Article
Infectious Diseases
Tejas Suresh Khire, Wei Gao, Brian Bales, Kuangwen Hsieh, Greg Grossmann, Dong Jin M. Park, Christine O'Keefe, Arnyah Brown-Countess, Sara Peterson, Fan-En Chen, Ralf Lenigk, Alex Trick, Tza-Huei Wang, Christopher Puleo, Gabriele Bianco
Summary: Antimicrobial resistance is a global threat caused by the incorrect and overuse of antibiotics, resulting in the evolution of multi- and extreme drug-resistant bacterial strains. This study aims to provide phenotypic antimicrobial susceptibility testing information by combining short growth periods with PCR assays to predict minimum inhibitory concentration values of antibiotic treatment. The use of a single-vessel reaction system and microfluidic manifold allows for rapid point-of-care diagnostics.
Article
Chemistry, Analytical
Pooya Azizian, Jasmina Casals-Terre, Elena Guerrero-SanVicente, Ruta Grinyte, Jordi Ricart, Joan M. Cabot
Summary: Microfluidics technology is used to enhance the performance of analytical techniques. We present a capillary-driven microfluidic device that improves the sensitivity of lateral flow immunoassays by offering an automated washing step. The device utilizes a 3D-printed multilevel microfluidic chip and quantitatively measures cortisol levels to demonstrate its efficacy.
Article
Chemistry, Multidisciplinary
Thomas Gervais, Yuksel Temiz, Lucas Aube, Emmanuel Delamarche
Summary: This study reports a capillary microfluidic architecture based on self-coalescence modules, which can store a large number of reagents in small aliquots and reconstitute them independently using a simple pipetting step. A mathematical model is provided to guide the spotting of reagents and enable the generation of complex multi-reagent chemical patterns. The results demonstrate the accurate and versatile formation of chemical patterns, as well as simple methods for integrating reagents and imaging the resulting patterns.
Article
Biochemical Research Methods
Sisi Huang, Yihao Wu, Yifan Wang, Xiaoling Hu, Kui Song
Summary: This research proposes and studies an embedded obstacle-type micromixer-concentration gradient generator based on capillary self-driven. The experimental results agree with the simulation results. The mixing efficiency increases along both the mixing channel and palisade length, with higher efficiency in the middle small channel of the palisade-shape area and lower efficiency on both sides.
Article
Thermodynamics
Amgad Salama, Jisheng Kou, Belal Dawoud, Carey Simonson
Summary: With the continuous advancement of technology, heat pipes have proven to be effective in transporting high-intensity heat loads from miniature components. This study focuses on capillary-driven flows in rectangular microchannels and develops a generalized model that works for various width profiles. The viscosity ratio and channel profile are found to have a significant influence on the rate at which the meniscus advances, and the model shows good agreement with experimental and modeling works.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2024)
Article
Chemistry, Multidisciplinary
Hye-Seon Jeong, Eunseo Kim, Jong Pil Park, Sei-Jung Lee, Hyomin Lee, Chang Hyung Choi
Summary: We developed PNIPAm-co-PEGDA hydrogel shelled microcapsules with a thin oil layer for tunable thermo-responsive release of small hydrophilic actives. By using a microfluidic device integrated with a temperature-controlled chamber, we were able to consistently produce the microcapsules using triple emulsion drops as capsule templates. The presence of an interstitial oil layer between the aqueous core and the hydrogel shell allowed for controlled release of the encapsulated substances upon reaching a critical temperature. Additionally, the incorporation of gold nanorods in the hydrogel shell enables spatiotemporal regulation of the active release using near infrared light.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Mechanics
Ludovic Keiser, Philippe Marmottant, Benjamin Dollet
Summary: In this study, we investigate the phenomenon of air invasion in a water-filled microchannel with a constriction. We find that the dynamics of the air bubble escaping the constriction is characterized by intermittent and jerky motion. This is due to the elasto-capillary coupling between the air-liquid interface and the elastic medium. The study provides insights into the role of channel geometry in the stop-and-go dynamics of the bubble. This research has important implications for biomimetic studies and understanding the propagation of air embolisms in plants.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Mechanics
Panayiotis Kolliopoulos, Krystopher S. Jochem, Daniel Johnson, Wieslaw J. Suszynski, Lorraine F. Francis, Satish Kumar
Summary: This study examines the capillary-flow dynamics in open rectangular microchannels using a combination of theory and experiment. The lubrication-theory-based model shows better agreement with experiments at smaller channel aspect ratios and equilibrium contact angles, highlighting the limitations of the modified Lucas-Washburn model. The model also quantitatively predicts the dynamics of fingers that extend ahead of the meniscus.
JOURNAL OF FLUID MECHANICS
(2021)
Article
Materials Science, Multidisciplinary
Henry Ordutowski, Cesar Parra-Cabrera, Clement Achille, Ruben Dochy, Francesco Dal Dosso, Jeroen Lammertyn, Rob Ameloot, Dragana Spasic
Summary: Although efficient diagnostic testing often relies on centralized laboratories, rapid diagnostics at the point-of-care (POC) are increasingly investigated to provide an affordable and easy-to-use alternative that requires minimal external equipment. 3D printing is a promising technology to enable the single-step fabrication of POC diagnostic devices. In this study, the researchers aimed to improve the time-to-result and detection limit of the 3D-printed microfluidic device used for enzyme-linked immunosorbent assay (ELISA) by designing a second-generation device and optimizing the IgE ELISA.
APPLIED MATERIALS TODAY
(2023)
Article
Chemistry, Analytical
Jeremy S. Link, Cody S. Carrell, Ilhoon Jang, Elijah J. O. Barstis, Zachary D. Call, Rae A. Bellows, John J. O'Donnell-Sloan, James S. Terry, Loran B. R. Anderson, Yosita Panraksa, Brian J. Geiss, David S. Dandy, Charles S. Henry
Summary: The SARS-CoV-2 pandemic has emphasized the need for rapid and affordable diagnostic tests. Traditional laboratory diagnostics like PCR and ELISA are sensitive but time-consuming and expensive. The CaDI device described in this study is a simple and automated alternative that can detect SARS-CoV-2 within 15-20 minutes visually or with image analysis. It shows comparable sensitivity to well-plate ELISA and can be easily adapted for other immunoassay applications. Evaluation: 8/10
ANALYTICA CHIMICA ACTA
(2023)
Article
Mechanics
Alexander T. Bradley, Ian J. Hewitt, Dominic Vella
Summary: We study a bendocapillary instability in a liquid droplet that fills a flexible walled channel. Inspired by experimental observations, we develop a mathematical model and use numerical and asymptotic analysis to understand this instability. We find that regardless of parameter values, configurations are unstable to small wavenumber perturbations, the growth rate of the instability highly depends on the volume of liquid in the channel, and both wetting and non-wetting configurations are susceptible to the same instability in the channel. Understanding these novel interfacial instabilities opens up possibilities for their control and utilization in processes such as microfabrication.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Mechanics
Panayiotis Kolliopoulos, Krystopher S. Jochem, Lorraine F. Francis, Satish Kumar
Summary: In this study, a theoretical model based on lubrication theory and kinetically limited evaporation was developed to examine the capillary flow of evaporating liquid solutions in open rectangular microchannels. The model considered the complex free-surface morphology, solvent evaporation, Marangoni flows, and finite-size reservoir effects. The research found significant differences in flow behavior between pure liquids and liquid solutions due to solvent evaporation and solute transport. Marangoni flows were found to promote more uniform solute deposition patterns.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Chemistry, Physical
Ariane Stucki, Petra Juskova, Nicola Nuti, Steven Schmitt, Petra S. Dittrich
Summary: Microfluidic methods for forming single and double emulsion droplets have greatly enhanced high-throughput screening capabilities for various applications. A new strategy is introduced for on-demand delivery of reactants in DEs using lipid vesicles as carriers, allowing synchronized release of content inside DEs to be triggered at any desired time.
Article
Chemistry, Multidisciplinary
Caleb R. Hoopes, Francisco J. Garcia, Akash M. Sarkar, Nicholas J. Kuehl, David T. Barkan, Nicole L. Collins, Glenna E. Meister, Taylor R. Bramhall, Chien-Hsiang Hsu, Michael D. Jones, Markus Schirle, Michael T. Taylor
Summary: This study presents a covalent modification method for tryptophan using photo-induced electron transfer, which is suitable for both individual protein modification and in situ analysis. The method allows efficient reactivity with surface-exposed tryptophan residues and can transfer useful functional groups to proteins.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Materials Science, Multidisciplinary
Jiaozhong Cai, Jiushuai Deng, Liang Wang, Mingzhen Hu, Hongxiang Xu, Xiaoan Hou, Bozeng Wu, Shimei Li
Summary: Ilmenite is an essential mineral for titanium extraction. Flotation has been applied in dressing plants for the recovery of fine ilmenite. The interactions between reagent groups and Ti/Fe sites on the ilmenite surface play a critical role in ilmenite flotation. Activators, mostly metal ions including lead ions, promote ilmenite flotation by increasing active sites on the surface. Combined reagents show better selectivity in ilmenite separation due to their synergistic effect. This study discusses reagent types and action mechanisms in ilmenite flotation and proposes a future outlook based on previous research.
INTERNATIONAL JOURNAL OF MINERALS METALLURGY AND MATERIALS
(2022)
Article
Chemistry, Analytical
Onur Gokce, Cristina Mercandetti, Emmanuel Delamarche
ANALYTICAL CHEMISTRY
(2018)
Article
Engineering, Biomedical
Ngoc M. Pham, Sebastian Rusch, Yuksel Temiz, Robert D. Lovchik, Hans-Peter Beck, Walter Karlen, Emmanuel Delamarche
BIOMEDICAL MICRODEVICES
(2018)
Review
Infectious Diseases
Ngoc Minh Pham, Walter Karlen, Hans-Peter Beck, Emmanuel Delamarche
Article
Multidisciplinary Sciences
Yuksel Temiz, Emmanuel Delamarche
SCIENTIFIC REPORTS
(2018)
Article
Engineering, Biomedical
Ngoc M. Pham, Sebastian Rusch, Yuksel Temiz, Hans-Peter Beck, Walter Karlen, Emmanuel Delamarche
BIOMEDICAL MICRODEVICES
(2019)
Article
Multidisciplinary Sciences
Onur Gokce, Samuel Castonguay, Yuksel Temiz, Thomas Gervais, Emmanuel Delamarche
Article
Multidisciplinary Sciences
Marie L. Salva, Yuksel Temiz, Marco Rocca, Yulieth C. Arango, Christof M. Niemeyer, Emmanuel Delamarche
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Analytical
Elisa Hemmig, Yuksel Temiz, Onur Gokce, Robert D. Lovchik, Emmanuel Delamarche
ANALYTICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Yulieth Arange, Yuksel Temiz, Onur Gokce, Emmanuel Delamarche
Article
Chemistry, Multidisciplinary
Marie L. Salva, Marco Rocca, Yong Hu, Emmanuel Delamarche, Christof M. Niemeyer
Review
Chemistry, Multidisciplinary
Emmanuel Delamarche, Yuksel Temiz, Robert D. Lovchik, Michael G. Christiansen, Simone Schuerle
Summary: Medication adherence is a global issue, and recent advancements in microfluidics technology can help enhance it. Capillary microfluidics, known for being self-powered and easy to use, has wide applications in drug monitoring.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Emmanuel Delamarche, Iago Pereiro, Aditya Kashyap, Govind Kaigala
Summary: This article summarizes the themes presented in a recent Langmuir Lecture on patterning biomolecules on surfaces, miniaturizing surface assays, and interacting with biointerfaces using microcontact printing, microfluidic networks, and microfluidic probes.
Article
Biochemical Research Methods
Marco Rocca, Yuksel Temiz, Marie L. Salva, Samuel Castonguay, Thomas Gervais, Christof M. Niemeyer, Emmanuel Delamarche
Summary: The study developed a rapid microfluidic chip for testing G6PD deficiency, allowing quantitative testing within 2 minutes with a small sample size. By developing a theoretical model and utilizing a powerful microfluidic module, the study successfully predicted enzymatic reactions, guided reagent spotting, and efficiently integrated multiple miniaturized assays.
Review
Engineering, Electrical & Electronic
Marie L. Salva, Marco Rocca, Christof M. Niemeyer, Emmanuel Delamarche
Summary: This review article discusses state-of-the-art methods for immobilizing functional receptors in microfluidic devices, essential for developing specific, sensitive (bio)chemical assays across various applications. The article covers principles and chemistry of immobilization techniques in microfluidics, including methods on static surfaces and mobile surfaces with a focus on hydrogel surfaces, magnetic and non-magnetic microbeads, and recent developments of new mobile supports.
MICRO AND NANO ENGINEERING
(2021)
Article
Computer Science, Hardware & Architecture
V. S. K. Balagurusamy, C. Cabral, S. Coomaraswamy, E. Delamarche, D. N. Dillenberger, G. Dittmann, D. Friedman, O. Gokce, N. Hinds, J. Jelitto, A. Kind, A. D. Kumar, F. Libsch, J. W. Ligman, S. Munetoh, C. Narayanaswami, A. Narendra, A. Paidimarri, M. A. P. Delgado, J. Rayfield, C. Subramanian, R. Vaculin
IBM JOURNAL OF RESEARCH AND DEVELOPMENT
(2019)