Article
Public, Environmental & Occupational Health
Kwadwo Asamoah Kusi, William van der Puije, Diana A. Asandem, Rawdat Baba-Adam, Hardy Agbevey, Bright Asare, Philip Segbefia, Lutterodt Bentum-Ennin, Audrey Annan, Frank Osei, Doreen Teye-Adjei, Elsie Sutaya Galevo, Gifty Odame, Gloria Ansa, Linda Amoah, Joseph Humphrey Kofi Bonney
Summary: In Ghana, there is a high prevalence of Hepatitis B virus (HBV) infection, but low vaccine coverage among adults. To address this issue, a community engagement and public-private partnership project was conducted, offering awareness and screening services for HBV to the community. The project achieved a 66% vaccination success rate and highlighted the importance of different approaches in raising awareness and implementing vaccination programs.
Review
Food Science & Technology
Jie Dan, Shuo Shi, Hao Sun, Zehui Su, Yanmin Liang, Jianlong Wang, Wentao Zhang
Summary: Food poisoning and environmental pollution are major threats to global public health and agricultural resources. Micro/nanomotors show great potential as a high-speed platform for detecting and removing food contaminants, and are an emerging technology that is moving towards mass production and important functions in food applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Maria Buti, Antonio Craxi, Graham R. Foster, Mojca Maticic, Francesco Negro, Stefan Zeuzem, Fabien Zoulim
Summary: This study focuses on the elimination of chronic viral hepatitis and explores the issues of goal setting and measurement.
JOURNAL OF HEPATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Adam Lavertu, Bianca Vora, Kathleen M. Giacomini, Russ Altman, Stefano Rensi
Summary: Adverse drug reactions are a major concern, leading to mandatory measures such as phase IV clinical trials and black box warnings. Real-world data and digital technologies are being used to inform decision making and ensure drug safety, however, they also present challenges in drug development.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Immunology
Amber N. Carrier, Anjali Verma, Muhammad Mohiuddin, Manuel Pascual, Yannick D. Muller, Alban Longchamp, Chandra Bhati, Leo H. Buhler, Daniel G. Maluf, Raphael P. H. Meier
Summary: Organ allotransplantation is hindered by the limited supply of human donor organs. Xenotransplantation has the potential to address this shortage by using organs from pigs with gene editing. Recent research progress in the United States includes successful trials of pig-to-human heart and kidney xenotransplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Biology
Matt Kaeberlein, Jessica K. Tyler
Summary: eLife is publishing a special issue on aging, geroscience and longevity to highlight the significant progress made in this field over the past decade, with a focus on mechanistic understanding and translational approaches with potential clinical impact.
Article
Infectious Diseases
Nattachai Srisawat, Usa Thisyakorn, Zulkifli Ismail, Kamran Rafiq, Duane J. Gubler
Summary: The ISNTD-ADVA World Dengue Day Forum held in June 2021 aimed to achieve international and multisectoral coordination in dengue control efforts. Experts around the world shared their strategies and best practices to tackle the growing threat of dengue, emphasizing the importance of sustained vector control, surveillance, case management, vaccine advocacy, capacity building, political commitment, and community engagement. The forum called for the establishment of World Dengue Day to improve global awareness, share best practices, and prioritize preparedness in the fight against dengue.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Chemistry, Medicinal
Abhishek Ranga, Aarti Gupta, Laxmi Yadav, Sachin Kumar, Priti Jain
Summary: Hepatitis B virus (HBV) is a genetically diverse blood-borne virus responsible for chronic hepatitis B. This study reviews various chemical classes developed to target different domains of the HBV polymerase and explores host factors that interact with the polymerase. A detailed analysis of the inhibitors' scope, limitations, and structure-activity relationship is provided, which can support the further development of more efficient inhibitors for HBV replication.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Gastroenterology & Hepatology
Efthymios P. Tsounis, Evanthia Tourkochristou, Athanasia Mouzaki, Christos Triantos
Summary: In summary, current treatment strategies for hepatitis B virus (HBV) infection are efficient in suppressing viral replication but face challenges in achieving a complete cure. Therefore, researchers are exploring innovative therapeutic approaches such as direct-acting antivirals and immune modulators, as well as breakthrough technologies like immune checkpoint inhibitors and genetically engineered T cells to elicit potent immune responses against HBV. Additionally, combination therapy involving multiple drugs is increasingly recognized as a necessary regimen for the elimination of HBV.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
News Item
Multidisciplinary Sciences
Anil Oza
Summary: The US National Science Foundation plans to utilize the historic site for biology and computer science education.
Review
Biochemistry & Molecular Biology
Einat Zalckvar, Maya Schuldiner
Summary: Metabolism is emerging as a central influencer of multiple disease states in humans, and the decreased function of peroxisomes is linked to various common diseases. However, research on the mechanisms underlying the contributions of peroxisomes to these diseases is still limited.
Editorial Material
Biochemistry & Molecular Biology
Abie Rohrig, Nir Eyal
Summary: This article describes the publication of the world's first COVID-19 human challenge trial two years into the pandemic. It reviews the findings and explains why conducting additional challenge trials for COVID-19 and other diseases is justified and important at this particular juncture.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Substance Abuse
Kate Seear, Suzanne Fraser, Adrian Farrugia, Kylie Valentine
Summary: The discussion on Australia's investment and prospects for hepatitis C treatment raises questions about the expectations post-cure lives. The authors argue that current treatment methods may lead to cognitive biases and propose a concept called "futurology of hepatitis C" to transcend problematic temporal logics.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2021)
Editorial Material
Chemistry, Organic
Andrei Dragan
Summary: As AsianJOC approaches its 10th anniversary, there will be various exciting events to celebrate this milestone. New members from the international organic chemistry community will join the Editorial and International Advisory Boards.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Ting Huang, Tianyuan Zhang, Jianqing Gao
Summary: Mitochondria, as the main energy suppliers in cells, play a significant role in regulating cellular processes. Dysfunctional mitochondria have been found to be associated with various diseases, and supplementation of functional mitochondria is considered a potential therapeutic strategy. This review summarizes the latest findings on mitochondrial delivery strategies and provides an overview of the role of mitochondria, mechanisms of intercellular mitochondrial transfer, therapeutic benefits, challenges, and prospects of mitochondrial delivery. Understanding mitochondrial delivery has the potential to improve the therapeutic outcomes of mitochondrial dysfunctional diseases in the future.
JOURNAL OF CONTROLLED RELEASE
(2022)
