Article
Engineering, Biomedical
Sihan Lin, Shi Yin, Junfeng Shi, Guangzheng Yang, Xutao Wen, Wenjie Zhang, Mingliang Zhou, Xinquan Jiang
Summary: In this study, the dose of bone morphogenetic protein-2 (BMP-2) was reduced and its safety and efficacy were improved through the regulation of magnesium ion (Mg2+). Magnesium ion enhanced cellular bioenergetic levels and the osteoinductivity of BMP-2. A co-delivery system, fabricated using microfluidic and 3D printing technologies, was able to rapidly and robustly induce bone regeneration.
BIOACTIVE MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Liwei Zhu, Yuzhe Liu, Ao Wang, Zhengqing Zhu, Youbin Li, Chenyi Zhu, Zhenjia Che, Tengyue Liu, He Liu, Lanfeng Huang
Summary: Bone morphogenetic protein (BMP) plays an important role in promoting bone healing, but its mechanism needs further exploration. By modifying implants to carry BMP and achieve slow and sustained release, effective bone healing can be stimulated.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Optics
Renata Goncalves Rando, Daniela Vieira Buchaim, Paula Cristina Cola, Rogerio Leone Buchaim
Summary: Alveolar bone repair is a vital and intricate process for restoring functions such as mastication, occlusion, and implant osseointegration. Various methods including biomaterial grafting, platelet-rich fibrin (PRF), and low-level laser therapy (LLLT) have been investigated to optimize this process. This review analyzed the use of LLLT as an auxiliary tool in alveolar bone repair, and found that it promotes repair by enhancing ATP production, activating growth factors, reducing inflammation, and inducing angiogenesis. The Gallium Aluminum Arsenide-GaAlAs laser with a wavelength of 830 nm was found to be the most effective. Overall, PBM with LLLT has beneficial effects on alveolar bone repair, accelerating the formation of new bone matrix and preserving or increasing the height and/or thickness of the alveolar bone ridge.
Article
Engineering, Environmental
Xiaoming Zhao, Jun Gao, Hao Han, Xiaoxiao Lou, Hongyun Ma, Xiaochen Su, Liuyang Zhang, Jing Tian, Bo Len, Yingang Zhang
Summary: In this study, a multifunctional bioactive bone cement reinforced with poly(citrate-silicon) nanospheres was developed to overcome the limitations of traditional polymethyl methacrylate (PMMA) bone cement. The reinforced cement showed improved properties such as increased injectability, extended setting time, increased hydrophilicity, reduced polymerization heat, and good degradability. It also exhibited antioxidant, antibacterial, and biomineralization properties. Cellular experiments showed enhanced osteogenic differentiation, mineral deposition, anti-inflammatory, and pro-angiogenic properties. In a rat model, the reinforced bone cement significantly promoted new bone formation and bone ingrowth, through improved osteogenic proteins and angiogenesis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Yili Wang, Hao Zhang, Yan Hu, Yingying Jing, Zhen Geng, Jiacan Su
Summary: As society ages, bone defects and fractures pose significant threats to health and quality of life. While bone grafting remains the gold standard for clinical treatment, limitations such as rejection and infection have led to the development of biomaterials for bone repair. Recent advances in osteoimmunology have highlighted the crucial role of macrophages in bone healing and the modulation of the osteoimmune microenvironment for promoting bone regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Medicinal
Nissrine Ballout, Agnes Boullier, Walaa Darwiche, Katia Ait-Mohand, Eric Trecherel, Theo Gallego, Cathy Gomila, Linda Yaker, Isabelle Gennero, Jose Kovensky, Jerome Ausseil, Sylvestre Toumieux
Summary: Bone fracture healing is a complex process involving hematoma formation, tissue formation, bony callus formation, and bone remodeling. Current therapeutic strategies for fracture repair include autografts, allografts, and tissue engineering. This study suggests that DP2, a disaccharide compound, may enhance fracture healing by promoting osteoblast differentiation and earlier mineralization in vitro. DP2 might serve as a potential therapeutic candidate for bone fracture repair.
Article
Oncology
Wangyang Meng, Han Xiao, Rong Zhao, Dong Li, Kuo Li, Yunchong Meng, Jiaping Chen, Yangwei Wang, Yongde Liao
Summary: In lung adenocarcinoma, BMP5 was identified as an independent protective prognostic factor, significantly correlated with EGFR expression and mutations, and potentially involved in targeted therapy. By co-expression with hub genes, the re-established risk model showed improved prognostic correlation and value.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Chaoqian Zhao, Chaoqin Shu, Jiangming Yu, Yufang Zhu
Summary: Bone defects caused by trauma, tumors, and osteoarthritis have a significant impact on the quality of life and health of patients. Biomaterials are widely used for repairing bone defects and treating orthopedic diseases, but their effectiveness is still unsatisfactory in cases involving tumor, inflammation, and bacterial infection. Metal-organic frameworks (MOFs) materials, with their high specific surface, high porosity, controlled degradability, and variable composition, have shown great potential for functionalizing biomaterials and have achieved significant improvements. This review summarizes recent progress in utilizing MOFs functionalized biomaterials for enhancing bone repair and therapeutic effects, including enhanced bone regeneration, antibacterial, anti-inflammatory, and anti-tumor functions.
MATERIALS TODAY BIO
(2023)
Article
Biotechnology & Applied Microbiology
Mi Eun Kim, Jong Keun Seon, Ju Yeon Kang, Taek Rim Yoon, Jun Sik Lee, Hyung Keun Kim
Summary: BFP-4 induces stronger osteogenic differentiation of BMSCs compared to BMP-7, as well as enhancing ALP activity, calcium concentration, and osteogenic factor production. This suggests that BFP-4-stimulated cell therapy may be a more efficient and cost-effective approach to bone regeneration and formation than BMP-7-based therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Endocrinology & Metabolism
Hao Zhang, Yan Hu, Xiao Chen, Sicheng Wang, Liehu Cao, Shiwu Dong, Zhongmin Shi, Yanxi Chen, Liming Xiong, Yunfei Zhang, Dianying Zhang, Baoqing Yu, Wenming Chen, Qining Wang, Peijian Tong, Ximing Liu, Jianzheng Zhang, Qiang Zhou, Feng Niu, Weiguo Yang, Wencai Zhang, Yong Wang, Shijie Chen, Jinpeng Jia, Qiang Yang, Peng Zhang, Yong Zhang, Jun Miao, Kuo Sun, Tao Shen, Bin Yu, Lei Yang, Lei Zhang, Dongliang Wang, Guohui Liu, Yingze Zhang, Jiacan Su
Summary: Osteoporotic fractures, prevalent in the elderly, bring significant social burdens. These fractures are characterized by poor bone quality, weak repair capacity, instability, and high failure rate of internal fixation. Common osteoporotic bone defects, such as proximal humerus, distal radius, tibia plateau, calcaneus, and spine, require appropriate materials for repair. The consensus from the Osteoporosis Group of Chinese Orthopaedic Association aims to standardize clinical practice in bone repair of osteoporotic fractures.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Agriculture, Dairy & Animal Science
Agata Wawrzyniak, Krzysztof Balawender
Summary: This article examines the development, structure, and remodeling of bone tissue. As an essential component of the skeleton, bone provides support and protection and maintains the concentration of calcium and phosphate in body fluids. Bone metabolism involves the balance of bone formation and resorption, regulated by various factors. Secretion of biologically active substances in bone tissue also influences bone function and metabolism.
Article
Multidisciplinary Sciences
Binisha H. Mishra, Pashupati P. Mishra, Emma Raitoharju, Saara Marttila, Nina Mononen, Harri Sievanen, Jorma Viikari, Markus Juonala, Marika Laaksonen, Nina Hutri-Kahonen, Mika Kahonen, Olli T. Raitakari, Terho Lehtimaki
Summary: This study analysed gene co-expression modules shared by early traits of osteoporosis and atherosclerosis, identifying two modules with significant joint association with both diseases. The significant member genes from these modules are involved in biological processes related to bone metabolism or atherosclerosis, potentially providing new joint biomarkers for both diseases.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Manufacturing
Li Wang, Xianhong Zeng, Xiaohu Chen, Xiyang Zeng, Kun Luo
Summary: In this study, a porous composite biocompatible bone scaffold based on shape memory polymer materials was developed. The scaffold showed good mechanical and biological properties, and had the ability to fill bone defects and recover its initial shape. Hydroxyapatite played a role in promoting mineralization and accelerating tissue repair. These programmable scaffolds have potential applications in minimal invasive bone repair.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2022)
Article
Engineering, Multidisciplinary
Qian Liu, Xueliang Peng, Xiaojia Liu, Xiaohui Mou, Yayuan Guo, Lihua Yang, Yufei Chen, Yaying Zhou, Zhuoya Shi, Zhilu Yang, Zhuoyue Chen
Summary: BMPs, members of the TGF-8 superfamily, have been extensively studied for their osteoinductive ability and multiple functions. Current research focuses on BMP delivery systems to achieve local administration and delay degradation. Researchers have combined BMPs with other growth factors to enhance their effect during osteoinduction. This paper reviews the progress in BMP research, including structure and function, binding to various materials, cells, and growth factors. It also summarizes the applications of BMPs in bone defect repair and proposes suggestions for improving their clinical application.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Cell Biology
Anthony Estienne, Lauriane Relav, Morad Benkoura, Danielle Monniaux, Fanny Morin, Stephane Fabre, Christopher A. Price
Summary: Increasing the efficiency of farm animal reproduction is important for reducing the environmental impact of food production systems. This study investigates the factors that decrease oocyte health and how fibroblast growth factor 18 (FGF18) is regulated in the ovarian follicle. The researchers found that FGF18 secretion is controlled by intrafollicular factors and is linked to fertility. They also discovered that BMP4 stimulates FGF18 secretion from thecal endothelial cells, which affects fertility. Understanding these processes can help improve reproductive efficiency in farm animals.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Leonardo Recena Aydos, Luane Aparecida do Amaral, Ana Cristina Jacobowski, Roberta Serafim de Souza, Eduardo Benedetti Parisotto, Mariana Biava de Menezes, Felipe Francisco Bittencourt Junior, Emely Schuindt Fernandes, Iandara Schettert Silva, Luciane Candeloro Portugal, Claudio Goncalves Oliveira, Gustavo Tsuyoshi Senra Masuko, Leandro Fontoura Cavalheiro, Carlos Eduardo Domingues Nazario, Elisvania Freitas dos Santos, Maria Ligia Rodrigues Macedo
Summary: The study found that supplementation of BPO may worsen metabolic disorders caused by a high-fat diet, exacerbating risk factors associated with MetS.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Fernanda Hussid, Felipe Xerez Cepeda, Camila P. Jordao, Rafaela R. P. Lopes-Vicente, Leslie Virmondes, Keyla Y. Katayama, Ezequiel F. de Oliveira, Luis V. F. Oliveira, Fernanda Marciano Consolim-Colombo, Ivani Credidio Trombetta
Summary: This study found that obesity in adolescents can lead to metabolic syndrome and endothelial dysfunction, with increased waist circumference and high blood pressure potentially contributing to these changes, while obstructive sleep apnea was observed in the majority of adolescents, regardless of obesity.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2021)
Article
Medicine, General & Internal
Glauber Sa Brandao, Glaudson Sa Brandao, Antonia A. C. Sampaio, Leandro Damas Andrade, Adriano L. Fonseca, Francisco K. R. Campos, Anderson S. Silva, Marcos M. Silva, Iranse Oliveira-Silva, Rodolfo P. Vieira, Claudio F. Donner, Rubens A. Silva, Aquiles A. Camelier, Luis V. F. Oliveira
Summary: The study aimed to test the hypothesis of a semi-supervised home physical exercise programme in improving the functional mobility and quality of life of elderly in the community. Results showed a significant improvement in functional mobility and quality of life for participants in the exercise programme.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Environmental Sciences
Silvio A. Oliveira-Junior, Daniel Boullosa, Maria L. M. Mendonca, Larissa F. C. Vieira, Wania W. Mattos, Bruna O. C. Amaral, Dayanne S. Lima-Borges, Filipe A. Reis, Marcelo D. M. Cezar, Luiz C. M. Vanderlei, Paula F. Martinez
Summary: The study showed that the CWIT had positive effects on physical fitness, quality of life, and heart rate variability in sedentary workers. Participants demonstrated improvements in aerobic capacity and flexibility, as well as greater quality of life scores. Interestingly, more HRV parameters improved in the seated position, suggesting the importance of considering different body positions in evaluating changes in HRV.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Chemistry, Physical
Luis Vicente Franco Oliveira, Nadua Apostolico, Juan Jose Uriarte, Renata Kelly da Palma, Renato A. Prates, Alessandro Melo Deana, Luis Rodolfo Ferreira, Joao Pedro Ribeiro Afonso, Rodolfo de Paula Vieira, Manoel Carneiro de Oliveira Junior, Daniel Navajas, Ramon Farre, Rodrigo Alvaro B. Lopes-Martins
Summary: The study aimed to evaluate the extracellular matrix and lung mechanical parameters of decellularized lungs undergoing sterilizing photodynamic therapy, showing no significant changes in lung properties after PDT and a reduction in fungal infection population following PDT. Further studies are needed to confirm the effectiveness of PDT in sterilizing lung scaffolds.
INTERNATIONAL JOURNAL OF PHOTOENERGY
(2021)
Article
Surgery
Alan Robson Trigueiro de Sousa, Wilson Rodrigues Freitas Junior, Eduardo Araujo Perez, Elias Jirjoss Ilias, Anderson Soares Silva, Vera Lucia Santos Alves, Joao Pedro Ribeiro Afonso, Miria Candida Oliveira, Adriano Luis Fonseca, Marcos Mota da Silva, Maria Eduarda Moreira Lino, Manoel Carneiro Oliveira Junior, Rodolfo Paula Vieira, Wilson Jose Sena Pedro, Andre Luis Lacerda Bachi, Giuseppe Insalaco, Carlos Alberto Malheiros, Luis Vicente Franco Oliveira
Summary: This study confirmed the effectiveness of weight loss induced by surgery in improving lipid profile and reducing chronic inflammatory status in severely obese women. The analysis of various indicators pre- and post-surgery showed significant changes, particularly in resistin, IGF-1, and IL-23 levels.
Article
Pharmacology & Pharmacy
Carlos Alberto-Silva, Samyr Machado Querobino, Cesar Augusto Melo-Silva, Maricilia Silva Costa, Luis Vicente Franco Oliveira, Stella Regina Zamuner
Summary: This study investigated the impact of low molecular weight peptides in the venom of Bothrops jararaca snake on lung mechanics and inflammation in mice. The results showed that both Bj-CV and Bj-PF injections led to changes in lung function and increased muscle and pulmonary inflammation.
Article
Medicine, Research & Experimental
Jamile Benite Palma Lopes, Isabela Marques Miziara, Danial Kahani, Rodolfo Borges Parreira, Natalia de Almeida Carvalho Duarte, Roberta Delasta Lazzari, Lucas Villalta Santos, Carlos Bandeira de Mello Monteiro, Deborah Carvalho da Silva Cardoso, Juliana de Oliveira Hassel Mendes, Vera Lucia Dos Santos Alves, Iranse Oliveira Silva, Luis Vicente Oliveira, Bernard Arthur Conway, Manuela Galli, Veronica Cimolin, Claudia Santos Oliveira
Summary: This study aims to investigate the application of virtual reality training and transcranial direct current stimulation (tDCS) in improving functional and sensory skills of children with Down syndrome. The study will involve observational research and clinical intervention analysis, collecting data through multiple evaluations and training sessions, and analyzing the results statistically.
Article
Cell Biology
Renilson Moraes-Ferreira, Maysa Alves Rodrigues Brandao-Rangel, Thiago Goncalves Gibson-Alves, Anamei Silva-Reis, Victor Hugo Souza-Palmeira, Helida Cristina Aquino-Santos, Claudio Ricardo Frison, Luis Vicente Franco Oliveira, Regiane Albertini, Rodolfo P. Vieira
Summary: Aerobic training has beneficial effects on asthma patients, reducing inflammation and improving anti-inflammatory and antifibrotic mediators.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Multidisciplinary Sciences
Salvatore Romano, Anna Lo Bue, Adriana Salvaggio, Luis V. F. Oliveira, Luigi Ferini-Strambi, Giuseppe Insalaco
Summary: This study validated a new, self-administered questionnaire (SANReSP) as a screening tool for obstructive sleep apnea (OSA). The questionnaire evaluates subjective symptoms only and performs similarly to other widely used questionnaires, with the advantage of not requiring anthropometric measurements.
Article
Physiology
Jeffeson Hildo Medeiros de Queiroz, Joao Paulo Frota, Filipe Abdala dos Reis, Rodrigo Ribeiro de Oliveira
Summary: The purpose of this study was to develop and validate the Brazilian Adductor Performance Test (BAPT) for predicting hip adductor muscle injuries in elite soccer athletes. A total of 108 soccer athletes were assessed, and the BAPT scores were compared between injured and uninjured athletes. The results showed that low BAPT scores increased the chance of injury, and the cutoff point for the number of repetitions in the BAPT was identified. The BAPT can be used to identify athletes at risk of hip adductor muscle injuries, potentially reducing the rate of this injury in soccer clubs.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Nutrition & Dietetics
Sandra M. B. P. Moreira, Andre L. L. Bachi, Elias I. Jirjos, Carlos A. A. Malheiros, Sergio Vencio, Vera L. S. Alves, Alan R. T. Sousa, Lucenda A. Felipe, Eduardo A. Perez, Maria E. M. Lino, Shayra K. A. Souza, Juliana M. B. Santos, Miria C. Oliveira, Adriano L. Fonseca, Carlos H. M. Silva, Rodolfo P. Vieira, Giuseppe Insalaco, Wilson R. R. Freitas Junior, Luis V. F. Oliveira
Summary: Obesity is a significant public health problem that increases the risk of various health complications. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB), is an effective treatment for severe obesity and associated comorbidities. This study investigated the effects of RYGB on women with severe obesity with and without metabolic syndrome (MetS) by analyzing biochemical, glucose, and inflammatory parameters. The results showed significant improvements in weight, body mass index, glucose, cholesterol, and leptin levels, as well as an increase in adiponectin/leptin ratio after RYGB. These findings highlight the beneficial effects of weight loss induced by RYGB on metabolic and inflammatory parameters in women with severe obesity.
Article
Surgery
Patricia Henrique Silva, Pamela Henrique Silva, Gilberto Goncalves Facco, Adalberto Vieira Corazza, Josivaldo Godoy da Silva, Iandara Schettert Silva
Summary: The effects of electrophysical resources laser therapy (LLLT), intravascular laser blood irradiation (ILIB), and cryotherapy on the healing process of neurotendinous injury were evaluated in an experimental model of type 1 diabetes associated with kidney injury. Cryotherapy and ILIB treatment in diseased animals resulted in reduction of inflammatory exudate, presence of fibroblasts, and organization of collagen, while LLLT showed increased inflammatory exudate and lower organization of collagen fibers. ILIB therapy also led to a significant reduction in glycemic levels in the group of diseased animals.
ACTA CIRURGICA BRASILEIRA
(2022)
Article
Surgery
Leticia Alves Paiva, Iandara Schettert Silva, Silvio Assis de Oliveira Junior, Albert Schiaveto de Souza, Claudio Osorio Brito Jacques
Summary: This study analyzed the effect of high-intensity interval training (HIIT) on bone mineral density (BMD) in a model of type 2 diabetes mellitus. The results showed that HIIT can increase BMD.
ACTA CIRURGICA BRASILEIRA
(2022)
Article
Surgery
Liliane de Mello Santos Bochenek, Eduardo Benedetti Parisotto, Evelyn de Andrade Salomao, Maria Jose Martins Maldonado, Iandara Schettert Silva
Summary: The study evaluated the oxidative stress in swine neonates exposed to hypoxia, revealing adverse effects of hypoxia on swine neonates, despite their natural physiological resistance to this insult. Parameters such as GSH, SOD, CAT, TBARS, MPO, and PC were analyzed as potential indicators for further research in an animal model of swine hypoxia.
ACTA CIRURGICA BRASILEIRA
(2021)