Article
Dentistry, Oral Surgery & Medicine
Ingemar Abrahamsson, Ahmed Almohandes, Carlotta Dionigi, Tord Berglundh
Summary: This study aimed to investigate early bone healing around implants with non-modified and modified surfaces. Four different surface characteristics were tested in the mandibles of 6 dogs. The results showed that implants with surface modifications had higher bone-to-implant contact and more newly formed bone within the defect area compared to implants with non-modified surfaces. Acid-etching in oxalic and hydrofluoric acid was found to promote early formation of bone-to-implant contact.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Review
Chemistry, Physical
Alexandra Ripszky Totan, Marina Melescanu Imre, Simona Parvu, Daniela Meghea, Radu Radulescu, Dan Sebastian Alexandru Enasescu, Mihai Radu Moisa, Silviu Mirel Pituru
Summary: This review explores the role of autophagy in dental implant surgery. Autophagy plays important roles in regulating immune response, promoting cell survival, and regulating osteoblast function in macrophages, endothelial cells, and osteoblasts, respectively. It also plays a critical role in alveolar bone remodeling and fibroblast apoptosis. Autophagy seems to have a dual role in dental implant surgery and further research is needed to fully understand its positive features.
Article
Chemistry, Multidisciplinary
Vadim Veiko, Yuliya Karlagina, Ekaterina Zernitckaia, Elena Egorova, Maxim Radaev, Andrey Yaremenko, Gennadiy Chernenko, Valery Romanov, Nadezhda Shchedrina, Elena Ivanova, Boris Chichkov, Galina Odintsova
Summary: Laser processing of dental implant surfaces allows for control of surface structure and the creation of biomimetic topographies. The study shows that implants with continuous topography have the best secondary stability and osseointegration.
Article
Dentistry, Oral Surgery & Medicine
Nicolas Rousseau, Ines Msolli, Patrick Chabrand, Arnaud Destainville, Olivier Richart, Jean-Louis Milan
Summary: This study evaluated the local effects and osseointegration of dental implants with surface micro/nanofeatures compared to untreated implants through various analyses after implantation in sheep femoral condyles for 4 and 13 weeks. The results showed that the surface-treated implants promoted faster bone healing and higher bone-to-implant contact in the coronal region compared to untreated implants.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Gabrielle Alencar Ferreira Silva, Fernanda Faot, Wander Jose da Silva, Altair Antoninha Del Bel Cury
Summary: The study evaluated the influence of hydrophilicity on the surface integrity of implants after insertion in low-density artificial bone. It was found that implants with hydrophilic surface treatment resulted in more titanium particle release into the bone bed. Surface damage was observed after insertion, mainly in the apical region of the implants.
Article
Multidisciplinary Sciences
Kristian Kniha, Benita Hermanns-Sachweh, Faruk Al-Sibai, Reinhold Kneer, Stephan Christian Moehlhenrich, Marius Heitzer, Frank Hoelzle, Ali Modabber
Summary: The purpose of this rat study was to investigate the feasibility of temperature thresholds affecting bone contact at the surface of implants in vivo. The results showed that thermal necrosis should be used for implant removal in subsequent in vivo studies. The study found that temperatures ranging from 48°C to 50°C led to a decrease in the BIC ratio, with significant differences observed between the 50°C group and the control group. However, there were no significant variations within the cold temperatures.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Waqar Ahmad, Novin Pishevar, Leonard J. Cochrane, Andrew Reynolds, Joseph Kim, Ivan Korostenskij, Vincenza L. Geiser, Matthew D. Carson, Amy J. Warner, Peng Chen, Hai Yao, Alexander Alekseyenko, Jessica D. Hathaway-Schrader, Chad M. Novince
Summary: The aim of this study was to evaluate the impact of antibiotic prophylaxis on dental implant placement surgery-induced osteoimmune wound healing and osseointegration. The results showed that prophylactic antibiotics caused bacterial dysbiosis, suppressed helper T-cell immune response, reduced the number of osteoblasts and osteoclasts, and weakened the bone-implant interface. These findings suggest that antibiotic prophylaxis dysregulates the osteoimmune wound healing process induced by implant surgery.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Dezheng Tang, Entang Wang, Yifan Xu, Chao Liang, Changying Liu, Xiao Lin, Jun Li
Summary: The study found higher failure rates among T2DM patients during the healing period, and identified multiple differentially expressed proteins between different groups. The results suggest that risk factors besides hyperglycemia may affect osseointegration during the healing period.
Article
Dentistry, Oral Surgery & Medicine
Yu-Sung Choi, In-Seok Song, Moon-Young Kim, Ho-Kyung Lim, Li Chongyang, Ji Suk Shim
Summary: This study aimed to evaluate the effect of aging on the changes in implant stability over time following implant placement. The results showed that the stability of implants in elderly patients is not related to age, but rather to the engagement of the implant with the bone.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Yifan Zhang, Karan Gulati, Ze Li, Ping Di, Yan Liu
Summary: Titanium and its alloys are ideal materials for dental implants, but long-term success may be hindered by implant-related infections and inadequate osseointegration. Recent development in nanotechnology has focused on nanoscale modifications and application of nanomaterials for improving dental implant performance.
Review
Medicine, General & Internal
Sukanya Mishra, Manoj Kumar, Lora Mishra, Rinkee Mohanty, Rashmita Nayak, Abhaya Chandra Das, Sambhab Mishra, Saurav Panda, Barbara Lapinska
Summary: This systematic review analyzed the use of Fractal Dimension (FD) as a tool to measure implant stability based on trabecular changes. The results showed that FD can serve as a measure of implant stability, but it should be used in conjunction with other methods and factors, as it may not be a sole indicator.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Javier Gil, Clara Sandino, Miguel Cerrolaza, Roman Perez, Mariano Herrero-Climent, Blanca Rios-Carrasco, Jose Vicente Rios-Santos, Aritza Brizuela
Summary: The purpose of this study was to investigate the biomechanical response of dental implants in different positions and cortical bone thicknesses. Numerical simulations and in vivo experiments showed that implants placed 0.5 mm below the bone level with smaller thickness had the best performance in terms of osseointegration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Giovanni-Battista Menchini-Fabris, Saverio Cosola, Paolo Toti, Myoung Hwan Hwang, Roberto Crespi, Ugo Covani
Summary: Immediate dental implant placement with an immediate non-loading provisional customized healing abutment could be a potential treatment strategy for patients with large chronic periapical and periradicular lesions in multiradicular teeth, providing rehabilitation and preserving soft tissue.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sanako Makishi, Tomohiko Yamazaki, Hayato Ohshima
Summary: This study analyzed the effects of various OPN modified protein/peptides coatings on the healing patterns of the bone-implant interface. The results showed that rOPN coated implant enhances direct osteogenesis during osseointegration following implantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Edmara T. P. Bergamo, Lukasz Witek, Ilana Ramalho, Adolfo C. O. Lopes, Vasudev Vivekanand Nayak, Estevam A. A. Bonfante, Nick Tovar, Andrea Torroni, Paulo G. G. Coelho
Summary: The aim of this study was to evaluate the bone healing of implants placed in the maxilla and mandible of subjects compromised with metabolic syndrome and type-2 Diabetes Mellitus. The results showed that healthy and metabolic syndrome subjects had higher bone-to-implant contact and bone area fraction occupancy within implant threads compared to type-2 Diabetes Mellitus subjects. In the mandible, healthy and metabolic syndrome subjects also had higher bone-to-implant contact and bone area fraction occupancy within implant threads compared to type-2 Diabetes Mellitus subjects. The amount of bone around implants was comparable in the maxilla and mandible.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Daniel Borbola, Gabor Berkei, Botond Simon, Laszlo Romanszky, Gyorgy Sersli, Michael DeFee, Walter Renne, Francesco Mangano, Janos Vag
Summary: The study compared the precision of various intraoral scanners and found that 3ShapeE4 and MeditT710 had slightly lower precision than ATOS, but significantly higher precision than other scanners. The trueness of 3ShapeE4 and MeditT710 was also found to be higher than other scanners. Mediti700's trueness was evaluated using ATOS, 3ShapeE4, and MeditT710, and no significant difference was found between them.
JOURNAL OF DENTISTRY
(2023)
Article
Anatomy & Morphology
Ugo E. E. Pazzaglia, Marcella Reguzzoni, Renata Manconi, Luca Lanteri, Guido Zarattini, Piero A. A. Zecca, Mario Raspanti
Summary: The macroscopic and microscopic morphology of the appendicular skeleton in Raja asterias and Torpedo marmorata was studied. The study compared the organization and structural layout of the pectoral, pelvic, and tail fin systems. The research found that the pectoral fin system in T. marmorata was affected by the presence of two electric organs, resulting in a reduced surface area and lower efficiency compared to R. asterias. The study also observed similarities and differences in the morphology and calcification pattern of the fin-ray structures in both species. The findings provided new insights into the structural layout of the wing-fins and its correlation to Batoid swimming behavior. The observations also suggest a possible cartilage-calcification process in the formation of the appendicular skeleton. The study is rated 9 out of 10 for its importance.
JOURNAL OF ANATOMY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Francesco Guido Mangano, Oleg Admakin, Henriette Lerner, Carlo Mangano
Summary: This study presents a novel protocol for dental implant planning using artificial intelligence and augmented reality. The protocol includes steps like 3D data acquisition, AI segmentation of CBCT, AR system for surgical planning, CAD software for surgical guide design, and patient surgery. The results show that this protocol is effective and time-efficient for simple cases of guided implant surgery in partially edentulous patients.
JOURNAL OF DENTISTRY
(2023)
Article
Medicine, General & Internal
Marcio de Carvalho Formiga, Helio Doyle Pereira da Silva, Bruna Ghiraldini, Rafael Shinoske Siroma, Lavinia Cosmina Ardelean, Adriano Piattelli, Jamil Awad Shibli
Summary: Primary stability is crucial for the success of dental implants. Osseodensification (OD) is a new bone site preparation method that increases bone-to-implant contact and primary stability. This study compared the effects of OD on cylindrical and conical implants with conventional instrumentation. The results showed that OD improved implant stability quotient (ISQ), insertion torque (IT), and removal torque (RT) for both types of implants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Caio Junji Tanaka, Jose Augusto Rodrigues, Joao Marcos Spessoto Pingueiro, Tatiane Tiemi Macedo, Magda Feres, Jamil Awad Shibli, Bruno Bueno-Silva
Summary: Bioactive materials with fluoride release and antimicrobial potential are widely used in dentistry. However, the antimicrobial activity of bioactive surface pre-reacted glass (S-PRG) coatings on periodontopathogenic biofilms has been insufficiently studied. This study investigated the antibacterial activity of S-PRG fillers on a multi-species subgingival biofilm. The results showed that the bioactive coating containing S-PRG modified the composition of the subgingival biofilm in vitro and reduced the bacterial activity by 25.7%.
Article
Infectious Diseases
Stella de Noronha Campos Mendes, Camila Machado Esteves, Juliana Alethusa Velloso Mendes, Magda Feres, Nathalia Figueiredo, Tamires Szeremeske de Miranda, Jamil Awad Shibli, Luciene Cristina Figueiredo
Summary: The study evaluated the effects of scaling and root planing combined with antimicrobial chemical control on different oral cavity sites. The use of antibiotics and chlorhexidine mouth rinse significantly reduced the proportion of red complex species. In conclusion, antimicrobial chemical control showed a beneficial effect on the composition of oral microbiota.
Article
Health Care Sciences & Services
Simona Tecco, Alessandro Nota, Laura Pittari, Chiara Clerici, Francesco Mangano, Enrico Felice Gherlone
Summary: Digital technologies provide new opportunities for the management of Temporomandibular joint disorders (TMDs), allowing for digital assessment and verification of treatment plans. This case series demonstrates the successful use of a digital device (ModJaw) to digitally plan and customize treatments for TMD patients. The digitization of mandibular kinematics enables more accurate diagnosis and faster execution of intraoral appliances through a digital workflow.
Review
Dentistry, Oral Surgery & Medicine
Magda Feres, Rodrigo Martins, Joao Gabriel S. Souza, Martinna Bertolini, Valentim A. R. Barao, Jamil A. Shibli
Summary: This review aimed to evaluate the efficacy of antibiotics in treating peri-implantitis. The results showed that the use of systemic metronidazole combined with ultrasonic debridement can effectively improve the outcomes of nonsurgical treatment. However, further research is needed to assess the clinical and microbiological effects of different antibiotic protocols.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Anatomy & Morphology
Piero Antonio Zecca, Marcella Reguzzoni, Marina Borgese, Marina Protasoni, Marta Filibian, Mario Raspanti
Summary: In this study, we investigated the interfaces of the epiphyseal plate with over- and underlying bone segments using an integrated approach of histochemistry, microtomography, and scanning electron microscopy. The two interfaces showed significant differences, with the diaphyseal side exhibiting active calcification and slow remodeling of cartilage into bone, while the epiphyseal side showed marginal and discontinuous mineralization and a loose trabecular bone structure. The calcification process in both sides involved the formation of spheroidal bodies, which is distinct from the calcification process in bone and other tissues.
JOURNAL OF ANATOMY
(2023)
Article
Materials Science, Multidisciplinary
Piero Antonio Zecca, Reguzzoni Marcella, Brambilla Andrea, Protasoni Marina, Borgese Marina, Raspanti Mario
Summary: This article explores the potential risks associated with using AI-generated images in microscopy, discussing limitations of current AI-based techniques and the consequences of illegal use, including falsified scientific data. It proposes solutions, such as robust authentication methods and ethical guidelines, to mitigate these risks. Additionally, a survey shows good recognition of authentic and entirely AI-generated images, but detection of hybrid images could be improved.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Anatomy & Morphology
Ugo E. Pazzaglia, Marcella Reguzzoni, Chiara Milanese, Renata Manconi, Luca Lanteri, Tiziana Cubeddu, Guido Zarattini, Piero A. Zecca, Mario Raspanti
Summary: This study compares the skeletal calcification pattern of batoid Raja asterias with mammalian Homo sapiens and teleost Xiphias gladius. Different techniques were used, including histology, histochemistry, SEM/EDAX analysis, TGA, DSC, and FTIR. The calcified cartilage of R. asterias diverges from the ossification models of H. sapiens and X. gladius, showing higher water release and more amorphous bioapatite. In R. asterias, the calcified cartilage remains un-remodeled throughout the lifespan, while in endochondral ossification, fetal calcified cartilage is replaced by bone matrix.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Vittorio Moraschini, Richard J. Miron, Carlos Fernando de Almeida Barros Mourao, Rafael Seabra Louro, Anton Sculean, Luiz Afonso Morgenstern da Fonseca, Monica Diuana Calasans Maia, Jamil Awad Shibli
Summary: This systematic review evaluated the antimicrobial potential of different types of platelet-rich fibrin (PRF) used in regenerative treatments. The findings showed that all types of PRF had significant antimicrobial action, with greater efficacy against bacteria compared to fungi. Future studies analyzing the clinical effect of PRF are important.
PERIODONTOLOGY 2000
(2023)
Article
Chemistry, Multidisciplinary
Ludovica Barone, Matteo Gallazzi, Federica Rossi, Roberto Papait, Mario Raspanti, Piero Antonio Zecca, Luca Buonarrivo, Barbara Bassani, Giovanni Bernardini, Antonino Bruno, Rosalba Gornati
Summary: This study compared the feasibility of two devices, which were generated by coupling soluble factors from human dental pulp mesenchymal stem cells (DPSCs) with a nanostructured scaffold, to support angiogenesis after transplantation in mice. The results showed that both DPSC-scaffold and DPSC soluble factors-scaffold were able to support angiogenesis, suggesting that DPSC-conditioned medium can be used as a cell-free preparation to support blood vessel formation.
Article
Chemistry, Multidisciplinary
Piero Antonio Zecca, Salvatore Bocchieri, Marina Borgese, Carolina Dolci, Alessandra Campobasso, Giovanni Battista, Alberto Caprioglio, Mario Raspanti
Summary: This scientific article investigates the mechanical properties of a novel three-dimensional-printing resin specifically designed for orthodontic aligners and compares it to other commonly used resins. The study found that blending two commercially available and certified resins can produce aligners with improved mechanical properties. The research provides valuable insights into the potential of the resin for orthodontic treatments and contributes to the advancement of personalized orthodontic care through three-dimensional-printing technology.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Vygandas Rutkunas, Ieva Gendviliene, Liudas Auskalnis, Francesco Mangano, Stefan Zlatev, Vasilena Ivanova, Eitan Mijiritsky, Rokas Borusevicius
Summary: This in vitro study evaluated the accuracy of fully guided dynamic implant navigation surgery in Kennedy class I, II, and III dental arch defects, using two different implant designs. The study found that dynamic implant guidance provides accurate spacing, angulation, depth, and position of the implants. Factors such as the number of missing teeth and implant position influenced the accuracy of the procedure.
JOURNAL OF DENTISTRY
(2023)
