Journal
LASER PHYSICS LETTERS
Volume 5, Issue 9, Pages 686-690Publisher
IOP PUBLISHING LTD
DOI: 10.1002/lapl.200810047
Keywords
laser scanning microscopy; tape stripping; skin; barrier cream; hand and foot syndrome
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Funding
- Donor Association for German Science and Humanities
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Laser scanning microscopy and tape stripping, in combination with optical methods, were used to analyze the distribution and penetration of a barrier cream into the horny layer (stratum corneum) of the human skin under in vivo conditions. The barrier cream contained microparticles of 10 100 mu m loaded with antioxidant substances. The cream was designed for protection of the skin surface against the destructive action of free radicals, produced by systemically applied chemotherapeutic agents reaching the skin surface via the sweat. Both methods were able to demonstrate that the barrier cream was distributed homogeneously on the skin surface forming a protection film. A penetration into deeper parts of the stratum corneum (SC) was not observed.
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