Article
Radiology, Nuclear Medicine & Medical Imaging
Tom D. Turmezei, Samantha B. Low, Simon Rupret, Graham M. Treece, Andrew H. Gee, James W. MacKay, John A. Lynch, Kenneth E. S. Poole, Neil A. Segal
Summary: Joint space mapping (JSM) of the knee using weight-bearing CT images is reproducible and feasible, showing a relationship between three-dimensional joint space width distribution and structural joint disease. Novice users can learn it reliably, and it can achieve a smallest detectable difference that is at least 50% smaller than that reported in radiography.
Article
Orthopedics
Caleb W. Grote, Matthew J. Mackay, Qinghua Lu, Xiangliang Liu, Anders R. Meyer, Jinxi Wang
Summary: This study developed a comprehensive histopathologic grading scheme for murine knee osteoarthritis (OA) that covers all-stage osteoarthritic changes in all major joint tissues. The new grading scheme showed high reproducibility and accuracy in assessing OA severity and progression. It is the first whole-joint grading scheme that includes periarticular soft-tissue ossification and is suitable for quick OA severity assessments of the entire femorotibial joint.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Patrick Haubruck, Raban Heller, Carina L. Blaker, Elizabeth C. Clarke, Susan M. Smith, Daniel Burkhardt, Yolanda Liu, Shihani Stoner, Sanaa Zaki, Cindy C. Shu, Christopher B. Little
Summary: A single slide for evaluating diverse histopathological changes in different joint tissues and disease stages can reduce scoring time and maintain sensitivity and specificity of the analysis.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Jae H. Lee, Keewon Kim, Sun G. Chung
Summary: The study found that knees with osteoarthritis exhibited differences in mechanical properties compared to other clinical parameters, showing increased intra-articular pressure and synovial stiffness. The synovium of knees with osteoarthritis stretched earlier, and intra-articular pressure characteristics could be used for clinical evaluation of the synovium.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Anesthesiology
Diana Amorim, Diana Fonseca-Rodrigues, Ana David-Pereira, Octavia Costa, Antonia Palhares Lima, Rosete Nogueira, Rute Cruz, Ana Sofia Martins, Liliana Sousa, Francisco Oliveira, Helder Pereira, Rogerio Pirraco, Antti Pertovaara, Armando Almeida, Filipa Pinto-Ribeiro
Summary: The injection of kaolin/carrageenan in the rat knee joint successfully models the physical and psychiatric features of human osteoarthritis. This experimental osteoarthritis allows for the study of disease mechanisms and evaluation of therapeutic strategies to halt disease progression at different stages.
Article
Engineering, Biomedical
Yamini Krishnan, Yun Jung Yang, Sieun K. Barnes, Han-Hwa K. Hung, Bradley D. Olsen, Paula T. Hammond, Alan J. Grodzinsky
Summary: There are currently no known drugs or treatment methods to prevent post-traumatic osteoarthritis (PTOA), but cationic delivery carriers can help overcome the challenge of drug delivery. In this study, a cationic green fluorescent protein (GFP) was used as a carrier to deliver Insulin-Like Growth Factor 1 (IGF-1) for potential therapeutic treatment of PTOA. Through in vitro experiments and the development of a predictive mathematical transport model, the study provides a foundation for translating these findings into preclinical and potentially clinical applications.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Moon-Chang Choi, Jiwon Jo, Myeongjin Lee, Jonggwan Park, Yoonkyung Park
Summary: The study found that the antimicrobial peptide Cramp induces chondrocyte catabolism via the NF-kappa B signaling pathway, accelerating the progression of OA and leading to cartilage degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
C. M. Parsons, A. Judge, R. Meyer, O. Bruyere, F. Petit-Dop, R. Chapurlat, J. -Y. Reginster, C. Cooper, H. Inskip
Summary: This study assessed the utility of two alternative statistical modelling methods for monitoring knee osteoarthritis progression. Results showed that estimates from frequentist linear mixed effect and Bayesian hierarchical modelling were more accurate predictors of pain change compared to crude change. Using these methods could reduce sample sizes and improve precision in clinical trials and epidemiological studies.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sara Ramezanpour, Thanat Kanthawang, John Lynch, Charles E. McCulloch, Michael C. Nevitt, Thomas M. Link, Gabby B. Joseph
Summary: This study investigates the impact of sustained synovitis on the progression of knee degenerative changes. The results suggest that sustained synovitis is associated with greater progression of structural degenerative disease.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Nutrition & Dietetics
Guangfeng Ruan, Chengliang Yang, Tao Meng, Shuang Zheng, Yan Zhang, Jimin Zhu, Han Cen, Yuanyuan Wang, Zhaohua Zhu, Weiyu Han, Yujin Tang, Jia Liu, Benny Antony, Tania Winzenberg, Anita E. Wluka, Flavia Cicuttini, Changhai Ding
Summary: The study found that higher diet quality, particularly a vegetable-based diet quality, was associated with greater lower limb muscle strength, fewer depressive symptoms, and higher quality of life in knee osteoarthritis patients, rather than being related to knee joint structures and OA symptoms.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yvonne Rellmann, Elco Eidhof, Uwe Hansen, Lutz Fleischhauer, Jonas Vogel, Hauke Clausen-Schaumann, Attila Aszodi, Rita Dreier
Summary: Ageing or obesity are risk factors for protein aggregation in the endoplasmic reticulum of chondrocytes, leading to the development of knee osteoarthritis. This study found that ER stress in chondrocytes results in the degeneration and apoptosis of knee cartilage, with young mice being less susceptible to OA. The findings suggest that inhibiting ER stress may be an attractive therapeutic target for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
M. A. Hunt, J. M. Charlton, D. T. Felson, A. Liu, G. J. Chapman, A. Graffos, R. K. Jones
Summary: The study found a moderate relationship between frontal plane rearfoot angle and knee adduction moment (KAM), which was mainly influenced by frontal plane knee kinematics. Other variables did not significantly alter this relationship.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Orthopedics
Mastour Saeed Alshahrani, Ravi Shankar Reddy, Faisal Asiri, Jaya Shanker Tedla, Adel Alshahrani, Praveen Kumar Kandakurti, Venkata Nagaraj Kakaraparthi
Summary: This study found a negative correlation between quadriceps endurance and knee joint position sense (JPS) in individuals with knee osteoarthritis (KOA). Compared to asymptomatic individuals, KOA individuals had lower quadriceps endurance and larger knee joint position errors.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Multidisciplinary Sciences
Haimuzi Xu, Ji-Hyoun Kang, Sung-Eun Choi, Dong-Jin Park, Sun-Seog Kweon, Young-Hoon Lee, Hye-Yeon Kim, Jung-Kil Lee, Min-Ho Shin, Shin-Seok Lee
Summary: The study found that serum adiponectin levels were positively associated with radiographic scores in knee osteoarthritis, but not in hand osteoarthritis. This suggests the involvement of different pathophysiologic mechanisms in the development of OA between knee and hand joints.
SCIENTIFIC REPORTS
(2021)
Article
Orthopedics
Yi Zhao, Zhaohua Zhu, Jun Chang, Guoliang Wang, Shuang Zheng, C. Kent Kwoh, John Lynch, David J. Hunter, Changhai Ding
Summary: This study found that changes in the morphology of PTFJ can predict the risk of TKR, indicating a potential role of PTFJ in knee OA.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Evy Dhondt, Jessica Van Oosterwijck, Barbara Cagnie, Rahmat Adnan, Stijn Schouppe, Jens Van Akeleyen, Tine Logghe, Lieven Danneels
JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION
(2020)
Review
Clinical Neurology
Stijn Schouppe, Sophie Van Oosterwijck, Lieven Danneels, Stefaan Van Damme, Jessica Van Oosterwijck
Article
Anesthesiology
Amanda Clauwaert, Stijn Schouppe, Jessica Van Oosterwijck, Lieven Danneels, Stefaan Van Damme
CLINICAL JOURNAL OF PAIN
(2020)
Article
Anesthesiology
Stijn Schouppe, Amanda Clauwaert, Jessica Van Oosterwijck, Stefaan Van Damme, Tanneke Palmans, Jan R. Wiersema, Enrique Sanchis-Sanchez, Lieven Danneels
Article
Rehabilitation
Robby De Pauw, Eveline Van Looveren, Dorine Lenoir, Lieven Danneels, Barbara Cagnie
Summary: This study provides a reliable tool for evaluating the movement control in patients with and without neck pain. The tool showed good inter-rater and intra-rater reliability and demonstrated discriminative validity in distinguishing patients from controls. It can effectively assess the sensorimotor impairment in the craniocervical and axioscapular region.
DISABILITY AND REHABILITATION
(2022)
Article
Anesthesiology
Ward Willaert, Anneleen Malfliet, Iris Coppieters, Dorine Lenoir, Robby De Pauw, Lieven Danneels, Nathalie Roussel, Mira Meeus, Barbara Cagnie, Jo Nijs, Jeroen Kregel
Article
Neurosciences
A. Clauwaert, D. M. Torta, B. Forster, L. Danneels, S. Van Damme
EXPERIMENTAL BRAIN RESEARCH
(2020)
Article
Orthopedics
Rahmat Adnan, Jessica Van Oosterwijck, Lieven Danneels, Tine Willems, Mira Meeus, Geert Crombez, Dorien Goubert
JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION
(2020)
Article
Orthopedics
Marijke Leysen, Jo Nijs, Paul Van Wilgen, Christophe Demoulin, Wim Dankaerts, Lieven Danneels, Lennard Voogt, Albere Koke, Laurent Pitance, Nathalie Roussel
Summary: The study examined the beliefs and adherence to clinical LBP guidelines among physical therapy students in Belgium and the Netherlands, revealing a shift from a purely biomedical model to a more biopsychosocial model from the 2nd to the 4th year of education. However, guideline adherence for activity and work recommendations remains low.
BRAZILIAN JOURNAL OF PHYSICAL THERAPY
(2021)
Article
Neurosciences
Stijn Schouppe, Jessica Van Oosterwijck, Jan R. Wiersema, Stefaan Van Damme, Tine Willems, Lieven Danneels
Article
Orthopedics
Iris Coppieters, Ward Willaert, Dorine Lenoir, Mira Meeus, Barbara Cagnie, Kelly Ickmans, Anneleen Malfliet, Lieven Danneels, Brenda De Petter, Jo Nijs
Summary: This study aims to compare the effectiveness of a contemporary neuroscience approach with conventional physical therapy in improving functioning, quality of life, and reducing pain, central sensitization, and psychological problems in people with chronic whiplash associated disorders. The multi-center randomized controlled trial will last for 1 year and involve 120 participants.
BRAZILIAN JOURNAL OF PHYSICAL THERAPY
(2021)
Article
Anesthesiology
Evy Dhondt, Lieven Danneels, Sophie Van Oosterwijck, Tanneke Palmans, Johan Rijckaert, Jessica Van Oosterwijck
EUROPEAN JOURNAL OF PAIN
(2020)
Review
Anesthesiology
Evy Dhondt, Sophie Van Oosterwijck, Thomas Van Branteghem, Jamie L. Rhudy, Lieven Danneels, Jessica Van Oosterwijck
Summary: This study systematically reviewed and meta-analyzed the effects of conservative therapy on spinal nociception measured through the assessment of the nociceptive flexion reflex (NFR). The findings suggest that conservative interventions can decrease NFR area and NFR magnitude, and increase NFR latency by activating descending inhibitory pathways. This is important for preventing and treating chronic pain characterized by enhanced spinal nociception.
Article
Anesthesiology
Thomas Bilterys, Eveline Van Looveren, Anneleen Malfliet, Jo Nijs, Mira Meeus, Lieven Danneels, Kelly Ickmans, Barbara Cagnie, Dorien Goubert, Maarten Moens, Liesbet De Baets, Wouter Munneke, Olivier Mairesse
Summary: This study aimed to evaluate the relationship and conformity between self-reported and objectively measured sleep parameters. The findings suggest a discrepancy between subjective and objective sleep parameters in people with chronic spinal pain and comorbid insomnia, with participants tending to underestimate total sleep time and overestimate sleep onset latency.
Article
Anesthesiology
Anneleen Malfliet, Robby De Pauw, Jeroen Kregel, Iris Coppieters, Mira Meeus, Nathalie Roussel, Lieven Danneels, Barbara Cagnie, Jo Nijs
