Article
Behavioral Sciences
Chloe C. Boyle, Julienne E. Bower, Naomi I. Eisenberger, Michael R. Irwin
Summary: Anhedonia, a common feature of depression, is characterized by impaired pleasurable response to reward, reduced reward motivation, and/or deficits in reward-related learning. Stress-induced inflammation may be a plausible mechanism for these reward deficits. This paper reviews evidence for the effects of stress and inflammation on reward function and highlights the need for further scientific inquiry to inform the development of precise interventions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Xiao Liu, Jingjing Huang, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Peng Yu, Jianyong Ma, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: This study investigated the inflammatory biomarker profiles of psychological treatment-naive individuals and found that levels of IL-6 and IL-8 were positively correlated with symptoms of depression, suggesting they may play a role in the pathogenesis of psychological disorders. However, these associations were not significant after multiple testing. Larger and longitudinal studies are needed to confirm these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
I. Patlan, M. P. Jeffrey, D. Lewis, J. Green-Johnson, S. Dogra
Summary: This study compared the effects of exercise in cold-dry and normal conditions on salivary cytokine levels and airway response in young healthy males. The results showed that IL-8 levels increased in normal conditions but not in cold-dry conditions, while the opposite trend was observed for IL-1RA.
Article
Immunology
Grzegorz Majka, Henryk Mazurek, Magdalena Strus, Marta Ciszek-Lenda, Rafal Szatanek, Agnieszka Pac, Edyta Golinska, Janusz Marcinkiewicz
Summary: The high concentration of sputum bacteria in cystic fibrosis patients with advanced lung disease is associated with increased levels of inflammatory markers and low levels of certain cytokines. Specific inflammatory biomarkers including blood CRP, NLR, and sputum elastase, IL-6, IL-8, and IL-10 are recommended for monitoring the disease.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Neurosciences
Michael Maes, Joao Victor Nani, Cristiano Noto, Lucas Rizzo, Mirian A. F. Hayashi, Elisa Brietzke
Summary: The study found that bipolar disorder is associated with simultaneous activation of the immune-inflammatory response system and the compensatory immune-regulatory system, which may be related to the staging of the illness. Immune injuries and HCMV infection in BD patients contribute to dysfunctional CIRS and exaggerated IRS responses, playing a key role in inflammation and neuroaffective toxicity.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, General & Internal
Jordan Bamford, Gerard Leavey, Michael Rosato, Natalie Divin, Gavin Breslin, Dagmar Corry
Summary: This study explores the relationship between adolescent mental well-being, religion, and family activities in a school-based sample from Northern Ireland. The findings suggest that non-religious adolescents may have lower mental well-being scores compared to their religious peers, regardless of religious denomination. This may be due to a lack of firm identity and a sense of marginalization. Additionally, poor family cohesion is associated with poorer mental well-being in adolescents.
Article
Biochemistry & Molecular Biology
Dan Mao, Hiroshi Inoue, Takuya Notomi, Seiji Goda
Summary: The p38a isoform is crucial for TNF-a-induced IL-8 production in Ca9-22 cells, and its activation is associated with the phosphorylation of threonine 180 and tyrosine 182. This study highlights p38a as a potential therapeutic target for preventing and treating periodontal disease.
Article
Biochemistry & Molecular Biology
Michal Tomaszewski, Paulina Mertowska, Martyna Janczewska, Agnieszka Styczen, Sebastian Mertowski, Kamil Jonas, Ewelina Grywalska, Grzegorz Kopec
Summary: Pulmonary arterial hypertension (PAH) is a complex disorder where cytokines play a crucial role in deregulation of the immune system. This study found that PAH patients have abnormal immune function with decreased percentages of immune cell subpopulations and changes in cytokine concentration. Furthermore, significant differences were observed between PAH subtypes and immunological parameters, suggesting the important role of the immune system in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xiaofei Xu, Errol Prens, Edwin Florencia, Pieter Leenen, Luis Boon, Patrick Asmawidjaja, Anne-Marie Mus, Erik Lubberts
Summary: The up-regulation of IL-19 and IL-24 induced by IL-17A in skin stromal cells contributes to keratinocyte proliferation. Depletion of IL-10 leads to increased expression of IL-23/IL-17 pathway related cytokines followed by significant up-regulation of IL-19 and IL-24.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Summer N. Millwood, Erika M. Manczak
Summary: Inflammation plays a critical role in physical and mental health outcomes, and chronic inflammation is linked with disease and mortality. Social support is associated with lower rates of mortality and psychopathology, but there is limited research on the association between social support and inflammation within racial groups. The current study found that perceived emotional social support during adolescence predicts inflammation during adulthood, but the relationship varies across racial groups, with White participants showing lower inflammation and individuals from other racial groups showing higher inflammation. The findings highlight the importance of studying relationship processes and health outcomes within racial groups.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Psychiatry
Emma Claesdotter-Knutsson, Carl Delfin, Natalie Laporte, Marta Wallinius
Summary: The study found that forensic psychiatric patients with a history of child and adolescent psychiatry contact and institutional placement demonstrate more externalizing disorders, higher number of criminal convictions, and lower age at first criminal activity.
PSYCHIATRY RESEARCH
(2021)
Review
Pediatrics
Daniel Hayes, Jemma Thievendran, Marinos Kyriakopoulos
Summary: Inpatient mental health services provide comprehensive assessment and treatment for adolescents severely affected by mental health difficulties. Collaboration between inpatient units, community teams, young people and their families is essential to ensure effective and efficient interventions that foster engagement, independence and optimal outcomes. Careful assessment and management of potential adverse effects associated with inpatient admissions is crucial.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Medicine, General & Internal
Yoshinori Sasaki, Masahide Usami, Shoko Sasaki, Hikaru Sunakawa, Yusuke Toguchi, Shuichi Tanese, Kiyoshi Saito, Rena Shinohara, Toshinari Kurokouchi, Kaori Sugimoto, Yuki Hakoshima, Kumi Inazaki, Yuta Yoshimura, Yuki Mizumoto, Takayuki Okada
Summary: This study aimed to evaluate the clinical characteristics of child and adolescent psychiatric patients with child-to-parent violence (CPV). The results showed that patients in the CPV group had significantly higher proportions of experiencing physical abuse, psychological abuse, and witnessing violence between parents. Additionally, there was a significant correlation between neurodevelopmental disorders and CPV, with impulsivity potentially being related to CPV.
Review
Immunology
Lauren A. Zenewicz
Summary: Cytokines, including IL-22, play crucial roles in inflammation, with their activity regulated by factors like IL-22BP. IL-22BP, a soluble receptor homolog, binds to IL-22 with greater affinity, impacting the biological functions of IL-22, yet further research is needed to fully understand its role and regulation mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Zane Vitenberga-Verza, Mara Pilmane, Ksenija Serstnova, Ivars Melderis, Lukasz Gontar, Maksymilian Kochanski, Andzelika Drutowska, Gergely Maroti, Beatriz Prieto-Simon
Summary: This study aimed to investigate the inflammatory and regulatory cytokines in the milk of dairy cows with subclinical and clinical mastitis. The results showed that IL-1 alpha, IL-4, and IL-17A drive the inflammatory responses in mastitis cases. Furthermore, the host defense response in mastitis is characterized by the continuation or resolution of the initial inflammation.
Article
Clinical Neurology
E. Forcadell, B. Garcia-Delgar, R. Nicolau, A. Perez-Vigil, C. Cordovilla, L. Lazaro, L. Ibanez, P. Mir, M. Madruga-Garrido, M. Correa-Vela, A. Morer
Summary: Most people with persistent tics report experiencing a premonitory urge before the tic. The Premonitory Urge for Tics Scale (PUTS) is a widely used tool for assessing these sensations. In this study, the Spanish-language version of the PUTS was found to be valid and reliable in assessing premonitory urges in children and adolescents, particularly those over the age of 10.
Article
Psychology, Developmental
Alexis Revet, Johannes Hebebrand, Dimitris Anagnostopoulos, Laura A. Kehoe, Gertraud Gradl-Dietsch, Paul Klauser
Summary: This report presents the findings from a survey on the impact of COVID-19 on child and adolescent psychiatry services in Europe. While service delivery was significantly affected at the beginning of the pandemic, the second survey showed a minor impact on care delivery. However, there was a dramatic increase in the perceived impact on the mental health and psychopathology of children and adolescents. Suicidal crises, anxiety disorders, eating disorders, and major depressive episodes were particularly affected. There was a substantial increase in referrals or requests for assessments, and CAP department heads expressed concerns about the long-term consequences of the crisis.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Editorial Material
Psychology, Developmental
Luisa Lazaro
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Matti Cervin, Blanca Garcia-Delgar, Rosa Calvo, Ana E. Ortiz, Luisa Lazaro
Summary: This study evaluates the performance of the OCI-CV questionnaire in identifying clinically significant symptoms of pediatric OCD. The results show that OCI-CV performs well in identifying contamination/cleaning symptoms, disturbing thoughts/checking symptoms, and symmetry/ordering symptoms, with high accuracy.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Oncology
Marta Espanol-Rego, Carlos Fernandez-Martos, Elena Elez, Carles Foguet, Leire Pedrosa, Nuria Rodriguez, Ana Ruiz-Casado, Estela Pineda, Joan Cid, Raquel Cabezon, Helena Oliveres, Miquel Lozano, Angels Gines, Angeles Garcia-Criado, Juan Ramon Ayuso, Mario Pages, Miriam Cuatrecasas, Ferran Torres, Timothy Thomson, Marta Cascante, Daniel Benitez-Ribas, Joan Maurel
Summary: This study investigated the potential of Avelumab combined with ADC vaccine as a treatment for MSS mCRC patients. The results showed that the combination therapy was safe and well tolerated, but had limited clinical activity. Additionally, the study found a post-therapy metabolic rewiring, which could represent novel immunotherapy-induced tumor vulnerabilities.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Oana J. Nicoara-Farcau, Juan J. Lozano, Cristina Alonso, Julia Sidorova, Candid Villanueva, Augustin Albillos, Joan Genesca, Elba Llop, Jose L. Calleja, Carles Aracil, Rafael Banares, Rosa Morillas, Maria Poca, Beatriz Penas, Salvador Augustin, Marcel Tantau, Marcos Thompson, Valeria Perez-Campuzano, Anna Baiges, Fanny Turon, Virginia G. Hernandez-Gea, Juan G. Abraldes, Edilmar A. Tapias, Ferran Torres, Jaime Bosch, Juan Garcia-Pagan
Summary: This study aims to evaluate the role of metabolomics in predicting clinical outcomes in compensated cirrhosis patients. The results show that metabolomics can provide similar predictive capacity as invasive HVPG testing.
Article
Gastroenterology & Hepatology
Ian Rowe, Candid E. Villanueva, Jessica Shearer, Ferran Torres, Agustin Albillos, Joan C. Genesca, Joan Garcia-Pagan, Dhiraj C. Tripathi, Peter Hayes, Jaume G. Bosch, Juan Abraldes
Summary: This study conducted a Bayesian reanalysis of PREDESCI and found that beta-blocker treatment is highly likely to prevent decompensation and provides a substantial gain in decompensation-free life years at the population level.
Article
Pharmacology & Pharmacy
Stella Pesiou, Rafel Barcelo, Marc Fradera, Ferran Torres, Caridad Pontes
Summary: Psychotropic use in pediatrics, especially off-label use, is common and carries potential risks. A retrospective study in Catalonia, Spain found that the prevalence of psychotropic use in pediatric patients was high, with hydroxyzine as the most commonly dispensed drug. Adolescents and boys were more likely to receive psychotropics, particularly psychostimulants like methylphenidate. About 12% of subjects had received off-label prescriptions, highlighting the need for further research on efficacy and safety in pediatric populations where extrapolation from adult data is unreliable.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Dan Ouchi, Carles Vilaplana-Carnerero, Ramon Monfa, Maria Giner-Soriano, Ana Garcia-Sangenis, Ferran Torres, Rosa Morros
Summary: This study aims to describe the impact of initiating a combination treatment to reduce glycated hemoglobin in patients with type 2 diabetes. The study found that combination therapy with insulin and glucagon-like peptide-1 achieved the goal faster, while combinations with sulfonylureas had poorer results. Medication adherence played an important role in glycated hemoglobin control.
DRUGS-REAL WORLD OUTCOMES
(2023)
Article
Endocrinology & Metabolism
Dan Ouchi, Maria Giner-Soriano, Carles Vilaplana-Carnerero, Ramon Monfa, Ferran Torres, Rosa Morros
Summary: The aim of this study was to analyze the initial and subsequent treatments prescribed to newly diagnosed type 2 diabetes mellitus patients. The majority of patients started treatment with a single metformin medication, while a smaller percentage began with combination therapy. Metformin was the most commonly used first and third-line therapy, while metformin with DPP4i or sulfonylurea combination therapy was more prevalent as second-line therapy.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Letter
Gastroenterology & Hepatology
Candid Villanueva, Ferran Torres, Dhiraj Tripathi, Jaume Bosch
JOURNAL OF HEPATOLOGY
(2023)
Article
Psychiatry
Patricia Camprodon-Boadas, Elena De La Serna, Maria Teresa Plana, Itziar Flamarique, Luisa Lazaro, Roger Borras, Inmaculada Baeza, Elisabet Tasa-Vinyals, Gisela Sugranyes, Ana Encarnacion Ortiz, Josefina Castro-Fornieles
Summary: This study analyzed the psychometric properties of the Brown Assessment of Beliefs Scale (BABS) in adolescents diagnosed with first-episode psychosis, obsessive-compulsive disorder, or anorexia nervosa. It found that the BABS scale is a valid and reliable tool for assessing delusionality in these adolescents, with significant differences observed among the disorders. Assessing these symptoms could have a positive impact on treatment management and prognosis.
PSYCHIATRY RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
David Elvira, Ferran Torres, Roser Vives, Gemma Puig, Merce Obach, Daniel Gay, Daniel Varon, Thais de Pando, Josep Tabernero, Caridad Pontes
Summary: This study evaluates the relationship between oncology and hematology drug prices and structured value parameters at the time of reimbursement decision in Spain. The results show that factors such as the type of standard of care, references to long-lasting responders, the convenience of drug use, and the impact of treatment on patient autonomy are associated with drug prices. The study suggests that implementing MCDA-EVIDEM methodologies may capture the influence of additional factors on pricing decisions.
FRONTIERS IN PUBLIC HEALTH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Elisa Pose, Cesar Jimenez, Giacomo Zaccherini, Daniela Campion, Salvatore Piano, Frank Erhard Uschner, Koos de Wit, Olivier Roux, Kohilan Gananandan, Wim Laleman, Cristina Sole, Sonia Alonso, Berta Cuyas, Xavier Ariza, Adria Juanola, Ann T. Ma, Laura Napoleone, Jordi Gratacos, Marta Tonon, Enrico Pompili, Jordi Sanchez-Delgado, Marta Carol, Martina Perez, Nuria Fabrellas, Judit Pich, Claudia Martell, Georgina Casanovas, Gemma Domenech, Ferran Torres, Victor Manuel, Vargas Blasco, Paolo Caraceni, Carlo Alessandria, Paolo Angeli, Jonel Trebicka, Ulrich Beuers, Claire Francoz, Raj Mookerjee, Rafael Banares, German Soriano, Ruben Hernaez, Andrew S. Allegretti, Manuel Morales-Ruiz, Miquel Serra, Hugh Watson, Juan G. Abraldes, Patrick S. Kamath, Pere Gines
JOURNAL OF HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)