Article
Oncology
Sebastian Kehrloesser, Simon Oberst, Willien Westerhuis, Astrid Wendler, Anke Wind, Harriet Blaauwgeers, Jean-Benoit Burrion, Peter Nagy, Gunnar Saeter, Eva Gustafsson, Paolo De Paoli, Jozsef Lovey, Claudio Lombardo, Thierry Philip, Dominique de Valeriola, Marjet Docter, Femke Boomsma, Mahasti Saghatchian, Marek Svoboda, Irene Philip, Francesco Monetti, Henk Hummel, Gordon McVie, Renee Otter, Wim van Harten
Summary: There is a persistent variation in cancer outcomes among and within European countries, with European policy moving towards addressing inequalities in access to high-quality cancer care. Comprehensive Cancer Centres demonstrate good compliance with quality standards and excel in translational research areas.
MOLECULAR ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Henriett Butz, Aniko Bozsik, Vince Grolmusz, Erika Szocs, Janos Papp, Attila Patocs
Summary: The interpretation of TP53 variants is challenging, especially in patients with attenuated LFS. A study in the Hungarian population of cancer patients found a high prevalence of pathogenic/likely pathogenic TP53 variants. The study highlights the importance of focused interpretation as automatic classification systems do not apply TP53-specific criteria.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Beth Russell, Charlotte Moss, Maria Monroy-Iglesias, Graham Roberts, Harvey Dickinson, Kate Haire, Kathryn Innes, Bansi Mulji-Shah, Fiona Castell, Omar Al-Salihi, Mary Lei, Angela Francis, Bill Dann, Vikash Jogia, Hisham Hamid, Ben Challacombe, Ricard Simo, Stephanie Fraser, Charalampos Gousis, Elinor Sawyer, Eirini Tsotra, Jose Roca, Muhammad Khan, Debra Josephs, Deborah Enting, Mieke Van Hemelrijck, Victoria Harris, Saoirse Dolly
Summary: This study evaluated the safety of radical anticancer treatments during the COVID-19 pandemic and found that although there were fewer patients receiving treatment, the effectiveness of the treatments and infection rates were similar to the pre-pandemic period.
BRITISH JOURNAL OF CANCER
(2022)
Article
Ecology
Matthias Weitzel, Toon Vandyck, Luis Rey Los Santos, Marie Tamba, Umed Temursho, Krzysztof Wojtowicz
Summary: This study analyzes the socio-economic consequences of the European Green Deal, focusing on alternative policy pathways to achieve greenhouse gas emission reduction targets. The results emphasize the heterogeneous impacts of climate policy on sectors, worker skill types, and income groups, highlighting the need for attention to ensure a fair transition to a low-carbon economy.
ECOLOGICAL ECONOMICS
(2023)
Article
Multidisciplinary Sciences
Carla Lopes de Castro, Magdalena Fundowicz, Alvar Rosello, Josep Jove, Letizia Deantonio, Artur Aguiar, Carla Pisani, Salvador Villa, Anna Boladeras, Ewelina Konstanty, Marta Kruszyna-Mochalska, Piotr Milecki, Diego Jurado-Bruggeman, Joana Lencart, Ignasi Modolell, Carles Munoz-Montplet, Luisa Aliste, Maria Gloria Torras, Montserrat Puigdemont, Luisa Carvalho, Marco Krengli, Ferran Guedea, Julian Malicki
Summary: The study evaluated adherence to standard clinical practice for patients undergoing prostate cancer radiotherapy in four European countries using clinical audits. While overall adherence was satisfactory, substantial inter-centre variability was found in variables such as staging MRI and time elapsed between initial visit to treatment initiation. The most common deviation from standard practice was inconsistent data registration, highlighting the importance of clinical audits in detecting deviations from standard clinical practices.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Julia Jeck, Sebastian M. Wingen-Heimann, Florian Jakobs, Anna Kron, Jennifer Franz, Oliver A. Cornely, Florian Kron
Summary: This study assessed the hospital costs of patients diagnosed with invasive fungal diseases (IFD) and treated with isavuconazole using real-world data. The results showed that treating IFD requires significant resources, often involves intensive care, and incurs high hospital treatment costs.
Article
Oncology
Daniel Lengyel, Ildiko Vereczkey, Krisztina Kohalmy, Kiarash Bahrehmand, Zoltan Novak
Summary: TVUS-guided core biopsy is a safe and effective histological sampling procedure, providing adequate tissue for pathological evaluation in the majority of cases. Compared to surgically obtained histology, this method offers reliable guidance for therapy and can benefit patients suspected of gynaecological malignancy.
Article
Oncology
Adam H. Fox, Mizuki Nishino, Raymond U. Osarogiagbon, M. Patricia Rivera, Lauren S. Rosenthal, Robert A. Smith, Farhood Farjah, Lynette M. Sholl, Gerard A. Silvestri, Bruce E. Johnson
Summary: Advances in biomarker-driven therapies for NSCLC offer opportunities to improve patient outcomes, but also pose challenges for equitable care delivery. Multidisciplinary teams face the challenge of completing comprehensive and timely biomarker testing and navigating the evolving evidence base for this complex and time-sensitive disease.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Oncology
Xin Hui Chew, Rehena Sultana, Eshani N. Mathew, David Chee Eng Ng, Richard H. G. Lo, Han Chong Toh, David Tai, Su Pin Choo, Brian Kim Poh Goh, Sean Xuexian Yan, Kelvin Siu Hoong Loke, Sue Ping Thang, Apoorva Gogna, Nanda Karaddi Venkatanarasimha, Aaron K. T. Tong, Fiona N. N. Moe, Jacelyn S. S. Chua, Reiko W. T. Ang, Aldwin D. Ong, Ashley W. Y. Ng, Marjorie T. Q. Hoang, Chow Wei Too, Choon Hua Thng, Wan Ying Chan, Wanyi Kee, Jaclyn H. M. Chan, Farah Irani, Sum Leong, Kiat Hon Lim, Michael L. C. Wang, Pierce K. H. Chow
Summary: Real-world data on clinical outcomes in hepatocellular carcinoma (HCC) validated the Consensus Guidelines for HCC at the National Cancer Centre Singapore (NCCS), indicating high overall compliance rate and satisfactory clinical outcomes when managing patients according to the guidelines.
Review
Oncology
Elise M. Garton, Mishka K. Cira, Patrick J. Loehrer, Linsey Eldridge, Allison Frank, Laura Prakash, Shine Chang, Ramzi G. Salloum, Henry Ciolino, Min He, Satish Gopal, Kalina Duncan
Summary: Global oncology research and training are crucial in addressing the growing burden of cancer worldwide. The survey of National Cancer Institute-designated cancer centers provides valuable information about global oncology activities and highlights the importance of these centers in global cancer research.
Article
Biochemistry & Molecular Biology
Xiaona Liu, Jiahao Yi, Tina Li, Jianguo Wen, Kexin Huang, Jiajia Liu, Grant Wang, Pora Kim, Qianqian Song, Xiaobo Zhou
Summary: Drug resistance is a significant challenge in cancer treatment, and single-cell profiling is used to investigate the underlying mechanisms. The DRMref database provides comprehensive characterization of drug resistance using single-cell data and includes various analyses and annotations.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Endocrinology & Metabolism
Fares Benmiloud, Christine Le Bihan, Stanislas Rebaudet, Patricia Marino, Philippe-Jean Bousquet, Elsa Bouee-Benhamiche
Summary: This study aimed to assess the economic burden of postoperative hypoparathyroidism after total thyroidectomy for cancer in France. It was found that patients who had hypoparathyroidism after thyroidectomy had significantly higher health expenditures compared to untreated patients during the first postoperative year.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Misba Majood, Sonali Rawat, Sujata Mohanty
Summary: This review highlights the crucial role of extracellular vesicles (EVs) in cancer formation and spread, and how they affect tumor growth through communication with surrounding cells. Understanding the mechanisms of EVs formation and cargo sorting is important for understanding carcinogenesis and may lead to the discovery of new biomarkers in liquid biopsy and the development of tumor-specific therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Physical
Yuan Feng, Haitao Yang, Xin Wang, Chaoquan Hu, Hailong Jing, Jiaxin Cheng
Summary: This review focuses on the role of transition metals (TMs) in oxygen evolution reaction (OER) catalysts and summarizes the synthesis strategies and mechanisms of different types of TMs-based catalysts. The challenges and prospects of developing economic and efficient TMs-based OER catalysts are also discussed.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Oncology
Sophie Therese Williams, Salma El Badri, Syed Anwer Hussain
Summary: This retrospective case series found that administration of anticancer treatment did not result in an apparent increase in symptomatic COVID-19 infections in urological cancer patients at one centre.
BRITISH JOURNAL OF CANCER
(2021)
