Journal
LAB ON A CHIP
Volume 14, Issue 17, Pages 3281-3284Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4lc00333k
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Funding
- Max Planck Society
- Max Planck Institute for Biophysical Chemistry
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Cryofixation yields outstanding ultrastructural preservation of cells for electron microscopy, but current methods disrupt live cell imaging. Here we demonstrate a microfluidic approach that enables cryofixation to be performed directly in the light microscope with millisecond time resolution and at atmospheric pressure. This will provide a link between imaging/ stimulation of live cells and post-fixation optical, electron, or X-ray microscopy.
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