Review
Food Science & Technology
Mingqi Zhao, Miao Wang, Xiaoguang Zhang, Yongan Zhu, Jing Cao, Yongxin She, Zhen Cao, Guangyue Li, Jing Wang, A. M. Abd El-Aty
Summary: Excessive use of pesticides poses a serious threat to the environment and human health. Rapid detection of pesticide residues in food is crucial, and recognition elements play a key role in sensors and testing methods. Improper recognition elements can lead to method defects. Molecular biological techniques provide an effective strategy for addressing these challenges. This review summarizes the molecular biological methods for five specific recognition elements and discusses their application in conjunction with biosensors and immunoassays.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Hyung Sub Park, A. M. Abd El-Aty, Ji Hoon Jeong, Taeseung Lee, Tae Woo Jung
Summary: The study revealed that capmatinib treatment can improve the adhesion between endothelial cells and monocytes caused by inflammation, through the PPARd/IL-10 dependent pathway, providing a theoretical basis for the treatment of atherosclerosis.
BIOMEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Esra cinar Tanriverdi, Mehmet Akif Nas, Kamber Kasali, Mehmet Emin Layik, A. M. Abd El-Aty
Summary: This study aimed to adapt and validate the Turkish version of the Professionalism Assessment Scale, which is used to evaluate the professionalism attitudes of medical students. The scale's translation-back-translation was performed and validated through various statistical analyses. The Turkish version of the Professionalism Assessment Scale was found to be a valid and reliable tool for assessing medical students' professionalism attitudes in Turkey.
Article
Chemistry, Analytical
Yong Shao, Run Tian, Jiaqi Duan, Miao Wang, Jing Cao, Zhen Cao, Guangyue Li, Fen Jin, A. M. Abd El-Aty, Yongxin She
Summary: A biosensor-based detection method was developed, using carboxylated modified magnetic beads incubated with NH2-polyA and then hybridized with polyT-glyphosate aptamer and complementary DNA. The method showed high sensitivity and good recovery rates, indicating its potential application in pesticide residue detection.
Article
Cell Biology
Sung Woo Choi, Heeseung Oh, Seung Yeon Park, Wonjun Cho, A. M. Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jung
Summary: Gremlin-1 (GR1) is a novel adipokine that is highly expressed in human adipocytes and has been shown to inhibit the BMP2/4-TGFβ signaling pathway, leading to insulin resistance in skeletal muscle, adipocytes, and hepatocytes. This study investigated the effect of GR1 on hepatic lipid metabolism and found that it promotes hepatic ER stress, lipid accumulation, and lipogenesis, while reducing autophagy. Targeting GR1 could be a potential therapeutic approach for metabolic diseases, including MAFLD.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Chemistry, Medicinal
Wonjun Cho, Seung Yeon Park, Heeseung Oh, A. M. Abd El-Aty, Ahmet Hacimuftuoglu, Dae-Sung Kim, Tae Woo Jung, Ji Hoon Jeong
Summary: This study aimed to investigate the effects of Humulus japonicus ethanol extracts (HE) and luteolin 7-O-beta-D-glucoside (LU) on ethanol-induced oxidative stress and lipid accumulation in primary hepatocytes. The results showed that both HE and LU attenuated ethanol-induced lipid accumulation, lipogenic protein expression, and cellular oxidative stress. Treatment with HE or LU increased PPAR alpha and SOD1 expression and catalase activity. Furthermore, orally administered HE treatment alleviated hepatic steatosis in ethanol-fed mice.
JOURNAL OF MEDICINAL FOOD
(2023)
Article
Agriculture, Multidisciplinary
Gonca Alak, Arzu Ucar, Veysel Parlak, Hasan Turkez, Esat Mahmut Kocaman, Muhammed Atamanalp, A. M. Abd El-Aty
Summary: The study investigated the effects of biofilm coatings obtained by immobilization of different borates with chitosan on the shelf life of rainbow trout fillets. The results showed that the coatings enriched with borates extended the shelf life by 3-6 days compared to the control group. Therefore, chitosan-enriched coatings of borates can be used as natural bioactive nanocarriers in the seafood processing industry.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Pharmacology & Pharmacy
Feng He, Haijie Wang, Pengfei Du, Tengfei Li, Weiting Wang, Tianyu Tan, Yaobo Liu, Yanli Ma, Yuanshang Wang, A. M. Abd El-Aty
Summary: Ensuring food safety is crucial worldwide, but developing effective detection methods for trace hazards in food can be challenging. The personal glucose meter (PGM) shows promise in food safety due to its unique advantages, and signal amplification technologies have the potential to improve its analytical performance and integration with biosensors. This review discusses the detection principle of PGM-based sensing strategies and reviews representative studies using signal amplification technologies in the field of food safety detection. Despite challenges such as sample preparation and lack of standardization, using PGMs with signal amplification technology is a promising rapid and cost-effective method for food safety hazard analysis.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Review
Food Science & Technology
Elif Ekiz, Emel Oz, A. M. Abd El-Aty, Charalampos Proestos, Charles Brennan, Maomao Zeng, Igor Tomasevic, Tahra Elobeid, Kenan Cadirci, Muharrem Bayrak, Fatih Oz
Summary: Ganoderma lucidum, a medicinal mushroom used in Chinese medicine for centuries, has various medicinal properties such as antioxidant, anti-inflammatory, and immune-boosting effects. Recent research has explored its potential benefits in treating metabolic disorders and infections caused by the coronavirus. However, further clinical trials are needed to confirm its effectiveness in preventing or treating coronavirus infections.
Article
Chemistry, Analytical
Yuanshang Wang, Xiaoran Wang, Yi Yan, Jia Wang, Youyou Lu, A. M. Abd El-Aty, Xiaohong Wang
Summary: A new technique utilizing phage T156-mediated aggregation of gold nanoparticles was developed for visual and precise detection of Salmonella. The method offers simplicity, speed, and the ability to distinguish between live and dead Salmonella, demonstrating remarkable sensitivity, specificity, and accuracy. It also presents a novel avenue for the rapid detection of other pathogenic bacteria.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Wonjun Cho, Heeseung Oh, Sung Woo Choi, A. M. Abd El-Aty, Oguzhan Birdal, Ji Hoon Jeong, Jin-Ho Song, Tae Woo Jung
Summary: CTRP4 alleviates endoplasmic reticulum stress in podocytes under hyperglycemic conditions, leading to the suppression of apoptosis and the restoration of epithelial-mesenchymal transition, through AMPK/autophagy-mediated signaling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Qian Wang, Miao Wang, Minghong Jia, Yongxin She, Jing Wang, Lufei Zheng, A. M. Abd El-Aty
Summary: Glyphosate, a widely used herbicide, and its metabolite aminomethyl phosphonic acid pose environmental and health risks. In this study, a method combining dummy molecularly imprinted solid-phase extraction (DMI-SPE) with liquid chromatography-tandem quadrupole mass spectrometry (LC/MS/MS) was developed for glyphosate detection. The optimized DMI-SPE-LC/MS/MS method achieved high sensitivity and specificity in detecting glyphosate and its metabolite in tea matrices.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemistry & Molecular Biology
Jaw Long Sun, Jae Hak Ryu, Wonjun Cho, Heeseung Oh, A. M. Abd El-Aty, Didem Ozkal Eminoglu, Ji Hoon Jeong, Tae Woo Jung
Summary: The study aimed to investigate the impact of CTRP4 on inflammation and the interaction between endothelial cells and monocytes under hyperlipidemic conditions. The results showed that CTRP4 reduced the attachment of THP-1 monocytes to HUVECs and decreased inflammation indicators in experimental cells exposed to hyperlipidemic conditions. Additionally, CTRP4 improved the interaction between endothelial cells and monocytes through the SIRT6/Nrf2-dependent pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Chemistry, Applied
Yongchang Liu, Zusheng Wei, Jiarui Wang, Yinliang Wu, Xin Xu, Bin Wang, M. Abd El-Aty
Summary: Corn films based on corn starch were fabricated and different plasticizers were incorporated to study their physicochemical characteristics. The effects of different ratios of plasticizers on starch modification were investigated. The results showed that increasing the proportion of D-mannitol could improve the performance of corn starch films.
Article
Biochemistry & Molecular Biology
Shasha Huang, Kuiyou Wang, Zheng Hua, Abd El-Aty Am, Mingqian Tan
Summary: This study developed size-controllable multifunctional nanoparticles using sea cucumber peptide (SCP), procyanidins (PCs), and vanillin. The results showed that SCP nanoparticles have potential for precision nutrition in cancer treatment due to their antioxidative properties and controllable sizes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)