4.6 Review

Perfusion Magnetic Resonance Imaging: A Comprehensive Update on Principles and Techniques

Journal

KOREAN JOURNAL OF RADIOLOGY
Volume 15, Issue 5, Pages 554-577

Publisher

KOREAN RADIOLOGICAL SOC
DOI: 10.3348/kjr.2014.15.5.554

Keywords

Perfusion; Perfusion MRI; Dynamic susceptibility contrast; Dynamic contrast-enhanced; Arterial spin-labeling

Funding

  1. Korean Health Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea [A092125]
  2. Korea Health Promotion Institute [HI09C1424010013, A092125] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Perfusion is a fundamental biological function that refers to the delivery of oxygen and nutrients to tissue by means of blood flow. Perfusion MRI is sensitive to microvasculature and has been applied in a wide variety of clinical applications, including the classification of tumors, identification of stroke regions, and characterization of other diseases. Perfusion MRI techniques are classified with or without using an exogenous contrast agent. Bolus methods, with injections of a contrast agent, provide better sensitivity with higher spatial resolution, and are therefore more widely used in clinical applications. However, arterial spin-labeling methods provide a unique opportunity to measure cerebral blood flow without requiring an exogenous contrast agent and have better accuracy for quantification. Importantly, MRI-based perfusion measurements are minimally invasive overall, and do not use any radiation and radioisotopes. In this review, we describe the principles and techniques of perfusion MRI. This review summarizes comprehensive updated knowledge on the physical principles and techniques of perfusion MRI.

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