Article
Chemistry, Multidisciplinary
Yurui Xu, Xiaomin Zhang, Anwei Zhou, Can Cheng, Kerong Chen, Xinyuan Zhou, Gui Zhang, Likang Ding, Xiaotong Wu, Haixiong Ge, Heming Wu, Xinghai Ning
Summary: The major challenge in oral cancer treatment is the lack of advanced methods that effectively cure cancer while preserving oral functions. Recent discoveries in tumor metabolic dependency provide opportunities for treatment. Researchers have developed a smart nano lock that improves cancer metabolic intervention by simultaneously inhibiting nutrient supply and energy production.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Sarkis Hamalian, Robert Guth, Farhana Runa, Francesca Sanchez, Eric Vickers, Megan Agajanian, Justin Molnar, Tuan Nguyen, Joshua Gamez, Jonathan D. Humphries, Anupma Nayak, Martin J. Humphries, Julia Tchou, Ioannis K. Zervantonakis, Jonathan A. Kelber
Summary: The study revealed that stromal PEAK1 expression predicts poor outcomes in HER2-positive breast cancer, and that high levels of PEAK1 in mesenchymal stem cells (MSCs) and cancer-associated fibroblasts (CAFs) promote tumorigenesis, drug resistance, and metastasis in a HER2-dependent manner. Additionally, the findings suggest targeting antiapoptotic and stress pathways as potential strategies to improve targeted therapy responses and patient outcomes in HER2-positive breast cancer and other stroma-rich malignancies.
Review
Biochemistry & Molecular Biology
Roberto Vendramin, Kevin Litchfield, Charles Swanton
Summary: Cancer evolution is not solely explained by the Darwinian model, but also involves factors such as macroevolutionary events, neutral evolution, and even the aging of somatic cells. These elements collectively form a model of cancer evolution that extends beyond Darwin.
Article
Multidisciplinary Sciences
Belinda Kingston, Rosalind J. Cutts, Hannah Bye, Matthew Beaney, Giselle Walsh-Crestani, Sarah Hrebien, Claire Swift, Lucy S. Kilburn, Sarah Kernaghan, Laura Moretti, Katie Wilkinson, Andrew M. Wardley, Iain R. Macpherson, Richard D. Baird, Rebecca Roylance, Jorge S. Reis-Filho, Michael Hubank, Iris Faull, Kimberly C. Banks, Richard B. Lanman, Isaac Garcia-Murillas, Judith M. Bliss, Alistair Ring, Nicholas C. Turner
Summary: Genomic profiling of advanced breast cancer using plasma circulating tumour DNA sequencing revealed diverse subclonal resistance mutations, with distinct mutational processes identified in ER-positive breast cancer. This study highlights the importance of subclonal diversification in pre-treated advanced breast cancer, presenting novel therapeutic opportunities.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Manuel Jesus Perez-Baena, Francisco Josue Cordero-Perez, Jesus Perez-Losada, Marina Holgado-Madruga
Summary: GAB1 is a pleckstrin homology domain-containing protein that plays a crucial role in cellular transformation and cancer progression, activating various signaling pathways and modulating resistance to anticancer therapies. Its deficiency leads to developmental abnormalities, while its dysregulation is associated with worse prognosis in multiple cancer types. Understanding the mechanisms of GAB1 in cancer could provide insights for future anticancer strategies.
Review
Cell Biology
Zehua Zhao, Tianming Li, Yuan Yuan, Yanmei Zhu
Summary: The tumor microenvironment plays a significant role in tumor development, and cancer-associated fibroblasts (CAFs) actively contribute to tumor progression, invasion, metastasis, and drug resistance. CAFs exhibit a high level of heterogeneity in terms of origin, biomarkers, and functions. The diverse origins of CAFs determine the complexity of CAF biomarkers, and distinct CAF subpopulations expressing different biomarkers may have contrasting roles in tumor progression. This review provides insights into emerging CAF biomarkers and their potential biological functions, which could enhance our understanding of the relationship between CAFs and tumor cells and facilitate breakthroughs in precision targeted therapy for tumors.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Khetam Sounbuli, Nadezhda Mironova, Ludmila Alekseeva
Summary: Neutrophils, the most abundant leukocytes in human blood, have been recognized as important players in the innate immune system and the first line of defense against invading pathogens. Recent studies have revealed their active involvement in the immune response during cancer development. They exhibit both pro-oncogenic and anti-tumor activities under the influence of various mediators in the tumor microenvironment. Furthermore, the existence of different subpopulations of neutrophils challenges the traditional concept of their homogeneity and opens new possibilities for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Shin Ariga
Summary: Human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase that is overexpressed in 20% of gastric or gastroesophageal junction cancers. While effective in breast cancer, the use of anti-HER2 agents in gastric cancer has not shown survival benefits compared to standard therapies due to inherent differences in tumor biology. However, the development of a novel anti-HER2 agent, trastuzumab deruxtecan, offers promising future prospects for HER2-targeted therapy in gastric cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Joao P. N. Silva, Barbara Pinto, Luis Monteiro, Patricia M. A. Silva, Hassan Bousbaa
Summary: Oral cancer is an aggressive tumor with high mortality rates. Conventional treatment strategies have significant side effects, but combination therapy has emerged as an effective approach in improving outcomes.
Review
Oncology
Behnaz Lahooti, Sagun Poudel, Constantinos M. Mikelis, George Mattheolabakis
Summary: Angiogenesis is crucial for tumor growth and metastasis, with miRNAs playing a role in tumor progression. Current anti-angiogenic approaches provide clinical benefit but come with significant side effects.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
David B. Gurevich, Deena T. David, Ananthalakshmy Sundararaman, Jatin Patel
Summary: The vasculature is composed of heterogeneous endothelial cells that play crucial roles in the formation, maintenance, and regeneration of the vascular system, particularly during wound healing. The diversity and plasticity of endothelial cells have significant implications in disease progression, specifically in scarring and fibrosis. This review focuses on seminal discoveries defining the phenotype and mechanisms of endothelial heterogeneity, with a specific emphasis on wound healing.
Review
Biochemistry & Molecular Biology
Chih-Lin Mao, Kok-Min Seow, Kuo-Hu Chen
Summary: This article summarizes the current literature on the molecular mechanisms, safety, and effects of bevacizumab for the treatment of advanced epithelial ovarian cancer. Bevacizumab, as an inhibitor of angiogenesis, has demonstrated significant therapeutic benefits when used in combination with standard chemotherapy. However, there are still many unknown aspects of bevacizumab that require further investigation for the treatment of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Xinglong Geng, Hongze Chen, Liang Zhao, Jisheng Hu, Wenbo Yang, Guanqun Li, Chundong Cheng, Zhongjie Zhao, Tao Zhang, Le Li, Bei Sun
Summary: The roles of CAFs in PDAC are diverse, with different subtypes supporting or inhibiting cancer cell proliferation. As research progresses, CAFs may be a key factor in the treatment of pancreatic cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Tiantian Wu, Wannian Yang, Aiqin Sun, Zhixiao Wei, Qiong Lin
Summary: CXC chemokines are small chemotactic and secreted cytokines that are dysregulated in multiple types of cancer and closely correlated with tumor progression. They play crucial roles in promoting angiogenesis, stimulating inflammatory responses, and facilitating tumor metastases. They have the potential to serve as diagnostic and prognostic biomarkers, as well as therapeutic targets for cancer treatment.
Review
Biochemistry & Molecular Biology
T. Bele, T. Turk, I. Krizaj
Summary: Nicotinic acetylcholine receptors (nAChRs) play a diverse physiological role in the human body and their expression is increased in certain cancers. This review focuses on nAChR-mediated signaling in cancer, highlighting their potential involvement in specific cases. It also discusses the development of innovative nAChR-based anticancer drugs and summarizes antagonists of nAChRs that could complement existing cancer therapies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Editorial Material
Genetics & Heredity
Lucila Ohno-Machado, Susanna-Assunta Sansone, George Alter, Ian Fore, Jeffrey Grethe, Hua Xu, Alejandra Gonzalez-Beltran, Philippe Rocca-Serra, Anupama E. Gururaj, Elizabeth Bell, Ergin Soysal, Nansu Zong, Hyeon-eui Kim
Review
Gastroenterology & Hepatology
Parambir S. Dulai, Siddharth Singh, Lucilla Ohno-Machado, William J. Sandborn
Article
Health Care Sciences & Services
David W. Bates, Suchi Saria, Lucila Ohno-Machado, Anand Shah, Gabriel Escobar
Article
Computer Science, Information Systems
Katherine K. Kim, Dennis K. Browe, Holly C. Logan, Roberta Holm, Lori Hack, Lucila Ohno-Machado
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Editorial Material
Computer Science, Information Systems
Lucila Ohno-Machado
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Editorial Material
Computer Science, Information Systems
L. Ohno-Machado
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Editorial Material
Computer Science, Information Systems
Lucila Ohno-Machado
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Editorial Material
Computer Science, Information Systems
Lucila Ohno-Machado
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Editorial Material
Computer Science, Information Systems
Lucila Ohno-Machado
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Article
Computer Science, Information Systems
Pinghao Li, Xiaoqian Jiang, Shuang Wang, Jihoon Kim, Hongkai Xiong, Lucila Ohno-Machado
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Article
Computer Science, Information Systems
Son Doan, Ko-Wei Lin, Mike Conway, Lucila Ohno-Machado, Alex Hsieh, Stephanie Feudjio Feupe, Asher Garland, Mindy K. Ross, Xiaoqian Jiang, Seena Farzaneh, Rebecca Walker, Neda Alipanah, Jing Zhang, Hua Xu, Hyeon-Eui Kim
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Article
Computer Science, Information Systems
Lucila Ohno-Machado, Zia Agha, Douglas S. Bell, Lisa Dahm, Michele E. Day, Jason N. Doctor, Davera Gabriel, Maninder K. Kahlon, Katherine K. Kim, Michael Hogarth, Michael E. Matheny, Daniella Meeker, Jonathan R. Nebeker
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Article
Computer Science, Artificial Intelligence
Aditya Krishna Menon, Xiaoqian Jiang, Jihoon Kim, Jaideep Vaidya, Lucila Ohno-Machado
Article
Biology
George Alter, Alejandra Gonzalez-Beltran, Lucila Ohno-Machado, Philippe Rocca-Serra
Review
Genetics & Heredity
Luca Bonomi, Yingxiang Huang, Lucila Ohno-Machado
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)