Chronic administration of EP4-selective agonist exacerbates albuminuria and fibrosis of the kidney in streptozotocin-induced diabetic mice through IL-6

Kidney Proximal Tubular Epithelial-Specific Overexpression of Netrin-1 Suppresses Inflammation and Albuminuria through Suppression of COX-2-Mediated PGE2 Production in Streptozotocin-Induced Diabetic Mice

(2012) Riyaz Mohamed et al.   AMERICAN JOURNAL OF PATHOLOGY

The intrinsic prostaglandin E2–EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice

(2012) Naoki Nakagawa et al.   KIDNEY INTERNATIONAL

Signaling via the prostaglandin E2 receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia

(2011) Xibin Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

Podocyte COX-2 Exacerbates Diabetic Nephropathy by Increasing Podocyte (Pro)renin Receptor Expression

(2011) H. Cheng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophages in Renal Disease

(2011) Y. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Obesity-induced renal impairment is exacerbated in interleukin-6-knockout mice

(2011) BROOKE E HARCOURT et al.   NEPHROLOGY

Prostaglandin E2, an Immunoactivator

(2010) Daiji Sakata et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A Maladaptive Role for EP4 Receptors in Podocytes

(2010) E. M. Stitt-Cavanagh et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

(2010) Y. Esaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic COX Inhibition Reduces Diabetes-Induced Hyperfiltration, Proteinuria, and Renal Pathological Markers in 36-Week B6-Ins2Akita Mice

(2009) Rania Nasrallah et al.   AMERICAN JOURNAL OF NEPHROLOGY

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

The Role of Inflammatory Cytokines in Diabetic Nephropathy

(2008) J. F. Navarro-Gonzalez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

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(2008) Carla Feitoza et al.   MOLECULAR MEDICINE