Review
Medicine, General & Internal
Martin Gorsky, Agnes Arnold-Forster
Summary: The Lancet, a medical journal with 200 years of history, has made significant contributions to shaping medicine in the UK and internationally. Through publishing pioneering articles and advocating for better healthcare, it has consistently worked towards the betterment of society.
Review
Medicine, General & Internal
Roger Williams, Charles Alessi, Graeme Alexander, Michael Allison, Richard Aspinall, Rachel L. Batterham, Neeraj Bhala, Natalie Day, Anil Dhawan, Colin Drummond, James Ferguson, Graham Foster, Ian Gilmore, Raphael Goldacre, Harriet Gordon, Clive Henn, Deirdre Kelly, Alastair MacGilchrist, Roger McCorry, Neil McDougall, Zulfiquar Mirza, Kieran Moriarty, Philip Newsome, Richard Pinder, Stephen Roberts, Harry Rutter, Stephen Ryder, Marianne Samyn, Katherine Severi, Nick Sheron, Douglas Thorburn, Julia Verne, John Williams, Andrew Yeoman
Summary: This review addresses the high mortality of liver disease patients in acute hospitals and emphasizes the need for integrated clinical services. It proposes the establishment of regional liver centers and emphasizes on early diagnosis and alcohol care teams to improve patient care and overall survival rates.
Article
Environmental Sciences
S. A. Rothwell, K. J. Forber, C. J. Dawson, J. L. Salter, R. M. Dils, H. Webber, J. Maguire, D. G. Doody, P. J. A. Withers
Summary: The UK food system heavily relies on imported phosphorus to meet its food production demand. However, inefficient use and poor management of phosphorus have led to its accumulation in agricultural soils, loss to aquatic environments, and wastage. This study identifies three key areas of inefficiency: agricultural soil surplus and accumulation, loss to aquatic environments, and disposal to landfill and construction. Improving the handling and recovery of phosphorus from manures, biosolids, and food system waste is crucial to enhance phosphorus efficiency and reduce accumulation and losses.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Editorial Material
Geosciences, Multidisciplinary
Natasha Dowey, Jenni Barclay, Ben Fernando, Sam Giles, Jacqueline Houghton, Christopher Jackson, Anjana Khatwa, Anya Lawrence, Keely Mills, Alicia Newton, Steven Rogers, Rebecca Williams
Summary: Geoscientists are crucial in addressing the challenges of the 21st century, but it is important for the field to tackle issues of diversity and inclusion. Steps need to be taken in the UK to improve racial diversity in the geosciences and create a more equitable environment.
Article
Multidisciplinary Sciences
Celeste McCracken, Zahra Raisi-Estabragh, Michele Veldsman, Betty Raman, Andrea Dennis, Masud Husain, Thomas E. Nichols, Steffen E. Petersen, Stefan Neubauer
Summary: This study explores the cross-sectional relationships across the heart-brain-liver axis using state-of-the-art imaging techniques. Significant associations between imaging-derived phenotypes of the heart, brain, and liver were observed, even after controlling for various demographic and clinical factors. Simultaneous three-organ modeling revealed differentially important pathways across the heart-brain-liver axis.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Theresa J. Hydes, Oliver J. Kennedy, Ryan Buchanan, Daniel J. Cuthbertson, Julie Parkes, Simon D. S. Fraser, Paul Roderick
Summary: Having non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular events (CVE) and worse survival in individuals with chronic kidney disease (CKD). The presence of NAFLD fibrosis is also associated with a higher risk of CVE and worse survival.
Review
Public, Environmental & Occupational Health
Ayesha I. T. Tulloch, Fiona Borthwick, Diana Bogueva, Mahmoud Eltholth, Amanda Grech, Dylan Edgar, Sinead Boylan, Geraldine McNeill
Summary: The EAT-Lancet Commission's report on food in the Anthropocene in 2019 proposed a planetary health diet to improve global health and reduce the environmental impact of food systems. Through a systematic review of articles from January 2019 to April 2021, it was found that the Commission had influenced a significant number of academic articles in terms of methods, results, and discourse. The influence was seen across various disciplines, including life sciences, health and medical sciences, and social sciences. Positive sentiments expressed the benefits of informing policy, public health, and raising awareness, while negative sentiments highlighted concerns regarding socioeconomic dimensions, feasibility, and non-emission environmental effects.
LANCET GLOBAL HEALTH
(2023)
Article
Endocrinology & Metabolism
Wencong Du, Haoyu Guan, Xinglin Wan, Zheng Zhu, Hao Yu, Pengfei Luo, Lulu Chen, Jian Su, Yan Lu, Dong Hang, Ran Tao, Ming Wu, Jinyi Zhou, Xikang Fan
Summary: This study found that the levels of circulating liver function markers were nonlinearly associated with the risk of COPD. Lower levels of ALT, TBIL, ALB, and TP and higher levels of GGT and ALP were associated with elevated COPD risk. AST levels showed a U-shaped relationship with COPD risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Oveis Jamialahmadi, Federica Tavaglione, Araz Rawshani, Charlotta Ljungman, Stefano Romeo
Summary: Sufficient evidence supports the link between fatty liver disease and cardiac dysfunction and remodelling, which can lead to cardiovascular disease and heart failure. This study found that fatty liver disease is independently associated with higher heart rate, cardiac remodelling, and reduced ventricular volumes.
LIVER INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Steven Masson, Helen Aldersley, Joanna A. Leithead, Ed Day, Andrew Langford, Pamela Healy, John O'Grady, Douglas Thorburn, Charlotte Parker, Liz Shepherd, Katherine Arndtz, Kerry Webb, Andrew Holt
Summary: Liver disease, particularly liver cirrhosis, is a significant cause of premature death in England, with mortality rates increasing by 25% in the last decade. Alcohol consumption is the main modifiable risk factor for disease progression in these patients, but there is variability in the distribution and outcomes of alcohol-related liver disease in the UK, with unequal access to tertiary transplantation services. A panel of experts in the UK has issued revised recommendations to standardize clinical management, improve quality of care, and enhance access to liver transplant assessment for patients with alcohol-related liver disease.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Yu Jia, Dongze Li, Yi You, Jing Yu, Wenli Jiang, Yi Liu, Rui Zeng, Zhi Wan, Yi Lei, Xiaoyang Liao
Summary: Metabolic dysfunction-associated fatty liver disease (MAFLD) is associated with various health conditions and causes of death. Intermediate diseases such as asthma, diabetes, and hypertension, and end-stage conditions such as organ failure and infectious diseases are attributed to MAFLD.
Article
Gastroenterology & Hepatology
Gwilym J. Webb, Ronan P. Ryan, Tom P. Marshall, Gideon M. Hirschfield
Summary: A retrospective cohort study using UK primary care records found a positive correlation between a more northerly latitude and the incidence of PBC and AIH, but not PSC. Further research is needed to confirm and explain this association.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Urology & Nephrology
Philip Kam-Tao Li, Gordon Chun-Kau Chan, Jianghua Chen, Hung-Chun Chen, Yuk-Lun Cheng, Stanley L-S Fan, John Cijiang He, Weixin Hu, Wai-Hon Lim, York Pei, Boon Wee Teo, Ping Zhang, Xueqing Yu, Zhi-Hong Liu
Summary: CKD is a global problem that requires early detection, prompt treatment, promotion of home-based dialysis therapy, and kidney transplantation for effective management.
Article
Nutrition & Dietetics
Wen Guo, Xinyuan Ge, Jing Lu, Xin Xu, Jiaxin Gao, Quanrongzi Wang, Ci Song, Qun Zhang, Chengxiao Yu
Summary: This large prospective cohort study reveals that an increased intake of food from the Western dietary pattern could be correlated with an increased risk of chronic liver diseases, while the prudent pattern was only correlated with a reduced risk of liver cirrhosis. Higher consumption of red meat and lower consumption of fruit, cereal, tea, and dietary fiber were significantly associated with a higher risk of NAFLD, cirrhosis, and liver cancer.
Article
Public, Environmental & Occupational Health
Oliver J. Kennedy, Jonathan A. Fallowfield, Robin Poole, Peter C. Hayes, Julie Parkes, Paul J. Roderick
Summary: The study found that all types of coffee are protective against chronic liver disease, which is significant given the increasing incidence of CLD worldwide and the potential of coffee as an intervention to prevent CLD onset or progression.