Article
Chemistry, Analytical
Ranjeet Ajit Bapat, Rohit Pandurangappa, Subrat Kumar Bhattamisra, Yap Kah Heng, Jukka P. Matinlinna, Umer Daood
Summary: The study aimed to achieve chairside identification of specific biomarkers for diagnosing periodontal disease in diabetic patients at a very early stage using spectroscopic probe design and parameters. Analysis showed a significant association between the severity of chronic periodontitis and the rate of MMP-8/CTX release in diabetic patients.
MICROCHEMICAL JOURNAL
(2021)
Article
Spectroscopy
Caroleny Villalba-Hernandez, Maria de los Angeles Moyaho-Bernal, Freddy Narea-Jimenez, Hector Nahum Chavarria-Lizarraga, Maria Cecilia Galeazzi-Minutti, Rosendo Carrasco-Gutierrez, Jorge Castro-Ramos
Summary: This study predicts periodontitis by analyzing Raman spectra and biomarkers in saliva, such as albumin and alanine aminotransferase (ALT). The study uses MATLAB for data processing and analysis, ORCA software to predict fundamental frequencies and intensities, and support vector machines for spectral distinction.
JOURNAL OF RAMAN SPECTROSCOPY
(2022)
Article
Medicine, General & Internal
Wioletta Pawlukowska, Bartlomiej Baumert, Agnieszka Meller, Anna Dziewulska, Alicja Zawislak, Katarzyna Grocholewicz, Przemyslaw Nowacki, Marta Masztalewicz
Summary: Periodontal diseases and saliva stimulation can affect the severity of ischemic stroke. Stimulation of the mouth and salivary glands in patients with stroke may have a positive effect on the course of the stroke.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Instruments & Instrumentation
Emma Buchan, Mike Hardy, Paulo de Carvalho Gomes, Liam Kelleher, Hin On Martin Chu, Pola Goldberg Oppenheimer
Summary: The study of salivary manifestation of various health disorders using Raman spectroscopy has the potential for early diagnosis and monitoring. The use of extracellular vesicles in medical applications is also highlighted, and the development and application of portable devices are discussed.
APPLIED SPECTROSCOPY REVIEWS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Seonghye Kim, Hyun-Joo Kim, Yuri Song, Hyun Ah Lee, Suhkmann Kim, Jin Chung
Summary: This study aimed to propose biomarker candidates for periodontitis through untargeted metabolomics analysis. 5 metabolites were identified as biomarkers that distinguished periodontitis patients from healthy controls, showing potential applications in periodontal screening, detection, and monitoring of treatment outcomes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Medicine, General & Internal
Ionut Luchian, Mihaela Moscalu, Ancuta Goriuc, Ludovica Nucci, Monica Tatarciuc, Ioana Martu, Mihai Covasa
Summary: Periodontitis results in destructive effects on periodontium, with increased levels of MMP-9. Periodontal treatment alone or combined with orthodontic treatment can improve clinical parameters and lower MMP-9 levels. The degree of malocclusion affects the treatment's impact on MMP-9 levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Spectroscopy
Shuo Chen, Haotian Wu, Chen Chen, Daheng Wang, Yaru Yang, Zheng Zhou, Ruochen Zhu, Xiaoning He, Yaping Pan, Chen Li
Summary: This study explored a pre-treatment saliva SERS based prognostic protocol to predict the prognosis of periodontal non-surgery therapy in periodontitis patients. Significant differences in the levels of ascorbic acid, uric acid, and glutathione were observed between good prognosis group and poor prognosis group, which can serve as potential prognostic markers. The proposed prognostic model achieved high accuracy, sensitivity, and specificity. The excellent performance of this method demonstrated its potential for fast, accurate, and non-invasive prognostic prediction in periodontal non-surgery therapy, benefiting timely and rational guidance on clinical interventions.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Instruments & Instrumentation
Mike Hardy, Liam Kelleher, Paulo de Carvalho Gomes, Emma Buchan, Hin On Martin Chu, Pola Goldberg Oppenheimer
Summary: This review summarizes the methods and applications of Raman spectroscopy combined with saliva, highlighting the need for standardization and further validation studies, while also recognizing the tremendous potential in improving speed, diagnostic accuracy, and portable device applications.
APPLIED SPECTROSCOPY REVIEWS
(2022)
Article
Chemistry, Analytical
Emma Buchan, Liam Kelleher, Michael Clancy, Jonathan James Stanley Rickard, Pola Goldberg Oppenheimer
Summary: This study systematically investigated the molecular spectral fingerprint of saliva and developed a non-destructive molecular profiling approach using hybrid artificial neural network algorithms and Raman spectroscopy. The classification algorithm successfully identified gender and age information from saliva, laying the platform for applications in forensics and biosensing. The discernible spectral molecular 'barcodes' primarily stemmed from amino acid, protein, and lipid changes in saliva.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biology
Valentina Mangolini, Alice Gualerzi, Silvia Picciolini, Francesca Roda, Angela Del Prete, Luana Forleo, Rudy Alexander Rossetto, Marzia Bedoni
Summary: Extracellular vesicles (EVs) isolated from saliva can be comprehensively characterized by Raman spectroscopy, providing valuable biomarkers for diagnosis. EVs from blood are difficult to separate from other particles and proteins, while saliva EVs can be easily analyzed. Despite the low concentration, Raman spectroscopy is capable of accurately characterizing salivary EVs. This suggests the potential of salivary EVs for diagnostic purposes, with Raman spectroscopy playing a key role.
Article
Dentistry, Oral Surgery & Medicine
Aino Salminen, Milla Pietiainen, Susanna Paju, Timo Sorsa, Paivi Mantyla, Kare Buhlin, Juha Sinisalo, Pirkko J. Pussinen
Summary: In this study, genetic variants of CFH were associated with periodontal parameters, while salivary concentrations of S100A8, S100A12, MMP-8, and TCC were strongly correlated with the number of periodontal pockets and alveolar bone loss.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Health Care Sciences & Services
Gerson Aparecido Foratori-Junior, Adrien Le Guennec, Tatiana Kelly da Silva Fidalgo, James Jarvis, Victor Mosquim, Marilia Afonso Rabelo Buzalaf, Guy Howard Carpenter, Silvia Helena de Carvalho Sales-Peres
Summary: This study aimed to compare the metabolic profile of unstimulated and stimulated saliva samples from pregnant women with/without obesity and periodontitis. Analysis of the samples showed similar metabolic pathways between stimulated and unstimulated saliva samples.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zohaib Akram, Sultan Aati, Ali Alrahlah, Fahim Vohra, Amr Fawzy
Summary: The study showed that cigarette smokers had higher deterioration of periodontal health compared to e-cigarette smokers. Smoking, MMP-8, and CTX were identified as prognostic factors for clinical attachment loss in both cigarette and e-cigarette smokers.
JOURNAL OF DENTISTRY
(2021)
Article
Cell Biology
Gerson Aparecido Foratori Jr, Talita Mendes Oliveira Ventura, Larissa Tercilia Grizzo, Bruno Gualtieri Jesuino, Ana Virginia Santana Sampaio Castilho, Marilia Afonso Rabelo Buzalaf, Silvia Helena de Carvalho Sales-Peres
Summary: This study compared the proteomic profiles of stimulated and unstimulated saliva samples from pregnant women with/without obesity and periodontitis. Proteins involved in immune response, antioxidant activity, and retina homeostasis were decreased or absent in stimulated saliva samples from all groups. Proteins related to carbohydrate metabolism and glucose metabolic process were absent in stimulated saliva, mainly from the obesity and periodontitis group.
Review
Immunology
Yuwei Zhang, Liang Ren, Qi Wang, Zhining Wen, Chengcheng Liu, Yi Ding
Summary: Oral diseases have a significant impact on global health, and are related to oral microbes. Effective measures for prevention and promotion of oral health are needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Engineering, Electrical & Electronic
E. N. Antonov, L. I. Krotova, N. V. Minaev, S. A. Minaeva, A. V. Mironov, V. K. Popov, V. N. Bagratashvili
QUANTUM ELECTRONICS
(2015)
Article
Physics, Atomic, Molecular & Chemical
S. E. Bogorodski, L. I. Krotova, S. V. Kursakov, S. A. Minaeva, V. K. Popov, V. I. Sevast'yanov
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B
(2015)
Article
Nanoscience & Nanotechnology
Stanislav Evlashin, Pavel Dyakonov, Roman Khmelnitsky, Sarkis Dagesyan, Andrey Klokov, Andrey Sharkov, Peter Timashev, Svetlana Minaeva, Konstantin Maslakov, Sergey Svyakhovskiy, Nikolay Suetin
ACS APPLIED MATERIALS & INTERFACES
(2016)
Article
Chemistry, Medicinal
E. N. Antonov, A. G. Dunaev, S. A. Minaeva, L. I. Krotova, V. K. Popov
PHARMACEUTICAL CHEMISTRY JOURNAL
(2018)
Article
Materials Science, Multidisciplinary
A. O. Rybaltovskiy, A. A. Ischenko, Y. S. Zavorotny, A. V. Garshev, S. G. Dorofeev, N. N. Kononov, N. V. Minaev, S. A. Minaeva, A. P. Sviridov, P. S. Timashev, I. I. Khodos, V. I. Yusupov, M. A. Lazov, V. Ya. Panchenko, V. N. Bagratashvili
JOURNAL OF MATERIALS SCIENCE
(2015)
Article
Optics
S. A. Gonchukov, T. V. Lonkina, S. A. Minaeva, A. V. Sundukov, T. E. Migmanov, J. Lademann, M. E. Darvin, V. N. Bagratashvili
LASER PHYSICS LETTERS
(2014)
Article
Physics, Atomic, Molecular & Chemical
E. N. Antonov, S. A. Minaeva, V. K. Popov
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B
(2013)
Article
Physics, Atomic, Molecular & Chemical
S. E. Bogorodskii, T. S. Zarkhina, E. V. Kuznetsov, S. A. Minaeva, V. K. Popov, A. B. Solov'eva, P. S. Timashev
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B
(2014)
Article
Optics
A. G. Shubny, E. O. Epifanov, N. Minaev, M. Yu Tsvetkov, A. P. Sviridov, S. A. Minaeva, V. Yusupov
LASER PHYSICS LETTERS
(2019)
Article
Crystallography
Y. S. Krivonosov, V. E. Asadchikov, A. V. Buzmakov, A. G. Ivanova, V. V. Artemov, A. A. Rusakov, V. V. Pantyushov, R. G. Saifutdinov, N. V. Minaev, S. A. Minaeva, M. A. Syachina, V. K. Popov
CRYSTALLOGRAPHY REPORTS
(2019)
Article
Engineering, Multidisciplinary
N. V. Minaev, A. V. Mironov, S. A. Minaeva, O. A. Mironova, M. A. Syachina, E. Krumins, S. Howdle, V. K. Popov
INSTRUMENTS AND EXPERIMENTAL TECHNIQUES
(2020)
Proceedings Paper
Optics
S. A. Minaeva, E. N. Antonov, A. N. Konovalov, N. V. Minaev, V. K. Popov
2018 INTERNATIONAL CONFERENCE LASER OPTICS (ICLO 2018)
(2018)
Proceedings Paper
Engineering, Electrical & Electronic
T. V. Baikova, S. A. Minaeva, A. V. Sundukov, T. S. Svistunova, V. N. Bagratashvili, M. V. Alushin, S. A. Gonchukov
23RD INTERNATIONAL LASER PHYSICS WORKSHOP (LPHYS'14)
(2015)
Proceedings Paper
Instruments & Instrumentation
Mikhail Yu. Tsvetkov, Stanislav A. Evlashin, Kirill V. Mironovich, Svetlana A. Minaeva, Nikolay V. Suetin, Victor N. Bagratashvili
PHOTONICS, DEVICES, AND SYSTEMS VI
(2015)
