Journal
PSYCHONEUROENDOCRINOLOGY
Volume 51, Issue -, Pages 444-458Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2014.08.020
Keywords
Posttraumatic stress disorder; PTSD; Combat-related PTSD; Biomarkers for PTSD; Risk markers for PTSD; Vulnerability markers for PTSD; Resilience markers for PTSD; Pre-trauma PTSD risk markers; Post-trauma PTSD risk markers; German Armed Forces (Bundeswehr) PTSD biomarker study; (Bw-BioPTSD)
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Funding
- Sanitatsamt der Bundeswehr (Medical Army Bureau of the German Armed Forces)
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Biomarkers allowing the identification of individuals with an above average vulnerability or resilience for posttraumatic stress disorder (PTSD) would especially serve populations at high risk for trauma exposure like firefighters, police officers and combat soldiers. Aiming to identify the most promising putative PTSD vulnerability markers, we conducted the first systematic review on potential imaging and non-genetic molecular markers for PTSD risk and resilience. Following the PRISMA guidelines, we systematically screened the PubMed database for prospective longitudinal clinical studies and twin studies reporting on pre-trauma and post-trauma PTSD risk and resilience biomarkers. Using 25 different combinations of search terms, we retrieved 8151 articles of which we finally included and evaluated 9 imaging and 27 molecular studies. In addition, we briefly illustrate the design of the ongoing prospective German Armed Forces (Bundeswehr) PTSD biomarker study (Bw-BioPTSD) which not only aims to validate these previous findings but also to identify novel and clinically applicable molecular, psychological and imaging risk, resilience and disease markers for deployment-related psychopathology in a cohort of German soldiers who served in Afghanistan. (C) 2014 Elsevier Ltd. All rights reserved.
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