Article
Oncology
Shreya Desai, Michelle J. Zhu, Ilana Lapidos-Salaiz
Summary: Low- and middle-income countries bear a high burden of preventable cervical cancer cases and deaths, with human papillomavirus DNA-based testing increasingly being the preferred screening method. This commentary discusses next steps and key considerations for the expansion of this screening approach.
Article
Public, Environmental & Occupational Health
Laura A. Marlow, Martin Nemec, Jessica Barnes, Jo Waller
Summary: This study tested the impact of different messages about extending cervical screening intervals on acceptance. The groups who received additional information were more likely to find the change acceptable. Emphasizing interval safety, test accuracy and cell changes resulted in more positive attitudes and a better understanding. However, those who were up-to-date with screening or had previous abnormal results were less accepting of longer intervals.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Medicine, General & Internal
Matejka Rebolj, Kate Cuschieri, Christopher S. Mathews, Francesca Pesola, Karin Denton, Henry Kitchener
Summary: This study provides evidence that the risk of CIN3+ and cervical cancer is significantly lower after a negative HPV test compared to cytology testing in primary cervical screening, especially for women under 50 years old. Results support extending screening intervals to five years after a negative HPV test for women aged 25-49, and longer for women aged 50 and older. Women with negative HPV tests at early recall after a positive HPV screening test should continue to be screened every three years.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Obstetrics & Gynecology
Tetsuro Oishi, Junzo Kigawa, Osamu Iwanari, Tokuzo Kasai, Tetsuji Kurokawa, Masao Hamada, Hiromasa Fujita, Hiroyuki Fujiwara, Masatoshi Yokoyama, Noriaki Sakuragi, Tasuku Harada, Mitsuaki Suzuki
Summary: This study assessed the diagnostic value and potential harm of HPV testing for cervical cancer screening in Japan. Results showed that the detection rates of CIN1, CIN2+, and CIN3+ were significantly higher in the co-testing group compared to the cytology-based group, suggesting that limiting the target age group may help minimize potential harm.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Oncology
Jack Cuzick, Rachael Adcock, Walter E. Kinney, Philip E. Castle, Michael M. Robertson, Ruth M. H. McDonald, Mark H. Stoler, Ruofei M. Du, Cosette M. Wheeler
Summary: HPV testing increases the diagnosis of precancer and reduces the incidence of cervical cancer more than cytology alone. A real-world evidence study conducted in New Mexico showed that adding HPV testing to cytology substantially increased the detection of CIN2+ and CIN3+ cases, supporting primary HPV-only screening in the United States.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Virology
Emel Yilmaz, Carina Eklund, Camilla Lagheden, Karin Dahlin Robertsson, Marina Lilja, Miriam Elfstrom, Laila Sara Arroyo Muhr, Joakim Dillner
Summary: This study provides the first global overview of the proficiency of HPV testing services for cervical cancer screening. The results indicate a high level of sensitivity and few false positives, but specificity still needs further improvement.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Review
Medicine, General & Internal
Flavia M. Correa, Arn Migowski, Liz M. De Almeida, Marcelo A. Soares
Summary: This review discusses the current strategies in Brazil for screening, treatment, and prevention (HPV vaccination) against cervical cancer, highlighting the country's large public health system and the disparities in access to healthcare. It also explores the potential integration of newer technologies to eliminate cervical cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Uraiwan Khomphaiboonkij, Nattapong Sreamsukcharoenchai, Supakorn Pitakkarnkul, Kristsanamon Rittiluechai, Siriwan Tangjitgamol
Summary: Knowledge about cervical cancer screening and HPV is important for women's awareness and adherence to the screening program. This study found that only 26.9% of women had good knowledge about cervical cancer screening, and similarly, only 20.1% of women who had heard about HPV had good knowledge about it. Providing information about these topics could improve women's knowledge and increase their participation in screening procedures.
Article
Obstetrics & Gynecology
Christer Borgfeldt, Anneli Leksell, Ola Forslund
Summary: This study investigated the proportion of severe dysplasia diagnosed by cytology and histological follow-up among women with Aptima HPV-negative tests. The results showed that only a small percentage of Aptima HPV-negative women had histologically confirmed HSIL, suggesting that adding cytology to HPV screening for women aged 40-42 years may not provide significant clinical benefit and is economically unreasonable.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Review
Public, Environmental & Occupational Health
Mohan Narasimhamurthy, Santhosh Upadhyaya Kafle
Summary: Nepal has a high burden of cervical cancer due to limited screening programs. Despite efforts by the Ministry of Health and Population and international collaborations, the current prevention and treatment methods are inadequate to meet WHO's goals. This article provides an overview of Nepal's efforts to address the growing burden of cervical cancer and discusses potential challenges and solutions.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Lindsay R. B. Locklar, D. Phuong Do
Summary: Rural women have lower rates of current cervical cancer screening compared to urban women, with the disparity explained by sociodemographic differences. Among those who do get screened, rural women are significantly less likely to undergo HPV testing than urban women in both 2016 and 2018. This may contribute to delayed diagnosis of cervical dysplasia and exacerbate rural/urban disparities in cervical cancer incidence and mortality.
JOURNAL OF RURAL HEALTH
(2022)
Article
Virology
Vijayalakshmi Ramshankar, Soundharya Ravindran, Komathi Arun, Kanchana Albert, Sakthi Lalitha Sri, Lalitha Ramasubramanian, Banumathy Satyaseelan
Summary: Cervical cancer can be eliminated by 2030 through a global strategy that includes HPV vaccination for young girls, screening for women aged 30-69, and treatment for women with precancerous lesions. However, implementing these strategies in countries like India poses challenges. A study using Cobas 4800 HPV test in a community screening program in South India found a high prevalence of high-risk HPV in younger women (30-40 years old) and a second peak in women aged 46-50.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Oncology
Alexandros Daponte, George Michail, Athina-Ioanna Daponte, Nikoletta Daponte, George Valasoulis
Summary: Despite significant advancements in cervical cancer prevention, many women still miss the opportunity for early detection. Self-sampling HPV modalities have shown promise in addressing this issue and are considered a feasible alternative strategy with enhanced population coverage.
Article
Obstetrics & Gynecology
Burak Tatar
Summary: This study examined the necessity of colposcopy for HPV types other than HPV 16 and 18, and the need for cytology incorporated into HPV testing. Results showed that HPV 16 was the most common type and had a significant prediction for CIN 2+ lesions. Furthermore, 19% of CIN 2+ lesions were detected in cases with cytological abnormalities and other high-risk HPV types. The study concludes that HPV 33 should be included in screening protocols, along with HPV 16 and 18 in specific regions, and that HPV-based screening with only HPV 16 and 18 may not be feasible.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Health Care Sciences & Services
Naomi Brewer, Sunia Foliaki, Michelle Gray, John D. Potter, Jeroen Douwes
Summary: This study explores the barriers and facilitators of HPV self-testing in Pasifika women through focus group discussions. The participants had varying levels of knowledge about cervical cancer screening, and the main challenges identified included personal privacy and confidentiality, as well as time management. There was a strong demand for self-testing, accompanied by the need for a collective/community approach consistent with Pasifika worldviews in the promotion and implementation of self-testing.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
