Article
Medicine, General & Internal
Carly R. Luke, Katherine Benfer, Leeann Mick-Ramsamy, Robert S. Ware, Natasha Reid, Arend F. Bos, Margot Bosanquet, Roslyn N. Boyd
Summary: Neurodevelopmental disorders have a significant impact on infants' cognitive and physical development. This study aims to investigate the effectiveness of early screening programs implemented in Queensland, Australia in identifying at-risk Aboriginal and Torres Strait Islander infants and to determine the accuracy and feasibility of early detection tools.
Article
Pediatrics
Fanny Soderstrom, Erik Normann, Maria Jonsson, Johan Agren
Summary: This study found that an actively managed approach to extremely preterm infants in a center resulted in similar survival rates for infants born at 22-24 weeks gestation, with over 50% survival even at 22 weeks. The majority of infants were neurologically normal at 2.5 years, suggesting that this approach did not lead to higher rates of long-term adverse neurological outcomes.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Article
Medicine, General & Internal
Marie Brossard-Racine, Emmanouille Rampakakis, Christine Lucas Tardif, Guillaume Gilbert, Angela White, Thuy Mai Luu, Anne Gallagher, Elana Pinchefsky, Tina Montreuil, Marie-Noelle Simard, Pia Wintermark
Summary: This study aims to comprehensively describe the developmental outcomes and associated brain structural profiles of neonates with NE treated with TH. It will be the largest follow-up study to date, conducted at 9 years of age. The findings will be disseminated in scientific journals and conferences, as well as presented to parental associations and healthcare providers to inform best practices.
Article
Medicine, General & Internal
Katherine Benfer, Roslyn N. Boyd, Yvette Roe, Ruth Fagan, Carly Luke, Leeann Mick-Ramsamy, Koa Whittingham, Iona Novak, Margot Bosanquet, Lynda McNamara, Gulam Khandaker, Lucy Fogarty, Yvonne Cadet-James, Alan Ruben, Tracy Comans, Anthony Smith, Robert S. Ware
Summary: This study aims to evaluate a culturally-adapted parent-delivered early intervention programme for First Nations Australian infants at high risk of cerebral palsy (CP). The study will conduct a randomised assessor masked controlled trial, recruiting infants with birth/postnatal risk factors. The findings will be disseminated through peer-reviewed journal publications and national/international conference presentations.
Article
Pediatrics
Christian Nunez, Christian Stephan-Otto, Gemma Arca, Thais Agut, Juan Arnaez, Malaika Cordeiro, Isabel Benavente-Fernandez, Nuria Boronat, Simon Pedro Lubian-Lopez, Eva Valverde, Montesclaros Hortiguela, Alfredo Garcia-Alix
Summary: In a prospective observational multicenter study of neonatal stroke, lesion location identified by MRI is associated with language, motor, and cognitive outcomes at two years of age. The study found correlations between speech therapy, gross motor function impairment, and cognitive impairment with specific lesion locations. This information can aid in predicting neurological impairments more accurately based on neonatal brain MRI.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Rocco Cuzzilla, Frances M. Cowan, Sheryle Rogerson, Peter J. Anderson, Lex W. Doyle, Jeanie Ling Yoong Cheong, Alicia Spittle
Summary: This study aimed to explore the relationship between early postnatal cranial ultrasound (cUS) linear measures of brain size and brain growth and neurodevelopment at 2 years in infants born <30 weeks' gestational age (GA). The results showed that larger measures of brain tissue and fluid spaces within the first weeks after birth were related to better cognitive and language development at 2 years. However, further research is needed to investigate the relationship between early cUS linear measures and fluid spaces and later neurodevelopment.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Clinical Neurology
Gauruv Bose, Brian C. Healy, Christian Barro, Bonnie Glanz, Hrishikesh A. Lokhande, Mariann Polgar-Turcsanyi, Charles R. G. Guttmann, Rohit Bakshi, Howard L. Weiner, Tanuja Chitnis
Summary: For patients with multiple sclerosis (MS) who have a disease duration of more than 10 years, an earlier age at onset is associated with worse outcomes at age 50, including higher disability, increased risk of secondary-progressive MS, more brain lesions, worse brain parenchymal fraction, and higher likelihood of unemployment due to MS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Runhua Zhang, Gaifen Liu, Yuesong Pan, Maigeng Zhou, Yongjun Wang
Summary: This study aimed to assess the association between hospital volume, processes of care, and outcomes after ischaemic stroke. The results showed no significant associations between hospital volume and mortality, recurrent stroke, and combined vascular events, but it may be associated with poor outcome at 1 year.
Article
Medicine, General & Internal
Andrew M. Gordon, Claudio L. Ferre, Maxime T. Robert, Karen Chin, Marina Brandao, Kathleen M. Friel
Summary: This study aims to determine the efficacy of transcranial direct current stimulation (tDCS) targeted to the hemisphere with corticospinal tract (CST) connectivity in children with unilateral spastic cerebral palsy (USCP) undergoing upper extremity training. The study will assess clinical and motor cortex physiology outcomes through a randomized clinical trial, with measurements taken before, immediately after, and 6 months after treatment.
Article
Medicine, General & Internal
A. M. Madelein van der Stouwe, Inge Tuitert, Ioannis Giotis, Joost Calon, Rahul Gannamani, Jelle R. Dalenberg, Sterre van der Veen, Marrit R. Klamer, Alex C. Telea, Marina A. J. Tijssen
Summary: The NEMO study aims to develop a novel approach to classify hyperkinetic movement disorders using machine learning, combining clinical information, electromyography, accelerometry, and video data. The study will involve single phenotype and mixed phenotype groups, with results expected to be published in multiple related fields of research.
Article
Medicine, General & Internal
Ingrid Heuch, Ivar Heuch, Knut Hagen, Kjersti Storheim, John-Anker Zwart
Summary: This study explored the associations between age at menarche and menopause and the risk of chronic low back pain (LBP). The findings indicate a U-shaped association between age at menarche and chronic LBP risk, while no association was found between age at menopause and LBP risk.
Article
Medicine, General & Internal
Thomas Whitfield, Cristina Fernandez, Kelly Davies, Sylviane Defres, Michael Griffiths, Cory Hooper, Rebecca Tangney, Girvan Burnside, Anna Rosala-Hallas, Perry Moore, Kumar Das, Mark Zuckerman, Laura Parkes, Simon Keller, Neil Roberts, Ava Easton, Saber Touati, Rachel Kneen, J. P. Stahl, Tom Solomon
Summary: Herpes simplex virus (HSV) encephalitis is a rare severe form of brain inflammation that may cause memory problems, especially verbal memory. The DexEnceph trial aims to determine if using dexamethasone alongside antiviral treatment can improve outcomes for patients with this condition.
Article
Medicine, General & Internal
Wijnand A. C. Palmbergen, Rob M. A. de Bie, Tim W. H. Alleman, Esther Verstraete, Korne Jellema, Wim I. M. Verhagen, Geert J. F. Brekelmans, Godard C. W. de Ruiter, Diederik van de Beek, Corianne A. J. M. de Borgie, Rob de Haan, Roy Beekman, Camiel Verhamme
Summary: The Dutch DISTRICTS trial aims to investigate the optimal treatment strategy for carpal tunnel syndrome by comparing the clinical outcomes and cost-effectiveness of initial surgery versus corticosteroid injection. This ongoing multicenter, open-label randomized controlled trial randomizes participants with carpal tunnel syndrome to receive either surgery or corticosteroid injection. The primary outcome is the proportion of participants recovered at 18 months.
Article
Medicine, General & Internal
Sonia Berrih-Aknin, Jacqueline Palace, Andreas Meisel, Kristl G. Claeys, Srikanth Muppidi, Francesco Sacca, Fatemeh Amini, Mark Larkin, Casey Quinn, Jon Beauchamp, Glenn Philips, Femke De Ruyck, Joyce Ramirez, Sandra Paci
Summary: This study aims to explore the impact of myasthenia gravis (MG) in the real world from a patient perspective. The study included MG patients from different countries and found that despite current treatments, patients still experience a significant burden.
Article
Medicine, General & Internal
Saif Huda, Daniel Whittam, Richard Jackson, Venkatraman Karthikeayan, Patricia Kelly, Sam Linaker, Kerry Mutch, Rachel Kneen, Mark Woodhall, Katy Murray, David Hunt, Patrick Waters, Anu Jacob
Summary: Male patients with spinal cord involvement at disease onset have a lower risk of relapsing disease and longer latency to first relapse. Steroid treatment for at least 1 month at first attack was also associated with a monophasic disease course. MOG-antibody negative seroconversion was associated with a lower risk of relapse and may help inform treatment decisions and duration.
