveolar bone ridge.
Review
Physiology
Kexin Lyu, Xueli Liu, Li Jiang, Yixuan Chen, Jingwei Lu, Bin Zhu, Xinyue Liu, Yujie Li, Dingxuan Wang, Sen Li
Summary: Low-level laser therapy (LLLT) has significant effects on tendon repair. It activates different mechanisms in the three phases of tendon repair, including promoting angiogenesis, increasing collagen type III production, and reducing inflammatory responses. However, excessive LLLT in the final phase of tendon repair may lead to tendon fibrosis, requiring further investigation of its functions and mechanisms.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Eloa Ferreira Yamada, Carolina dos Santos Stein, Rafael Noal Moresco, Franciane Bobinski, Juliete Palandi, Paula Franson Fernandes, Vanderlei Folmer, Morgana Duarte da Silva
Summary: The study showed that both PBMT and S. tuberculata extracts can reduce oxidative stress and inflammation, contributing to a decrease in pain sensation. Although the combination of therapies did not have significant effects, PBMT alone was sufficient to minimize the signs and symptoms of knee OA in the rat model.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Pediatrics
Franciane R. Dos Anjos, Adriane M. Nakato, Paula Karina Hembecker, Percy Nohama, Ana Lucia F. Sarquis
Summary: The study aimed to evaluate the effects of hydrotherapy and tactile-kinesthetic stimulation on the birth weight of preterm infants. The results showed that the hydrotherapy group had a significantly increased weight after the interventions, while there was no significant difference in weight gain in the tactile-kinesthetic stimulation group.
JORNAL DE PEDIATRIA
(2022)
Article
Integrative & Complementary Medicine
Daniel Tassinari Felber, Rafael Tamborena Malheiros, Victor Novo Tentardini, Andreia Caroline Fernandes Salgueiro, Francisco Jose Cidral-Filho, Morgana Duarte da Silva
Summary: The study showed that dry needling improved muscle strength, functionality, and locomotor activity in a rat model of muscle pain. Twitch needling induced an antioxidant effect.
ACUPUNCTURE IN MEDICINE
(2022)
Article
Nursing
Anita Batista dos Santos Heberle, Alexandrina Aparecida Maciel Cardelli, Ieda Harumi Higarashi, Maria Dalva de Barros Carvalho, Percy Nohama, Sandra Marisa Pelloso
Summary: The study compared the ergonomics of two models of breastfeeding bras, with results showing that the bra in group B performed better in terms of physical and psycho-aesthetic comfort, meeting the needs of breastfeeding women.
REVISTA BRASILEIRA DE ENFERMAGEM
(2022)
Article
Plant Sciences
Hemerson Silva da Rosa, Mari Castro Santos, Marcio Tavares Costa, Andreia Salgueiro, Morgana Duarte da Silva, Daniele Rubert Nogueira-Librelotto, Cristiano Jesse, Michel Mansur Machado, Luis Flavio Souza de Oliveira, Vanderlei Folmer, Andreas S. L. Mendez
Summary: The study evaluated the cytotoxic and anti-inflammatory properties of Sida tuberculata extracts in vitro and in vivo. The results showed that the extracts had stronger cytotoxic effects on tumor cell lines, and the leaf extract significantly reduced acute inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Wally auf der Strasse, Daniel Prado Campos, Celso Junio Aguiar Mendonca, Jamil Faissal Soni, Joaquim Mendes, Percy Nohama
Summary: Non-contact infrared sensors are widely used for initial screening of body temperature during the COVID-19 pandemic. This study investigated the thermal differences in different anatomical points and found that the temperature at the temple region is higher than other regions, suggesting it should be considered for initial screening.
MEDICAL ENGINEERING & PHYSICS
(2022)
Article
Engineering, Biomedical
Wally auf der Strasse, Daniel Prado Campos, Celso Junio Aguiar Mendonca, Jamil Faissal Soni, Joaquim Mendes, Percy Nohama
Summary: This study investigates the feasibility of clinical diagnosis of bone trauma through medical infrared thermography in a hospital emergency room. The results show that infrared imaging has a high potential as a tool for quick diagnosis of bone fractures in emergency medical settings. The analysis of thermal images can accurately locate fractures and provide physiological data correlated with radiographic examinations.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Neurosciences
Fabricio Finamor, Vanessa Leal Scarabelot, Liciane Fernandes Medeiros, Dirson Joao Stein, Morgana Duarte da Silva, Etiane Callai, Wolnei Caumo, Andressa de Souza, Iraci L. S. Torres
Summary: This study evaluated the involvement of GABAergic, glutamatergic, opioidergic systems, and BDNF levels in trigeminal neuropathic pain (TNP) in rats. The results suggest that GABA, phenobarbital, and morphine can reverse the hyperalgesia induced by TNP. Glutamatergic antagonists can increase pain threshold, and BDNF levels are elevated in TNP and normal tissues. These findings contribute to our understanding of the neural mechanisms underlying TNP.
NEUROSCIENCE LETTERS
(2023)
Article
Dermatology
Rosane Schenkel de Aquino, Aledson Rosa Torres, Alcir Luiz Dafre, Adair Roberto Soares Santos
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Plant Sciences
Scheila Iria Kraus, Jeane Bachi Ferreira, Jhonatan Augusto Ribeiro, Kelly Cattelan Bonorino, Vinicius Alexandre Wippel, Michele Debiasi Alberton, Andreia Caroline Fernandes Salgueiro, Carlos Henrique Lemos Soares, Morgana Duarte da Silva
Summary: This study evaluated the toxicological effects of Eugenia brasiliensis and its antinociceptive and anti-inflammatory activity. The results showed that the extract did not have significant toxic effects and exhibited important antinociceptive, anti-inflammatory, and antioxidant potential.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jhenifer Karvat, Tassiane Emanuelle Servare Andrade, Scheila Iria Kraus, Larissa May Beppler, Gustavo dos Santos Catarina de Jesus, Jeane Bachi Ferreira, Morgana Duarte da Silva
Summary: The study aimed to evaluate the effects of diacerein in a mice model of sciatic nerve crush. The results showed that diacerein treatment accelerated sensorimotor recovery and inhibited hopelessness, anhedonia, and lack of well-being in the animals. Additionally, diacerein treatment restored the diameter of nerve fibers, axons, and myelin sheaths, and regulated the levels of interleukin-1 beta and brain-derived growth factor.
PHARMACOLOGICAL REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Bianca Zimmermann dos Santos, Rafael Cypriano Dutra, Adair Roberto Soares dos Santos, Maisa Casarin, Eliane Maria Goldfeder, Vera Lucia Bosco, Mabel Mariela Rodriguez Cordeiro
Summary: Understanding the biological mechanisms behind root resorption in deciduous teeth is crucial for the development of preventive measures and treatments. This study compared the expression and immunostaining of several substances in the periodontal ligament of deciduous teeth with different types of root resorption. The results showed that inflammatory root resorption exhibited higher expression of certain factors and enzymes related to tissue degradation, which explains the increased susceptibility of deciduous teeth to root resorption.
BRAZILIAN ORAL RESEARCH
(2022)
Proceedings Paper
Engineering, Biomedical
Wally auf der Strasse, A. Pinto, M. F. F. Vara, E. L. Santos, M. Ranciaro, P. Nohama, J. Mendes
Summary: This study evaluated the analgesic effect of acupuncture and the thermal distribution of the treatment in patients with chronic pain and vascular disorders in the lower limbs. Infrared thermography was used to measure the skin temperature before and after acupuncture treatment. The results suggest that infrared thermography may be applicable in monitoring and diagnosing chronic pain related to vascular disorders in the lower limbs.
XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020
(2022)
Proceedings Paper
Biophysics
G. Margraf, B. L. Fernandes, P. Nohama
Summary: This project aims to evaluate the production process of impregnating copper particles into nonwoven fabric to enhance the sterilization effect of disposable protective masks. Through experimental analysis, we found that copper particles can significantly reduce the survival time of viruses and bacteria on masks, showing potential for application.
2022 GLOBAL MEDICAL ENGINEERING PHYSICS EXCHANGES/PAN AMERICAN HEALTH CARE EXCHANGES (GMEPE/PAHCE)
(2022)
Proceedings Paper
Biophysics
W. A. D. Strasse, M. P. Clemente, C. Faria, S. B. Machado, J. M. Amarante, P. Nohama, J. Mendes
Summary: This study evaluated the effectiveness of TENS treatment for patients with TMD using medical infrared thermography. The results showed consistent thermal distribution and decreased temperature asymmetry after TENS treatment, indicating its success. Thus, thermography can be a promising complementary method in TENS analgesic therapy for TMD patients.
2022 GLOBAL MEDICAL ENGINEERING PHYSICS EXCHANGES/PAN AMERICAN HEALTH CARE EXCHANGES (GMEPE/PAHCE)
(2022)