Article
Multidisciplinary Sciences
Yin-Chen Hsu, Chih-Hsiang Yu, Yan-Ming Chen, Kathryn G. Roberts, Yu-Ling Ni, Kai-Hsin Lin, Shiann-Tarng Jou, Meng-Yao Lu, Shu-Huey Chen, Kang-Hsi Wu, Hsiu-Hao Chang, Dong-Tsamn Lin, Shu-Wha Lin, Ze-Shiang Lin, Wei-Tzu Chiu, Chia-Ching Chang, Bing-Ching Ho, Charles G. Mullighan, Sung-Liang Yu, Yung-Li Yang
Summary: Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukaemia (ALL) is a high-risk subtype with genomic alterations that activate cytokine receptor and kinase signalling. Patients with non-Ph kinase fusions have inferior outcomes compared to those with other common genetic alterations. The prevalence of non-Ph kinase fusions in Taiwanese cohort was lower than in Caucasian populations, suggesting potential implications for future clinical trials with tyrosine kinase inhibitors in Taiwan.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Lichun Xie, Qingling Long, Guichi Zhou, Sixi Liu, Fei-Qiu Wen
Summary: This case report describes a 10-year-old patient with Philadelphia chromosome-positive ALL who developed acute Candida tropicalis osteomyelitis. The patient was successfully treated with antifungal therapy, surgery, and chemotherapy, achieving complete clinical remission. Using combined modalities of treatment seems to be crucial in the successful management of Ph-positive ALL.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Hematology
Stephen P. Hunger, Thai Hoa Tran, Vaskar Saha, Meenakshi Devidas, Maria Grazia Valsecchi, Julie M. Gastier-Foster, Giovanni Cazzaniga, Shalini C. Reshmi, Michael J. Borowitz, Anthony Moorman, Nyla A. Heerema, Andrew J. Carroll, Patricia Martin-Regueira, Mignon L. Loh, Elizabeth A. Raetz, Kirk R. Schultz, William B. Slayton, Gunnar Cario, Martin Schrappe, Lewis B. Silverman, Andrea Biondi
Summary: A study found that the second-generation ABL-class inhibitor dasatinib, when combined with intensive chemotherapy, is effective and safe in the treatment of newly diagnosed Ph-positive acute lymphoblastic leukaemia in children. The 3-year event-free survival rate is similar to previous studies, despite the limited use of hematopoietic stem cell transplantation (HSCT) in the first complete remission.
LANCET HAEMATOLOGY
(2023)
Article
Hematology
Isamu Sugiura, Noriko Doki, Tomoko Hata, Ryuko Cho, Toshiro Ito, Youko Suehiro, Masatsugu Tanaka, Shinichi Kako, Mitsuhiro Matsuda, Hisayuki Yokoyama, Yuichi Ishikawa, Yasuhiro Taniguchi, Maki Hagihara, Yukiyasu Ozawa, Yasunori Ueda, Daiki Hirano, Toru Sakura, Masaaki Tsuji, Tsuyoshi Kamae, Hiroyuki Fujita, Nobuhiro Hiramoto, Masahiro Onoda, Shin Fujisawa, Yoshihiro Hatta, Nobuaki Dobashi, Satoshi Nishiwaki, Yoshiko Atsuta, Yukio Kobayashi, Fumihiko Hayakawa, Shigeki Ohtake, Tomoki Naoe, Yasushi Miyazaki
Summary: This study evaluated the use of dasatinib-based 2-step induction in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The results showed that this treatment approach significantly improved the 3-year event-free survival rate in these patients.
Article
Hematology
Hisashi Ishida, Yuki Arakawa, Daiichiro Hasegawa, Ikuya Usami, Yoshiko Hashii, Yasuyuki Arai, Satoshi Nishiwaki, Dai Keino, Keisuke Kato, Maho Sato, Nao Yoshida, Yukiyasu Ozawa, Keiko Okada, Moe Hidaka, Yuki Yuza, Masatsugu Tanaka, Kenichiro Watanabe, Junko Takita, Yoshiyuki Kosaka, Naoto Fujita, Junji Tanaka, Atsushi Sato, Yoshiko Atsuta, Toshihiko Imamura
Summary: In this study, data of Ph+ALL patients receiving HSCT in Japan were retrospectively collected, showing that RIC regimen in HSCT for younger patients had comparable long-term leukemia-free survival rates to the traditional MAC regimen, with RIC being an independent favorable prognostic factor.
ANNALS OF HEMATOLOGY
(2023)
Article
Oncology
Jan Zuna, Lenka Hovorkova, Justina Krotka, Amelie Koehrmann, Michela Bardini, Lucie Winkowska, Eva Fronkova, Julia Alten, Rolf Koehler, Cornelia Eckert, Lisa Brizzolara, Marie Trkova, Jan Stuchly, Martin Zimmermann, Paola De Lorenzo, Maria Grazia Valsecchi, Valentino Conter, Jan Stary, Martin Schrappe, Andrea Biondi, Jan Trka, Marketa Zaliova, Giovanni Cazzaniga, Gunnar Cario
Summary: In this retrospective analysis, the prognostic relevance of minimal residual disease (MRD) and other features in BCR::ABL1-positive ALL were investigated. The study found that BCR::ABL1-positive ALL can be divided into typical ALL and CML-like subtype. The overall prognosis of typical ALL and CML-like patients was similar, but there were differences in relapse rates and mortality. MRD had a significant prognostic role in typical ALL, while it was not significant in CML-like patients. The study suggests that early distinguishing between typical BCR::ABL1-positive ALL and CML-like patients is important for optimal treatment approaches.
Review
Oncology
Khalil Saleh, Alexis Fernandez, Florence Pasquier
Summary: The outcome of patients with Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) has dramatically improved in the past 20 years with the introduction of tyrosine kinase inhibitors and monoclonal antibodies. These treatments have shown great efficacy in young and fit patients, leading to questioning the reliance on chemotherapy and stem cell transplantation. They can also be safely used in elderly patients, who make up the majority of Ph+ ALL patients. This review focuses on the recent changes in the management of Ph+ ALL patients and the development of new therapeutic strategies.
Article
Health Care Sciences & Services
Jiaoyang Cai, Hu Liu, Yumei Chen, Jie Yu, Ju Gao, Hua Jiang, Xiaowen Zhai, Xiuli Ju, Xuedong Wu, Ningling Wang, Xin Tian, Changda Liang, Yongjun Fang, Fen Zhou, Hong Li, Lirong Sun, Liangchun Yang, Jing Guo, Aiguo Liu, Chi-kong Li, Yiping Zhu, Jingyan Tang, Jun J. Yang, Shuhong Shen, Cheng Cheng, Ching-Hon Pui
Summary: This study aimed to compare the effects of first-generation and second-generation ABL-targeted tyrosine kinase inhibitors (TKIs) on the growth of children with Ph+ ALL. The results showed that dasatinib and imatinib had similar adverse impacts on children's growth.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Oncology
Giovanni Martinelli, Nicolas Boissel, Patrice Chevallier, Oliver Ottmann, Nicola Goekbuget, Alessandro Rambaldi, Ellen K. Ritchie, Cristina Papayannidis, Catherine A. Tuglus, Joan D. Morris, Anthony Stein
Summary: The study evaluated the long-term durability of Blinatumomab in adults with relapsed/refractory Ph+ B-cell precursor acute lymphoblastic leukemia, showing that 35.6% of patients achieved complete remission within the first two treatment cycles. The median overall survival was 9.0 months, with a longer duration seen in patients who achieved complete remission.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Hematology
Ryujiro Hara, Makoto Onizuka, Eri Kikkawa, Sawako Shiraiwa, Kaito Harada, Yasuyuki Aoyama, Daisuke Ogiya, Masako Toyosaki, Rikio Suzuki, Sinichiro Machida, Ken Ohmachi, Yoshiaki Ogawa, Hiroshi Kawada, Hiromichi Matsushita, Kiyoshi Ando
Summary: This study retrospectively analyzed data of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) and found that measurable residual disease (MRD) kinetics was a significant predictor for disease-free survival (DFS) and relapse rates.
ANNALS OF HEMATOLOGY
(2021)
Article
Oncology
Yong Guo, Fang-Fang Wang, Bing Xiang, Hong-Bing Ma, Yu-Ping Gong
Summary: The study revealed that tanshinone IIA significantly enhanced the cytotoxic and apoptotic induction effects of imatinib in Ph+ ALL cells by regulating signaling pathways and inhibiting specific proteins. The experimental results in animal models also showed that the combination therapy of imatinib and tanshinone IIA synergistically reduced leukemia burden without increasing side effects.
Article
Hematology
Josep-Maria Ribera, Olga Garcia-Calduch, Jordi Ribera, Pau Montesinos, Isabel Cano-Ferri, Pilar Martinez, Jordi Esteve, Daniel Esteban, Maria Garcia-Fortes, Natalia Alonso, Jose Gonzalez-Campos, Arancha Bermudez, Anna Torrent, Eulalia Genesca, Santiago Mercadal, Joaquin Martinez-Lopez, Ramon Garcia-Sanz
Summary: The combination of ponatinib and chemotherapy has been proven effective in treating Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in adults. The Ponatinib With Chemotherapy for Young Adults Ph Positive Acute Lymphoblastic Leukemia (PONALFIL) trial demonstrated positive outcomes in newly diagnosed Ph+ ALL patients aged 18 to 60 years, with high rates of hematologic and molecular response and good event-free survival (EFS) rates.
Article
Medicine, General & Internal
J. Feng, Frankie W. T. Cheng, Alan K. S. Chiang, Grace K. S. Lam, Terry T. W. Chow, S. Y. Ha, C. W. Luk, C. H. Li, S. C. Ling, P. W. Yau, Karin K. H. Ho, Alex W. K. Leung, Natalie P. H. Chan, Margaret H. L. Ng, C. K. Li
Summary: Compared with young children with acute lymphoblastic leukaemia (ALL), adolescents with ALL have less favourable genetic features and poorer response to initial treatment, leading to lower survival rates primarily due to a higher incidence of treatment-related death (TRD).
HONG KONG MEDICAL JOURNAL
(2022)
Article
Hematology
Simona Soverini, Margherita Martelli, Luana Bavaro, Caterina De Benedittis, Cristina Papayannidis, Chiara Sartor, Federica Sora, Francesco Albano, Sara Galimberti, Elisabetta Abruzzese, Mario Annunziata, Sabina Russo, Manuela Stulle, Annalisa Imovilli, Massimiliano Bonifacio, Elena Maino, Fabio Stagno, Claudia Maria Basilico, Erika Borlenghi, Claudio Fozza, Flavio Mignone, Roberta Minari, Stefania Stella, Michele Baccarani, Michele Cavo, Giovanni Martinelli
Summary: Our study compared the results of Sanger sequencing and next-generation sequencing in Ph+ ALL patients, revealing that NGS provides more accurate and sensitive detection of mutations, particularly in cases of hematologic resistance and minimal residual disease.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Editorial Material
Hematology
Fadi G. Haddad, Hampig Raphael Kourie, Khalil Saleh
Summary: Chemotherapy-free regimens are changing the way Philadelphia chromosome-positive acute lymphoblastic leukaemia is treated. The combination of dasatinib and prednisone is found to be effective for induction and early consolidation. Survival rates are improved in patients who undergo allogeneic stem cell transplantation.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Fanny Delehaye, Jeremie Rouger, David Brossier, Meinolf Suttorp, Adalet Meral Gunes, Petr Sedlacek, Birgitta Versluys, Chi Kong Li, Krzysztof Kalwak, Birgitte Lausen, Culic Srdjana, Michael Dworzak, Andrea Hraskova, Barbara De Moerloose, Farah Roula, Anais Briant, Jean-Jacques Parienti, Frederic Millot
Summary: The clinical presentation of chronic myeloid leukemia (CML) differs in children compared to adults. Anemia at diagnosis is frequent in pediatric CML and may be considered as a prognostic factor. Moderate and severe anemia at diagnosis in children with CML is significantly associated with younger age, asthenia, splenomegaly, increased leukocyte and basophil counts, delayed major and deep molecular responses, and more frequent failure of imatinib treatment. However, the hemoglobin level is not significantly associated with survival.
ANNALS OF HEMATOLOGY
(2023)
Article
Oncology
Franco Locatelli, Gerhard Zugmaier, Carmelo Rizzari, Joan D. D. Morris, Bernd Gruhn, Thomas Klingebiel, Rosanna Parasole, Christin Linderkamp, Christian Flotho, Arnaud Petit, Concetta Micalizzi, Yi Zeng, Rajendra Desai, William N. N. Kormany, Cornelia Eckert, Anja Moericke, Mary Sartor, Ondrej Hrusak, Christina Peters, Vaskar Saha, Luciana Vinti, Arend von Stackelberg
Article
Oncology
Chung-tin Ma, Ho Wing Chou, Teddy Tai-ning Lam, Yan Tung Tung, Yat Wing Lai, Lai-ka Lee, Vivian Wing-yan Lee, Nelson Chun-yiu Yeung, Alex Wing-Kwan Leung, Smita Bhatia, Chi Kong Li, Yin Ting Cheung
Summary: This study evaluated the short-term effectiveness of a personalized survivorship care plan (SCP) in improving cancer-related literacy among childhood cancer survivors. It found that the provision of a personalized SCP showed preliminary effectiveness in improving survivors' understanding of their treatment-related late effects (LEs).
PEDIATRIC BLOOD & CANCER
(2023)
Article
Hematology
Yin Ting Cheung, Chung Tin Ma, Henry Hon Wai Lam, Siu Cheung Ling, Kevin Kwok, Chak Ho Li, Chung Yin Ha, Sze Fai Yip, Raymond Siu Ming Wong, Winnie Chiu Wing Chu, Chi Kong Li
Summary: This study aimed to evaluate the impact of microstructural changes and psychosocial factors on cognitive function in patients with haemophilia. The results showed that a considerable proportion of patients with haemophilia demonstrated cognitive impairment, particularly in higher-order thinking skills. Screening for cognitive deficits should be integrated into routine care, and further research is needed to examine the association between cognitive function and occupational outcomes.
Article
Oncology
Anindita Dutta, Tushar Mungle, Nandita Chowdhury, Pritha Banerjee, Anisha Gehani, Saugata Sen, Mohandas Mallath, Paromita Roy, Shekhar Krishnan, Sandip Ganguly, Sudeep Banerjee, Manas Roy, Vaskar Saha
Summary: The north and north-eastern regions of India have a high incidence of gallbladder cancer. This study analyzed the clinicopathological characteristics and outcomes of GBC patients in India. The majority of patients were diagnosed at advanced stages and early detection remains challenging. Surgical/chemotherapy approach showed the best outcomes and further clinical trials are urgently needed.
Article
Oncology
Calvin Pui Lun Hoo, Alex Wing Kwan Leung, Joyce Pui Kwan Chan, Yin Ting Cheung, Frankie Wai Tsoi Cheng, Terry Tin Wai Chow, Grace Kee See Lam, Sau Yin Ha, Alan Kwok Shing Chiang, Rever Chak Ho Li, Chi Kong Li
Summary: This study retrospectively evaluated the incidence, risk factors, and clinical outcomes of avascular necrosis (AVN) among Chinese children with acute lymphoblastic leukemia (ALL). The results showed that the incidence of AVN in Chinese ALL patients was comparable to Western population studies. Age was identified as the most important risk factor, with a significantly higher incidence in adolescents above 10 years old compared to those below 10 years old. Treatment protocol, immunophenotype, and gender were not predictive of AVN.
Article
Oncology
Yin Ting Cheung, Kenneth Kin-Wah To, Rong Hua, Chui Ping Lee, Agnes Sui-Ying Chan, Chi Kong Li
Summary: This study evaluated the associations of biomarkers of inflammation with attention and neurobehavioral outcomes in survivors of childhood acute lymphoblastic leukemia (ALL). The results suggest that cancer-related inflammation may be a mechanism underlying neurobehavioral problems in pediatric ALL survivors.
FRONTIERS IN ONCOLOGY
(2023)
Letter
Health Care Sciences & Services
Esther Chui Yan Wong, Phillip Lung Wai Au-Doung, Yvonne Yuen Ling Chu, Sandy Sin Yuet Wong, Chi Kong Li, Yin Ting Cheung
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Biology
Chi-Keung Cheng, Yuk-Lin Yung, Hoi-Yun Chan, Kam-Tong Leung, Kathy Y. Y. Chan, Alex W. K. Leung, Frankie W. T. Cheng, Chi-Kong Li, Thomas S. K. Wan, Xi Luo, Herbert-Augustus Pitts, Joyce S. S. Cheung, Natalie P. H. Chan, Margaret H. L. Ng
Summary: A genomic analysis of pediatric acute myeloid leukemia patients reveals extensive gene fusion events and mutations, providing new insights into the genetic complexities of this cancer. The study highlights the importance of understanding the genetic basis of pediatric AML for improving prognostic classification and treatment options.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Chun Sing Lam, Chung Tin Ma, Michael Can Heng Li, Cho Lee Wong, Herbert Ho-Fung Loong, Alex Wing Kwan Leung, Chi Kong Li, Ho Kee Koon, Yin Ting Cheung
Summary: This study examined the use of traditional, complementary, and integrative medicines (TCIM) among adolescent and young adult cancer patients, as well as their preferences for TCIM education. The results showed that 60.2% of patients used TCIM, with the most common modalities being vitamin supplements (24.0%) and Chinese herbal medicine (22.0%). Patients used TCIM to improve general health and manage chronic symptoms. The study suggests that a tailored education program should be provided based on patients' preferences and needs, and healthcare professionals should communicate with patients and make evidence-based referrals/recommendations.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Article
Biochemistry & Molecular Biology
Claudia Rossi, Rossella Ferrante, Silvia Valentinuzzi, Mirco Zucchelli, Carlotta Buccolini, Sara Di Rado, Daniela Trotta, Liborio Stuppia, Luca Federici, Maurizio Arico
Summary: Gaucher disease is a lysosomal storage disease caused by a deficiency in lysosomal glucocerebrosidase, leading to the accumulation of glucosylceramide in various organs. Early detection and intervention are crucial for improving clinical outcomes.
Article
Pediatrics
Anthea Mariani, Federica Cavallo, Saverio La Bella, Giusi Graziano, Martina Passarelli, Carlo Crescenzi, Daniela Trotta, Maurizio Arico
Summary: This study observed two main patterns of clinical presentation in patients with HAdV infection, respiratory symptoms and gastrointestinal involvement. There was a correlation between higher CRP levels and certain clinical symptoms. A high copy number of HAdV from a pharyngeal swab was associated with pharyngitis. Molecular testing allowed for quick diagnosis and appropriate management of patients with reduced discomfort for families.
Article
Hematology
Marta Verna, Marta Canesi, Valentino Conter, Lawrence Faulkner, Attilio Maria Rovelli, Daniela Silvestri, Ignazio Majolino, Andrea Biondi, Chra Nawfal Abdullah, Vian Faeq Mohammed
Summary: Thalassemia is a common and life-threatening disorder in children in regions prone to hemoglobinopathy, such as the Middle East. Hematopoietic stem cell transplantation (HSCT) is a highly effective and cost-effective treatment for thalassemia. A study in Iraqi Kurdistan demonstrated the successful establishment of an HSCT unit for both adults and children, achieving comparable results to international standards. The success of the program relied on meeting minimum requirements, international collaboration, and capacity-building efforts.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Alessandro Cattoni, Giulia Capitoli, Sara Casagranda, Paola Corti, Marta Adavastro, Alessandro Molinaro, Filiberto Di Gennaro, Sonia Bonanomi, Andrea Biondi, Stefania Galimberti, Adriana Balduzzi
Summary: This retrospective study aimed to assess the prevalence, severity, risk factors, and management of iron overload (IOL) in pediatric patients who underwent hematopoietic stem cell transplantation (HSCT). The results showed that 73% of patients had some degree of IOL, with a higher severity observed in patients with malignant diseases. Pre-HSCT and maximum post-HSCT ferritin levels were statistically higher in patients with malignancies, and radiologic assessment confirmed a more severe degree of IOL in these patients.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Albina Tummolo, Giacomina Brunetti, Mario Giordano, Vincenza Carbone, Maria Felicia Faienza, Maurizio Arico, Sabino Pesce
JOURNAL OF ULTRASOUND
(2023)