Article
Public, Environmental & Occupational Health
Ivo Mueller, Amelie Vantaux, Stephan Karl, Moses Laman, Benoit Witkowski, Anais Pepey, Rebecca Vinit, Michael White, Alyssa Barry, James G. Beeson, Leanne J. Robinson
Summary: The Asia-Pacific International Center of Excellence in Malaria Research (ICEMR) is using various research approaches to gain a comprehensive understanding of malaria transmission in Papua New Guinea and Cambodia. They have identified the challenges of forest-based transmission of malaria in Cambodia and the complex interactions between hosts, vectors, and parasites in Papua New Guinea.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Review
Public, Environmental & Occupational Health
Holger W. Unger, Sanjaya Acharya, Lachlan Arnold, Connie Wu, Anna Maria van Eijk, Georgia R. Gore-Langton, Feiko O. ter Kuile, Elvin Lufele, R. Matthew Chico, Ric N. Price, Brioni R. Moore, Kamala Thriemer, Stephen J. Rogerson
Summary: Half of all pregnancies at risk of malaria occur in the Asia-Pacific region, where the co-existence of Plasmodium falciparum and Plasmodium vivax is common. Malaria control in pregnancy faces challenges due to high-grade antimalarial resistance and the need for more sensitive diagnostic tests. A more systematic approach is needed to prevent malaria in pregnancy in the Asia-Pacific region.
LANCET GLOBAL HEALTH
(2023)
Article
Environmental Sciences
Ce Wang, Bikash Thakuri, Amit Kumar Roy, Nitish Mondal, Yi Qi, Amit Chakraborty
Summary: The association between malaria incidence and climatic factors is controversial, hindering the progress of the Global Malaria Program. This study evaluated the relationship across all malaria endemic countries in Africa and the Asia-Pacific region. Using two decades of data, the study found heterogeneity in malaria incidence and reductions in the disease burden in Asia-Pacific countries, with exceptions in Africa. The study also identified positive associations between malaria incidence, minimum temperature, and precipitation in African countries, while several Asia-Pacific countries showed negative effects of precipitation.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Nutrition & Dietetics
Tomoko Aoyama, Donglai Li, Jacquie Lindsay Bay
Summary: Nutrition and weight gain during pregnancy have an impact on the long-term health of offspring. Clinical practice guidelines on gestational weight gain and maternal nutrition in the Asia-Pacific region are generally of poor quality and show significant variability in recommendations, highlighting the need for improvement to ensure appropriate advice for pregnant women.
Review
Gastroenterology & Hepatology
Ankur Jindal, Shiv K. Sarin
Summary: The global burden of deaths caused by liver failure is substantial. The Asia-Pacific region accounted for more than half of the global population and a significant proportion of liver disease deaths in 2015. The causes of liver failure vary in different countries and include viruses, drugs, toxins, and autoimmune reactions. Rising alcohol misuse and metabolic syndrome pose a concern. Accurate estimates of the burden of liver failure are critical for determining clinical, research, and policy priorities.
LIVER INTERNATIONAL
(2022)
Article
Business, Finance
Ashish Kumar, K. N. Badhani, Elie Bouri, Tareq Saeed
Summary: This paper expands the existing literature on herding behavior in commodity markets by focusing on major economies in the Asia-Pacific region. The study shows that herding behavior is heterogeneous across Asian economies and varies under different market and liquidity conditions. There is evidence of up/down market herding asymmetry, with herding being more pronounced during periods of high volatility. Notably, herding behavior varies with time and appears to be influenced by volatility.
FINANCE RESEARCH LETTERS
(2021)
Article
Immunology
Jeffrey Hii, John Hustedt, Michael J. Bangs
Summary: The systematic review on residual malaria transmission (RMT) highlighted significant gaps and deficiencies needing urgent attention, such as developing standardized procedures and methods to estimate risk exposure, analytical approaches to measure key human-vector interactions, seasonal location-specific agricultural or forest use calendars, and establishing the collection of longitudinal human and vector data close in time and location.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Respiratory System
Duminda Yasaratne, N. Sabrina Idrose, Shyamali C. Dharmage
Summary: This study provides a comprehensive synthesis of the burden, risk factors, and challenges of asthma management in developing countries, with a specific focus on the Asia-Pacific Region. The study highlights the higher burden of asthma in low and low-middle-income countries in the region compared to high-income countries. The challenges include inequitable distribution of healthcare, lack of advanced diagnostic measures, unavailability and unaffordability of novel therapeutics, cultural beliefs and practices, and diverse disease phenotypes.
Review
Environmental Sciences
Miroslaw Janik, Peter Bossew, Md. Mahamudul Hasan, Giorgia Cinelli
Summary: Indoor radon is a major health hazard and a leading cause of lung cancer. Radon research in Asia has increased due to growing awareness of its harm. Analysis of literature data revealed that certain regions in Asia-Oceania have little indoor radon problems due to climate and low Rn ground. Countries have their own approaches and techniques, though measurement techniques are compared through intercomparison exercises. Certain countries in seismically active zones, like India and Taiwan, lead in radon research, along with Italy. The number of indoor radon measurements per million inhabitants increases with higher human development index (HDI).
Article
Business
Nguyen Cong Thang, Vo The Anh, Pham Ngoc Thach, Do Thanh Trung, Vo Hong Duc
Summary: This study examined attitudes towards income inequality in the Asia-Pacific region and found gender-based differences, with social class being a key determinant across all countries in the region.
EMERGING MARKETS FINANCE AND TRADE
(2021)
Article
Medicine, General & Internal
Frederick K. Ho, Nirmala Rao, Keith T. S. Tung, Rosa S. Wong, Wilfred H. S. Wong, Joanna Y. L. Tung, Gilbert T. Chua, Winnie W. Y. Tso, John Bacon-Shone, Ian C. K. Wong, Aisha Yousafzai, Charlotte Wright, Patrick Ip
Summary: Stunting, BMI-for-age, and body fat proportion were found to be independently associated with early child development in this study, suggesting the importance of considering these parameters in estimating child underdevelopment and exploring the causal relationships in future nutritional trials.
Review
Ophthalmology
Mayinuer Yusufu, Javaria Bukhari, Xiaobin Yu, Timothy P. H. Lin, Dennis S. C. Lam, Ningli Wang
Summary: The Asia-Pacific region, with a population of 4.3 billion and rapidly aging population, faces increasing demand for eye care. Despite significant achievements in the past decades, challenges lie ahead, including the rising number of blind people and high prevalence of blinding eye diseases. Additionally, the uneven distribution of ophthalmic resources poses a significant challenge for the region.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Emilia Antonio, Nicolas Pulik, Jieun Lee, Tanu Soni, Hans-Eckhardt Hagen, Choong-Min Ryu, Alice Norton
Summary: This study analyzed the funders and funding sources supporting research on infectious diseases in the Asia-Pacific region. The findings show that there are numerous COVID-19 research funders and funding sources in the region, but they are concentrated in a few countries. Additionally, there is limited research involving Asia-Pacific countries in the funded COVID-19 projects, with the majority of funding focused on social sciences and less emphasis on research priorities such as animal and environmental health and ethics considerations.
Article
Business, Finance
Barry Williams, Gulasekaran Rajaguru
Summary: This study examines the impact of bank risk, capital holdings, and regulatory quality on the determination of bank non-interest income and net interest income. The findings suggest that changes in non-interest income have a negligible effect on net interest income, while increased non-interest income is associated with higher capital holdings and worsening loan quality.
PACIFIC-BASIN FINANCE JOURNAL
(2022)
Article
Environmental Sciences
Mohammad Mazibar Rahman, Nishat Anan, Abu Hashan Md Mashud, Mahmudul Hasan, Ming-Lang Tseng
Summary: This study evaluates the CO2 emission factors of 17 countries in Asia and the Pacific region, focusing on their consumption of products and services. It finds significant emissions from China, Japan, and India, with the household sector being the main contributor. The study highlights the importance of understanding the effects of consumption on carbon emissions and formulating effective carbon mitigation plans.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Obstetrics & Gynecology
Theophilus K. Adu-Bredu, Marcus J. Rijken, Albaro Jose Nieto-Calvache, Vedran Stefanovic, Rozi Aditya Aryananda, Karin Anneliese Fox, Sally L. Collins
Summary: This article provides a simple three-step approach to guide clinicians and sonographers with minimal experience in placenta accreta spectrum through risk stratification and basic prenatal screening for this condition.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Stephanie Thierens, Annelien van Binsbergen, Barbara Nolens, Thomas van den Akker, Kitty Bloemenkamp, Marcus J. Rijken
Summary: Comparison of vacuum extraction (VE) and second-stage caesarean section (SSCS) revealed no significant difference in adverse outcomes for mothers and infants. VE should be recommended when safe anesthesia and surgery are not immediately available.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Medicine, General & Internal
Makoto Saito, Rose McGready, Halidou Tinto, Toussaint Rouamba, Dominic Mosha, Stephen Rulisa, Simon Kariuki, Meghna Desai, Christine Manyando, Eric M. Njunju, Esperanca Sevene, Anifa Vala, Orvalho Augusto, Christine Clerk, Edwin Were, Sigilbert Mrema, William Kisinza, Josaphat Byamugisha, Mike Kagawa, Jan Singlovic, Mackensie Yore, Anna Maria van Eijk, Ushma Mehta, Andy Stergachis, Jenny Hill, Kasia Stepniewska, Melba Gomes, PhilippeJ Guerin, Francois Nosten, Feiko O. ter Kuile, Stephanie Dellicour
Summary: This study compared adverse pregnancy outcomes in the first trimester of pregnancy after artemisinin-based treatment (ABT) versus non-ABTs. The results showed no evidence of embryotoxicity or teratogenicity associated with ABT during the first trimester. Artemether-lumefantrine was found to be the preferred treatment for uncomplicated P falciparum malaria in the first trimester, with fewer adverse pregnancy outcomes compared to quinine.
Editorial Material
Medicine, General & Internal
Lindsey Baden, Flaminia Catteruccia, Abdoulaye Diabate, Cristina Donini, Francois Nosten, Scott O'Neill, Faith Osier, Aung Pyae Phyo, Nicholas White
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Immunology
Isobel S. Walker, Stephen J. Rogerson
Summary: This article reviews the latest developments in the immunogenicity and pathogenesis of malaria, with a focus on the leading malaria killer, Plasmodium falciparum. Pathogenic factors include parasite-derived toxins and variant surface antigens that cause sequestration in the deep vasculature. The host response to these toxins and antigens plays a crucial role in determining disease severity.
Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Priyanka Barua, Michael F. Duffy, Laurens Manning, Moses Laman, Timothy M. E. Davis, Ivo Mueller, Ali Haghiri, Julie A. Simpson, James G. Beeson, Stephen J. Rogerson
Summary: In children from Papua New Guinea with severe or uncomplicated malaria, antibody recognition of homologous but not heterologous isolates was boosted in convalescence and showed variations with ABO blood group. Patterns of var gene transcription distinguished severe from uncomplicated malaria. ABO blood group may influence antibody acquisition to VSAs and susceptibility to severe malaria.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Eva Legendre, Laurent Lehot, Sokhna Dieng, Stanislas Rebaudet, Aung Myint Thu, Jade D. Rae, Gilles Delmas, Florian Girond, Vincent Herbreteau, Francois Nosten, Jordi Landier, Jean Gaudart
Summary: This research developed a dynamic clustering approach to improve the stratification of malaria transmission areas, providing more information for decision-making.
Article
Biochemistry & Molecular Biology
Nicoletta Basilico, Silvia Parapini, Sarah D'Alessandro, Paola Misiano, Sergio Romeo, Giulio Dondio, Vanessa Yardley, Livia Vivas, Shereen Nasser, Laurent Renia, Bruce M. Russell, Rossarin Suwanarusk, Francois Nosten, Anna Sparatore, Donatella Taramelli
Summary: The novel pyrrolizidinylmethyl derivative MG3 showed excellent antimalarial activity against drug-resistant parasites, both in vitro and in vivo. The compound exhibited comparable or better efficacy than chloroquine and other quinolines in rodent models of malaria, and its pharmacological profile met the requirements for further development.
Review
Public, Environmental & Occupational Health
Ahmar Hashmi, Mu Chae Darakamon, Ko Ko Aung, Mu Mu, Prapatsorn Misa, Podjanee Jittamala, Cindy Chu, Aung Pyae Phyo, Claudia Turner, Francois Nosten, Rose McGready, Verena I. I. Carrara
Summary: This study examined the care and outcomes of preterm neonates in a special care baby unit (SCBU) along the Myanmar-Thailand border. The study found significant reductions in neonatal mortality rates and identified implementation factors that impact the delivery of evidence-based care, such as financial issues and social support systems.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Makoto Saito, Aung Pyae Phyo, Cindy Chu, Stephane Proux, Marcus J. Rijken, Candy Beau, Htun Htun Win, Laypaw Archasuksan, Jacher Wiladphaingern, Nguyen H. Phu, Tran T. Hien, Nick P. Day, Arjen M. Dondorp, Nicholas J. White, Francois Nosten, Rose Mcgready
Summary: This study aimed to identify factors predicting higher maternal mortality and describe the fetal mortality and morbidity associated with severe falciparum malaria in pregnancy. Coma, hypotension, and respiratory failure were associated with maternal mortality. Maternal death, fetal loss, and preterm birth commonly occurred within a week of severe malaria diagnosis.
Article
Infectious Diseases
Navaporn Posayapisit, Jutharat Pengon, Philip J. Shaw, Chairat Uthaipibull, Darin Kongkasuriyachai, Aung Pyae Phyo, Francois Nosten, Yongyuth Yuthavong, Sumalee Kamchonwongpaisan
Summary: The effectiveness of antimalarial drug P218 against artemisinin-resistant Plasmodium falciparum is still uncertain, despite its efficacy against other drug-resistant parasites.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Immunology
Aude Mondeilh, Emmanuel Yovo, Manfred Accrombessi, Cornelia Hounkonnou, Gino Agbota, William Atade, Olaiitan T. Ladikpo, Murielle Mehoba, Auguste Degbe, Bertin Vianou, Dariou Sossou, Nicaise Tuikue Ndam, Achille Massougbodji, Rose McGready, Nadine Fievet, Marcus J. Rijken, Gilles Cottrell, Valerie Briand
Summary: This study evaluated the effect of malaria in pregnancy on uterine artery and umbilical artery blood flow. The results showed that malaria infections in the early stages of pregnancy can impair placental blood flow, highlighting the need to prevent malaria from the very beginning of pregnancy.
OPEN FORUM INFECTIOUS DISEASES
(2023)
