Article
Infectious Diseases
Jonathan Mnkai, Thomas F. Marandu, Jacklina Mhidze, Agatha Urio, Lucas Maganga, Antelmo Haule, Godfrey Kavishe, Elizabeth Ntapara, Nhamo Chiwerengo, Petra Clowes, Sacha Horn, Maureen Mosoba, Wilfred Lazarus, Abdallah Ngenya, Akili Kalinga, Alex Debrah, Friedrich Riess, Elmar Saathoff, Christof Geldmacher, Achim Hoerauf, Michael Hoelscher, Mkunde Chachage, Inge Kroidl
Summary: This study demonstrates a significant reduction in the prevalence of lymphatic filariasis (LF) in the Southwest region of Tanzania after seven years of annual treatment and three years of surveillance. The national control program has achieved successful treatment outcomes. Risk factors for W. bancrofti infection include occupation as a farmer, male sex, and older age.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
Veenu Bala, Yashpal S. Chhonker, Abdullah Alshehri, Constant Edi, Catherine M. Bjerum, Benjamin G. Koudou, Christopher L. King, Daryl J. Murry
Summary: The study developed a population pharmacokinetics (PK) model for DEC and identified body weight and gender as significant covariates for DEC volume of distribution (V/F), which provided a comprehensive description of the pharmacokinetics of DEC in the studied population.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Multidisciplinary Sciences
Hugh Shirley, Adrienne Orriols, Dylan Hogan, Kingford Chimfwembe, Alinaswe Balya, Kaala Sibbuku, Janelle Lardizabal, Sophie Tillotson, Philip Espinola Coombs, Richard Wamai
Summary: Zambia is progressing in limiting cases of lymphatic filariasis and this study aims to understand the current state of research in order to identify knowledge and intervention gaps and provide information for surrounding countries in the region.
Article
Immunology
Joseph Pryce, Lisa J. Reimer
Summary: The study conducted a systematic review and meta-analysis, showing the clear potential of MX as a tool for detecting LF-infected communities and predicting human mf prevalence. The results indicated that MX had high sensitivity and a linear relationship with human mf prevalence within a certain range. Factors such as mosquito sample size and mf prevalence were found to be important in influencing MX results.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Shannon Quek, Darren A. N. Cook, Yang Wu, Amy E. Marriott, Andrew Steven, Kelly L. Johnston, Louise Ford, John Archer, Janet Hemingway, Stephen A. Ward, Simon C. Wagstaff, Joseph D. Turner, Mark J. Taylor
Summary: The research reveals that lymphatic filariasis microfilariae depleted of Wolbachia lose their ability to develop in the mosquito vector rapidly due to a down-regulation of chitinase enzymes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Public, Environmental & Occupational Health
Samuel Opoku Asiedu, Alexander Kwarteng, Emmanuel Kobla Atsu Amewu, Priscilla Kini, Bill Clinton Aglomasa, John Boulard Forkuor
Summary: The study evaluated the quality of life of lymphatic filariasis (LF) patients using the LFSQQ questionnaire in rural Ghana. Results showed a negative correlation between disease severity and quality of life, and a positive correlation between disease burden and pain/discomfort. Financial status was found to have a significant impact on the overall well-being of patients.
Article
Immunology
Housseini Dolo, Yaya Coulibaly, Moussa Sow, Massitan Dembele, Salif S. Doumbia, Siaka Y. Coulibaly, Moussa B. Sangare, Ilo Dicko, Abdallah A. Diallo, Lamine Soumaoro, Michel E. Coulibaly, Dansine Diarra, Robert Colebunders, Thomas B. Nutman, Martin Walker, Maria-Gloria Basanez
Summary: The seroprevalence of Ov16 and Wb123 among children in Bakoye and Faleme is consistent with achieving the goals of onchocerciasis elimination and LF elimination as a public health problem after 24-25 years of treatment. Testing and follow-up are suggested for the few Ov16-seropositive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Allassane F. Ouattara, Catherine M. Bjerum, Meite Aboulaye, Olivier Kouadio, Vanga K. Marius, Britt Andersen, Daphne Lew, Charles W. Goss, Gary J. Weil, Benjamin G. Koudou, Christopher L. King
Summary: This study found that semiannual treatment with albendazole alone can effectively kill Wuchereria bancrofti and lead to sustained reductions in microfilaremia. This safe and effective regimen can be used to eliminate lymphatic filariasis in areas where ivermectin cannot be used.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Choden Lama Yonzon, Retna Siwi Padmawati, Raj Kumar Subedi, Sagun Paudel, Ashmita Ghimire, Elsa Herdiana Murhandarwati
Summary: The study found that most respondents lacked knowledge about hydrocele as a clinical manifestation of LF and its transmission through mosquito bites. Patients mostly believed in and practiced home remedies, while fear of surgery, embarrassment, lack of funds, and unawareness of free hydrocele surgery were identified as barriers to accessing treatment.
Article
Immunology
E. L. Davis, J. Prada, L. J. Reimer, T. D. Hollingsworth
Summary: Vector control is considered an important tool for lymphatic filariasis elimination, with evidence showing it can have a significant impact on program outcomes and halt transmission. However, implementation is costly. Modelling studies often simplify vector dynamics and focus on human prevalence trends, making them less suitable for analyzing vector control measures directly.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Angela M. Cadavid Restrepo, Katherine Gass, Kimberly Y. Won, Meru Sheel, Keri Robinson, Patricia M. Graves, Saipale Fuimaono, Colleen L. Lau
Summary: This study aims to determine if antibodies (Abs) may have provided a timelier indication of LF resurgence in American Samoa. The study found that schools with higher prevalence of specific antibodies were more likely to be antigen-positive in subsequent surveys. Therefore, antibodies could potentially provide earlier signals of resurgence and enable a timelier response.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Management
Doris Eglseer, Selvedina Osmancevic, Manuela Hoedl, Christa Lohrmann, Silvia Bauer
Summary: The study highlights significant improvements in nursing quality over a 10-year period, particularly in pressure injury care. Maintaining nursing databases is crucial for providing high-quality nursing care and safe nursing practice.
JOURNAL OF NURSING MANAGEMENT
(2021)
Article
Infectious Diseases
Abinet Teshome, Mekuria Asnakew Asfaw, Chuchu Churko, Manaye Yihune, Yilma Chisha, Birhanu Getachew, Nebiyu Negussu Ayele, Fikre Seife, Tamiru Shibiru, Zerihun Zerdo
Summary: A survey in the Itang special district of Gambella region in Ethiopia found that the coverage for LF treatment was 81.5%. The study revealed a significant difference in treatment coverage between school age children (5-14) and individuals aged 15 and above.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Public, Environmental & Occupational Health
Reda M. R. Ramzy, Abdul Samid Al Kubati
Summary: Over the past two decades, progress has been made in controlling and eliminating LF in the Eastern Mediterranean Region. Egypt and Yemen have been successfully validated by WHO for LF elimination, with Sudan scaling up MDA efforts. The four suspected countries showed no signs of LF transmission, eliminating the need for MDA.
INTERNATIONAL HEALTH
(2021)
Article
Parasitology
Ameyo Monique Dorkenoo, Adjaho Koba, Wemboo A. Halatoko, Minongblon Teko, Komlan Kossi, Kossi Yakpa, Rachel N. Bronzan
Summary: A study in Togo showed that while the Wb123 ELISA may have limitations in surveillance for lymphatic filariasis, there is still a need to develop a reliable test for post-elimination surveillance.
PARASITES & VECTORS
(2021)
