Article
Medicine, General & Internal
Maria Goncalves, Christina Gsaxner, Andre Ferreira, Jianning Li, Behrus Puladi, Jens Kleesiek, Jan Egger, Victor Alves
Summary: Head and neck cancer, with its complex anatomical structures, can be accurately predicted for prognosis using radiomics and machine learning techniques.
Article
Pharmacology & Pharmacy
Chien-Chen Huang, Yu-Cih Yang, Iona MacDonald, Ching-Yuan Lai, Cheng-Hao Tu, Yi-Hung Chen
Summary: The study in Taiwan found that chemotherapy is a risk factor for stroke in cancer patients, but the use of traditional Chinese medicine can significantly reduce this risk and decrease the mortality rate associated with chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ruixia Zhao, Linlin Wang, Yibing Liu, Mingyi Shao, Wei Yang, Yu Fu, Qilong Gao, Jun'an Feng, Yunfei Xing, Xinghua Xiang
Summary: This study found that adjuvant treatment with traditional Chinese medicine has a protective effect on the prognosis of patients with primary liver cancer, improving their survival rate and overall survival time.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Wei-Tai Shih, Pei-Rung Yang, Yi-Chia Shen, Yao-Hsu Yang, Ching-Yuan Wu
Summary: This study investigated the use of traditional Chinese medicine (TCM) in gastric cancer patients in Taiwan after surgery and adjuvant chemotherapy. Results showed that TCM users had a decreased risk of death compared to nonusers, especially long-term users. Similar trends were observed in short-term and long-term TCM users among different genders and age groups. The most commonly prescribed single herb and herbal formula were Radix Hedysari and Xiang-Sha-Liu-Jun-Zi-Tang, respectively. Overall, TCM could be considered as a complementary and alternative therapy for gastric cancer patients post-surgery and adjuvant chemotherapy.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Geriatrics & Gerontology
Chung-Yen Lu, Shu-Ru Lee, Chee-Jen Chang, Pei-Chun Chen
Summary: This study investigated whether the use of adjuvant traditional Chinese medicine (TCM) therapy is associated with long-term mortality after stroke. The results showed that the use of adjuvant TCM therapy, particularly acupuncture, in the acute and subacute stages of stroke recovery is associated with a reduced risk of long-term mortality.
Article
Oncology
Cecilie D. de la Cour, Christian von Buchwald, Christian Dehlendorff, Martin Garset-Zamani, Christian Gronhoj, Amanda-Louise F. Carlander, Soren Friis, Susanne K. Kjaer
Summary: This nationwide cohort study did not find an association between postdiagnostic low-dose aspirin use and cancer-specific mortality in patients with head and neck squamous cell cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Huixin Yuan, Qianqian Niu, Xiaofei Shang, Liang Zhang, Li Li, Huasheng Yang, Chunyan Gou, Jingying Li, Hongyan Li, Xiuhui Li
Summary: Traditional Chinese medicine (TCM) has been found to alleviate symptoms and improve the quality of life for hepatocellular carcinoma (HCC) patients. A retrospective study was conducted to determine the impact of TCM adjuvant therapies on the prognosis of HCC after conventional treatments. The results showed that TCM adjuvant therapies can postpone disease progression in HCC patients and may extend overall survival in patients with intermediate HCC when used for over 3 months per year.
INTEGRATIVE CANCER THERAPIES
(2023)
Article
Plant Sciences
Te-Chien Ku, Pin-Han Wang, Jhen-Ling Huang, Hsing-Yu Chen, Ji-Tseng Fang, Hsi-Lung Hsieh, Jiun-Liang Chen
Summary: The study demonstrated that external use of traditional Chinese medicine can significantly improve the 3-year and 5-year overall survival rates in nasopharyngeal cancer patients with radiotherapy-related adverse effects. Particularly, this improvement was more significant in patients with advanced-stage disease, and showed lower mortality risks in certain chronic disease patients.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yiwen Li, Yanfei Liu, Jing Cui, Hui Zhao, Yue Liu, Luqi Huang
Summary: In recent years, there has been a significant increase in cohort studies focusing on the treatment of chronic non-communicable diseases with traditional Chinese medicine, particularly in the areas of tumor, cardiovascular, and cerebrovascular diseases. While the overall quality of cohort studies needs improvement, there has been a noticeable growth in the number of studies in the past 5 years.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Li-Tzu Wang, Ping-Hao Chiang, Chi-Hsiang Chung, Mingyang Song, Sait Ashina, Wu-Chien Chien, Kevin Sheng-Kai Ma
Summary: This pilot study found a higher risk of head and neck cancers in patients with migraine, especially those with migraine with aura. Non-nasopharyngeal cancers were more commonly associated with migraine. Larger studies are needed to confirm these findings.
Article
Nutrition & Dietetics
Daniel Sat-Munoz, Brenda-Eugenia Martinez-Herrera, Javier-Andres Gonzalez-Rodriguez, Leonardo-Xicotencatl Gutierrez-Rodriguez, Benjamin Trujillo-Hernandez, Luis-Aaron Quiroga-Morales, Aldo-Antonio Alcaraz-Wong, Carlos Davalos-Cobian, Alejandro Solorzano-Melendez, Juan-Daniel Flores-Carlos, Benjamin Rubio-Jurado, Mario Salazar-Paramo, Gabriela-Guadalupe Carrillo-Nunez, Eduardo Gomez-Sanchez, Arnulfo-Hernan Nava-Zavala, Luz-Ma-Adriana Balderas-Pena
Summary: Malnutrition is common in patients with head and neck cancer, and low phase angle is a crucial predictor of survival and a risk factor for death in these patients.
Article
Oncology
Tobias Jagomast, Christian Idel, Luise Klapper, Patrick Kuppler, Anne Offermann, Eva Dreyer, Karl-Ludwig Bruchhage, Julika Ribbat-Idel, Sven Perner
Summary: This study investigated the clinical implications of CDK7 and pMED1 as potential biomarkers in head and neck squamous-cell cancer (HNSCC). The results showed that high levels of CDK7 were associated with lower survival rates and disease-free survival rates in HNSCC patients. Additionally, CDK7 expression was significantly elevated in immune cell infiltrated tumors. In vitro studies also demonstrated the potential of CDK7 inhibition as a therapeutic target.
Review
Pharmacology & Pharmacy
Yu Wang, Yuezhen Xue, Hai-dong Guo
Summary: Cardiovascular diseases, including myocardial infarction, are the leading cause of global mortality. Stem cell therapy is a promising treatment method, but the low retention and poor survival of injected stem cells are major obstacles. Chinese medicine plays a role in promoting various functions of stem cells for myocardial infarction treatment, but there are limitations to traditional Chinese medicine therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Otorhinolaryngology
Kate Ingarfield, Alex D. McMahon, Katrina Hurley, Stu Toms, Miranda Pring, Steve J. Thomas, Andrea Waylen, Michael Pawlita, Tim Waterboer, Andy R. Ness, David I. Conway
Summary: This study analyzed the UK Head and Neck 5000 prospective clinical cohort, finding that inequalities in survival among head and neck cancer patients could be explained by age, sex, health, and behavioral factors related to deprivation category, highest education level, and financial concerns. However, the inequality associated with annual household income or the proportion of income of benefits remained unexplained by the potential explanatory factors.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Chieh Wang, Kent Yu-Hsien Lin, Mei-Yao Wu, Cheng-Li Lin, Jaung-Geng Lin, Cherry Yin-Yi Chang, Wu-Chou Lin, Hung-Rong Yen
Summary: This study investigated the benefits of complementary Chinese herbal medicine (CHM) among cervical cancer patients in Taiwan, finding that CHM may have positive effects in reducing mortality rate and improving survival probability. The most commonly prescribed single herb and Chinese herbal formula were Herba Oldenlandiae (Hedyotis diffusa) and Jia-Wei-Xiao-Yao-San, respectively. Further evidence-based pharmacological investigations and clinical trials are needed to confirm the findings.
INTEGRATIVE CANCER THERAPIES
(2021)
Article
Otorhinolaryngology
Li-Hsiang Cheng, Pei-Chuan Wu, Cheng-Ping Shih, Hsing-Won Wang, Hsin-Chien Chen, Yuan-Yung Lin, Yueng-Hsiang Chu, Jih-Chin Lee
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2019)
Article
Otorhinolaryngology
Hsing-Won Wang, Jih-Chin Lee, Pei-Chuan Wu, Yueng-Hsiang Chu, Yuan-Yung Lin, Li-Hsiang Cheng
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2019)
Article
Surgery
Xu-Zhi Zheng, Yueng-Hsiang Chu, Chien-Sung Tsai, Chih-Yuan Lin
ANNALS OF VASCULAR SURGERY
(2019)
Article
Otorhinolaryngology
Sheng-Yao Cheng, Po-Jun Chen, Yueng-Hsiang Chu
ENT-EAR NOSE & THROAT JOURNAL
(2019)
Article
Otorhinolaryngology
Wen-Sen Lai, Yuan-Yung Lin, Yueng-Hsiang Chu, Jih-Chin Lee
ENT-EAR NOSE & THROAT JOURNAL
(2019)
Editorial Material
Otorhinolaryngology
Wen-Sen Lai, Yuan-Yung Lin, Yueng-Hsiang Chu, Jih-Chin Lee
ENT-EAR NOSE & THROAT JOURNAL
(2020)
Article
Otorhinolaryngology
Yueng-Hsiang Chu, Wen-Sen Lai, Yuan-Yung Lin, Shao-Cheng Liu, Jih-Chin Lee
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2020)
Article
Surgery
Chih-Yu Chen, Yu-Lung Chiu, Sarina Rajbhandari, Sheng-Yao Cheng, Hung-Che Lin, Yueng-Hsiang Chu, Jih-Chin Lee
Article
Engineering, Biomedical
Chung-Feng Jeffrey Kuo, Yu-Ching Li, Wei-Han Weng, Kathya Belen Pinos Leon, Yueng-Hsiang Chu
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2020)
Article
Biophysics
Yi-Jui Liu, Yi-Hsiung Lee, Hing-Chiu Chang, Hsiao-Wen Chung, Chih-Wei Wang, Cheng-Hsuan Juan, Yueng-Hsiang Chu, Jih-Chin Lee, Chun-Jung Juan
NMR IN BIOMEDICINE
(2020)
Editorial Material
Otorhinolaryngology
Chao-Yin Kuo, Yueng-Hsiang Chu, Chih-Hung Wang
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Article
Otorhinolaryngology
Ai-Ho Liao, Wan-Ting Lin, Hang-Kang Chen, Cheng-Ping Shih, Chih-Hung Wang, Yueng-Hsiang Chu
Summary: The combination of atorvastatin with MB-conjugated CDDP has a synergistic inhibitory effect on head neck cancer, suggesting a potential new treatment approach.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Environmental Sciences
Hung-Che Lin, Cheng-Ping Shih, Hsin-Chien Chen, Chun-An Cheng, Yuahn-Sieh Huang, Chen-Shien Lin, Chi-Hsian Chung, Bor-Rong Huang, Jih-Chin Lee, Wei-Chuan Shangkuan, Wu-Chien Chien, Chi-Ming Chu
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Environmental Sciences
Chun-Gu Cheng, Yu-Hsuan Chen, Shang-Yih Yen, Hui-Chen Lin, Hung-Che Lin, Kuei-Ru Chou, Chun-An Cheng
Summary: This study confirmed the lag effect and association of sudden sensorineural hearing loss (SSHL) with air pollution exposure. We discussed possible mechanisms, explored potential biological hypotheses, and called for further research. Large-scale studies including participants from different ethnicities and investigating causal relationships are needed to validate our findings.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biology
Hung-Che Lin, Hao-Ai Shui, Kuo-Yang Huang, Wei-Zhi Lin, Hsin-Yi Chang, Hwei-Jen Lee, Ying-Chih Lin, Yuahn-Sieh Huang, Guan-Ru Chen, Ya-Ting Yang, Hsiu-Lin Liu, Yi-Syuan Wu, Chia-Shiang Cheng, Ching-Lung Ko, Yu-Tien Chang, Jih-Chin Lee, Chen-Shien Lin, Chih-Hung Wang, Chi-Ming Chu
Summary: Both the annotation and identification of genes in pathogenic parasites are challenging. In this study, we successfully identified a novel nitric oxide synthase (NOS) in Trichomonas vaginalis (TV) that was previously annotated incorrectly as a hydrogenase. Through in silico modeling and enzymatic activity assays, we showed that this NOS is a functional enzyme. This study provides an innovative approach to identify incorrectly annotated genes and highlights a novel NOS that may play a role as a virulence factor in TV.