Journal
PSYCHOPHYSIOLOGY
Volume 52, Issue 9, Pages 1131-1139Publisher
WILEY
DOI: 10.1111/psyp.12445
Keywords
Learning; Normal volunteers; EEG; fMRI; PET; MRI
Funding
- Norwegian Financial Mechanism through the Norwegian-Estonian Research Cooperation Programme
- ERC Advanced Grant
- Estonian Ministry of Science and Education [IUT02-13]
- Lundbeck Foundation [R204-2015-871] Funding Source: researchfish
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Mismatch negativity (MMN), an ERP elicited by a deviant stimulus in a train of standard stimuli, has been suggested to be associated to glutamatergic neurotransmission, mediated by glutamatergic NMDA receptors. In this study, we examined the relationship between interindividual variation of H-1-MRS-measured glutamate+glutamine (Glx) in the superior temporal gyrus and MMN for duration and frequency deviants in 19 healthy young adults (9 male). We found a significant relationship between the peak latency of the duration-MMN peak and creatine-scaled Glx (p=.0003, (2)=.43), with increased Glx level being associated to earlier peak of the duration-MMN (r=-.63). In contrast, the amplitude of the duration-MMN was not related to Glx. There was no significant relationship between Glx and the frequency-MMN. The present study is the first to demonstrate that interindividual variation in the glutamatergic neurotransmission affects the MMN response in healthy individuals.
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