Article
Medicine, General & Internal
Yu Liu, Yan Yang, Qiya Hu, Ahmed Badughaish, Hanbing Zhang, Feng Qi, Yuedong Hou
Summary: The study demonstrates that latent MTrPs injection shows better efficacy and tolerability in patients with persistent moderate to severe AR compared to sublingual immunotherapy in both short and long-term follow-up.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Huijie Zhao, Yanting Zhang, Xiaodi Fu, Chaoren Chen, Saadullah Khattak, Honggang Wang
Summary: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver, and it is also the leading cause of cancer-related death worldwide. Despite numerous studies conducted on HCC, the molecular mechanisms and effective treatment options are not fully understood. Hydrogen sulfide (H2S), previously considered a toxic gas, has been found to have multiple biological functions, but its role and mechanism in HCC remain unclear.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Allergy
Torpong Thongngarm, Chamard Wongsa, Phichayut Phinyo, Paraya Assanasen, Pongsakorn Tantilipikorn, Mongkhon Sompornrattanaphan
Summary: This study compared the efficacy of as-needed and regular use of INCS in patients with moderate to severe perennial allergic rhinitis. The results showed that both as-needed and regular use had similar improvements in nasal symptoms and quality of life scores. As-needed use resulted in half of the cumulative INCS dose compared to regular use.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Immunology
Olga Branicka, Edyta Jura-Szoltys, Barbara Rogala, Joanna Gluck
Summary: This study found significantly higher sCD48 levels in NAR patients compared to PAR and healthy controls, with a significant correlation between sCD48 levels and eosinophils. ECP and eotaxin-1/CCL11 levels were also significantly higher in the NAR group.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dandan Zhang, Xiuqin Hong, Jia Wang, Yu Jiang, Ying Zhang, Jian Chen, Xiaona Niu
Summary: The study demonstrates that estrogen can play a protective role in patients with hyperhomocysteinemia and hypertension, which is associated with Hcy metabolism and endogenous hydrogen sulfide production. Estrogen reverses the expression of enzymes responsible for H2S production in endothelial cells treated with Hcy, indicating its potential therapeutic effects.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Chemistry, Analytical
Yan Jia, Yiying Wang, Yongli Zhang, Jiayue Wang, Yanxi Pei, Zhiqing Wang, Peng Li, Keli Han
Summary: The study developed novel fluorescent probes CBLP and CSEP for effective monitoring of cystathionine lyase activity, providing a new approach for the analysis of cystathionine lyase in biological processes.
ANALYTICAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Rongrong Wu, Lvhua Dong, Huajie Mao, Jianjun Wang, Dijiang Ma, Jianing Sun
Summary: Posterior nasal nerve combined with anterior ethmoid neurotomy is a safe and reliable surgical method for the treatment of moderate to severe persistent allergic rhinitis, which has various benefits such as symptomatic relief, improved quality of life, and reduced adverse reactions.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Otorhinolaryngology
Li-Xin Wang, Zhi-Chao Yang, Zhao-Peng Kang, Ling-Ling Di, Yan Tan, Xian-Bing Peng, Jie Liu
Summary: The study investigated the effect of drug treatment combined with psychological intervention on mental disorders in patients with persistent moderate-severe allergic rhinitis. The results showed that this combined treatment significantly improved anxiety and depression symptoms, as well as quality of life, and was superior to drug treatment alone.
ENT-EAR NOSE & THROAT JOURNAL
(2021)
Article
Immunology
Zhan Zhao, Yuqin Deng, Lei Xiang, Jin Chen, Jing Wan, Jinli Sun, Yonggang Kong, Qingquan Hua
Summary: This study aimed to evaluate the clinical efficacy of omalizumab in patients with allergic rhinitis by analyzing the ratio of total IgE level at week 16 to baseline. Retrospective analysis of 62 patients showed that 48 patients demonstrated significant improvement after 16 weeks of treatment, while 14 patients did not show significant improvements. The ratio of total IgE levels at week 16 to baseline was higher in responders compared to non-responders. In conclusion, the ratio of total IgE level at week 16 to baseline correlated with the clinical response to omalizumab in moderate to severe allergic rhinitis patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rong-Hsuan Wang, Yu-Hsin Chu, Kai-Ti Lin
Summary: Hydrogen sulfide, while important for physiological functions, is also associated with aberrant expression in cancer development; understanding the roles of tumor-derived H2S in cancer provides opportunities for targeted therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Maria Peleli, Kristina S. Lyngso, Frantz Rom Poulsen, Pernille B. L. Hansen, Andreas Papapetropoulos, Jane Stubbe
Summary: This study explores the role of cystathionine-gamma lyase(CSE), an enzyme producing hydrogen sulfide (H2S), in intracerebral arterioles. The results suggest that CSE plays a role in regulating vasoconstriction through H2S, eNOS, and sGC mechanisms, while secondary dilatation is regulated by eNOS and sGC but not by CSE.
Article
Medical Laboratory Technology
Lisha Li, Yonglin Liu, Qiang Wang, Zixi Wang, Le Cui, Yingyang Xu, Kai Guan
Summary: This study evaluated the application value of nasal exhaled hydrogen sulfide (NeH2S) measurement in the diagnosis and assessment of allergic rhinitis (AR). Results showed that the NeH2S levels in AR patients were lower compared to the general population, indicating a potential for using NeH2S as a biomarker in AR diagnosis and severity assessment. Further studies with larger sample sizes are needed to clarify the relationship between NeH2S level and AR.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Allergy
Zheng Gu, Ping Wei, Wei Kou, Xin-Ye Tang, Hong-Bing Yao, En-Mei Liu
Summary: This study investigated the comorbidities associated with allergic rhinitis (AR) in Chinese children and analyzed the influencing factors. The results showed that the comorbidities of AR in children included atopic dermatitis, asthma, allergic conjunctivitis, and chronic rhinosinusitis. Factors such as age, familial history of allergy, and types of allergens were associated with the occurrence of different comorbidities.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Allergy
Myung Woul Han, Song Hee Kim, Inbo Oh, Yang Ho Kim, Jiho Lee
Summary: Obesity is associated with an increased risk of allergic rhinitis (AR) in children, with leptin and IL-1 beta playing key roles in exacerbating AR severity. Parental history of AR, elevated leptin levels, and high expression of IL-1 beta emerged as significant risk factors for moderate to severe persistent AR symptoms. Changes in BMI influenced AR symptoms through leptin and IL-1 beta modulation.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Review
Allergy
Ludger Klimek, William E. Berger, Jean Bousquet, Paul K. Keith, Peter Smith, Dirceu Sole, Glenis Scadding, Hans Christian Kuhl, Duc Tung Nguyen, Ferdinand Kopietz, Arkady Koltun
Summary: The study systematically reviewed the efficacy and safety of MP-AzeFlu for treating allergic rhinitis, finding that it provides effective relief of nasal and ocular symptoms, acts quickly, and controls allergic rhinitis faster. Long-term use is safe and beneficial for children, adults, and those over 65 years old.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)