Review
Respiratory System
Neeraj M. Shah, Joerg Steier, Nicholas Hart, Georgios Kaltsakas
Summary: Chronic respiratory disease can worsen sleep quality, and non-invasive ventilation is a complex intervention used for improving sleep-disordered breathing and nocturnal hypoventilation. However, the impact on sleep quality depends on measurement tools and patient population.
Review
Critical Care Medicine
Rosanna Vaschetto, Alessandro Pecere, Gavin D. Perkins, Dipesh Mistry, Gianmaria Cammarota, Federico Longhini, Miguel Ferrer, Renata Pletsch-Assuncao, Michele Carron, Francesca Moretto, Haibo Qiu, Francesco Della Corte, Francesco Barone-Adesi, Paolo Navalesi
Summary: In patients with non-hypercapnic hypoxemic acute respiratory failure, early extubation followed by noninvasive ventilation (NIV) has been shown to reduce the duration of invasive mechanical ventilation, decrease the risk of ventilatory associated pneumonia, and shorten the overall time spent in ICU and hospital. This approach does not affect ICU mortality.
Article
Critical Care Medicine
Nicholas A. Barrett, Nicholas Hart, Kathleen J. R. Daly, Martina Marotti, Eirini Kostakou, Chris Carlin, Stephanie Lua, Suveer Singh, Andrew Bentley, Abdel Douiri, Luigi Camporota
Summary: This study demonstrates that the use of ECCO2R in AECOPD patients leads to a shorter time to improvement in arterial blood gases and patient comfort compared to NIV, with no severe complications. However, the ICU and hospital lengths of stay are longer with ECCO2R compared to NIV.
ANNALS OF INTENSIVE CARE
(2022)
Article
Pediatrics
Soutrik Seth, Bijan Saha, Anindya Kumar Saha, Suchandra Mukherjee, Avijit Hazra
Summary: The study found no significant difference in extubation failure rates between nHFOV and NIPPV in premature infants between 26 and 36 weeks of gestation. However, nHFOV showed potential benefits in improving feed tolerance rates and pCO2 elimination. Further larger multicentre studies are needed to explore the benefits of nHFOV.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Critical Care Medicine
Audrey De Jong, Anne Bignon, Francois Stephan, Thomas Godet, Jean-Michel Constantin, Karim Asehnoune, Aude Sylvestre, Juliette Sautillet, Raiko Blondonnet, Martine Ferrandiere, Philippe Seguin, Sigismond Lasocki, Amelie Rolle, Pierre-Marie Fayolle, Laurent Muller, Emmanuel Pardo, Nicolas Terzi, Severin Ramin, Boris Jung, Paer-Selim Abback, Philippe Guerci, Benjamine Sarton, Hadrien Roze, Claire Dupuis, Joel Cousson, Marion Faucher, Virginie Lemiale, Bernard Cholley, Gerald Chanques, Fouad Belafia, Helena Huguet, Emmanuel Futier, Elie Azoulay, Nicolas Molinari, Samir Jaber
Summary: This study compared non-invasive ventilation (NIV) and oxygen therapy (high-flow nasal oxygen [HFNO] or standard oxygen) following extubation in critically ill patients with obesity, and found that NIV was effective in reducing treatment failure within 3 days. The results are relevant to clinical practice and support the use of NIV after extubation in critically ill patients with obesity.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Biology
M. D. P. Godoy, L. C. de Souza, A. E. da Silva Neto, J. R. Lugon
Summary: The study aimed to determine whether the TIE index predicts successful extubation at a similar rate as the T-piece trial with less time required. A non-inferiority randomized controlled trial was conducted with ICU subjects, with 80 participants allocated to the TIE group and the T-piece group. The results showed that the TIE group had significantly lower time required for successful extubation compared to the T-piece group, and there were no significant differences in successful weaning and survival rate between the two groups.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yan Li, Qiufen Wei, Dan Zhao, Yan Mo, Liping Yao, Lingxiao Li, Wei Tan, Xinnian Pan, Jiayan Yao, Wei Dai, Danni Zhong
Summary: This study compared the effectiveness and safety of non-invasive high-frequency oscillatory ventilation (NHFOV), nasal intermittent positive pressure ventilation (NIPPV), and nasal continuous positive airway pressure (NCPAP) in post-extubation preterm infants. The results showed that NHFOV had a lower reintubation rate, shorter non-invasive ventilation duration and hospital stay, and reduced incidence of bronchopulmonary dysplasia compared to NIPPV and NCPAP. NHFOV also resulted in less nasal injury than NCPAP.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Emergency Medicine
Judith C. Finn, Deon Brink, Nicole Mckenzie, Antony Garcia, Hideo Tohira, Gavin D. Perkins, Glenn Arendts, Daniel M. Fatovich, Delia Hendrie, Brendan McQuillan, Quentin Summers, Antonio Celenza, Ashes Mukherjee, Ben Smedley, Gavin Pereira, Stephen Ball, Teresa Williams, Paul Bailey
Summary: The study demonstrates that prehospital CPAP by EMS paramedics can effectively reduce dyspnoea and tachypnoea in patients with severe respiratory distress, but does not impact hospital length of stay.
EMERGENCY MEDICINE JOURNAL
(2022)
Article
Medicine, Research & Experimental
Weipeng Jiang, Yuanlin Song
Summary: This study evaluates the effectiveness and safety of IOT-based noninvasive positive pressure ventilation for patients with chronic obstructive pulmonary disease. The randomized controlled trial compares the outcomes and safety of IOT-based management with usual treatment. The results will provide new evidence for future home ventilation treatment.
Article
Critical Care Medicine
Malcolm Lemyze, Jihad Mallat, Nicolas Vangrunderbeek, Maxime Granier
Summary: This study aimed to compare the use of under-the-nose face mask with standard over-the-nose face mask in patients with acute hypercapnic respiratory failure. The results showed that under-the-nose face mask significantly reduced the incidence of facial pressure sores compared to the standard face mask. However, a higher rate of unintentional air leaks with the new mask may necessitate switching to another interface.
CRITICAL CARE MEDICINE
(2023)
Review
Critical Care Medicine
N. Ovtcharenko, E. Ho, W. Alhazzani, A. Cortegiani, B. Ergan, R. Scala, G. Sotgiu, D. Chaudhuri, S. Oczkowski, K. Lewis
Summary: The current evidence suggests that in patients with acute hypercapnic respiratory failure, HFNC is not significantly more effective than NIV in reducing mortality, intubation rates, or hospital length of stay, and there is no difference in carbon dioxide pressure change between the two treatments.
Article
Pediatrics
Milena Tana, Anthea Bottoni, Francesco Cota, Patrizia Papacci, Alessia Di Polito, Arianna Del Vecchio, Anna Laura Vento, Benedetta Campagnola, Sefora Celona, Laura Cricenti, Ilaria Bastoni, Chiara Tirone, Claudia Aurilia, Alessandra Lio, Angela Paladini, Stefano Nobile, Alessandro Perri, Annamaria Sbordone, Alice Esposito, Simona Fattore, Paola Emilia Ferrara, Gianpaolo Ronconi, Giovanni Vento
Summary: This study evaluated the effect of early respiratory physiotherapy on the need for mechanical ventilation in preterm infants with respiratory failure during the first week of life. The results showed that early respiratory physiotherapy did not significantly reduce the need for mechanical ventilation, but it significantly reduced the occurrence of hemodynamically significant patent ductus arteriosus (PDA).
Article
Critical Care Medicine
Mickael Landais, Mai-Anh Nay, Johann Auchabie, Noemie Hubert, Aurelien Frerou, Aihem Yehia, Alain Mercat, Maud Jonas, Frederic Martino, Mikael Moriconi, Anne Courte, Vincent Robert-Edan, Alexandre Conia, Florent Bavozet, Pierre-Yves Egreteau, Cedric Bruel, Anne Renault, Olivier Huet, Marc Feller, Nicolas Chudeau, Martine Ferrandiere, Anne Rebion, Alain Robert, Bruno Giraudeau, Jean Reignier, Arnaud W. Thille, Elsa Tavernier, Stephan Ehrmann
Summary: This study compared the effects of continuing enteral nutrition until extubation versus fasting before extubation in ICU patients. The results showed that continuing enteral nutrition until extubation was non-inferior to fasting in terms of extubation failure within 7 days, suggesting it as a potential alternative strategy.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Yaseen M. Arabi, Haytham Tlayjeh, Sara Aldekhyl, Hasan M. Al-Dorzi, Sheryl Ann Abdukahil, Mohammad Khulaif Al Harbi, Husain Al Haji, Mohammed Al Mutairi, Omar Al Zumai, Eman Al Qasim, Wedyan Al Wehaibi, Saad Al Qahtani, Fahad Al-Hameed, Jamal Chalabi, Mohammed Alshahrani, Talal Albrahim, Abdulrahman Alharthy, Ahmed Mady, Abdulhadi Bin Eshaq, Ali A. Al Bshabshe, Zohair Al Aseri, Zainab Al Duhailib, Ayman Kharaba, Rakan Alqahtani, Adnan Al Ghamdi, Ali Altalag, Khalid Alghamdi, Mohammed Almaani, Haifa Algethamy, Ahmad Al Aqeily, Faisal Al Baseet, Hashem Al Samannoudi, Mohammed Al Obaidi, Yassin T. Ismaiel, Abdulrahman A. Al-Fares
Summary: This study compares the effectiveness of helmet NIV with usual care alone in reducing mortality in patients with COVID-19 pneumonia. A total of 320 patients will be enrolled, with the primary outcome being 28-day all-cause mortality.
Article
Critical Care Medicine
Bharath A. Chhabria, Kuruswamy Thurai Prasad, Sahajal Dhooria, Valliappan Muthu, Ashutosh Nath Aggarwal, Ritesh Agarwal, Raghava Rao Gandra, Inderpaul Singh Sehgal
Summary: This study compared the efficacy of neurally adjusted ventilator assist (NAVA-NIV) with adaptive support ventilation (ASV-NIV) in non-invasive ventilation (NIV) for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The results showed no significant difference between the two methods in reducing NIV failure rates, number of physician manipulations, asynchrony index, and 90-day mortality.
JOURNAL OF CRITICAL CARE
(2023)
Letter
Critical Care Medicine
Adrian Ceccato, Raquel Perez-Arnal, Anna Motos, Ferran Barbe, Antoni Torres
INTENSIVE CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Ignacio Martin-Loeches, Anna Motos, Rosario Menendez, Albert Gabarrus, Jessica Gonzalez, Laia Fernandez-Barat, Adrian Ceccato, Raquel Perez-Arnal, Dario Garcia-Gasulla, Ricard Ferrer, Jordi Riera, Jose Angel Lorente, Oscar Penuelas, Jesus F. Bermejo-Martin, David de Gonzalo-Calvo, Alejandro Rodriguez, Ferran Barbe, Luciano Aguilera, Rosario Amaya-Villar, Carme Barbera, Jose Barberan, Aaron Blandino Ortiz, Elena Bustamante-Munguira, Jesus Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalan-Gonzalez, Cristobal Galban, Victor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili Diaz, Elena Gallego, Jose Luis Garcia Garmendia, Jose Garnacho-Montero, Jose M. Gomez, Ruth Noemi Jorge Garcia, Ana Loza-Vazquez, Judith Marin-Corral, Amalia Martinez de la Gandara, Ignacio Martinez Varela, Juan Lopez Messa, Guillermo M. Albaiceta, Mariana Andrea Novo, Yhivian Penasco, Pilar Ricart, Luis Urrelo-Cerron, Angel Sanchez-Miralles, Susana Sancho Chinesta, Lorenzo Socias, Jordi Sole-Violan, Luis Tamayo Lomas, Pablo Vidal, Antoni Torres
Summary: Persistent post-COVID-19 symptoms were found in more than two-thirds of patients, with female sex, duration of ICU stay, development of ICUAP, and ARDS identified as independent factors contributing to poor health post-COVID-19. Preventing ICUAP may have beneficial effects on post-COVID-19 recovery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Antoni Torres, Ana Motos, Catia Cilloniz, Adrian Ceccato, Laia Fernandez-Barat, Albert Gabarrus, Jesus Bermejo-Martin, Ricard Ferrer, Jordi Riera, Raquel Perez-Arnal, Dario Garcia-Gasulla, Oscar Penuelas, Jose Angel Lorente, David de Gonzalo-Calvo, Raquel Almansa, Rosario Menendez, Andrea Palomeque, Rosario Amaya Villar, Jose M. Anon, Ana Balan Marino, Carme Barbera, Jose Barberan, Aaron Blandino Ortiz, Maria Victoria Boado, Elena Bustamante-Munguira, Jesus Caballero, Maria Luisa Canton-Bulnes, Cristina Carbajales Perez, Nieves Carbonell, Mercedes Catalan-Gonzalez, Raul de Frutos, Nieves Franco, Cristobal Galban, Victor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili Diaz, Angel Estella, Elena Gallego, Jose Luis Garcia Garmendia, Jose M. Gomez, Arturo Huerta, Ruth Noemi Jorge Garcia, Ana Loza-Vazquez, Judith Marin-Corral, Maria Cruz Martin Delgado, Amalia Martinez de la Gandara, Ignacio Martinez Varela, Juan Lopez Messa, Guillermo M. Albaiceta, Maite Nieto, Mariana Andrea Novo, Yhivian Penasco, Felipe Perez-Garcia, Juan Carlos Pozo-Laderas, Pilar Ricart, Victor Sagredo, Angel Sanchez-Miralles, Susana Sancho Chinesta, Mireia Serra-Fortuny, Lorenzo Socias, Jordi Sole-Violan, Fernando Suarez-Sipmann, Luis Tamayo Lomas, Jose Trenado, Alejandro Ubeda, Luis Jorge Valdivia, Pablo Vidal, Ferran Barbe
Summary: The use of corticosteroids in ICU-admitted patients with COVID-19 can reduce 90-day mortality, but early administration may be harmful. Different patient subgroups may have varied efficacy of corticosteroids based on factors such as age, severity of illness, baseline inflammation, and mechanical ventilation.
INTENSIVE CARE MEDICINE
(2022)
Editorial Material
Critical Care Medicine
Catia Cilloniz, Antoni Torres
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Catia Cilloniz, Logan Ward, Mads Lause Mogensen, Juan M. Pericas, Raul Mendez, Albert Gabarrus, Miquel Ferrer, Carolina Garcia-Vidal, Rosario Menendez, Antoni Torres
Summary: This study applies a CPN model to predict mortality in CAP patients and compares it with other scoring systems. The results show that the SeF-ML model has higher predictive accuracy, suggesting its potential for improving mortality prediction in CAP patients.
Letter
Infectious Diseases
Catia Cilloniz, Anna Motos, Tatiana Castaneda, Albert Gabarrus, Ferran Barbe, Antoni Torres
JOURNAL OF INFECTION
(2023)
Article
Biotechnology & Applied Microbiology
Rocco Mazzolini, Irene Rodriguez-Arce, Laia Fernandez-Barat, Carlos Pinero-Lambea, Victoria Garrido, Agustin Rebollada-Merino, Anna Motos, Antoni Torres, Maria Jesus Grillo, Luis Serrano, Maria Lluch-Senar
Summary: Engineered bacteria have been developed to effectively treat lung infections and dissolve biofilms associated with ventilator-associated pneumonia. These bacteria have been genetically modified to target and kill harmful bacteria in the lungs, providing a potential new treatment option for respiratory infections.
NATURE BIOTECHNOLOGY
(2023)
Review
Medicine, General & Internal
Huzaifa Ahmad Cheema, Amna Siddiqui, Sidhant Ochani, Alishba Adnan, Mahnoor Sukaina, Ramsha Haider, Abia Shahid, Mohammad Ebad Ur Rehman, Rehmat Ullah Awan, Harpreet Singh, Natalie Duric, Brigitta Fazzini, Antoni Torres, Tamas Szakmany
Summary: A meta-analysis was performed to evaluate the efficacy and safety of awake prone positioning (APP) in non-intubated patients with COVID-19-related acute hypoxemic respiratory failure and to identify the subpopulations that may benefit the most from it. The results showed that APP reduced the risk of intubation in the overall population, especially in patients requiring higher levels of respiratory support in an ICU setting, but did not decrease the overall mortality risk.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Ignacio Martin-Loeches, Antoni Torres, Blin Nagavci, Stefano Aliberti, Massimo Antonelli, Matteo Bassetti, Lieuwe Bos, James Chalmers, Lennie Derde, Jan de Waele, Jose Garnacho-Montero, Marin Kollef, Carlos Luna, Rosario Menendez, Michael Niederman, Dimitry Ponomarev, Marcos Restrepo, David Rigau, Marcus Schultz, Emmanuele Weiss, Tobias Welte, Richard Wunderink
Summary: The ERS, ESICM, ESCMID and ALAT have developed the first international guidelines for severe community-acquired pneumonia (sCAP). These guidelines provide evidence-based recommendations for diagnosis, empirical treatment and antibiotic therapy for sCAP.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Infectious Diseases
Antoni Torres, Michele Wible, Margaret Tawadrous, Paurus Irani, Gregory G. Stone, Alvaro Quintana, Dmitri Debabov, Margaret Burroughs, Patricia A. Bradford, Marin Kollef
Summary: This post hoc analysis provides evidence of the efficacy and safety of ceftazidime/avibactam in patients with infections caused by beta-lactamase-producing Gram-negative pathogens.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Respiratory System
Antoni Torres, Alona Kuraieva, Gregory G. Stone, Catia Cilloniz
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for a variety of problematic infections in the community and healthcare settings, including pneumonia, with severe disease and high mortality rates. Ceftaroline fosamil has been shown to be a possible alternative treatment for MRSA pneumonia.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Biochemistry & Molecular Biology
Adrian Ceccato, Marta Camprubi-Rimblas, Lieuwe D. J. Bos, Pedro Povoa, Ignacio Martin-Loeches, Carles Forne, Aina Areny-Balaguero, Elena Campana-Duel, Luis Morales-Quinteros, Sara Quero, Paula Ramirez, Mariano Esperatti, Antoni Torres, Lluis Blanch, Antonio Artigas
Summary: The measurement and dynamics of Pancreatic Stone Protein (PSP) do not contribute to the early diagnosis of Ventilator-associated pneumonia (VAP).
Article
Critical Care Medicine
Enric Barbeta, Marta Arrieta, Ana Motos, Joaquim Bobi, Hua Yang, Minlan Yang, Giacomo Tanzella, Pierluigi Di Ginnatale, Stefano Nogas, Carmen Rosa Vargas, Roberto Cabrera, Denise Battaglini, Andrea Meli, Kasra Kiarostami, Nil Vazquez, Laia Fernandez-Barat, Montserrat Rigol, Ricard Mellado-Artigas, Gerard Frigola, Marta Camprubi-Rimblas, Pau Ferrer, Daniel Martinez, Antonio Artigas, Carlos Ferrando, Miquel Ferrer, Antoni Torres
Summary: This study successfully established an accurate animal model of ARDS induced by pulmonary sepsis. The model was created in pigs by inducing ARDS through pneumonia, the most common risk factor in humans, and analyzed the additional effect of ventilator-induced lung injury.
Article
Microbiology
Rosario Menendez, Antoni Torres, Pedro Pablo Espana, Jose Alberto Fernandez-Villar, Jose Maria Marimon, Raul Mendez, Catia Cilloniz, Mikel Egurrola, Maribel Botana-Rial, Maria Ercibengoa, Cristina Mendez, Isabel Cifuentes, Bradford D. Gessner
Summary: This study describes the evolution and distribution of serotypes in adult community-acquired pneumonia (CAP) in Spain, showing that serotypes included in the 20-valent pneumococcal conjugate vaccine (PCV20) are the predominant causes of pneumococcal CAP.
Article
Respiratory System
Michael S. Niederman, Antoni Torres
Summary: This review article comprehensively discusses six controversial aspects of severe community-acquired pneumonia, including microbial diagnosis using PCR molecular techniques, the role of biomarkers in initial management, treatment duration, choice between macrolides or quinolones in initial empirical antibiotic therapy, modification of initial empiric therapy based on prediction scores for drug-resistant pathogens, the use of noninvasive mechanical ventilation and high-flow nasal oxygen, and the use of corticosteroids as adjunctive therapy.
EUROPEAN RESPIRATORY REVIEW
(2022)