Review
Biochemistry & Molecular Biology
Citlalli Netzahualcoyotzi, Luis Miguel Rodriguez-Serrano, Maria Elena Chavez-Hernandez, Mario Humberto Buenrostro-Jauregui
Summary: The endocannabinoid system plays a crucial role in regulating behavior and neuroplasticity, particularly during the adolescent-young adulthood phase. Maintaining balance in this system is important for proper neurogenesis and behavioral outcomes. Disruption of the ECS may lead to significant modifications in the genesis of new neurons and subsequent behavioral changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Renee C. Waters, Hunter M. Worth, Betsy Vasquez, Elizabeth Gould
Summary: Early life adversity increases the risk of developing neuropsychiatric illnesses, and adult neurogenesis may play a role in buffering against the detrimental stress-induced outcomes. This study suggests that there may be sex differences in the role of adult-born neurons in regulating behavior changes induced by early life adversity.
NEUROBIOLOGY OF STRESS
(2022)
Article
Neurosciences
Julia Leschik, Antonietta Gentile, Cigdem Cicek, Sophie Peron, Margaryta Tevosian, Annika Beer, Konstantin Radyushkin, Anna Bludau, Karl Ebner, Inga Neumann, Nicolas Singewald, Benedikt Berninger, Volkmar Lessmann, Beat Lutz
Summary: The neurotrophin brain-derived neurotrophic factor (BDNF) affects adult neurogenesis, structural plasticity and function of serotonergic neurons. Both BDNF/TrkB signaling and serotonergic system regulate behavioral responses to stress. Overexpression of BDNF in serotonergic neurons enhances hippocampus-dependent contextual learning and reduces the impact of chronic social defeat stress (CSDS). Increased neurogenesis is correlated with improved stress resilience.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Eric M. Schoenfeld, Nishant K. Gupta, Shariful A. Syed, Anna Rozenboym, Sasha L. Fulton, Andrea P. Jackowski, Tarique D. Perera, Jeremy D. Coplan
Summary: The study suggests that bonnet macaques reared under stress, carrying the ?s?-allele and having smaller adolescent hippocampal volume, exhibit reduced neurogenesis in adulthood. The positive impact of ipsilateral hippocampal volume on neurogenesis levels was observed.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Barbara D. Fontana, Alistair J. Gibbon, Madeleine Cleal, William H. J. Norton, Matthew O. Parker
Summary: The study found that the 7-day chronic unpredictable early-life stress (CUELS) protocol decreased anxiety in both young and adult zebrafish, while exposure to 14 days of CUELS led to an opposite anxious phenotype. However, memory and cognition, social behavior, and cortisol levels did not show significant changes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Alla B. Salmina, Yana V. Gorina, Yulia K. Komleva, Yulia A. Panina, Natalia A. Malinovskaya, Olga L. Lopatina
Summary: Early life stress causes long-lasting changes in brain plasticity, primarily through hyperactivation of hypothalamic-pituitary-adrenal axis, development of neuroinflammation, aberrant neurogenesis and angiogenesis, and significant alterations in brain metabolism. These changes are associated with mitochondrial dysfunction and deregulation of metabolic reprogramming.
Article
Psychology, Clinical
Congcong Liu, Lei Xu, Jialin Li, Feng Zhou, Xi Yang, Xiaoxiao Zheng, Meina Fu, Keshuang Li, Cornelia Sindermann, Christian Montag, Yina Ma, Dirk Scheele, Richard P. Ebstein, Shuxia Yao, Keith M. Kendrick, Benjamin Becker
Summary: Early life stress is associated with emotional dysregulations and altered brain structure, with serotonin playing a key role in neuroplasticity. The TPH2 gene modulates the impact of early life stress on brain function, with findings suggesting a phenotype characterized by facilitated threat avoidance in interaction with neural organization of limbic-prefrontal circuits.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sarfraj Ahmad Siddiqui, Sanjay Singh, Atul Rawat, Md Arshad, Sudhir Kumar
Summary: Stress-related neuropsychiatric disorders affect nearly everyone worldwide, with females experiencing higher levels of stress and anxiety. The role of serotonin receptor in stress and anxiety is thought to contribute to the sex-based difference between male and female animals. The current preclinical study investigates the role of serotonin 5HT-5A and 5B receptor in stress and anxiety in male and female rodents, revealing a region-specific association between these receptors under stressful conditions.
Article
Clinical Neurology
Chunmei Lan, Congcong Liu, Keshuang Li, Zhiying Zhao, Jiaxin Yang, Yina Ma, Dirk Scheele, Shuxia Yao, Keith M. Kendrick, Benjamin Becker
Summary: The present study provides the first evidence that the effects of oxytocin on stress-associated amygdala-hippocampal-midbrain pathways are critically mediated by the serotonin system in humans.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
David P. Herzog, Diego Pascual Cuadrado, Giulia Treccani, Tanja Jene, Verena Opitz, Annika Hasch, Beat Lutz, Klaus Lieb, Inge Sillaber, Michael A. Van der Kooij, Vijay K. Tiwari, Marianne B. Mueller
Summary: The study revealed differentially expressed genes associated with paroxetine treatment and candidate mechanisms related to good treatment response, such as neuropeptide signaling and synaptic transmission. The results suggest that general paroxetine effects can be distinguished from treatment response-associated molecular signatures, offering potential new targets for future antidepressant treatments.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Qixue Wang, Mengna Lu, Xinyu Zhu, Xinyi Gu, Ting Zhang, Chenyi Xia, Li Yang, Ying Xu, Mingmei Zhou
Summary: Anxiety in early life is linked to an increased risk of Alzheimer's disease (AD) later in life. Mitochondria dysfunction caused by anxiety-triggered oxidative stress might be a possible mechanism that connects early life anxiety to AD. Mitochondria play crucial roles in maintaining brain function, and disruptions in glucose homeostasis can lead to oxidative stress. Targeting mitochondria to reduce oxidative stress may prevent or delay the onset of AD in individuals with anxiety disorders.
Review
Biochemistry & Molecular Biology
Viktor Aniol, Anna Manolova, Natalia Gulyaeva
Summary: The dentate gyrus (DG), an important part of the hippocampus, is affected by early life stress, which can cause long-lasting changes in its structure and functioning. This review comprehensively discusses the effects of early life events on the maturation of neurons and glial cells in the DG.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Rachelle Larivee, Natalie Johnson, Natalie R. Freedgood, Heather A. Cameron, Timothy J. Schoenfeld
Summary: Stressors during adolescence can affect brain development and have long-lasting impacts on behavior. This study used a transgenic neurogenesis ablation rat model to investigate the functional effects of reduced hippocampal neurogenesis during adolescence. The results showed that long-term neurogenesis ablation starting in adolescence can lead to hippocampal atrophy and increased behavioral caution and despair in stressful environments.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Courtney S. Wilkinson, Harrison L. Blount, Marek Schwendt, Lori A. Knackstedt
Summary: This study used a rat model of PTSD to investigate the effects of stress on monoamine concentrations in brain regions associated with PTSD in female rats. The findings indicate that stress exposure can lead to long-term alterations in monoamine function in female rats, suggesting potential interventions using MAOIs as a treatment for PTSD in women.
Article
Medicine, Research & Experimental
Xia Qin, Xiao-Xuan Liu, Yu Wang, Dan Wang, Ying Song, Jia-Xin Zou, Han-Qing Pan, Xiao-Zhou Zhai, Yong-Mei Zhang, Yang-Bo Zhang, Ping Hu, Wen-Hua Zhang
Summary: Early life stress (ELS) increases the risk of anxiety disorders and depression in later life, potentially through hyperactivation of basolateral amygdala (BLA) neurons. In a mouse model mimicking ELS through maternal separation (MS), it was found that MS significantly increased anxiety-like behavior in adulthood and altered neuronal activity and synaptic transmission in BLA projection neurons. This study provides new insights into the mechanisms underlying ELS-induced anxiety disorders.
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)