Article
Obstetrics & Gynecology
Rebecca Horgan, Yara Hage Diab, Jerri Waller, Alfred Abuhamad, George Saade
Summary: The dosage and timing of aspirin initiation are crucial for reducing the risk of preeclampsia. Initiating a dosage of >100 mg of aspirin daily before 16 weeks' gestation seems to be the most effective approach. Randomized control trials are needed to evaluate the safety and efficacy of different aspirin dosages available in the United States.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Medicine, General & Internal
Jennifer Horwitz, Shi Wu Wen, Hongzhuan Tan, Shujin Zhou, Chang Ye, Minxue Shen, Ravi Retnakaran
Summary: This cohort study examines the relationship between preconception paternal smoking and neonatal outcomes.
Article
Obstetrics & Gynecology
Li Lin, Jing Huai, Boya Li, Yuchun Zhu, Juan Juan, Meihua Zhang, Shihong Cui, Xianlan Zhao, Yuyan Ma, Yangyu Zhao, Yang Mi, Hongjuan Ding, Dunjin Chen, Weishe Zhang, Hongbo Qi, Xiaotian Li, Guanlin Li, Jiahui Chen, Huijing Zhang, Mengting Yu, Xiaotong Sun, Huixia Yang
Summary: The use of 100 mg aspirin for prevention of preeclampsia in high-risk pregnant women in China did not show significant efficacy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Oncology
Mattias Hammarstroem, Marike Gabrielson, Alessio Crippa, Andrea Discacciati, Martin Eklund, Cecilia Lundholm, Magnus Baecklund, Yvonne Wengstroem, Signe Borgquist, Jenny Bergqvist, Mikael Eriksson, Jose Tapia, Kamila Czene, Per Hall
Summary: Based on questionnaire data from a randomized controlled trial, low-dose tamoxifen was associated with fewer side effects compared to standard dose tamoxifen in healthy women. These side effects mainly included hot flashes, night sweats, cold sweats, vaginal discharge, and muscle cramps. The dose-dependent difference was primarily influenced by menopausal status.
BRITISH JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Jacqueline E. Rudolph, Kwangho Kim, Edward H. Kennedy, Ashley I. Naimi
Summary: This study aims to assess the incremental effects of time-varying exposure, using data from an experiment on the impact of aspirin on pregnancy outcomes. The results suggest that increasing women's probability of taking aspirin has little impact on pregnancy rates.
Article
Obstetrics & Gynecology
Si Sun, HongYang Qian, Congcong Li, Qiaohong Wang, Aimin Zhao
Summary: This study retrospectively investigated the safety of low dose aspirin (LDA) during pregnancy. The results showed that the use of aspirin did not increase the risk of fetal congenital anomalies. Additionally, a previous history of fetal abnormalities was found to be an independent risk factor for congenital anomalies.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Cardiac & Cardiovascular Systems
Qiongjie Zhou, Xingzhong Zhao, Jinghui Xu, Yu Xiong, Jon F. R. Barrett, Xing-Ming Zhao, Xiaotian Li
Summary: This retrospective study aimed to describe the frequency of preeclampsia and aspirin use in real-world practice among women with twin pregnancies. The results showed that the use of low-dose aspirin was associated with a higher incidence of preeclampsia, possibly due to poor compliance with the medication. Further randomized controlled trials or prospective cohort studies are needed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Obstetrics & Gynecology
Ellen Kupka, Susanne Hesselman, Roxanne Hastie, Riccardo Lomartire, Anna Karin Wikstrom, Lina Bergman
Summary: This study aimed to investigate the association between low-dose aspirin use and preterm birth among women with a previous preterm birth. A Swedish register-based cohort study found that low-dose aspirin use was associated with a reduced risk of preterm birth, particularly in spontaneous preterm births.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Respiratory System
Sahajal Dhooria, Inderpaul Singh Sehgal, Ritesh Agarwal, Valliappan Muthu, Kuruswamy Thurai Prasad, Pooja Dogra, Uma Debi, Mandeep Garg, Amanjit Bal, Nalini Gupta, Ashutosh Nath Aggarwal
Summary: This study found that high-dose prednisolone was not superior to a lower dose in improving outcomes or health-related quality of life in sarcoidosis and was associated with similar adverse effects.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Rachel Shvartsur, Galila Agam, Sarit Uzzan, Abed N. Azab
Summary: Mounting evidence suggests that immune-system dysfunction and inflammation play a role in the pathophysiology and treatment of mood disorders. This study found that chronic combined treatment attenuated LPS-induced hypothermia and reduced cytokine levels, suggesting a potential approach for treating inflammation-related mental illness. The treatment also showed antidepressant-like effects.
Article
Medicine, General & Internal
Alice Beardmore-Gray, Nicola Vousden, Paul T. Seed, Bellington Vwalika, Sebastian Chinkoyo, Victor Sichone, Alexander B. Kawimbe, Umesh Charantimath, Geetanjali Katageri, Mrutyunjaya B. Bellad, Laxmikant Lokare, Kasturi Donimath, Shailaja Bidri, Shivaprasad Goudar, Jane Sandall, Lucy C. Chappell, Andrew H. Shennan
Summary: This study aimed to evaluate the effectiveness of planned delivery between 34+0 and 36+6 weeks' gestation in reducing maternal mortality and morbidity without increasing perinatal complications in India and Zambia. The results showed that planned delivery did not significantly differ from expectant management in terms of maternal outcomes, but was non-inferior in terms of perinatal outcomes. Planned delivery also reduced the risk of severe maternal hypertension and stillbirth. Therefore, planned delivery from 34 weeks' gestation should be considered as an intervention to reduce pre-eclampsia associated mortality and morbidity in low-income or middle-income countries.
Article
Oncology
Zev A. Wainberg, Arun S. Singh, Gottfried E. Konecny, Kelly E. McCann, Jonathan Goldman, Bartosz Chmielowski, Richard S. Finn, Neil O'Brien, Erika Von Euw, Megan M. Price, Diego Martinez, Lisa Yonemoto, Meghan Brennan, John A. Glaspy, Dennis J. Slamon
Summary: This study aimed to investigate the efficacy and tolerability of low-dose chemotherapy in combination with a PARP inhibitor. The results showed that talazoparib with low-dose temozolomide or irinotecan demonstrated clinical activity in various types of cancers. Randomized trials are currently ongoing to further evaluate the combination therapy in small cell lung cancer and ovarian cancer.
CLINICAL CANCER RESEARCH
(2023)
Article
Endocrinology & Metabolism
Xiaofeng Xu, Jing Wang, Damin Zhu, Jiaqian Yin, Jinxian Liu, Xiao Wu, Wenjuan Yang, Qian Hu, Yu Ren, Zhiguo Zhang, Ping Zhou, Zhaolian Wei, Huijuan Zou, Yunxia Cao
Summary: This study found that the levels of HMGB1 were significantly higher in URSA patients, and low-dose aspirin can decrease the concentrations of HMGB1 and IFN-γ, providing a protective effect.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Satu-Maarit Bjorkstedt, Hannu Koponen, Hannu Kautiainen, Mika Gissler, Pirjo Pennanen, Johan G. Eriksson, Merja K. Laine
Summary: The impact of preconception severe mental disorders on pregnancy outcomes in primiparous women was evaluated in this study. The well-being of newborns was good despite the presence of severe mental disorders in the mothers. Depression and anxiety disorders were the most common severe mental health disorders.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Obstetrics & Gynecology
Ying Ye, Li Wen, Xiyao Liu, Lan Wang, Yamin Liu, Richard Saffery, Mark D. Kilby, Chao Tong, Hongbo Qi, Philip Baker
Summary: The study found that the use of low-dose aspirin in twin pregnancies significantly reduced the risk of preeclampsia and preterm birth, with possible benefits in lowering the rate of small for gestational age babies. Furthermore, the use of low-dose aspirin did not increase the risk of postpartum hemorrhage.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Multidisciplinary Sciences
Amy E. Millen, Runda Dahhan, Jo L. Freudenheim, Kathleen M. Hovey, Lu Li, Daniel McSkimming, Chris A. Andrews, Michael J. Buck, Michael J. LaMonte, Keith L. Kirkwood, Yijun Sun, Vijaya Murugaiyan, Maria Tsompana, Jean Wactawski-Wende
Summary: Limited research exists on the association between carbohydrate intake and oral microbiome diversity and composition. This study investigated the relationship between carbohydrate intake and the oral microbiome in post-menopausal women. The results showed that higher intake of total carbohydrates, glycemic load, starch, lactose, and sucrose were negatively associated with oral microbiome diversity. The microbial composition also varied based on the intake of carbohydrates and glycemic load. Specific bacteria were associated with the intake of sucrose, glycemic load, and lactose.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Howard D. Sesso, Pamela M. Rist, Aaron K. Aragaki, Susanne Rautiainen, Lisa G. Johnson, Georgina Friedenberg, Trisha Copeland, Allison Clar, Samia Mora, M. Vinayaga Moorthy, Ara Sarkissian, Jean Wactawski-Wende, Lesley F. Tinker, William R. Carrick, Garnet L. Anderson, JoAnn E. Manson
Summary: Daily use of multivitamin-multimineral (MVM) supplements did not significantly decrease the incidence of total cancer among older adults, but had a protective effect on lung cancer.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Ako Adams Ako, Yvonne L. Michael, Lucy F. Robinson, Jean Wactawski-Wende, Aladdin H. Shadyab, Lorena Garcia, Bede N. Nriagu, Nazmus Saquib, Rami Nassir, Simin Liu, Robert B. Wallace
Summary: This study found that postmenopausal women with gallbladder disease have an increased risk of developing type 2 diabetes, especially among those with central obesity. The results support further research to determine whether interventions in older women with gallbladder disease would reduce the risk of type 2 diabetes.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Oncology
Rita Peila, Mace Coday, Tracy E. Crane, Nazmus Saquib, Aladdin H. Shadyab, Fred K. Tabung, Xiochen Zhang, Jean Wactawski-Wende, Thomas E. Rohan
Summary: This study found that a healthy lifestyle is associated with a reduced risk of pancreatic cancer in postmenopausal women.
CANCER CAUSES & CONTROL
(2022)
Meeting Abstract
Oncology
Rebecca Nelson, Kathy Pan, Rowan Chlebowski, Thomas E. Rohan, Joanne Mortimer, Jean Wactawski-Wende, Dorothy Lane, Laura Kruper
Article
Public, Environmental & Occupational Health
Jonathan Fix, Macarius M. Donneyong, Stephen R. Rapp, Maryam Sattari, Beverly M. Snively, Jean Wactawski-Wende, Emily W. Gower
Summary: Predictors associated with pneumococcal and seasonal influenza vaccination among older women include race, health insurance, and residential area. The study emphasizes the need to improve access, education, and provider recommendations for vaccination.
PUBLIC HEALTH REPORTS
(2023)
Article
Geriatrics & Gerontology
Bonnie C. Sachs, Sarah A. Gaussoin, Gretchen A. Brenes, Ramon Casanova, Rowan T. Chlebowski, Jiu-Chiuan Chen, Juhua Luo, Stephen R. Rapp, Aladdin H. Shadyab, Sally Shumaker, Jean Wactawski-Wende, Gretchen L. Wells, Kathleen M. Hayden
Summary: The relationship between optimism and cognitive functioning is not fully understood. This study found that less pessimism was associated with a lower risk of mild cognitive impairment (MCI) and dementia, while more optimism did not have a significant relationship with these conditions.
AGING & MENTAL HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Alexi Vasbinder, Richard K. Cheng, Susan R. Heckbert, Hilaire Thompson, Oleg Zaslavksy, Rowan T. Chlebowski, Aladdin H. Shadyab, Lisa Johnson, Jean Wactawski-Wende, Gretchen Wells, Rachel Yung, Lisa Warsinger Martin, Electra D. Paskett, Kerryn Reding
Summary: This study aimed to investigate the associations between biomarkers and long-term radiation-induced cardiovascular disease (RICVD) in breast cancer survivors. The results showed that a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting that oxidative DNA damage may be a potential pathway for RICVD.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lindsey J. Mattick, Jennifer W. Bea, Kathy M. Hovey, Jean Wactawski-Wende, Jane A. Cauley, Carolyn J. Crandall, Lili Tian, Heather M. Ochs-Balcom
Summary: We investigated the effects of two endogenous hormones on bone health in older women. Higher levels of follicle-stimulating hormone (FSH) were associated with bone disease, particularly in lower levels of estradiol. FSH attenuates the relationship between estradiol and bone density, which may have implications for future clinical interventions on bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Hailey R. Banack, Michael J. LaMonte, JoAnn E. Manson, Kexin Zhu, William J. Evans, Mahalakshmi Shankaran, Jean Wactawski-Wende
Summary: This study found an association between D3Cr muscle mass and insulin-glucose homeostasis, and that obesity is a stronger predictor of insulin resistance compared to muscle mass.
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Aaron Holman-Vittone, Brian Monahan, Erin S. LeBlanc, Simin Liu, Rami Nassir, Nazmus Saquib, Peter F. Schnatz, Aladdin H. Shadyab, Rachel Sinkey, Jean Wactawski-Wende, Robert A. Wild, Lisa Chasan-Taber, JoAnn E. Manson, Cassandra N. Spracklen
Summary: Preterm birth is associated with increased risk of developing type 2 diabetes at an earlier age, but not with overall risk of incident type 2 diabetes. The association between preterm birth and type 2 diabetes may exist during early years but wane over time.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sandi L. Navarro, G. A. Nagana Gowda, Lisa F. Bettcher, Robert Pepin, Natalie Nguyen, Mathew Ellenberger, Cheng Zheng, Lesley F. Tinker, Ross L. Prentice, Ying Huang, Tao Yang, Fred K. Tabung, Queenie Chan, Ruey Leng Loo, Simin Liu, Jean Wactawski-Wende, Johanna W. Lampe, Marian L. Neuhouser, Daniel Raftery
Summary: Demographic and clinical factors have an influence on the metabolome. A study on 444 post-menopausal women found correlations between serum and urine metabolites and demographic and clinical parameters.
Article
Medicine, General & Internal
Diddier Prada, Carolyn J. Crandall, Allison Kupsco, Marianthi-Anna Kioumourtzoglou, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Andrea Ramirez, Jean Wactawski-Wende, Yike Shen, Gary Miller, Iuliana Ionita-Laza, Eric A. Whitsel, Andrea A. Baccarelli
Summary: Osteoporosis has a major impact on postmenopausal women, and it is influenced by environmental exposures. This study found that criteria air pollutants, such as PM10, NO, NO2, and SO2, were negatively associated with bone mineral density in postmenopausal women. Nitrogen oxides exposure was identified as the leading contributor to bone loss in this population.
Article
Oncology
Ana Babic, Qiao-Li Wang, Alice A. Lee, Chen Yuan, Nader Rifai, Juhua Luo, Fred K. Tabung, Aladdin H. Shadyab, Jean Wactawski-Wende, Nazmus Saquib, Jihye Kim, Peter Kraft, Howard D. Sesso, Julie E. Buring, Edward L. Giovannucci, JoAnn E. Manson, Meir J. Stampfer, Kimmie Ng, Charles S. Fuchs, Brian M. Wolpin
Summary: The study found that high levels of adiponectin in the prediagnostic period were associated with shorter survival among women with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR were associated with patient survival.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)