Journal
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
Volume 14, Issue 5, Pages 257-263Publisher
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
DOI: 10.4196/kjpp.2010.14.5.257
Keywords
Neuroprotection; Kainic acid; Hippocampus; Visnagin; Cytokines
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Funding
- Ministry of Health, Welfare & Family Affairs, Republic of Korea [A081028]
- National Research Foundation of Korea (NRF) [NRF 2009 0094072]
- Ministry of Education, Science and Technology [2009K001254]
- Korea Health Promotion Institute [A081028] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [22-2009-00-007-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g][1]-benzopyran-5-one), which is an active principle extracted from the fruits of Ammi visnaga, has been used as a treatment for low blood-pressure and blocked blood vessel contraction by inhibition of calcium influx into blood cells However, the neuroprotective effect of visnagin was not clearly known until now Thus, we investigated whether visnagin has a neuroprotective effect against kainic acid (KA)-induced neuronal cell death In the cresyl violet staining, pre-treatment or post-treatment visnagin (100 mg/kg, p o or 1 p) showed a neuroprotective effect on KA (0 1 mu g) toxicity KA-induced gliosis and proinflammatory marker (IL-1 beta, TNF-alpha, IL-6, and COX-2) inductions were also suppressed by visnagin administration These results suggest that visnagin has a neuroprotective effect in terms of suppressing KA-induced pathogenesis in the brain, and that these neuroprotective effects are associated with its anti-inflammatory effects
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