Article
Medicine, General & Internal
Na Ri Choi, Jeong Nam Kim, Min Ji Kwon, Jong Rok Lee, Sang Chan Kim, Min Jae Lee, Woo-gyun Choi, Byung Joo Kim
Summary: Grape seed powder can regulate gastrointestinal motility and may serve as a potential therapeutic agent for gastrointestinal motility disorders.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Donghun Han, Jeong Nam Kim, Min Ji Kwon, Taewon Han, Yun Tai Kim, Byung Joo Kim
Summary: Research showed that Salvia miltiorrhiza can increase the contractility of the small intestine by depolarizing the pacemaker potentials of ICCs, leading to a higher intestinal transit rate in mice. This effect may be mediated through estrogen receptor beta and G protein pathways, regulated by extracellular Ca2+ and Na+ levels.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Na Ri Choi, Jeong Nam Kim, Byung Joo Kim
Summary: This study investigated the effects of trypsin on pacemaker potentials in murine small intestinal ICCs, finding that trypsin depolarized pacemaker potentials through NK1 and NK2 receptors, depending on G protein, phospholipase C, protein kinase C, inositol triphosphate pathways, and extracellular Ca2+ but independent of the TRPV4 pathway.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Na Ri Choi, Jeong Nam Kim, Min Jae Lee, Byung Joo Kim
Summary: JYGCT can inhibit the pacemaker potential of the interstitial cells of Cajal (ICC), regulate gastrointestinal motility, and alleviate the symptoms of irritable bowel syndrome through various pathways.
APPLIED SCIENCES-BASEL
(2022)
Article
Biology
Moriya Shushan, Michal Shoshkes-Carmel
Summary: Researchers have identified a FOXL1+ intestinal subepithelial network of telocytes (TCs) that play a crucial role in the proliferation and regeneration of epithelial stem and progenitor cells. These FOXL1+ lineage cells are found not only along the intestinal epithelium, but also within the muscle layers. The study suggests that there is a mutual origin for TCs and smooth muscle cells (SMCs).
Article
Medicine, Research & Experimental
Yujin Wang, Hua Jiang, Lijun Wang, Huiping Gan, Xinchun Xiao, Liangwu Huang, Wenxin Li, Zongrun Li
Summary: This study evaluated the laxative effects of arctiin on functional constipation in mice. Results showed that arctiin reversed the constipation symptoms induced by loperamide, improved fecal condition and intestinal motility. Furthermore, arctiin reduced inflammation induction and aquaporin expression levels.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Egan L. Choi, Negar Taheri, Elijah Tan, Kenjiro Matsumoto, Yujiro Hayashi
Summary: This article discusses the role of interstitial cells of Cajal (ICC) in neurointestinal diseases and their association with various gastrointestinal disorders. Understanding the functions of ICC could provide new perspectives on modulating gastrointestinal motility and could lead to innovative therapeutic paradigms, enhancing efforts to combat neurointestinal diseases.
Article
Pharmacology & Pharmacy
Marilisa Straface, Marie -Ange Koussai, Raj Makwana, Ellie Crawley, Alexandra Palmer, Weigang Cai, Armen Gharibans, Miriam Adebibe, John Loy, Greg O'Grady, Paul L. R. Andrews, Gareth J. Sanger
Summary: Software was developed to measure muscle tone and parameters defining contractions in human stomach. The study found that only E-4031 and CaCC blockers influenced myogenic contractions, not muscle tone.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Suk Bae Moon, Na Ri Choi, Jeong Nam Kim, Min Ji Kwon, Bo-Sung Kim, Ki-Tae Ha, Eun Yeong Lim, Yun Tai Kim, Byung Joo Kim
Summary: This study investigated the effects of black garlic extract on pacemaker potentials of ICC in the small intestines of mice and its potential to regulate gastrointestinal motility. The study also explored the antioxidant activity of black garlic extract. The results showed that black garlic extract depolarizes the pacemaker potentials of ICC and increases the intestinal transit rate. Additionally, black garlic extract exhibited antioxidant activity.
ANIMAL CELLS AND SYSTEMS
(2022)
Article
Gastroenterology & Hepatology
Haisheng Qian, Yanjuan Wang, Xiaosu Chen, Lin Lin, Weifeng Zhang, Yun Wang, Nana Tang, Xinmin Si, Chunhua Jiao, Guoxin Zhang, Bixing Ye
Summary: This study preliminarily explored the association between muscularis macrophages (MM phi) and achalasia. The findings showed that patients with achalasia had fewer interstitial cells of Cajal (ICC) and higher levels of M1 macrophages in the lower esophageal sphincter (LES). There were significant correlations between M2/MM phi and the numbers of ICC and glial cells, suggesting that MM phi may be associated with the occurrence and development of achalasia.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lori B. Dershowitz, Li Li, Anca M. Pasca, Julia A. Kaltschmidt
Summary: The study reveals that the human enteric nervous system starts to develop during the second trimester and follows a similar pattern to embryonic mice in terms of gastrointestinal motility. These findings are crucial for comparing with animal models, which can improve disease investigations and drug testing.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Hyo Eun Kwon, Jeong Nam Kim, Min Ji Kwon, Jong Rok Lee, Sang Chan Kim, Joo Hyun Nam, Byung Joo Kim
Summary: The study found that BJIT significantly increased intestinal transit rate and motilin levels, influenced GI motility by affecting c-kit expression, and affected the pacemaker potential of ICCs. Furthermore, BJIT was also shown to inhibit specific ion channels, making it a potential effective medication for controlling GI motility.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Biology
Lisa Klemm, Robert Seydewitz, Tobias Siebert, Markus Boel
Summary: The contraction activation of smooth muscle in the stomach wall (SW) is coordinated by slow electrical waves initiated and propagated by interstitial cells of Cajal (ICC). This model integrates a biophysically based model of ICC pacemaker activity and a mechanical feedback mechanism to simulate gastric slow waves induced by abnormal stretching of the antral SW. The model predicts stretch-induced gastric arrhythmias, such as the emergence of an ectopic pacemaker in the gastric antrum.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Cell & Tissue Engineering
Sue Ann Mah, Recep Avci, Jean-Marie Vanderwinden, Peng Du
Summary: This study employed fractal parameters to analyze the structure of gastric ICC networks. The results showed differences in fractal dimension, lacunarity, and succolarity among ICC networks in different regions, providing better understanding of the structural-functional relationship between ICC networks and the conduction of gastric slow waves.
CELLULAR AND MOLECULAR BIOENGINEERING
(2023)
Article
Immunology
Yi Yuan, Yan Lu, Zhihua Zhang, Weixia Cheng, Kunlong Yan, Yucan Zheng, Yu Jin, Zhifeng Liu
Summary: Children with refractory constipation show lower colonic motility, altered ICCs, and distinct intestinal microbiota composition compared to healthy controls. These findings provide valuable insights into the pathophysiological mechanisms and potential therapeutic strategies for children with refractory constipation.
MICROBIAL PATHOGENESIS
(2023)
Article
Gastroenterology & Hepatology
Ik Hyun Jo, Kang-Moon Lee, Dae Bum Kim, Ji Won Kim, Jun Lee, Yoon Tae Jeen, Tae-Oh Kim, Joo Sung Kim, Jae Jun Park, Sung Noh Hong, Dong Il Park, Hyun-Soo Kim, Yoo Jin Lee, Youngdoe Kim
Summary: The study found that HRQL improved in patients with moderate-to-severe UC after one year. A higher partial Mayo score was significantly associated with poorer HRQL on both IBDQ and SF-12. Inflammatory markers such as CRP or erythrocyte sedimentation rate were negatively correlated with HRQL.
Article
Medicine, General & Internal
Bora Han, Ji-Yun Hong, Eun Myung, Hyung-Hoon Oh, Hee-Chan Yang, Sang-Wook Kim, Jun Lee, Seong-Jung Kim, Yeom-Dong Han, Geom-Seok Seo, Gun-Young Hong, Ho-Dong Kim, Hyun-Soo Kim, Young-Eun Joo
Summary: The study found that procedure time was significantly associated with the technical success of SEMS placement, while longer length of obstruction, the use of covered stents, and longer procedure time were significant independent predictive factors for the clinical success of SEMS placement. Stage IV colorectal cancer and the use of covered stents were significant independent predictive factors for the development of complications after SEMS placement.
Article
Gastroenterology & Hepatology
Seung Yong Shin, Soo Jung Park, Young Kim, Jong Pil Im, Hyo Jong Kim, Kang-Moon Lee, Ji Won Kim, Sung-Ae Jung, Jun Lee, Sang-Bum Kang, Sung Jae Shin, Eun Sun Kim, You Sun Kim, Tae Oh Kim, Hyun-Soo Kim, Dong Il Park, Hyung Kil Kim, Eun Soo Kim, Young-Ho Kim, Do Hyun Kim, Dennis Teng, Jong-Hwa Kim, Wonyong Kim, Chang Hwan Choi
Summary: The study showed that ADA is effective and safe for induction and maintenance therapy in Korean patients with UC, regardless of prior anti-TNF-alpha therapy. ADA drug level is associated with the efficacy of induction therapy, and patients with better short-term outcomes may predict those with an improved long-term response.
INTESTINAL RESEARCH
(2022)
Article
Cell Biology
Seok Choi, Hyunhyo Seo, Kyungmin Lee, Dong Hoon Shin, Mei Jin Wu, Wenhao Wu, Xingyou Huang, Jingwei Zhang, Chansik Hong, Jae Yeoul Jun
Summary: The study revealed the presence of HCN channels in colonic ICC and their involvement in generating pacemaking potentials, suggesting that HCN channels could be therapeutic targets for disturbed colonic motility disorders.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Surgery
Seong-Jung Kim, Su Young Kim, Jun Lee
Summary: This study investigated the risk factors and prognosis of post-colorectal ESD electrocoagulation syndrome (PECS) and found that larger lesion size, lesions with fibrosis, longer procedure time, older age, and a larger amount of submucosal injection were independent risk factors for PECS. PECS patients also had longer fasting days, hospital stays, and higher medical costs compared to non-PECS patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Su Bum Park, Seong-Jung Kim, Jun Lee, Yoo Jin Lee, Dong Hoon Baek, Geom Seog Seo, Eun Soo Kim, Sang-Wook Kim, So Yeong Kim
Summary: Sigmoidoscopy can be considered a sufficient substitute for colonoscopy in evaluating disease activity in ulcerative colitis, as they show a high concordance rate. However, colonoscopy should still be considered in patients with previous extensive colitis.
BMC GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Seung Wook Hong, Byong Duk Ye, Jae Hee Cheon, Ji Hyun Lee, Ja Seol Koo, Byung Ik Jang, Kang-Moon Lee, You Sun Kim, Tae Oh Kim, Jong Pil Im, Geun Am Song, Sung-Ae Jung, Hyun Soo Kim, Dong Il Park, Hyun-Soo Kim, Kyu Chan Huh, Young-Ho Kim, Jae Myung Cha, Geom Seog Seo, Chang Hwan Choi, Hyun Joo Song, Gwang Ho Baik, Ji Won Kim, Sung Jae Shin, Young Sook Park, Chang Kyun Lee, Jun Lee, Sung Hee Jung, Yunho Jung, Sung Chul Park, Young-Eun Joo, Yoon Tae Jeen, Dong Soo Han, Suk-Kyun Yang, Hyo Jong Kim, Won Ho Kim, Joo Sung Kim
Article
Cell Biology
Byeongseok Jeong, Tae Sik Sung, Dongju Jeon, Kyu Joo Park, Jae Yeoul Jun, Insuk So, Chansik Hong
Summary: This study investigated the molecular mechanism of tricyclic antidepressants (TCAs) in the gastrointestinal (GI) tract. The findings suggest that TCAs inhibit the TRPC4 channels in colonic myocytes, ultimately leading to constipation. These findings provide clinical insights into abnormal intestinal motility and IBS therapy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Seung Woo Lee, Jun Lee, Seong Jung Kim, Ran Hong
Summary: This article reports a case of GCT-ST identified in the colon. Although GCT-ST generally has a benign clinical course, complete resection should be performed to prevent recurrence and metastasis.
BMC GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Jun Lee
Summary: In patients with inflammatory bowel disease who do not respond to steroid or immunomodulatory treatment, a diagnostic evaluation for cytomegalovirus (CMV) infection is required. However, an accurate diagnostic method for CMV infection in patients with IBD is still unclear, and it is difficult to distinguish exacerbation of ulcerative colitis from CMV colitis.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Jun Lee, Seong-Jung Kim, Sang-Wook Kim, Hyo-Yeop Song, Geom Seog Seo, Dong-Hyun Kim, Dae-Seong Myung, Hyun-Soo Kim, Young-Eun Joo, So Yeong Kim
Summary: This study compared the effectiveness of 1 L polyethylene glycol (PEG) with ascorbic acid and sodium picosulfate (PICO) with magnesium citrate for bowel cleansing. The results showed that overall bowel cleansing success was similar between the two groups. High-quality bowel cleansing was slightly higher in the 1 L PEG with ascorbic acid group. Patient satisfaction was better in the PICO with magnesium citrate group, but compliance and side effects were similar in both groups.
Letter
Gastroenterology & Hepatology
Jun Lee
INTESTINAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Seok Choi, Jun Hyung Lee, Dong Hoon Shin, Wenhao Wu, Xingyou Huang, Chansik Hong, Jae Yeoul Jun
Summary: Adenosine plays an important role in GI motility by regulating pacemaker activity through A1 receptors. Adenosine depolarizes the membrane and increases pacemaker frequency, which can be blocked by A1 receptor antagonists. Adenosine also modulates pacemaker activity through activation of HCN channels and intracellular Ca2+ mechanisms.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Seong-Jung Kim, Jun Lee, Dae Youb Baek, Jun Hyung Lee, Ran Hong
Summary: This study found that patients with early gastric neoplasms (EGNs) have a higher incidence of colorectal adenomas, and old age and a history of EGN are independent risk factors for colorectal adenomas.
Meeting Abstract
Gastroenterology & Hepatology
Susan Y. Quan, Mike Wei, Jun Lee, Raja Mohi-Ud-Din, Radman Mostaghim, Ritu M. Sachdev, David Siegel, Shai Friedland