Review
Peripheral Vascular Disease
David L. Mattson, John Henry Dasinger, Justine M. Abais-Battad
Summary: Salt-sensitive hypertension in patients with high blood pressure is associated with higher morbidity, mortality, and renal damage compared to those with normal blood pressure or salt-resistant hypertension. Dietary components other than salt play a role in modulating hypertension, and immunity and inflammation are key factors that amplify the development of salt-sensitive hypertension.
Review
Medicine, Research & Experimental
Lin Zhou, Tian Wang, Yawen Yu, Mingan Li, Xiaohui Sun, Wenhao Song, Yunjie Wang, Ce Zhang, Fenghua Fu
Summary: Approximately one in three ischemic stroke survivors suffer from post-stroke depression (PSD), which affects functional rehabilitation and quality of life. This study focuses on the stroke-induced hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and its role in PSD. The review summarizes possible etiologies of PSD, including stress and proinflammatory cytokines release, and discusses the effects of HPA axis hyperactivity on specific brain structures, enzymes expression, excitotoxicity, intestinal permeability, microglial activation, neuroendocrine regulation, inflammation, and therapy options.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Behavioral Sciences
Kerstin Camile Creutzberg, Alice Sanson, Thiago Wendt Viola, Francesca Marchisella, Veronica Begni, Rodrigo Grassi-Oliveira, Marco Andrea Riva
Summary: Exposure to prenatal stress can have long-lasting effects on the HPA axis and inflammatory cytokines in adult offspring, with changes in hormone levels and receptors. Sex and duration of prenatal stress protocol moderate these effects, while the impact on glucocorticoid receptor and cytokines remains insignificant. Researchers should consider the mixed outcomes of prenatal stress on inflammatory markers in the adult brain.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Medicine, Research & Experimental
Hao-lu Sun, Qiu-ying Ma, He-ge Bian, Xiao-ming Meng, Juan Jin
Summary: The gastrin-releasing peptide receptor (GRPR), a member of G protein-coupled receptors (GPCRs), plays various biological roles by binding to ligands such as gastrin-releasing peptide (GRP). The GRP/GRPR signaling is involved in the pathophysiological processes of inflammatory diseases, cardiovascular diseases, neurological diseases, and different types of cancers. The potential of the GRP/GRPR axis as a therapeutic target for multiple diseases and its crucial role in disease progression emphasize the importance of studying this signaling axis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Alice Weiglein, Evelyn Gaffal, Anne Albrecht
Summary: This article provides an overview of the interaction between inflammatory skin diseases and the brain, and provides an overview of current mouse models and assays. By studying the molecular mechanisms of the skin-brain axis in inflammatory cutaneous diseases, further research on neuropsychiatric comorbidities can be promoted, driving the development of novel therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Naoual El Menyiy, Aicha El Allam, Sara Aboulaghras, Imane Jaouadi, Saad Bakrim, Nasreddine El Omari, Mohammad Ali Shariati, Alevtin Miftakhutdinov, Polrat Wilairatana, Mohammad S. Mubarak, Abdelhakim Bouyahya
Summary: Autoimmune diseases are caused by the overactivity of the immune system towards self-constituents. Natural compounds derived from medicinal plants have shown potential in modulating the inflammatory responses of these diseases, presenting a promising approach for treatment and prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Microbiology
Ousman Bajinka, Lucette Simbilyabo, Yurong Tan, John Jabang, Shakeel Ahmed Saleem
Summary: The appreciation of human microbiome is gaining strong grounds in biomedical research, focusing on the lung-brain axis in addition to the gut-brain axis. Interdisciplinary approaches based on emerging studies are recommended to develop effective treatments for lung induced neurodegenerative diseases. In-depth understanding of the bi-directional communication between host and microbiome in the lung could confer treatment to respiratory infections, alleviate stress, anxiety, and enhance neurological effects.
CRITICAL REVIEWS IN MICROBIOLOGY
(2022)
Review
Rheumatology
Michael Bonelli, Andreas Kerschbaumer, Kastriot Kastrati, Kamran Ghoreschi, Massimo Gadina, Leonhard X. Heinz, Josef S. Smolen, Daniel Aletaha, John O'Shea, Arian Laurence
Summary: Fundamental insight gained over the last decades has led to the discovery of cytokines as key drivers of inflammatory diseases. This understanding has revolutionized the treatment options for patients with inflammatory disorders, with JAK inhibitors playing a crucial role in targeting cytokine pathways.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Pharmacology & Pharmacy
Tian Zhang, Shuai Guo, Fangzhou Li, Xinmiao Lan, Yaru Jia, Jinchao Zhang, Yuanyu Huang, Xing-Jie Liang
Summary: This review emphasizes the importance of timely and accurate assessment and diagnosis for various diseases, introduces the application of molecular imaging technology in disease diagnosis and treatment, and aims to promote the development of related technologies and fields.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Caitlin A. Moran, Lauren F. Collins, Nour Beydoun, Puja K. Mehta, Yetunde Fatade, Ijeoma Isiadinso, Tene T. Lewis, Brittany Weber, Jill Goldstein, Igho Ofotokun, Arshed Quyyumi, May Y. Choi, Kehmia Titanji, Cecile D. Lahiri
Summary: Immune responses differ between men and women, with women more prone to chronic autoimmune diseases. Current ASCVD risk assessment tools underestimate the risk in immune dysregulation populations, especially women. This review focuses on the impact of immune dysregulation on ASCVD and discusses factors contributing to ASCVD in women with immune disorders.
CIRCULATION RESEARCH
(2022)
Review
Hematology
Mitri K. Khoury, Huan Yang, Bo Liu
Summary: Macrophages play a key functional role in the pathogenesis of various cardiovascular diseases by accumulating within the vessel wall and leading to sustained local inflammatory responses. Recent findings focus on the origin, survival/death, and phenotypic switching of macrophages within vessel walls.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Neurosciences
Julia N. Khantakova, Natalia P. Bondar, Elena V. Antontseva, Vasiliy V. Reshetnikov
Summary: Adverse factors during the neonatal period can affect the development of certain brain structures, leading to reduced cognitive abilities and increased risk of psychopathologies throughout an individual's lifespan. Neonatal immune activation-induced neuroinflammation may cause disturbances in neurotransmission, reprogramming of brain cells, and changes in stress reactivity, ultimately resulting in depressive-like behavior in adult males under aversive conditions with local inflammation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Maria Maddalena Sirufo, Lia Ginaldi, Massimo De Martinis
Summary: For patients with anorexia nervosa, a complex evaluation of cardiovascular autonomic regulation is recommended for early diagnosis, personalized therapy, and monitoring of therapeutic interventions. This approach can effectively prevent cardiovascular complications, especially in vulnerable adolescents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Henriette Schermacher Marstein, Birgit Nomeland Witczak, Kristin Godang, Nicoleta Christina Olarescu, Thomas Schwartz, Berit Flato, Oyvind Molberg, Jens Bollerslev, Ivar Sjaastad, Helga Sanner
Summary: In long-term juvenile dermatomyositis (JDM), patients showed altered adipose tissue distribution and subclinical cardiac dysfunction. Leptin levels were higher in JDM patients compared to controls, and apelin-12 and visfatin were higher in JDM-active patients compared to JDM-inactive patients.
Review
Neurosciences
Julia N. Khantakova, Natalia P. Bondar, Anna A. Sapronova, Vasiliy V. Reshetnikov
Summary: Inflammation during the postnatal period can be harmful to brain development, increasing the risk of mental illnesses and cognitive impairment later in life. Limited research has been done on the long-term effects of infectious agents causing neuroinflammation, leading to dysregulation of the hypothalamic-pituitary-adrenal axis and imbalances in the neurotransmitter system.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Victoria E. Kettle, Mark Hamer, Fehmidah Munir, Jonathan Houdmont, Kelly Wilson, Robert Kerr, Ken Addley, Lauren B. Sherar, Stacy A. Clemes
Summary: This study found that long sitting time at work on workdays and prolonged TV viewing on workdays and non-workdays are associated with increased odds of engaging in multiple unhealthy behaviors.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Alice Sullivan, Matt Brown, Mark Hamer, George B. Ploubidis
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Endocrinology & Metabolism
Emma Jenkinson, Iris Knoop, Joanna L. Hudson, Rona Moss-Morris, Ruth A. Hackett
Summary: Diabetes-related distress is common among diabetes patients, and cognitive behavioral therapy (CBT) and third-wave CBT show promise in alleviating this distress and depression, with third-wave CBT also reducing anxiety.
Article
Clinical Neurology
Hugues Sampasa-Kanyinga, Jean-Philippe Chaput, Bo-Huei Huang, Mitch J. Duncan, Mark Hamer, Emmanuel Stamatakis
Summary: This study examined the bidirectional association between discretionary screen time (DST) and sleep patterns in adults. The findings suggest that high DST is associated with poor sleep, and poor sleep is associated with high DST.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Psychology, Clinical
Simone Jayakumar, Stacey Jennings, Kristoffer Halvorsrud, Christophe Clesse, Muhammad Magdi Yaqoob, Livia A. Carvalho, Kamaldeep Bhui
Summary: This study reviewed and analyzed multiple studies to find that depression in CKD/ESKF patients is associated with increased inflammation levels and decreased levels of anti-inflammatory cytokines.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Aiden J. Chauntry, Nicolette C. Bishop, Mark Hamer, Nicola J. Paine
Summary: Sitting for long periods without interruption and the way we respond to short-term stress are linked to heart disease risk. Breaking up sitting with light activity can lower heart disease risk.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Psychology, Clinical
Verity Hailey, Abi Fisher, Mark Hamer, Daisy Fancourt
Summary: This study analyzed data from the COVID-19 lockdown period and found that social support played an important role in maintaining physical activity during the lockdown, while loneliness and social isolation did not show a significant association with physical activity.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Clinical Neurology
J. M. Blodgett, J. J. Mitchell, E. Stamatakis, S. Chastin, M. Hamer
Summary: This study found that spending more time on moderate to vigorous physical activity (MVPA) relative to sedentary behavior (SB), sleep, or light-intensity physical activity (LIPA) is associated with a lower risk of depression. Replacing sleep, SB, or LIPA with MVPA time was strongly associated with lower depression risk. Reallocating time between SB, sleep, or LIPA had minimal to no effect on depression risk.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Sport Sciences
Le Wei, Matthew N. Ahmadi, Hsiu-Wen Chan, Sebastien Chastin, Mark Hamer, Gita D. Mishra, Emmanuel Stamatakis
Summary: This study aimed to examine the associations between different types and contexts of stepping behaviors and cardiometabolic risk. The results showed that all stepping behaviors were beneficial to cardiometabolic health, with higher stair steps and peak 30-min walking intensity associated with a steep decline of adiposity biomarkers. Purposeful steps showed more consistent associations with cardiometabolic biomarkers than incidental steps.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Sport Sciences
J. J. Mitchell, M. Hamer, J. M. Blodgett, G. S. Wannamethee, B. J. Jefferis
Summary: Evidence suggests that engaging in sporting leisure time physical activity (sporting-LTPA) is associated with healthy cognition in adults. This relationship may be due to the physiological effects of physical activity or other psychosocial factors related to sports. This study examined the association between sporting-LTPA and cognition, while controlling for device-measured physical activity volume, in both midlife and later-life participants. The results showed that there were positive associations between sporting-LTPA and cognition, and sports with team/partner elements were particularly beneficial.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Sport Sciences
S. M. Pinto Pereira, J. J. Mitchell, J. M. Blodgett, M. Hamer, T. Norris
Summary: The study found an association between non-exercise testing cardiorespiratory fitness and cognitive function in middle age. However, this association disappeared when confounding factors were considered.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Psychology, Multidisciplinary
Joseph Chilcot, Ruth A. Hackett
Summary: This study found that higher levels of optimism were associated with a reduced risk of stroke. Individuals with more conscientious and open personality types also had a lower risk of stroke. However, the strongest effect was seen for optimism, where optimistic individuals had a lower stroke risk regardless of their clinical risk or health behaviors. It is still unclear why optimism may help reduce the risk of stroke, but the study suggests that optimism may be related to higher levels of physical activity, which in turn helps reduce the risk of stroke. Further research is needed to understand the relationship between personality, health behaviors, and stroke risk reduction.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Nicholas Scicluna, Mark Hamer, Joanna M. Blodgett
Summary: This study investigated the association between adolescent participation in exercise and sport and device-assessed physical activity (PA) levels in midlife. The results showed that active adolescents had higher total daily PA levels in midlife, but there was no evidence of an association with moderate to vigorous PA (MVPA) levels. This highlights the potential of early PA interventions to improve PA levels in adulthood.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Lydia Poole, Antonio I. Lazzarino, Kimberley J. Smith, Ruth A. Hackett
Summary: Cardiovascular disease and diabetes are leading causes of morbidity and mortality worldwide. The combination of low socioeconomic position and elevated C-reactive protein (CRP) has been found to increase the risk of future incident cardiometabolic diseases.
SSM-POPULATION HEALTH
(2023)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)