Article
Biochemistry & Molecular Biology
Rania Magadmi, Reem Alyoubi
Summary: This study aimed to assess the impact of demographic and clinical characteristics on the likelihood of developing drug resistance in children with epilepsy. Among the 101 children included in the study, 56 showed a good response to antiseizure medications, while 45 had a poor response. Younger patients, those without parental consanguinity and family history of epilepsy, and those diagnosed with partial seizures without adverse effects showed a statistically significant good response to antiseizure medications.
Article
Business
Eric Van Tassel
Summary: In a market where risky entrepreneurs seek external funds, crowdfunding and financial intermediation can be compatible methods of investment. This study finds that investors prefer to utilize both crowdfunding and financial intermediation when the risk of crowdfunding investment is at an intermediate level. The research also suggests that crowdfunding becomes more optimal when the transaction costs of investment are high.
SMALL BUSINESS ECONOMICS
(2023)
Article
Environmental Sciences
Virginia Iglesias, Anna E. Braswell, Matthew W. Rossi, Maxwell B. Joseph, Caitlin McShane, Megan Cattau, Michael J. Koontz, Joe McGlinchy, R. Chelsea Nagy, Jennifer Balch, Stefan Leyk, William R. Travis
Summary: Losses from natural hazards are increasing, with development contributing to the exposure of vulnerable assets and populations to risks. Studies show that a large number of buildings are located in hazard hotspots, a result of decades of sustained growth, indicating potential for even larger future losses if development in hazardous areas is not limited.
Review
Pharmacology & Pharmacy
Balazs Kiss, Janos Borbely
Summary: Recent developments in ADCs aim to enhance the cytotoxic effect and therapeutic window of mAbs by linking them to highly toxic drugs. The global ADCs market was valued at USD 1387 million in 2016 and is estimated to reach USD 7.82 billion in 2022, with a projected increase to USD 13.15 billion by 2030. The linkage of substituents to mAb functional groups plays a critical role in increasing efficacy against cancer cells.
Article
Clinical Neurology
Seyyed Reza Ebadi, Kiarash Saleki, Tanin Adl Parvar, Negin Rahimi, Vajiheh Aghamollaii, Sara Ranji, Abbas Tafakhori
Summary: This study explored the efficacy and safety of cannabidiol (CBD) as an add-on treatment for treatment-resistant frontal lobe epilepsy. The results demonstrated that CBD showed promising results in reducing seizure frequency and improving quality of life in patients with refractory epilepsy. Further research with larger sample sizes and longer follow-ups is recommended.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rania Magadmi, Reem Alyoubi, Tahani Moshrif, Duaa Bakhshwin, Bandar A. Suliman, Fatemah Kamel, Maha Jamal, Abdulhadi S. Burzangi, Sulman Basit
Summary: This study investigated the association between single-nucleotide polymorphisms (SNPs) of the ABCB1 gene and the response to anti-seizure medications in Saudi pediatric epileptic patients. The results showed a significant association between the rs1045642 and rs2032582 variants and patient responsiveness. Despite the small sample size, the study highlights the importance of personalized treatment for epileptic patients.
Article
Economics
Luciana Juvenal, Paulo Santos Monteiro
Summary: In this study, we integrate the canonical trade model with heterogeneous firms, love for variety, and trade costs into the consumption CAPM model. This leads to a structural gravity equation that incorporates an additional factor related to risk premia. Empirical evidence based on firm-level data confirms the significance of cross-sectional heterogeneity in risk and time-varying risk premia in shaping bilateral trade flows. The augmented structural gravity model, which accounts for fluctuations in risk premia, provides a compelling explanation for trade collapses during abrupt economic downturns.
JOURNAL OF THE EUROPEAN ECONOMIC ASSOCIATION
(2023)
Article
Neurosciences
Anton Tokariev, Michael Breakspear, Mari Videman, Susanna Stjerna, Lianne H. Scholtens, Martijn P. van den Heuvel, Luca Cocchi, Sampsa Vanhatalo
Summary: In utero exposure to antiepileptic medication can impact cortical activity during neonatal sleep, with effects differing between drugs. These effects on functional brain networks provide prognostic information for later neurodevelopment. This study offers bedside metrics sensitive to the effects of antiepileptic drugs on postnatal neurodevelopment.
Article
Medicine, General & Internal
Vanessa Cavallera, Gillian Lancaster, Melissa Gladstone, Maureen M. Black, Gareth McCray, Ambreen Nizar, Salahuddin Ahmed, Arup Dutta, Romuald Kouadio E. Anago, Alexandra Brentani, Fan Jiang, Yvonne Schoenbeck, Dana C. McCoy, Patricia Kariger, Ann M. Weber, Abbie Raikes, Marcus Waldman, Stef van Buuren, Raghbir Kaur, Michelle Perez Maillard, Muhammad Imran Nisar, Rasheda Khanam, Sunil Sazawal, Arsene Zongo, Mariana Pacifico Mercadante, Yunting Zhang, Arunangshu D. Roy, Katelyn Hepworth, Guenther Fink, Marta Rubio-Codina, Fahmida Tofail, Iris Eekhout, Jonathan Seiden, Rebecca Norton, Abdullah H. Baqui, Jamila Khalfan Ali, Jin Zhao, Andreas Holzinger, Symone Detmar, Samuel Nzale Kembou, Farzana Begum, Said Mohammed Ali, Fyezah Jehan, Tarun Dua, Magdalena Janus
Summary: The aim of this study is to validate the Global Scales for Early Development (GSED) and create reference scores for its short form and long form. The study will be conducted in seven countries with a total of 1248 children, using cross-sectional and longitudinal methods. The findings will be disseminated through various channels.
Article
Clinical Neurology
Andrei Brinzeu, Marc Sindou
Summary: At the end of the 1950s, Pierre Wertheimer established the Pierre Wertheimer Neurological and Neurosurgical Hospital in Lyon, which served as a center for neuroscience, combining hospital and training facilities. The hospital's structure focused on spatial unity, specialized fields, a large patient population, structured training, and cross-communication between areas. The hospital made significant contributions to functional neurosurgery, pain surgery, physiology, epilepsy surgery, and spasticity surgery, fostering collaboration between different teams and laying the groundwork for a neuroscientific doctoral school.
JOURNAL OF NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Benjamin M. Davies, Alvaro Yanez Touzet, Oliver D. Mowforth, Keng Siang Lee, Danyal Khan, Julio C. Furlan, Michael G. Fehlings, James S. Harrop, Carl Moritz Zipser, Ricardo Rodrigues-Pinto, James Milligan, Ellen Sarewitz, Armin Curt, Vafa Rahimi-Movaghar, Bizhan Aarabi, Timothy F. Boerger, Lindsay Tetreault, Robert Chen, James D. Guest, Sukhvinder Kalsi-Ryan, Iwan Sadler, Shirley Widdop, Angus G. K. McNair, Brian K. Kwon, Mark R. N. Kotter
Summary: Inconsistent measurement and reporting in degenerative cervical myelopathy (DCM) research hinder progress, highlighting the need for a core measurement set (CMS). This protocol outlines the steps for developing the CMS, including identifying constructs to be measured, conducting systematic reviews to identify measurement tools, and selecting the instruments through a consensus meeting. The CMS implementation guidance will be developed following instrument selection.
Article
Medicine, General & Internal
Tagore Nakornchai, Elena Conci, Anke Hensiek, J. William L. Brown
Summary: Telephone consultations in neurological outpatient settings are considered effective, convenient, and popular, especially in predesignated subgroups of patients with certain diseases. The majority of clinicians and patients achieved their consultation goals via telephone, and most patients found telephone consultations convenient.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Masafumi Sanefuji, Ayako Senju, Masayuki Shimono, Masanobu Ogawa, Yuri Sonoda, Michiko Torio, Yuko Ichimiya, Reiko Suga, Yasunari Sakai, Satoshi Honjo, Koichi Kusuhara, Shouichi Ohga
Summary: The study confirmed the association between continuous breastfeeding and reduced developmental delay at 1 year old, with exclusive breastfeeding showing benefits for infant development. Sibling pair analysis further supported this association.
Article
Pediatrics
Setyo Handryastuti, Dianing Latifah, Evita Karianni Bermanshah, Hartono Gunardi, Muzal Kadim, R. Adhi Teguh Perma Iskandar
Summary: This study aims to establish and test a scoring system consisting of clinical manifestations to diagnose tuberculous meningitis (TBM) in children. A retrospective study was conducted using a diagnostic multivariable prediction model. The scoring system, consisting of systemic and neurological features, can be used to predict the diagnosis of TBM in children.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Business
Yueshu Zhou, Yuanyuan Peng, Rashid Latief
Summary: This study analyzes the impact of non-interest business development on the performance of Chinese rural commercial banks (RCBs), finding a U-shaped relationship between non-interest income and RCBs' performance. The research also identifies a threshold effect, with non-interest business development significantly affecting performance when the cost ratio exceeds 0.2213.
EMERGING MARKETS FINANCE AND TRADE
(2021)
