Article
Public, Environmental & Occupational Health
Javier Perez-Saez, Justin Lessler, Elizabeth C. Lee, Francisco J. Luquero, Espoir Bwenge Malembaka, Flavio Finger, Jose Paulo Langa, Sebastian Yennan, Benjamin Zaitchik, Andrew S. Azman
Summary: Cholera seasonality is widespread in sub-Saharan Africa, affecting approximately 86% of the population. Differences in seasonality patterns exist between countries and regions, with distinct clusters in West Africa, the Sahel, East Africa, and Southern Africa. Precipitation has the most consistent and positive correlation with cholera seasonality, followed by temperature and flooding.
LANCET GLOBAL HEALTH
(2022)
Article
Multidisciplinary Sciences
Richard Gyan Aboagye, Bright Opoku Ahinkorah, Abdul-Aziz Seidu, Stephen Kofi Anin, James Boadu Frimpong, John Elvis Hagan Jr
Summary: This study examined the association between mother and newborn skin-to-skin contact (SSC) and timely initiation of breastfeeding in sub-Saharan Africa (SSA). The results showed that mothers who practiced newborn SSC were more likely to initiate breastfeeding in a timely manner. The study recommends implementing more interventions to improve mother and newborn SSC to enhance timely initiation of breastfeeding in SSA.
Review
Allergy
Chrysanthi Skevaki, James S. Ngocho, Caroline Amour, Peter Schmid-Grendelmeier, Blandina T. Mmbaga, Harald Renz
Summary: Sub-Saharan Africa is currently undergoing a transformation process due to economic development and urbanization, leading to a significant increase in prevalence of noncommunicable diseases such as allergies and asthma. Despite some progress, there is still a great need for support in education, training, resource transfer, and cooperation with pharmaceutical and diagnostic companies to achieve adequate treatment and sustainability in managing allergies, asthma, and eczema in the region.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Euzebiusz Jamrozik, Nchangwi Syntia Munung, Lucie Abeler-Dorner, Michael Parker
Summary: Phylogenetic analyses of HIV help clarify transmission patterns and identify high-risk populations for targeted public health interventions. While transmission clusters are significant in high-income countries, they play a minor role in sub-Saharan Africa. Nevertheless, phylogenetic analysis can still guide HIV program design for sub-populations with concentrated transmission events.
Review
Oncology
Ulrick Sidney Kanmounye, Claire Karekezi, Arsene Daniel Nyalundja, Ahmed K. Awad, Tsegazeab Laeke, James A. Balogun
Summary: This scoping review aimed to map out the landscape of adult brain tumors in Sub-Saharan Africa (SSA) based on published literature. The results showed a significant disease burden of brain tumors in the region, but also highlighted challenges such as heterogeneity in data quality and reporting standards. The study highlights the need for increased research and investment in brain tumor care in SSA.
Review
Clinical Neurology
Felix Bongomin, Elly Katabira, Martha Sajatovic, Mark Kaddumukasa
Summary: This study found limited data on the prevalence of epilepsy among persons aged 60 years or older in Africa. The burden of epilepsy among older adults remains a challenge in Africa, highlighting the need for more information to improve care.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Behavioral Sciences
Nithin Gupta, Rohin Singh, Andreas Seas, Prince Antwi, Martin N. Kaddumukasa, Angelina Kakooza Mwesige, Mark Kaddumukasa, Michael M. Haglund, Anthony T. Fuller, Deborah C. Koltai, Alvan-Emeka K. Ukachukwu
Summary: This study examines the epidemiological profile of idiopathic epilepsy in the older population in Sub-Saharan Africa (SSA) for the first time and finds that older adults in this region suffer a greater disease burden and higher mortality compared to the global population.
EPILEPSY & BEHAVIOR
(2023)
Article
Hematology
Clement D. Okello, Nixon Niyonzima, Marta Ferraresso, Sylivestor Kadhumbula, Henry Ddungu, Katherine Tarlock, Joyce Balagadde-Kambugu, Abrahams Omoding, Louis Ngendahayo, Alfred Karagu, Julius Mwaiselage, John M. Harlan, Thomas S. Uldrick, Suzanne D. Turner, Jackson Orem
Summary: Haematological malignancies account for almost 10% of cancer diagnoses in sub-Saharan Africa, and more research is needed to understand their natural history and improve treatment outcomes. Various factors negatively impact the outcome of haematological malignancies in the region, highlighting the need for improved understanding and collaboration to facilitate prevention, early detection, diagnosis, and appropriate treatment.
LANCET HAEMATOLOGY
(2021)
Editorial Material
Food Science & Technology
David Laborde, Valeria Pineiro
Summary: The Russia-Ukraine conflict had an impact on staple crop prices and stimulated interest in tropical wheat production. Regional consumption patterns and trade have a better potential to guide effective and sustainable food security policy strategies.
Article
Environmental Sciences
Hari S. Iyer, Peter James, Linda Valeri, Francis Bajunirwe, Joan Nankya-Mutyoba, Marina Njelekela, Faraja Chiwanga, Vikash Sewram, IkeOluwapo Ajayi, Clement Adebamowo, Shona Dalal, Todd G. Reid, Timothy R. Rebbeck, Hans-Olov Adami, Michelle D. Holmes
Summary: In SSA, population growth, demographic transitions, and urbanization are expected to increase the burden of NCDs. A multi-country cross-sectional study found a correlation between neighborhood greenness and NCDs, showing that higher NDVI values were associated with lower BMI, lower odds of overweight/obesity, diabetes, and allostatic load components. This suggests that greening strategies could be beneficial as part of broader public health interventions for NCDs.
ENVIRONMENTAL RESEARCH
(2021)
Review
Immunology
Khalid Eltom, Khalid Enan, Abdel Rahim M. El Hussein, Isam M. Elkhidir
Summary: This study conducted a systematic review and meta-analysis on DENV infection in Sub-Saharan Africa, revealing a high prevalence of DENV infection in the region. It suggests the need for cost-efficient vector control strategies to be designed and implemented to adapt to the low-resource nature of this area.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Thomas P. Higginbottom, Roshan Adhikari, Ralitza Dimova, Sarah Redicker, Timothy Foster
Summary: The study reveals that only 16% of the proposed irrigated area is being delivered in 79 irrigation schemes across sub-Saharan Africa, with 25% delivering over 80% and 20% completely inactive. The findings are attributed to low economic viability, excessive optimism, and inadequate central bureaucratic systems in irrigation development.
NATURE SUSTAINABILITY
(2021)
Article
Environmental Sciences
C. Wade Ross, Niall P. Hanan, Lara Prihodko, Julius Anchang, Wenjie Ji, Qiuyan Yu
Summary: This study explores the socioenvironmental conditions shaping the distribution of woody vegetation in sub-Saharan Africa and evaluates ecosystem responses to various scenarios. Climate change is projected to have a negative impact on above-ground woody biomass, exacerbated by population growth, human pressures, and changes in fire behavior. Regional perturbations show increased carbon storage potential in East Africa, while deficits are seen in West, Central, and Southern Africa.
NATURE CLIMATE CHANGE
(2021)
Article
Agronomy
Vijesh V. Krishna, Maximina A. Lantican, B. M. Prasanna, Kevin Pixley, Tahirou Abdoulaye, Abebe Menkir, Marianne Banziger, Olaf Erenstein
Summary: This study examines the adoption and impacts of CGIAR-related maize varieties in sub-Saharan Africa from 1995 to 2015. It finds that a significant proportion of maize varieties released during this period had CGIAR parentage, and that the cultivation of these varieties contributed to substantial economic benefits. The study also highlights the methodological challenges involved in large-scale impact assessments.
FIELD CROPS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Benjamin L. Rice, Akshaya Annapragada, Rachel E. Baker, Marjolein Bruijning, Winfred Dotse-Gborgbortsi, Keitly Mensah, Ian F. Miller, Nkengafac Villyen Motaze, Antso Raherinandrasana, Malavika Rajeev, Julio Rakotonirina, Tanjona Ramiadantsoa, Fidisoa Rasambainarivo, Weiyu Yu, Bryan T. Grenfell, Andrew J. Tatem, C. Jessica E. Metcalf
Summary: The SARS-CoV-2 pandemic has shown low burdens in sub-Saharan Africa compared to other regions, potentially influenced by factors such as climate and population demographics. Caution is needed when interpreting analyses that aggregate data from low- and middle-income settings. Heterogeneity in connectivity across sub-Saharan Africa may contribute to variance in the pace of viral spread.
Review
Endocrinology & Metabolism
Mamadou Adama Sow, Julien Magne, Laurence Salle, Estelle Nobecourt, Pierre-Marie Preux, Victor Aboyans
Summary: This study systematically reviewed and meta-analyzed the prevalence, determinants, and prognostic value of coronary artery calcium score (CACS) in asymptomatic patients with diabetes, finding that age, male sex, non-black ethnicity, and diabetes duration were risk factors for high CACS. An increase in CACS was strongly associated with an increased risk for all-cause mortality and/or fatal and non-fatal cardiovascular events, with women potentially having a higher risk than men.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Behavioral Sciences
Zeinab Tarhini, Jeremy Jost, Voa Ratsimbazafy, Pierre -Marie Preux, Pascale Salameh, Amal Al-Hajje, Farid Boumediene, Lara Mroueh
Summary: This study examined the association between sociodemographic characteristics, clinical factors, knowledge of epilepsy, and the quality of life (QoL) and the presence of psychiatric comorbidities in Lebanese people with epilepsy. The results showed that good knowledge of epilepsy and the absence of psychiatric comorbidities are important predictors of good QoL in Lebanese people with epilepsy.
EPILEPSY & BEHAVIOR
(2022)
Article
Public, Environmental & Occupational Health
Farid Boumediene, Benoit Marin, Jaime Luna, Vincent Bonneterre, William Camu, Emmeline Lagrange, Gerard Besson, Florence Esselin, Elisa De la Cruz, Geraldine Lautrette, Pierre Marie Preux, Philippe Couratier
Summary: Through investigating the spatial aggregation of ALS cases, 13 areas that warrant further investigation were identified.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Neurosciences
Angeladine Kenne Malaha, Clemence Thebaut, Dayna Achille, Pierre-Marie Preux, Maelenn Guerchet
Summary: The proportion of people living with dementia in LMICs is expected to reach 71% by 2050. The costs of dementia increase with the severity of the disease, with medical costs highest in the mild stage and social and informal care costs highest in the moderate and severe stages. Annual cost estimates per patient range from PPP$131.0 to PPP$66,143.6. Accurate data is needed to guide public health policies in LMICs.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Salmane Ariyoh Amidou, Yessito Corine Houehanou, Gwladys Nadia Gbaguidi, Philippe Lacroix, Victor Aboyans, Arnaud Sonou, Julien Magne, Dominique Saka, Kamel Lafia, Martin Dedounougbo Houenassi, Pierre-Marie Preux, Dismand Stephan Houinato
Summary: This study aimed to establish normal limits for major ECG variables and explore the electrocardiographic impact of hypertension in a rural sub-Saharan African population. The results indicated that the normal limits for ECG variables in this population differed slightly from those in hypertensive patients and emphasized the importance of considering ethnicity in ECG interpretation.
JOURNAL OF ELECTROCARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Deo Harimenshi, Theodore Niyongabo, Pierre-Marie Preux, Victor Aboyans, Ileana Desormais
Summary: Currently, the life expectancy of people living with HIV is similar to the general population. Hypertension is a major public health issue in Africa and is often undiagnosed. The prevalence of hypertension among HIV-infected adults on ART in Burundi is 17.4%, and approximately 47.25% of HIV patients with hypertension are undiagnosed. Factors associated with hypertension include being overweight, obesity, longer duration of HIV infection, diabetes, and age.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Jessica Gong, Katie Harris, Darren M. Lipnicki, Erico Castro-Costa, Maria Fernanda Lima-Costa, Breno S. Diniz, Shifu Xiao, Richard B. Lipton, Mindy J. Katz, Cuiling Wang, Pierre-Marie Preux, Maelenn Guerchet, Antoine Gbessemehlan, Karen Ritchie, Marie-Laure Ancelin, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Mary H. Kosmidis, Antonio Guaita, Elena Rolandi, Annalisa Davin, Oye Gureje, Stella Trompet, Jacobijn Gussekloo, Steffi Riedel-Heller, Alexander Pabst, Susanne Rohr, Suzana Shahar, Devinder Kaur Ajit Singh, Nurul Fatin Malek Rivan, Martin van Boxtel, Sebastian Kohler, Mary Ganguli, Chung-Chou Chang, Erin Jacobsen, Mary Haan, Ding Ding, Qianhua Zhao, Zhenxu Xiao, Kenji Narazaki, Tao Chen, Sanmei Chen, Tze Pin Ng, Xinyi Gwee, Katya Numbers, Karen A. Mather, Marcia Scazufca, Antonio Lobo, Concepcion De-la-Camara, Elena Lobo, Perminder S. Sachdev, Henry Brodaty, Maree L. Hackett, Sanne A. E. Peters, Mark Woodward
Summary: This meta-analysis of data from 21 cohorts across six continents found that women have a higher risk of developing dementia than men, especially in low- and lower-middle-income economies. Longer education and former alcohol use are stronger risk factors for dementia in men than in women, while other risk factors have similar effects in both genders.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Gowsaly Mahalingam, Suraj Samtani, Ben Chun Pan Lam, Darren M. Lipnicki, Maria Fernanda Lima-Costa, Sergio Luis Blay, Erico Castro-Costa, Shifu Xiao, Maelenn Guerchet, Pierre-Marie Preux, Antoine Gbessemehlan, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Themis Dardiotis, Ki-Woong Kim, Steffi Riedel-Heller, Susanne Roehr, Alexander Pabst, Suzana Shahar, Katya Numbers, Mary F. Ganguli, Tiffany Hughes, Chung-Chou H. Chang, Michael Crowe, Tze Pin Ng, Xinyi Gwee, Denise Qian Ling Chua, Joanna Rymaszewska, Karin Wolf-Ostermann, Anna-Karin Welmer, Jean Stafford, Rene Melis, Myrra Vernooij-Dassen, Yun-Hee Jeon, Perminder S. Sachdev, Henry Brodaty
Summary: Based on individual participant data from 13 longitudinal ageing studies, the study found that social connections are associated with lower risks of mild cognitive impairment, dementia, and mortality. Specifically, good social connection structure and quality are linked to lower risk of incident mild cognitive impairment, while social connection structure and function are related to lower risk of incident dementia and mortality. In Asian cohorts, being married/in a relationship is associated with reduced risk of dementia, and having a confidante is associated with reduced risk of dementia and mortality.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Dieu donne Gnonlonfoun, Arlos Sowanou, Pupchen Gnigone, Antoine Gbessemehlan, Jennifer Nyangui Mapaga, Wilson Aballo, Blaise Choki, Julien Magne, Farid Boumediene, Pierre-Marie Preux, Dismand Houinato
Summary: This study aimed to investigate the prevalence and associated factors of peripheral neuropathies (PN) in the general population of Adjohoun, Benin. The overall prevalence of PN was found to be 6.9%, with the main types being polyneuropathies (4.8%) and polyradiculoneuropathies (1.6%). Factors independently associated with PN included age greater than or equal to 40 years, diabetes, and hypertension. Taking action to reduce modifiable associated factors such as diabetes and hypertension could help reduce the occurrence of PN and their potential harmful consequences.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Health Care Sciences & Services
Achille Tchalla, Delphine Marchesseau, Noelle Cardinaud, Cecile Laubarie-Mouret, Thomas Mergans, Patrick-Joel Kajeu, Sandrine Luce, Patrick Friocourt, Didier Tsala-Effa, Isabelle Tovena, Pierre-Marie Preux, Caroline Gayot
Summary: This study aimed to evaluate the feasibility and effectiveness of a 12-month remote monitoring program in preventing rehospitalizations in older patients with two or more chronic diseases returning home after hospitalization. The results showed that the risk of rehospitalization for chronic disease decompensation was significantly reduced in the intervention group receiving remote monitoring compared to the control group. The program combined home life technology, telecare, and biometric sensors.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Cardiac & Cardiovascular Systems
David Vandroux, Yessito Corine Houehanou, Julien Magne, Dominique Saka, Arnaud Sonou, Salmane Amidou, Dismand Houinato, Pierre Marie Preux, Victor Aboyans, Philippe Lacroix
Summary: This study aims to establish normal reference values for echocardiographic cardiac chambers dimensions and Doppler parameters in a Sub-Saharan African population. The results show that normal values in West Africa differ from those established in Caucasian populations, with greater left ventricular mass and wall thicknesses.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Obstetrics & Gynecology
B. Marin, I. Arnulf, M. Latour, C. Vauzelle, B. Coulm, D. Beghin, Y. Dauvilliers, E. Elefant
Summary: Central disorders of hypersomnolence include different types of narcolepsy, idiopathic hypersomnia, and hypersomnia associated with medical or mental disorders. Treatment options include non-pharmacological and pharmacological methods, but one of the first-line medications, modafinil, has been linked to a potential risk of birth defects when taken during organogenesis. Existing epidemiological studies have produced contradictory results, making it difficult to confirm or deny the risk. In clinical practice, it is recommended to suspend modafinil treatment during the first 10 weeks of pregnancy if possible. Further research is needed to clarify the teratogenic impact of modafinil.
GYNECOLOGIE OBSTETRIQUE FERTILITE & SENOLOGIE
(2023)
Article
Geriatrics & Gerontology
Suraj Samtani, Gowsaly Mahalingam, Ben Chun Pan Lam, Darren M. Lipnicki, Maria Fernanda Lima-Costa, Sergio Luis Blay, Erico Castro-Costa, Xiao Shifu, Maelenn Guerchet, Pierre-Marie Preux, Antoine Gbessemehlan, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Ki-Woong Kim, Steffi Riedel-Heller, Susanne Rohr, Alexander Pabst, Suzana Shahar, Katya Numbers, Mary Ganguli, Erin Jacobsen, Tiffany F. Hughes, Michael Crowe, Tze Pin Ng, Jane Maddock, Anna Marseglia, Rene Melis, Dorota Szczegniak, Henrik Wiegelmann, Myrra Vernooij-Dassen, Yun-Hee Jeon, Perminder S. Sachdev, Henry Brodaty
Summary: This study found that good social connections, including living with others, weekly community group engagement, weekly interaction with family and friends, and rarely feeling lonely, are associated with slower cognitive decline.
LANCET HEALTHY LONGEVITY
(2022)
Meeting Abstract
Clinical Neurology
A. P. Wachinou, C. Houehanou, S. Ade, T. Totah, M. Berger, G. Solelhac, S. Amidou, A. Fiogbe, F. Alovokpinhou, P. Lacroix, P. -M. Preux, P. Marques-Vidal, G. Agodokpessi, D. Houinato, R. Heinzer
Article
Clinical Neurology
Isaac J. Egesa, Charles R. J. C. Newton, Symon M. Kariuki
Summary: The study found that the two ILAE classification schemes are broadly consistent, but the introduction of the combined onset seizure category in ILAE-2017 significantly reduces the proportion of mutually exclusive focal and generalized seizures. The comprehensive classification of etiology categories in ILAE-2017 will facilitate appropriate treatment and improve prognosis.
