☆ 4.7 Editorial Material

Global burden of human papillomavirus-positive head and neck cancers

LANCET ONCOLOGY (2014)

Journal

LANCET ONCOLOGY

Volume 15, Issue 12, Pages 1282-1283

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ELSEVIER SCIENCE INC

DOI: 10.1016/S1470-2045(14)71029-0

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Vaccine Strategies for Human Papillomavirus-Associated Head and Neck Cancers

Jade Z. Zhou, Jessica Jou, Ezra Cohen

Summary: This article reviews the incidence and pathogenesis of HPV-related cancers worldwide, the development and use of HPV prophylactic vaccines, and the progress and challenges in the development of HPV therapeutic vaccines.

CANCERS (2022)

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Article Oncology

Treatment De-Intensification for Patients With HPV-Positive Head and Neck Cancers

Maura L. Gillison

Summary: Cisplatin and 70 Gy of intensity-modulated radiotherapy remain the standard of care in HPV-positive head and neck cancer. De-escalation and replacement therapies have shown compromises in tumor control and survival. More multicenter, randomized studies with clear endpoints are needed to move forward.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2022)

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Article Biochemistry & Molecular Biology

Effect of ATR Inhibition in RT Response of HPV-Negative and HPV-Positive Head and Neck Cancers

Ruveyda Dok, Mary Glorieux, Marieke Bamps, Sandra Nuyts

Summary: Combining ATR inhibition with radiotherapy can enhance the therapeutic response of both HPV-negative and HPV-positive HNSCC cell lines. ATR inhibition improves DNA repair in cells, leading to an increase in micronucleation and ultimately strengthening the effects of radiotherapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

The Key Differences between Human Papillomavirus-Positive and -Negative Head and Neck Cancers: Biological and Clinical Implications

Steven F. Powell, Lexi Vu, William C. Spanos, Dohun Pyeon

Summary: Head and neck cancer (HNC) is the sixth most common form of cancer worldwide, with two distinct subtypes associated with smoking/drinking and/or human papillomavirus (HPV) infection. While the incidence of non-viral HNC is decreasing, HPV-positive HNC has seen a dramatic increase in recent years. Molecular and clinical differences between HPV-positive and -negative HNC have been observed, with distinct risk factors and complex molecular signatures within the same anatomical subtypes.

CANCERS (2021)

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Review Oncology

HPV-related head and neck cancers: Pathology and biology

Maelle Saliba, Ronald Ghossein, Bin Xu

Summary: The discovery of HPV's key role in head and neck carcinogenesis has revolutionized the approach to cancers. Understanding the oncogenic mechanisms of HPV-driven tumorigenesis and optimizing detection methods are crucial for diagnosing HPV-driven neoplasia clinically.

JOURNAL OF SURGICAL ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Genetically engineered mouse models of head and neck cancers

Jason Tasoulas, Sonal Srivastava, Xiaonan Xu, Valentina Tarasova, Anastasios Maniakas, Florian A. Karreth, Antonio L. Amelio

Summary: The head and neck region is highly susceptible to cancer, with over 1.5 million new cases reported worldwide in 2020. Significant progress has been made in understanding the disease mechanisms and tailoring treatments to individual tumor characteristics using genetically engineered mouse models. These models have successfully replicated various aspects of head and neck cancers.

ONCOGENE (2023)

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Review Oncology

Vaccine-Based Immunotherapy for Head and Neck Cancers

Simon Beyaert, Jean-Pascal Machiels, Sandra Schmitz

Summary: Therapeutic vaccines are administered to cancer patients to stimulate an immune T cell response against specific antigens, with the challenge of considering tumor heterogeneity. Current research in therapeutic vaccines focuses on viral or non-viral antigens, particularly in head and neck cancers, with advancements seen in clinical trials and FDA approvals for certain treatments.

CANCERS (2021)

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Review Oncology

Molecular Tumor Subtypes of HPV-Positive Head and Neck Cancers: Biological Characteristics and Implications for Clinical Outcomes

Tingting Qin, Shiting Li, Leanne E. Henry, Siyu Liu, Maureen A. Sartor

Summary: This study highlights the increasing incidence of HPV infections in head and neck cancers, with a focus on the molecular subtypes of HPV-positive HNC and their implications on treatment and prognosis.

CANCERS (2021)

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Article Pathology

Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers

Prokopios P. Argyris, Peter E. Wilkinson, Matthew C. Jarvis, Kelly R. Magliocca, Mihir R. Patel, Rachel I. Vogel, Rajaram Gopalakrishnan, Ioannis G. Koutlas, Reuben S. Harris

Summary: The DNA cytosine deaminase APOBEC3B (A3B) is overexpressed in various tumors, particularly those associated with HPV infection; Immunohistochemical analysis suggests that A3B expression may undergo a gradual transition in HPV-negative head/neck cancers, potentially serving as a marker for advanced oral dysplasia and cancer.

MODERN PATHOLOGY (2021)

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Article Oncology

Analysis of human leukocyte antigen associations in human papillomavirus-positive and -negative head and neck cancer: Comparison with cervical cancer

Chameera Ekanayake Weeramange, Danhua Shu, Kai Dun Tang, Jyotsna Batra, Rahul Ladwa, Lizbeth Kenny, Sarju Vasani, Ian H. Frazer, Riccardo Dolcetti, Jonathan J. Ellis, Richard A. Sturm, Paul Leo, Chamindie Punyadeera

Summary: The risk of human papillomavirus (HPV)-positive head and neck cancer (HNC) is associated with distinct human leukocyte antigen (HLA) variants, some of which are shared by both cervical cancer and HPV-positive HNC. Several previous genome-wide association studies were replicated in this study, but the associations were limited to the HPV-positive HNC group.

CANCER (2022)

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Article Oncology

Prevalence of human papillomavirus in head and neck cancers at tertiary care centers in the United States over time

Nicholas Scott-Wittenborn, Gypsyamber D'Souza, Sakshi Tewari, Lisa Rooper, Tanya Troy, Virginia Drake, Elaine O. Bigelow, Melina J. Windon, William R. Ryan, Patrick K. Ha, Ana P. Kiess, Brett Miles, William H. Westra, Wojciech K. Mydlarz, David W. Eisele, Carole Fakhry

Summary: The prevalence of Human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinomas (OPSCCs) is increasing, especially among men and White individuals. Similar trends have also been observed in women and non-Whites. The prevalence of p16- and ISH-positive tumors has also increased in non-OPSCCs.

CANCER (2022)

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Article Microbiology

Human Papillomavirus and Risk of Head and Neck Squamous Cell Carcinoma in Iran

Abbas Karimi, Elham Mohebbi, Sandrine Mckay-Chopin, Hamideh Rashidian, Maryam Hadji, Vahideh Peyghambari, Maryam Marzban, Ahmad Naghibzadeh-Tahami, Mahin Gholipour, Farin Kamangar, Massimo Tommasino, Tarik Gheit, Kazem Zendehdel

Summary: This study analyzed the detection of alpha-, beta-, and gamma-HPVs in oral rinse samples of HNSCC cases and controls in Iran, finding that the contribution of alpha-HPVs to HNSCC in Iran is lower than global prevalence, and high-risk alpha-HPVs or cutaneous beta- and gamma-HPVs were not associated with HNSCC development.

MICROBIOLOGY SPECTRUM (2022)

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Review Oncology

STINGing Viral Tumors: What We Know from Head and Neck Cancers

Emma Saulters, John F. Woolley, Shankar Varadarajan, Terence M. Jones, Lekh N. Dahal

Summary: Viruses, even if not directly oncogenic, can impact tumor biology and immune behavior, raising the question of whether virus-associated tumors should be distinct. HPV infection in HNSCC may lead to unique etiology and clinical outcomes, potentially due to greater immunogenicity associated with HPV infection.

CANCER RESEARCH (2021)

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Article Oncology

Detection of circulating tumor human papillomavirus DNA before diagnosis of HPV-positive head and neck cancer

Eleni M. Rettig, Daniel L. Faden, Shaiba Sandhu, Kristine Wong, William C. Faquin, Chloe Warinner, Phil Stephens, Sunil Kumar, Charlotte Kuperwasser, Jeremy D. Richmon, Ravindra Uppaluri, Mark Varvares, Rosh Sethi, Glenn J. Hanna, Herve Sroussi

Summary: This study found that circulating tumor HPV DNA can be detected at least several years before the diagnosis of HPV-positive head and neck squamous cell carcinoma (HNSCC) in some patients, which may serve as a biomarker for early diagnosis of HPV16-positive HNSCC.

INTERNATIONAL JOURNAL OF CANCER (2022)

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Article Medicine, Research & Experimental

Myeloid cell-targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell-mediated immunity

Dayson Moreira, Sagus Sampath, Haejung Won, Seok Voon White, Yu-Lin Su, Marice Alcantara, Chongkai Wang, Peter Lee, Ellie Maghami, Erminia Massarelli, Marcin Kortylewski

Summary: The study suggests that targeted inhibition of STAT3 in tumor-associated myeloid cells enhances the efficacy of radiotherapy against HNSCC by promoting the recruitment of CD8(+) T cells and suppressing tumor growth.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Editorial Material Oncology

Real-World HPV Vaccine Effectiveness Studies: Guideposts for Interpretation of Current and Future Studies

Nicole G. Campos, Anil K. Chaturvedi, Aimee R. Kreimer

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

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Article Gastroenterology & Hepatology

Population Attributable Risks of Subtypes of Esophageal and Gastric Cancers in the United States

Shao-Ming Wang, Hormuzd A. Katki, Barry I. Graubard, Lisa L. Kahle, Anil Chaturvedi, Charles E. Matthews, Neal D. Freedman, Christian C. Abnet

Summary: A study conducted from 1995 to 2011 on 490,605 individuals showed that smoking, obesity, and gastroesophageal reflux disease are the main modifiable risk factors leading to ESCC, EAC, GCA, and GNCA.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

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Article Oncology

Management of Lung Cancer Screening Results Based on Individual Prediction of Current and Future Lung Cancer Risks

Hilary A. Robbins, Li C. Cheung, Anil K. Chaturvedi, David R. Baldwin, Christine D. Berg, Hormuzd A. Katki

Summary: This study proposes a risk-tailored approach for managing lung cancer screening results by incorporating individual risk factors and LDCT image features, which can recommend screening intervals based on calculated risks. Results show that using individualized risk models can substantially reduce the number of screens or increase early detection.

JOURNAL OF THORACIC ONCOLOGY (2022)

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Article Oncology

Sex disparities in the incidence of 21 cancer types: Quantification of the contribution of risk factors

Sarah S. Jackson, Morgan A. Marks, Hormuzd A. Katki, Michael B. Cook, Noorie Hyun, Neal D. Freedman, Lisa L. Kahle, Philip E. Castle, Barry Graubard, Anil K. Chaturvedi

Summary: Men have a higher risk of cancer than women at most shared anatomic sites, but this male predominance is largely unexplained by risk factors, underscoring a role for sex-related biologic factors.

CANCER (2022)

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Editorial Material Oncology

The Evolving Epidemiology of Oral Cavity and Oropharyngeal Cancers

Anil K. Chaturvedi, Neal D. Freedman, Christian C. Abnet

Summary: This article introduces the etiology and prevention measures of oropharyngeal cancers. Early studies showed associations between smoking and alcohol consumption with oropharyngeal cancers, while recent research has identified human papillomavirus (HPV) as the major cause. Therefore, controlling smoking and alcohol use, as well as HPV vaccination, are the most effective methods for preventing oropharyngeal cancers. Additionally, the carcinogenic effects of alternative tobacco products are also being investigated.

CANCER RESEARCH (2022)

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Article Oncology

The Current Burden of Oropharyngeal Cancer: A Global Assessment Based on GLOBOCAN 2020

Valentina Lorenzoni, Anil K. Chaturvedi, Jerome Vignat, Mathieu Laversanne, Freddie Bray, Salvatore Vaccarella

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2022)

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Article Oncology

Exclusive use of different types of tobacco products, exposure to secondhand tobacco smoke and risk of subtypes of head and neck cancer among Indian males

Devyani Gholap, Rajesh Dikshit, Pankaj Chaturvedi, Anil K. Chaturvedi, Ankita Manjrekar, Sharayu Mhatre

Summary: This study found a strong association between the exclusive use of smokeless tobacco products and the risk of various subtypes of head and neck cancer (HNC) in India. Chewing gutka had the highest risk, followed by betel quid with tobacco, tobacco quid, Khaini, Mawa, and Mishri. Bidi smoking and exposure to secondhand smoke were also independently associated with an increased risk of HNC. This suggests that tobacco control policies should focus on raising awareness about the risks of different tobacco products and emphasize that switching between types is not a safe alternative to quitting completely.

INTERNATIONAL JOURNAL OF CANCER (2023)

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Article Medicine, General & Internal

IARC Perspective on Oral Cancer Prevention

Veronique Bouvard, Suzanne T. Nethan, Deependra Singh, Saman Warnakulasuriya, Ravi Mehrotra, Anil K. Chaturvedi, Tony Hsiu-Hsi Chen, Olalekan A. Ayo-Yusuf, Prakash C. Gupta, Alexander R. Kerr, Wanninayake M. Tilakaratne, Devasena Anantharaman, David Conway, Ann Gillenwater, Newell W. Johnson, Luiz P. Kowalski, Maria E. Leon, Olena Mandrik, Toru Nagao, Vinayak M. Prasad, Kunnambath Ramadas, Felipe Roitberg, Pierre Saintigny, Rengaswamy Sankaranarayanan, Alan R. Santos-Silva, Dhirendra N. Sinha, Patravoot Vatanasapt, Rosnah B. Zain, Beatrice Lauby-Secretan

Summary: An expert panel review by the International Agency for Research on Cancer (IARC) suggests that smoking, smokeless tobacco use, areca nut exposure, and heavy alcohol consumption are major contributors to oral cancer.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Letter Medicine, General & Internal

Variation in Human Papillomavirus Vaccination Effectiveness in the US by Age at Vaccination

Didem Egemen, Hormuzd A. Katki, Anil K. Chaturvedi, Rebecca Landy, Li C. Cheung

Summary: This survey study examined the self-reported status and timing of HPV vaccination among female participants in the National Health and Nutrition Examination Survey from 2011 to 2018.

JAMA NETWORK OPEN (2022)

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Article Oncology

Oral microbiome and risk of incident head and neck cancer: A nested case-control study

Zeni Wu, Yongli Han, Yunhu Wan, Xing Hua, Samantha S. Chill, Kedest Teshome, Weiyin Zhou, Jia Liu, Dongjing Wu, Amy Hutchinson, Kristine Jones, Casey L. Dagnall, Belynda D. Hicks, Linda Liao, Heather Hallen-Adams, Jianxin Shi, Christian C. Abnet, Rashmi Sinha, Anil Chaturvedi, Emily Vogtmann

Summary: This study found a relationship between oral microbiome and head and neck cancer. The presence of multiple microbial species, including periodontal pathogens, as well as higher microbial alpha-diversity and the presence of oral fungi, were associated with reduced risk of HNC. Larger studies are needed to further evaluate these associations.

ORAL ONCOLOGY (2023)

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Meeting Abstract Oncology

The oral microbiome and the risk of head and neck cancer: A nested case-control study in the NIH-AARP

Zeni Wu, Yongli Han, Yunhu Wan, Xing Hua, Casey L. Dagnall, Kristine Jones, Amy Hutchinson, Belynda D. Hicks, Weiyin Zhou, Linda Liao, Heather Hallen-Adams, Jianxin Shi, Christian C. Abnet, Rashmi Sinha, Anil Chaturvedi, Emily Vogtmann

CANCER RESEARCH (2022)

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Proceedings Paper Computer Science, Artificial Intelligence

Extraction of Ruler Markings For Estimating Physical Size of Oral Lesions

Zhiyun Xue, Kelly Yu, Paul Pearlman, Tseng-Cheng Chen, Chun-Hung Hua, Chung Jan Kang, Chih-Yen Chien, Ming-Hsui Tsai, Cheng-Ping Wang, Anil Chaturvedi, Sameer Antani

Summary: In this paper, we propose an approach to automatically extract measurement information from oral cavity images taken during oral cancer screening and follow up. We address challenges faced in real world use and with analysis of retrospectively collected data, providing multiple ways of extracting ruler markings and measurement calculation based on specific conditions.

2022 26TH INTERNATIONAL CONFERENCE ON PATTERN RECOGNITION (ICPR) (2022)

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Proceedings Paper Medical Informatics

Oral Cavity Anatomical Site Image Classification and Analysis

Zhiyun Xue, Paul C. Pearlman, Kelly Yu, Anabik Pal, Tseng-Cheng Chen, Chun-Hung Hua, Chung Jan Kang, Chih-Yen Chien, Ming-Hsui Tsai, Cheng-Ping Wang, Anil K. Chaturvedi, Sameer Antani

Summary: Oral cavity cancer is a common and highly lethal cancer that leads to various issues. However, there is limited research on the automated visual evaluation of oral cavity lesions using deep learning. This study successfully generates labels and applies a high-performance network to analyze images of oral cavity cancer, achieving satisfactory results. The analysis of class activation maps further helps improve algorithms and assist the development of other components in the screening process of oral cancer.

MEDICAL IMAGING 2022: IMAGING INFORMATICS FOR HEALTHCARE, RESEARCH, AND APPLICATIONS (2022)

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Meeting Abstract Oncology

Potential effect on racial/ethnic disparities of removing racial/ethnic variables from risk models: The example of lung-cancer screening

Corey D. Young, Li C. Cheung, Christine D. Berg, Patricia Rivera, Hilary A. Robbins, Anil K. Chaturvedi, Hormuzd A. Katki, Rebecca Landy

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2022)

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Meeting Abstract Oncology

Estimating the influence of sex on cancer risk: An analysis in a large US prospective cohort study.

Sarah S. Jackson, Morgan A. Marks, Hormuzd Katki, Barry I. Graubard, Michael D. Cook, Anil Chaturvedi

CANCER RESEARCH (2021)

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Global burden of human papillomavirus-positive head and neck cancers

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ELSEVIER SCIENCE INC

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