Article
Crystallography
Xuan Luc Le, Sung-Hoon Choa
Summary: In this study, an Au-NiCo MEMS vertical probe with enhanced current-carrying capacity was proposed to reduce damage to various interconnect structures. The probe showed a 150% higher CCC than conventional NiCo probes, with less contact force, stress, and deformation of interconnect structures. The results suggest that the Au-NiCo probe is a promising candidate for advanced wafer-level testing, offering better probing efficiency and higher test yield and reliability.
Article
Engineering, Marine
Yi Yang, Tze W. Chow, Yi Q. Zhang, Peter K. N. Yu, Chi C. Ko, Rudolf S. S. Wu
Summary: Existing methods for monitoring radionuclides in aquatic environments are often impractical due to the need for frequent sampling and tedious analytical procedures. This study explored the feasibility of using 'Artificial Mussels' (AMs) as a new tool for radionuclide monitoring in marine environments. Results showed that AMs could effectively accumulate U-238, Sr-88, and Cs-133 from water, reaching equilibrium within 7 to 8 weeks with high concentration factors. These findings suggest that AMs can overcome the limitations of existing methods and offer a practical solution for radionuclide monitoring.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Review
Chemistry, Applied
Qiannan Tang, Hening Li, Haoliang Hu, Linxi Chen
Summary: This review introduces the role of the endoplasmic reticulum (ER) in cellular processes and discusses the research progress of fluorescent probes for imaging physiological or pathological events in the ER. The study contributes to the discovery of targeted therapeutics and promotes interdisciplinary research.
Review
Chemistry, Inorganic & Nuclear
Lizhi Gai, Yanfei Liu, Zhikuan Zhou, Hua Lu, Zijian Guo
Summary: The hypoxic environment is a significant characteristic of solid tumors, resulting from an imbalance between oxygen supply and consumption. Recent progress has been made in designing hypoxia probes derived from BODIPY scaffolds. These probes have attracted particular attention and are closely related to tumor resistance to various therapies. This review focuses on the construction strategies, recognition mechanisms, and biological imaging applications of various BODIPY-based hypoxia probes, aiming to inspire novel approaches and innovations for designing fluorescent probes for imaging hypoxic environments and promoting the development of tumor diagnostics and hypoxia-responsive anti-cancer nanomedicines.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Spectroscopy
Hongbin Zhuang, Wei Shi, Guijie Zhao, Yunfan Yang, Yongqing Li
Summary: This study provides a detailed investigation on the excited-state intramolecular proton transfer (ESIPT) processes of a new fluorescent probe named BTT and the mechanism of detecting Zn2+ ions. The photochemical behavior and photophysical changes were explained at the molecular level for the first time, and the calculated spectral values were in agreement with experiments. The study not only confirms the excited state hydrogen-bond strengthening, but also provides insights into the structure of the BTT-Zn2+ complex and the excitation type of intraligand charge transfer. Additionally, the photophysical phenomenon of BTT for detecting Zn2+ ions is explained through the calculation of electronic spectra and energy gap.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Felix Y. Telegin, Viktoria S. Karpova, Anna O. Makshanova, Roman G. Astrakhantsev, Yuriy S. Marfin
Summary: This research focuses on gathering a high-quality dataset of BODIPYs in various solvents. The dataset includes 115 individual compounds in 71 solvents with spectral and photophysical properties. Solvatochromic sensitivity is calculated for each dye and the dataset is classified into clusters based on this sensitivity. The analysis results are visualized using polarity mapping plots, showing the relationship between absorption, emission, stokes shift, and quantum yield. The collected fluorophores in this study form a valuable dataset for analytical and bioanalytical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Sara Gimondi, Helena Ferreira, Rui L. L. Reis, Nuno M. M. Neves
Summary: The use of nanoparticles in nanomedicine has great potential in overcoming the limitations of conventional therapies and improving early diagnosis and follow-up of diseases. Microfluidic systems offer an efficient and cost-effective method for nanoparticle synthesis and screening by simulating dynamic fluid flows and specific microenvironments. Microfluidic devices allow for controlled synthesis of nanoparticles, enhancing batch-to-batch reproducibility, and provide versatile platforms for rapid and efficient in vitro and in vivo screening. This review summarizes the major microfluidic platforms for controlled nanoparticle synthesis, discusses innovative platforms for mimicking in vitro environments and organism-on-a-chip, and evaluates the current challenges and future directions of microfluidic systems in nanomedicine.
Article
Biochemical Research Methods
Didem Rodoplu, Jefunnie Sierra Matahum, Chia-Hsien Hsu
Summary: This study presents a microfluidic hanging drop-based spheroid co-culture device (mu-CCD) for the generation and co-culturing of embryoid bodies (EBs) and tumor spheroids (TSs). The device allows the confrontation of EB and TS pairs to culture EB-TS spheroids and investigate tumor-induced angiogenic sprouting. The optimized physical parameters of the device ensure the long-term stability of hanging droplets. Confocal imaging results demonstrate increased vessel percentage area and total vessel length after 6 days of co-culturing, indicating tumor angiogenesis. The mu-CCD provides a simple and efficient method for cell spheroid generation and co-culturing.
Article
Automation & Control Systems
Haobin Shi, Jingchen Li, Meng Liang, Maxwell Hwang, Kao-Shing Hwang, Yun-Yu Hsu
Summary: This article proposes an adaptive coverage path planning method using deep reinforcement learning and attention interface to address the issue of randomly scattering wafer probing. The experimental results demonstrate the efficiency of this method in terms of reducing overlap and steps, and it outperforms other methods in learning a better path planning strategy for wafer probing.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
Article
Chemistry, Analytical
Xiangtang Li, Hang Hu, Julia Laskin
Summary: In this study, a new integrated microfluidic probe (iMFP) was developed for high spatial resolution imaging of biological samples. The new probe design increased the robustness and throughput of imaging, making it suitable for high-resolution imaging of large tissue sections. This technology is important for understanding biological systems.
ANALYTICA CHIMICA ACTA
(2023)
Article
Materials Science, Multidisciplinary
Ayoub Glia, Muhammedin Deliorman, Pavithra Sukumar, Farhad K. Janahi, Bisan Samara, Ayoola T. Brimmo, Mohammad A. Qasaimeh
Summary: In this work, a novel herringbone microfluidic probe (HB-MFP) was developed for efficient capture of circulating tumor cells (CTCs) expressing specific antigens. The HB-MFP enables high throughput sample processing and offers potential for cancer diagnosis and treatment through multiplexed profiling of CTCs.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Biochemical Research Methods
Vyacheslav Tretyachenko, Vaclav Voracek, Radko Soucek, Kosuke Fujishima, Klara Hlouchova
Summary: CoLiDe is a computational tool that offers precise control over protein sequence composition, length, and diversity for designing combinatorial libraries. It uses an evolutionary approach to provide solutions for degenerate DNA templates and can prepare purified protein library samples with up to 10^11 - 10^12 unique sequences. CoLiDe presents a composition-centric approach to protein design for different functional phenomena.
Review
Chemistry, Multidisciplinary
Roberto El-Khoury, Masad J. Damha
Summary: FANA is an ideal tool for mimicking DNA secondary structures and probing biomolecular interactions, showing high binding affinity and implications in therapeutics. It also holds promise in stabilizing noncanonical DNA structures and playing a role in biological research.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Physics, Multidisciplinary
M. Maekawa, A. Miyashita, S. Sakai, S. Li, S. Entani, A. Kawasuso, Y. Sakuraba
Summary: By using spin-polarized positrons, researchers studied the surface density of states of various materials and found characteristic negative spin polarizations on Ni and Co surfaces, which disappeared upon deposition of graphene. The surface properties of CFGG and CMS exhibited weak spin polarizations, suggesting that the expected half-metallicity of these bulk states was not present at the surfaces.
PHYSICAL REVIEW LETTERS
(2021)
Article
Engineering, Environmental
Zengfu Zhang, Haiqing Wang, Mingjun Ma, Huiling Liu, Zhicheng Zhang, Weijia Zhou, Hong Liu
Summary: The elaborately designed hybrid nanostructure of RuO2 strongly coupled with structurally controllable NiMoO wafer arrays exhibited superior electrocatalytic activity in alkaline water electrolysis, emphasizing the crucial role of synergistic effects in enhancing catalytic performance.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Weiwei Cui, Meihang He, Luye Mu, Zuzeng Lin, Yanyan Wang, Wei Pang, Mark Reed, Xuexin Duan
Article
Physics, Applied
Sonya D. Sawtelle, Zachary A. Kobos, Mark A. Reed
APPLIED PHYSICS LETTERS
(2018)
Article
Nanoscience & Nanotechnology
S. D. Sawtelle, Z. A. Kobos, M. A. Reed
Article
Multidisciplinary Sciences
Tian Li, Sylvia Xin Li, Weiqing Kong, Chaoji Chen, Emily Hitz, Chao Jia, Jiaqi Dai, Xin Zhang, Robert Briber, Zuzanna Siwy, Mark Reed, Liangbing Hu
Review
Chemistry, Physical
Samuel Faucher, Narayana Aluru, Martin Z. Bazant, Daniel Blankschtein, Alexandra H. Brozena, John Cumings, J. Pedro de Souza, Menachem Elimelech, Razi Epsztein, John T. Fourkas, Ananth Govind Rajan, Heather J. Kulik, Amir Levy, Arun Majumdar, Charles Martin, Michael McEldrew, Rahul Prasanna Misra, Aleksandr Noy, Tuan Anh Pham, Mark Reed, Eric Schwegler, Zuzanna Siwy, YuHuang Wang, Michael Strano
JOURNAL OF PHYSICAL CHEMISTRY C
(2019)
Article
Chemistry, Multidisciplinary
Sylvia Xin Li, Nam S. Kim, Kim McKelvey, Chanyuan Liu, Henry S. White, Gary W. Rubloff, Sang Bok Lee, Mark A. Reed
Article
Biochemical Research Methods
Shupeng Ning, Shuchang Liu, Yunjie Xiao, Guanyu Zhang, Weiwei Cui, Mark Reed
Summary: A high-throughput acoustofluidic device is presented for separating bacteria from human blood cells efficiently, utilizing a serpentine microfluidic design and standing surface acoustic waves. The device enhances flow rate without compromising separation purity or cell recovery, offering advantages such as low cost, high biocompatibility, label-free separation, and integration potential with on-chip biosensors for clinical point-of-care diagnostics.
Article
Biochemical Research Methods
Pedro A. Duarte, Lukas Menze, Gaser N. Abdelrasoul, Shari Yosinski, Zak Kobos, Riley Stuermer, Mark Reed, Jian Yang, Xiujie S. Li, Jie Chen
Article
Chemistry, Multidisciplinary
Weiwei Cui, Luye Mu, Xuexin Duan, Wei Pang, Mark A. Reed
Article
Materials Science, Multidisciplinary
S. D. Sawtelle, M. A. Reed
Article
Nanoscience & Nanotechnology
Weiwei Zhou, Luye Mu, Jinfeng Li, Mark Reed, Peter J. Burke
Article
Chemistry, Multidisciplinary
Xiaokai Li, Marina Mariano, Lyndsey McMillon-Brown, Jing-Shun Huang, Matthew Y. Sfeir, Mark A. Reed, Yeonwoong Jung, Andre D. Taylor
Article
Chemistry, Analytical
Luye Mu, Ilia A. Droujinine, Jieun Lee, Mathias Wipf, Paschall Davis, Chris Adams, Jennifer Hannant, Mark A. Reed
ANALYTICAL CHEMISTRY
(2017)
Article
Nanoscience & Nanotechnology
Ning Tang, Luye Mu, Hemi Qu, Yanyan Wang, Xuexin Duan, Mark A. Reed
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Biophysics
Jieun Lee, Mathias Wipf, Luye Mu, Chris Adams, Jennifer Hannant, Mark A. Reed
BIOSENSORS & BIOELECTRONICS
(2017)