Article
Microbiology
Martha Alemayehu Menberu, Sha Liu, Clare Cooksley, Andrew James Hayes, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde
Summary: Corynebacterium accolens is a dominant species in healthy human nasal microbiota and shows potential antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus. Culture supernatants from C. accolens exhibited significant antibacterial activity and reduced the metabolic activity and biofilm biomass of S. aureus and MRSA clinical isolates, indicating its promise for probiotic therapies to promote sinus health.
Article
Pharmacology & Pharmacy
Alessandra Cataldo Russomando, Ronit Vogt Sionov, Michael Friedman, Irith Gati, Ron Eliashar, Doron Steinberg, Menachem Gross
Summary: The study demonstrated that coating SNS with SRV-CHX can provide sustained release of chlorhexidine, inhibiting the growth of Staphylococcus aureus and Pseudomonas aeruginosa, and significantly reducing biofilm formation.
Article
Otorhinolaryngology
Dong-Jin Lim, Harrison M. Thompson, Christopher R. Walz, Samrath Ayinala, Daniel Skinner, Shaoyan Zhang, Jessica W. Grayson, Do-Yeon Cho, Bradford A. Woodworth
Summary: The study demonstrated that azithromycin released from the CASS effectively reduced IL-8 production in HSNECs without compromising cell integrity and function. The anti-inflammatory properties of the CASS, in addition to its antibacterial activity, could provide further benefits for patients with recalcitrant CRS.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Annina Wuokko-Landen, Karin Blomgren, Anni Suomalainen, Hannamari Valimaa
Summary: The study found that odontogenic causes are often overlooked in diagnosing chronic rhinosinusitis (CRS), highlighting the need for routine assessment of patients' dental history, careful radiograph evaluation, utilization of microbial findings, and close cooperation with dentists to provide adequate treatment.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Otorhinolaryngology
Tirth R. Patel, Bobby A. Tajudeen, Hannah Brown, Paolo Gattuso, Phillip LoSavio, Peter Papagiannopoulos, Pete S. Batra, Mahboobeh Mahdavinia
Summary: This study revealed that exposure to ambient air pollutants may contribute to the pathogenesis of chronic rhinosinusitis, with increased ozone exposure associated with higher tissue inflammation and the presence of eosinophilic aggregates and Charcot-Leyden crystals in patients with CRSwNP.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2021)
Review
Biochemistry & Molecular Biology
Seung-Heon Shin, Mi-Kyung Ye, Dong-Won Lee, Sang-Yen Geum
Summary: Airborne fungi are present everywhere in the environment and can cause airway inflammatory diseases. While the innate immune system is effective in eliminating most inhaled fungi, some can lead to the development of chronic rhinosinusitis (CRS). CRS patients may exhibit different immune responses to airborne fungi compared to healthy individuals. Fungal-bacterial interactions in the sinonasal mucosa and the interplay between the mycobiome and microbiome can also impact local inflammation and chronicity in CRS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Arthur W. Wu, Akaber M. Halawi, Elisa A. Illing, Dennis M. Tang, Philip G. Chen, Edward C. Kuan, Jonathan Y. Ting, Daniel A. Norez, Stacey A. Kim, Dhruv Sharma, Douglas D. Reh, Sanjeet V. Rangarajan, Kent K. Lam, Randall A. Ow, J. Wesley Sublett, Thomas S. Higgins
Summary: The study aimed to create a new grading system, the Postoperative Polyp Scale (POPS), to accurately describe polyp recurrence in the postoperative sinus cavities. The POPS was established using consensus opinion among 13 otolaryngologists and allergists. The reliability of the POPS was tested by scoring postoperative endoscopy videos from 50 patients with chronic rhinosinusitis. The results showed that the POPS is an easy-to-use, reliable, and novel objective endoscopic grading scale that accurately describes polyp recurrence in the postoperative state.
Article
Health Care Sciences & Services
Eugenio De Corso, Silvia Baroni, Stefano Settimi, Maria Elisabetta Onori, Rodolfo Francesco Mastrapasqua, Eliana Troiani, Giacomo Moretti, Donatella Lucchetti, Marco Corbo, Claudio Montuori, Alessandro Cantiani, Davide Paolo Porru, Simone Lo Verde, Giuseppe Alberto Di Bella, Cristiano Caruso, Jacopo Galli
Summary: This study evaluated the inflammatory load and cytokine profiles in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Two distinct clusters were identified based on cytokine levels and eosinophil count, with IL-5 being the most reliable biomarker for differentiation. This research highlights the potential role of type 2 biomarkers, particularly IL-5, in identifying patients with a more severe phenotype.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Otorhinolaryngology
Erin M. Lopez, Zainab Farzal, Meghan Norris, Michael W. Canfarotta, Andrew K. Pappa, Griffin D. Santarelli, Stephen C. Hernandez, Brian D. Thorp, Brent A. Senior, Adam M. Zanation, Charles S. Ebert, Julia S. Kimbell, Adam J. Kimple
Summary: This study on the anatomic effects of balloon sinuplasty in a cadaveric model showed that while the procedure aims to improve natural sinonasal drainage, it may not achieve this goal in all cases and could occasionally create unintended changes in sinonasal anatomy. These unrecognized changes may be responsible for post-procedure symptoms experienced by some patients.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2021)
Article
Immunology
Sang Hag Lee, Sung Hoon Kang, Mun Soo Han, Ji Won Kwak, Hyeon Geun Kim, Tae Hoon Lee, Da Bin Lee, Tae Hoon Kim
Summary: The EphA2 receptor and ephrin ligands play a role in virus infection, epithelial permeability, and chemokine secretion. This study found that ephrinA1/ephA2 signaling is involved in the antiviral immune response in the sinonasal mucosa of patients with chronic rhinosinusitis (CRS) induced by rhinovirus (RV). Inhibiting ephA2 can decrease chemokine secretion induced by RV infection or poly (I:C) treatment, while enhancing the production of antiviral immune mediators.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Karina Bayer, Selmir Hamidovic, Gerold Besser, Christian A. Mueller, David T. Liu
Summary: This study aimed to assess which factors and phenotypes of CRS are associated with revision surgery in patients undergoing ESS. Based on a retrospective analysis, age, gender, AERD, asthma, and allergies were found to be associated with higher odds of revision surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Yuanqiong He, Yijie Fu, Yuqi Wu, Tianmin Zhu, Hui Li
Summary: This article discusses the potential contribution of sinonasal epithelium dysfunction to chronic rhinosinusitis (CRS) pathogenesis and explores current and developing therapeutic options targeting the sinonasal epithelium. Results indicate that impaired mucociliary clearance and an abnormal sinonasal epithelial barrier are usually considered to be the main causative factors in CRS. Moreover, existing treatment options can help relieve the main symptoms associated with CRS to some extent.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Georgi Popov, Radoslav Aleksandrov, Veronika Petkova, Radka Kaneva, Raina Gergova, Todor Kundurzhiev, Diana Popova
Summary: Chronic rhinosinusitis (CRS) affects a significant portion of the adult population in developed countries and can be attributed to various factors, including bacterial biofilm infections. This research examined the relationship between biofilm formation and mucin expression levels in CRS by analyzing samples from 85 patients. The findings showed a higher prevalence of bacterial biofilms in CRS patients, as well as elevated levels of MUC5B expression, suggesting a potential role for MUC5B in CRS development. However, there was no direct correlation between biofilm presence and mucin expression levels, highlighting the complex connection between these factors in CRS etiology.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Lisa M. Rooper, Marissa J. White, Amy S. Duffield, Jeffrey Gagan, Nyall R. London, Elizabeth A. Montgomery, Justin A. Bishop
Summary: This study confirms the presence of RDD-like histiocytes in chronic sinusitis patients and validates the diagnostic and immunohistochemical features of RDD in these cases. While patients do not exhibit systemic symptoms or tumor formation, they are at high risk for recurrent sinus diseases.
Article
Otorhinolaryngology
Jacqueline Ho, Raquel Alvarado, Janet Rimmer, William A. Sewell, Sophie Walter, Peter Earls, Raewyn G. Campbell, Raymond Sacks, Larry H. Kalish, Richard J. Harvey
Summary: This study compared sinonasal tissue response to anti-IL-5 biologic therapies in patients with eCRS, showing that mepolizumab led to predominantly eosinophilic inflammation, while benralizumab resulted in more severe lymphoplasmacytic inflammation.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2022)
Article
Otorhinolaryngology
Ahmed Bassiouni, Judy Ou, Sukanya Rajiv, Daniel Cantero, Sarah Vreugde, Peter-John Wormald
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2016)
Article
Otorhinolaryngology
Edward John Cleland, Ahmed Bassiouni, Sarah Vreugde, Peter-John Wormald
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2016)
Article
Clinical Neurology
Alistair Jukes, Jae Murphy, Sarah Vreugde, Alkis Psaltis, P. J. Wormald
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2017)
Article
Otorhinolaryngology
Chloe Swords, Neil Cheng-Wen Tan, Nico Jonas
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2017)
Letter
Allergy
Aden Lau, Susan Lester, Sophia Moraitis, Judy Ou, Alkis J. Psaltis, Shaun McColl, Maureen Rischmueller, Peter-John Wormald, Sarah Vreugde
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Article
Otorhinolaryngology
Dijana Miljkovic, Judy Ou, Chandra Kirana, Kathryn E. Hulse, Ehud Hauben, Alkis Psaltis, Peter-John Wormald, Sarah Vreugde
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2017)
Article
Immunology
Amanda J. Drilling, Mian L. Ooi, Dijana Miljkovic, Craig James, Peter Speck, Sarah Vreugde, Jason Clark, Peter-John Wormald
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Otorhinolaryngology
Chun Ling Chan, David Wabnitz, Ahmed Bassiouni, Peter-John Wormald, Sarah Vreugde, Alkis James Psaltis
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2017)
Article
Otorhinolaryngology
Neil C. -W. Tan, Rachel Goggin, Alkis J. Psaltis, Peter-John Wormald
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2018)
Article
Clinical Neurology
Benjamin Harley, Agadha Wickremesekera, Neil Tan, Elgan Davies, Simon Robinson, Campbell Baguley, Peter J. Wormald
JOURNAL OF CLINICAL NEUROSCIENCE
(2019)
Article
Otorhinolaryngology
P. Coyle, N. Tan, N. Jonas
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2019)
Review
Otorhinolaryngology
Neil C. W. Tan, Alkis J. Psaltis
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2020)
Review
Otorhinolaryngology
A. Ashman, A. J. Psaltis, P. J. Wormald, N. C-W Tan
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2020)
Letter
Medicine, General & Internal
Neil C. Tan, Samuel C. Leong
Article
Ophthalmology
David S. Curragh, Alkis J. Psaltis, Neil C. Tan, Dinesh Selva
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
(2019)