Review
Biochemistry & Molecular Biology
Juan Antonio Rojas-Murillo, Mario A. Simental-Mendia, Nidia K. Moncada-Saucedo, Paulina Delgado-Gonzalez, Jose Francisco Islas, Jorge A. Roacho-Perez, Elsa N. Garza-Trevino
Summary: Cartilage tissue engineering is a promising alternative for chondral defect repair, using cells, scaffolds, and signaling factors to mimic natural tissue structure and improve tissue function. Fibrin, a biocompatible biomaterial, can enhance damaged cartilage regeneration when combined with other materials or biological components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Arya Amirhekmat, Wendy E. Brown, Evelia Y. Salinas, Jerry C. Hu, Kyriacos A. Athanasiou, Dean Wang
Summary: The mechanical properties of fibrin sealants for intra-articular surgical fixation of cartilage fragments and implants were investigated in this study. The adhesive properties of the sealants were not affected by the type or number of applications, but were found to be less than desired for cartilage repair implants. These findings highlight the need for improved cartilage-specific adhesives for cartilage repair applications.
Article
Engineering, Biomedical
Jonathan H. Galarraga, Hannah M. Zlotnick, Ryan C. Locke, Sachin Gupta, Natalie L. Fogarty, Kendall M. Masada, Brendan D. Stoeckl, Lorielle Laforest, Miguel Castilho, Jos Malda, Riccardo Levato, James L. Carey, Robert L. Mauck, Jason A. Burdick
Summary: Soft norbornene-modified hyaluronic acid (NorHA) hydrogels were reinforced with polycaprolactone using melt electrowriting (MEW) to fabricate composite scaffolds. These scaffolds supported chondrogenesis and cartilage formation of encapsulated porcine mesenchymal stromal cells (pMSC) and exhibited suitable mechanical properties. Fixation of the composites with biodegradable pins or fibrin glue ensured implant retention, but the use of pins resulted in inferior cartilage repair compared to the use of glue.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Pharmacology & Pharmacy
Luis Fernandez-Vega-Cueto, Mairobi Persinal-Medina, Natalia Vazquez, Manuel Chacon, Belen Alfonso-Bartolozzi, Sergio Alonso-Alonso, Teresa Sanchez, Silvia Berisa-Prado, Laura Maria Martinez-Lopez, Jesus Merayo-Lloves, Alvaro Meana
Summary: The study proposes a method to prepare autologous bio-based fibrin glue for ophthalmic surgery. The adhesive strength of FG increased with fibrinogen concentration, and FG2 and FG3 showed successful results in conjunctival autografts with equivalent properties compared to commercial FG and reduced inflammation.
Article
Immunology
Luciana P. F. Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Ana Beatriz B. de C. O. Lima, Gabriela R. Haddad, Marcia A. N. Gatti, Natalia Bronzatto Medolago, Marcia Tonin Rigotto Carneiro, Lucilene Delazari dos Santos, Rui Seabra Ferreira, Benedito Barraviera
Summary: The study evaluated the safety and efficacy of HFS in treating chronic venous ulcers, showing promising results in healing ulcers. However, further multicentric phase III clinical trials are needed to confirm these findings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Chemical
Vijai Laxmi, Suhas S. Joshi, Amit Agrawal
Summary: The study successfully developed a microdevice using microfluidic technology to efficiently isolate platelet-poor plasma with a purity of 94.7%, without affecting the shape and size of platelets. The microdevice is compact, easy to fabricate, reliable, and suitable for rapid and convenient point-of-care applications.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Lisha Yu, Zhaodi Liu, Zongrui Tong, Yihang Ding, Zhefeng Qian, Weilin Wang, Zhengwei Mao, Yuan Ding
Summary: A sequential crosslinking fibrin glue (SCFG) is developed, which forms the initial network within 2 seconds and locks the gelatin methacryloyl precursor for construction of the second network to enhance wet adhesion and durability for tissues. SCFG shows ultrafast gelation, strong adhesion and durability, excellent compatibility, and easy manufacture, making it a promising hemostatic adhesive.
Article
Orthopedics
Baris Gorgun, Alper Gamli, Mehmet Emin Duran, Berhan Bayram, Tekin Kerem Ulku, Baris Kocaoglu
Summary: This study compared the efficacy of single-step all-arthroscopic treatment of osteochondral lesions of the talus (OLT) with and without the use of a collagen scaffold. The results showed no significant difference between the two groups in terms of clinical and radiological outcomes.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Alexandre Dufour, Frederic Mallein-Gerin, Emeline Perrier-Groult
Summary: In this study, a combination of soluble factors, fibrin hydrogel, direct perfusion, and human articular chondrocytes was used to engineer large cartilage tissues. Perfusion preconditioning improved the quality and spatial distribution of the cartilage matrix, resulting in the reconstruction of hyaline cartilage and increased production of the main component of the pericellular matrix by chondrocytes.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Diego Trucco, Laura Riacci, Lorenzo Vannozzi, Cristina Manferdini, Lorenzo Arrico, Elena Gabusi, Gina Lisignoli, Leonardo Ricotti
Summary: A stable adhesion to the cartilage is crucial for hydrogels used in cartilage regeneration. Fibrin glue and cellulose nanofibers can improve adhesion strength, while catecholamines do not meet clinically acceptable levels. Stem cells embedded in hydrogels are still suitable for in vivo applications.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Polymer Science
Carlos Henrique Bertoni Reis, Daniela Vieira Buchaim, Adriana de Cassia Ortiz, Simone Ortiz Moura Fideles, Jefferson Aparecido Dias, Maria Angelica Miglino, Daniel de Bortoli Teixeira, Eliana de Souza Bastos Mazuqueli Pereira, Marcelo Rodrigues da Cunha, Rogerio Leone Buchaim
Summary: Fibrin, a biopolymer derived from proteins involved in blood clotting, has various applications in the health area. Its combination with photobiomodulation (PBM) can stimulate cell activity, angiogenesis, osteoblast activation, and collagen synthesis.
Article
Surgery
Ahmed Fawzy, M. Ashraf Balbaa, Ahmed Gaber
Summary: The study showed that using fibrin glue in inguinal lymph node dissection significantly reduced the incidence of seroma formation, total amount of serous fluid, time to remove drains, and hospital stay. However, there were no significant differences between the two groups in occurrences of hematoma, infection or superficial skin edge necrosis. Future studies need to standardize the definition of seroma and determine the optimal dosage and technique of fibrin glue in ILND.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Yuuki Shirai, Junko Okano, Takahiko Nakagawa, Miwako Katagi, Yuki Nakae, Atsuhiro Arakawa, Shinya Koshinuma, Gaku Yamamoto, Hideto Kojima
Summary: This article investigates the regenerating effect of gelatin sponges as scaffolds in deep wounds with periosteal defects in rats. The study demonstrates that the microenvironment provided by the gelatin sponges enables bone marrow-derived cells to form a vascular niche, leading to the regeneration of periosteum, skin, and skin appendages. These findings emphasize the importance of vascular niche formation in the regeneration of heterogeneous tissues in deep wounds.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Roozbeh Riazi Moghadam, Hamid Keshvari, Rana Imani, Masoumeh Haghbin Nazarpak
Summary: This study developed a three-layered fiber/hydrogel scaffold that replicated the structural features of healthy articular cartilage tissue. The scaffold exhibited favorable mechanical properties and cytocompatibility. It has the potential to be used for articular cartilage tissue regeneration.
BIOMEDICAL MATERIALS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
David Yurui Lim, Mark Wang, Kabilan Chokkappan, Kristen Alexa Lee, Sum Leong, Keng Sin Ng, Chow Wei Too
Summary: Percutaneous glue embolization has shown good efficacy and safety in the treatment of bronchopleural fistulae and alveolar-pleural fistulae associated with persistent air leak.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Otorhinolaryngology
Seda Turkoglu Babakurban, Omer Vural, Yesim Korkmaz Kasap, Evren Hizal, Erkan Yurtcu, Adnan Fuat Buyuklu
Summary: This study aimed to investigate whether budesonide and triamcinolone acetate cause DNA fractures in nasal mucosa and septal cartilage cells. The results showed that both drugs significantly led to genotoxic damage in both epithelial tissue and cartilage tissue, at different doses and time points.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2023)
Article
Physics, Multidisciplinary
Melek Ece ongel, Cennet Yildiz, Oezge Baser, Bayram Yilmaz, Mustafa ozilgen
Summary: Organisms maintain structure by importing energy and exporting entropy, but accumulation of entropy causes aging. According to Hayflick's concept, lifespan is determined by entropy generation. This study suggests that intermittent fasting can increase longevity. Shifting to a healthier diet may also increase life expectancy in non-alcoholic fatty liver disease patients.
Review
Genetics & Heredity
Ege Baltaci, Ferah Kazanci, Feride Iffet Sahin
Summary: BRCA mutations can lead to fertility problems and oocyte aging in young cancer patients. This review analyzes the association between BRCA mutations and infertility, explores fertility preservation options, and gathers results from various disciplines. The aim is to provide insights for counseling BRCA mutation carriers on fertility preservation methods and implications.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Cell Biology
Yavuz Yavuz, Gamze Yesilay, Bilge Guvenc Tuna, Akif Maharramov, Mustafa Culha, Cihan Suleyman Erdogan, Gunseli Ayse Garip, Bayram Yilmaz
Summary: Gold nanoparticles (GNPs) are widely used in medicine for their multifunctional properties. In this study, the effects of transferrin-conjugated GNPs (Tf-GNPs) on anxiety and locomotor behavior, as well as hippocampal neuronal activity, were investigated. The results showed that Tf-GNP induced anxiety-like behavior without altering the firing rate of hippocampal neurons. These findings highlight the need to evaluate the neurobiological effects of Tf-GNP before their medical applications. Overall, a rating of 7.5 out of 10 is given for the importance of this article.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Developmental Biology
Fatih Mete, Signem Eyuboglu, Ayca Vitrinel, Ulkan Kilic, Cihan Suleyman Erdogan, Ertugrul Kilic, Bayram Yilmaz
Summary: Maintenance of body temperature within physiological range is critical for the fetal and neonatal development. Hyperthermia can lead to neurobehavioral deficits in young male rats, including decreased locomotor activity, increased anxiety, and impaired motor function. These effects were more pronounced at higher temperatures. The study also found that hyperthermia caused decreased neuronal survival, increased apoptosis, and decreased cell proliferation in specific regions of the brain.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Cell Biology
Elif Gunalan, Meyli Ezgi Karagoz, Cihan Civan Civas, Volkan Adem Bilgin, Cihan Suleyman Erdogan, Aylin Guven, Bayram Yilmaz, Burcu Gemici
Summary: CD36 and GPR120 are involved in the perception and preference for fat-rich food consumption. The study aimed to investigate the relationship between oro-gustatory perception of lipids, fatty taste preference, and maternal (Gestation + Lactation)-maturation period nutrition status in offspring Sprague-Dawley rats. The results suggest that maternal diet during gestation and lactation periods can influence the fat perception and preference in offspring.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Zeynep Dila Oz, Emine Kacar, Ihsan Serhatlioglu, Mehmet Ridvan Ozdede, Busra Atila, Mert Ali Horoz, Gaye Goksu Avcu, Gulendam Ozbeg, Aslisah Ozgen, Fatih Tan, Gokhan Zorlu, Abdullah Yasar, Bayram Yilmaz, Haluk Kelestimur
Summary: The study found that chronic administration of asprosin has a positive impact on sexual motivation and olfactory performance in female rats. Furthermore, it was observed that the use of asprosin also led to increased levels of oxytocin and estradiol in the serum of female rats.
NEUROENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Nihal Sahin Uysal, Feride Iffet Sahin, Yunus Kasim Terzi
Summary: Non-syndromic cleft lip and/or palate (NSCL/P) is a congenital malformation with a prevalence of 1:700 births. The development of NSCL/P involves interactions between genes that regulate cell growth, proliferation, differentiation, epithelial-to-mesenchymal transition, and apoptosis. Whole genome/exome analysis and genome-wide association studies provide opportunities to identify the genetic factors contributing to NSCL/P development. In cases of cleft lip and/or palate detected on ultrasonography without associated anomalies, collaboration with a clinical geneticist is essential to evaluate the patient and consider the involvement of various genes and environmental factors in the etiopathogenesis of NSCL/P, leading to a possible genetic diagnosis roadmap.
JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION
(2023)
Article
Psychology, Biological
Firas Khoubbieh, Cihan Suleyman Erdogan, Tugce Onel, Ecem Yildirim, Engin Sumer, Aylin Yaba, Bayram Yilmaz
Summary: This study investigated the effects of chronic MPH administration on reproductive parameters in children with ADHD and found that it can affect the reproductive functions in both male and female rats. However, these effects are transient.
PHYSIOLOGY & BEHAVIOR
(2023)
Meeting Abstract
Physiology
Fatih Tan, Zeynep Dila Oz, Mehmet Ridvan Ozdede, Gokhan Zorlu, Gaye Goksu Avcu, Abdullah Yasar, Emine Kacar, Ihsan Serhatlioglu, Bayram Yilmaz, Haluk Kelestimur
Meeting Abstract
Physiology
Zeynep Dila Oz, Mehmet Ridvan Ozdede, Busra Atila, Mert Ali Horoz, Abdullah Yasar, Emine Kacar, Ihsan Serhatlioglu, Bayram Yilmaz, Haluk Kelestimur
Meeting Abstract
Physiology
Gulendam Ozbeg, Zeynep Dila Oz, Mehmet Ridvan Ozdede, Aslisah Ozgen, Samet Ramazan Kocoglu, Abdullah Yasar, Emine Kacar, Ihsan Serhatlioglu, Bayram Yilmaz, Haluk Kelestimur
Meeting Abstract
Physiology
Mehmet Ridvan Ozdede, Zeynep Dila Oz, Nalan Kaya Tektemur, Ibrahim Halil Gungor, Aslihan Cakir, Gaffari Turk, Abdullah Yasar, Emine Kacar, Ihsan Serhatlioglu, Bayram Yilmaz, Haluk Kelestimur
Meeting Abstract
Physiology
Deniz Oyku Ozen, Yavuz Yavuz, Ozge Baser, Bayram Yilmaz
Meeting Abstract
Physiology
Huseyin Bugra Ozgun, Yavuz Yavuz, Ozge Baser, Cihan Suleyman Erdogan, Habibe Goren, Bayram Yilmaz
