Article
Obstetrics & Gynecology
Vivak Hansrani, David Riding, Mourad W. W. Seif, Ann-Louise Caress, Katherine Payne, Jonathan Ghosh, Charles N. N. McCollum
Summary: This study found that transvenous occlusion of incompetent pelvic veins can effectively improve symptoms and quality of life in women with chronic pelvic pain (CPP), based on a randomized controlled trial.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Bruce L. Wilkoff, Gerasimos Filippatos, Christophe Leclercq, Michael R. Gold, Ahmad S. Hersi, Kengo Kusano, Wilfried Mullens, Michael Felker, Charan Kantipudi, Mikhael F. El-Chami, Vidal Essebag, Bertrand Pierre, Francois Philippon, Francisco Perez-Gil, Eugene S. Chung, Juan Sotomonte, Stanley Tung, Balbir Singh, Babak Bozorgnia, Satish Goel, Hans Holger Ebert, Niraj Varma, Kara J. Quan, Fiorella Salerno, Bart Gerritse, Janelle van Wel, Daniel E. Schaber, Dedra H. Fagan
Summary: Compared with conventional CRT, adaptive CRT did not significantly reduce the incidence of all-cause death or intervention for heart failure decompensation in the included population of patients with heart failure, left bundle branch block, and intact AV conduction. Death and heart failure decompensation rates were low with both CRT therapies, suggesting a greater response to CRT occurred in this population than in patients in previous trials.
Article
Medicine, General & Internal
Huan Chen, Xiaoxu Liu, Yan Yan, Hangyu Shi, Zhishun Liu
Summary: This study aims to evaluate the efficacy and safety of electroacupuncture in relieving symptoms of POP stage II and III among women. A randomized controlled trial will be conducted to compare electroacupuncture with sham electroacupuncture. The results of this study are expected to be published in peer-reviewed journals.
Article
Pediatrics
Shripada Rao, Meera Esvaran, Liwei Chen, Anthony D. Keil, Ian Gollow, Karen Simmer, Bernd Wemheuer, Patricia Conway, Sanjay Patole
Summary: This study evaluated the effect of probiotic supplementation on gut dysbiosis in neonates with congenital gastrointestinal surgical conditions (CGISC). The results showed that probiotic supplementation reduced the relative abundance of potentially pathogenic families and increased the relative abundance of Bifidobacteriaceae.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Shripada Rao, Meera Esvaran, Liwei Chen, Anthony D. Keil, Ian Gollow, Karen Simmer, Bernd Wemheuer, Patricia Conway, Sanjay Patole
Summary: This study evaluated the effects of probiotic supplementation on gut dysbiosis in neonates with congenital gastrointestinal surgical conditions. The results showed that probiotic supplementation attenuated gut dysbiosis and significantly reduced the relative abundance of potentially pathogenic families, while increasing the relative abundance of Bifidobacteriaceae.
PEDIATRIC RESEARCH
(2022)
Article
Medicine, General & Internal
Bernd Loewe, Yvonne Nestoriuc, Viola Andresen, Eik Vettorazzi, Antonia Zapf, Sina Huebener, Kerstin Maehder, Luisa Peters, Ansgar W. Lohse
Summary: This study aims to compare the common and disease-specific factors in the persistence and modification of gastrointestinal symptoms in UC and IBS patients, and evaluate the effectiveness of improving symptoms by modifying dysfunctional symptom expectations and illness-related anxiety.
Article
Medicine, General & Internal
Anne Asnong, Andre D'Hoore, Marijke Van Kampen, Nele Devoogdt, An De Groef, Kim Sterckx, Hilde Lemkens, Albert Wolthuis, Yves Van Molhem, Bart Van Geluwe, Lynn Debrun, Inge Geraerts
Summary: This study aims to investigate the impact of pelvic floor muscle training on the quality of life after surgery for rectal cancer. The research design is a multicentre single blind prospective, randomised controlled trial, analyzing outcomes such as severity of bowel, urinary, and sexual dysfunction symptoms, as well as quality of life.
Article
Medicine, General & Internal
Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Naveena Singh, Andy Ryan, Chloe Karpinskyj, Giulia Carlino, Julie Taylor, Susan K. Massingham, Maria Raikou, Jatinderpal K. Kalsi, Robert Woolas, Ranjit Manchanda, Rupali Arora, Laura Casey, Anne Dawnay, Stephen Dobbs, Simon Leeson, Tim Mould, Mourad W. Seif, Aarti Sharma, Karin Williamson, Yiling Liu, Lesley Fallowfield, Alistair J. McGuire, Stuart Campbell, Steven J. Skates, Ian J. Jacobs, Mahesh Parmar
Summary: The long-term follow-up of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) did not show a significant reduction in deaths due to ovarian or tubal cancer with screening. While there was an increase in early-stage cancer detection in the MMS group, it did not translate into lives saved, highlighting the importance of specifying cancer mortality as the primary outcome in screening trials. Consequently, general population screening for ovarian and tubal cancer cannot be recommended.
Article
Medicine, General & Internal
Melle Spruijt, Manon Kerkhof, Marian Rombouts, Richard Brohet, Wenche Klerkx
Summary: This randomized controlled trial aims to investigate the efficacy and safety of botulinum toxin A (BTA) injection compared with placebo injections in women with chronic pelvic pain. The study includes 94 women with at least 6 months of pelvic pain without anatomical cause and pelvic floor hypertonicity. The findings will be disseminated through international conferences and peer-reviewed scientific journals.
Article
Psychology, Clinical
Trudie Chalder, Meenal Patel, Matthew Hotopf, Rona Moss-Morris, Mark Ashworth, Katie Watts, Anthony S. David, Paul McCrone, Mujtaba Husain, Toby Garrood, Kirsty James, Sabine Landau
Summary: This study evaluated the clinical efficacy and cost-effectiveness of a therapist-delivered, transdiagnostic cognitive behavioural intervention (TDT-CBT) plus standard medical care (SMC) versus SMC alone for the treatment of patients with medically unexplained symptoms (PPS). The results showed that TDT-CBT + SMC may have a treatment effect on certain secondary outcomes, but further research is needed to confirm these findings.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Fei-Wan Ngai, Ling-Ling Gao
Summary: This study demonstrates significant and sustained reduction in depressive symptoms for Chinese couples at 6 weeks and 6 months postpartum, highlighting the importance of incorporating couple-based IPT into perinatal services.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Cheng Chen, Bangwei Zeng, Dan Xue, Rongxiang Cao, Siqin Liao, Yong Yang, Zhihua Li, Mingqiang Kang, Chun Chen, Benhua Xu
Summary: This study aims to evaluate the efficacy and safety of pirfenidone in preventing radiation-induced lung injury (RILI) in patients with oesophageal squamous cell carcinoma (ESCC) during thoracic radiation therapy. The study design is a randomized, placebo-controlled phase 2 trial, with the primary endpoint being the incidence of lung injury.
Article
Medicine, General & Internal
Sophie Ansems, Marjolein Berger, Patrick van Rheenen, Karin Vermeulen, Gina Beugel, Maria Couwenberg, Gea Holtman
Summary: This study aims to evaluate whether a testing strategy including FCal-POCT can reduce the referral rate of children with chronic gastrointestinal symptoms. It plans to recruit 158 GP practices to recruit 406 children for a pragmatic cluster randomised controlled trial.
Article
Gastroenterology & Hepatology
Caecilie Crawley, Nadia Savino, Cecilie Halby, Stine Dydensborg Sander, Anne-Marie Nybo Andersen, Manimozhiyan Arumugam, Joseph Murray, Robin Christensen, Steffen Husby
Summary: This study investigated whether gluten induces gastrointestinal symptoms and mental health symptoms in adolescents. The results showed that compared with placebo, adding gluten to the diet did not induce gastrointestinal symptoms or worsened mental health.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
H. Jervoise N. Andreyev, Jennifer Matthews, Carolyn Adams, Lone Gothard, Claire Lucy, Holly Tovey, Sue Boyle, Selvakumar Anbalagan, Annette Musallam, John Yarnold, David Abraham, Judith Bliss, Bahja Ahmed Abdi, Alexandra Taylor, Martin Hauer-Jensen
Summary: This study aimed to test the efficacy of Tocovid SupraBio and pentoxifylline in improving gastrointestinal symptoms after radiotherapy. However, no clinical benefit was demonstrated. Biochemical data suggest that this intervention has anti-inflammatory and anti-fibrotic effects.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Geriatrics & Gerontology
Vasileios Stamou, Jenny La Fontaine, Heather Gage, Bridget Jones, Peter Williams, Mary O'Malley, Jacqueline Parkes, Janet Carter, Jan Oyebode
Summary: Young onset dementia patients and family members have distinctive support needs, with specialist services showing better quality and satisfaction. More specialist services are needed to ensure access to appropriate care for all young onset dementia patients.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Nursing
Adam Black, Molly Courtenay, Christine Norton, Bryony Dean Franklin, Trevor Murrells, Heather Gage
Summary: The study found that nurse medication provision by both nurse prescribers and patient group direction users is safe and associated with high patient satisfaction. Effects on clinic processes and costs were similar for both groups, indicating that both methods are effective in providing medication services.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Nursing
Adam Black, Heather Gage, Christine Norton, Bryony Dean Franklin, Trevor Murrells, Molly Courtenay
Summary: The survey results showed that patients managed by independent nurse prescribers and nurses using patient group directions were highly satisfied with the consultation and medication information received. Patients reported that nurses were friendly, instilled confidence and trust, and explained medication reasons clearly.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Gastroenterology & Hepatology
Anna Jones, Kay Rodgers, Debbie Jeffrey, Waqas Ali, H. J. N. Andreyev
Summary: Immune checkpoint inhibition is a common treatment for advanced cancers, but its side effects may hinder its effectiveness. Current management recommendations mainly focus on oncology rather than gastroenterology. This report highlights a case of pancreatic insufficiency in a patient receiving PD-1 inhibitor therapy. This problem affects approximately 1 in 100 patients but often goes unrecognized. Gastroenterologists should be aware of the range of gastrointestinal disorders that may occur after immunotherapy for cancer.
FRONTLINE GASTROENTEROLOGY
(2023)
Article
Oncology
H. Jervoise N. Andreyev, Jennifer Matthews, Carolyn Adams, Lone Gothard, Claire Lucy, Holly Tovey, Sue Boyle, Selvakumar Anbalagan, Annette Musallam, John Yarnold, David Abraham, Judith Bliss, Bahja Ahmed Abdi, Alexandra Taylor, Martin Hauer-Jensen
Summary: This study aimed to test the efficacy of Tocovid SupraBio and pentoxifylline in improving gastrointestinal symptoms after radiotherapy. However, no clinical benefit was demonstrated. Biochemical data suggest that this intervention has anti-inflammatory and anti-fibrotic effects.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Philip H. Pucher, Annie Coombes, Orla Evans, Joanna Taylor, Jonathan L. Moore, Annabelle White, Jesper Lagergren, Cara Baker, Mark Kelly, James A. Gossage, Jason Dunn, Sebastian Zeki, Ben E. Byrne, Jervoise Andreyev, Andrew R. Davies
Summary: This study surveyed patients who underwent oesophago-gastric surgery to understand their preferences and satisfaction regarding post-operative follow-up. The results showed that longer follow-up and involvement of dietitians improved patient satisfaction.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Multidisciplinary Sciences
Dennis Poon, Graham R. Law, Giles Major, H. Jervoise N. Andreyev
Summary: Treatable gastrointestinal disorders may be overlooked in patients with symptoms typical for irritable bowel syndrome (IBS). Prevalence rates of various gastrointestinal conditions were assessed in consecutive patients meeting diagnostic criteria for IBS, including bile acid diarrhea, carbohydrate malabsorption, microscopic colitis, pancreatic exocrine insufficiency, and small intestinal bacterial overgrowth. The rates of these conditions were significantly higher than in healthy controls, suggesting that a significant proportion of patients with IBS may have an underlying organic condition explaining their symptoms.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Darren C. R. Fernandes, Sangeetha Srinivasan, Hubert Jervoise N. Andreyev
Summary: Our case highlights the importance of appropriate radiological imaging and alerts clinicians to consider osteomyelitis as a differential diagnosis in patients presenting with severe anorectal pain after treatment for rectal cancer.
OXFORD MEDICAL CASE REPORTS
(2022)
Review
Microbiology
Darren Fernandes, Jervoise Andreyev
Summary: The human gut microbiome plays a crucial role in regulating host physiology, with the microbiota and the gut working together in a stable state. Various factors, including disease states and treatments, can affect the overall stability of the intestinal flora. This review compares the well-characterized abnormalities in the microbiome in idiopathic inflammatory bowel disease and radiation enteropathy, and discusses how these changes may function at a molecular level and the potential role of manipulating the microbiome to reduce the severity of the underlying condition.
Article
Medicine, Research & Experimental
Mirthe Muilwijk, Marie Loh, Sara Mahmood, Saranya Palaniswamy, Samreen Siddiqui, Wnurinham Silva, Gary S. Frost, Heather M. Gage, Marjo-Riitta Jarvelin, Ravindra P. Rannan-Eliya, Sajjad Ahmad, Sujeet Jha, Anuradhani Kasturiratne, Prasad Katulanda, Khadija Khawaja, Jaspal S. Kooner, Ananda R. Wickremasinghe, Irene G. M. van Valkengoed, John C. Chambers
Summary: The iHealth-T2D trial aims to compare the effectiveness of an intensive family-based lifestyle modification programme for South Asians at high risk of T2D with usual care. The trial includes a total of 3682 participants across India, Pakistan, Sri Lanka and the UK, and evaluates primary and secondary outcomes over a period of 3 years.
Letter
Oncology
Miguel R. Ferreira, Jervoise N. Andreyev, Linda Wedlake, David P. Dearnaley
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Andrew Davies, Melanie Waghorn, Megan Roberts, Heather Gage, Simon S. Skene
Summary: The 'CHELsea II' trial is a cluster randomised trial aiming to evaluate the effect of clinically assisted hydration (CAH) in patients in the last days of life. The trial will assess the impact of CAH on delirium, pain, and overall survival, as well as the tolerability and health economic impact of CAH. The results of the trial will be published in medical/palliative care journals and presented at conferences.
Article
Geriatrics & Gerontology
Khalid Ali, Ekow A. Mensah, Eugene Ace McDermott, Frances A. Kirkham, Jennifer Stevenson, Victoria Hamer, Nikesh Parekh, Rebekah Schiff, Tischa Van der Cammen, Stephen Nyangoma, Sally Fowler-Davis, Graham Davies, Heather Gage, Chakravarthi Rajkumar
Summary: This study aims to reduce medication-related harm (MRH) among older adults after hospital discharge by combining a Medicines Management Plan (MMP) and Discharge Medical Service (DMS). The study uses a randomized control trial design and recruits 682 older adults aged 65 and above who are about to be discharged from the hospital. The occurrence of MRH will be verified through telephone interviews and review of medical records. An economic and process evaluation will also be conducted to assess the cost and acceptability of the study methods.
Article
Gastroenterology & Hepatology
Alok Mathew, Darren Fernandes, H. Jervoise N. Andreyev
Summary: This retrospective study reports that pancreatic enzyme replacement therapy (PERT) may lead to improvement in gastrointestinal symptoms in patients with faecal elastase-1 (FE-1) levels between 200 and 500 mu g/g. A clinical response was seen in 71% of the patients, particularly in those with potentially predisposing conditions and functional diarrhoea.
FRONTLINE GASTROENTEROLOGY
(2023)
Article
Endocrinology & Metabolism
Morro M. L. Touray, David R. Cohen, Simon Robert Pask Williams, Mohammed Fasihul Alam, Sam Groves, Mirella Longo, Heather Gage
Summary: This study explores the relationship between bodyweight and individuals' time preference, finding that individuals with normal weight tend to have lower time preference and are more likely to invest in future health benefits. Additionally, significant relationships are found between bodyweight and employment status, physical activities, income levels, family orientation, and ethnicity. These findings have important implications for designing intervention programs to prevent overweight and obesity.