Article
Geriatrics & Gerontology
Varinderpal S. Dhillon, Permal Deo, Ann Chua, Phil Thomas, Michael Fenech
Summary: The study investigated the relationship between red blood cell fatty acid status and lymphocyte telomere length (LTL) in 174 healthy older South Australians. Results showed that saturated and monounsaturated fatty acids were negatively associated with LTL, while polyunsaturated fatty acids, particularly arachidonic acid (C20:4n-6), were positively correlated with LTL. Further research is warranted into the significant association of fatty acids, especially C20:4n-6, with telomere length.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Cell Biology
Yingying Ma, Meiqi Yi, Weixuan Wang, Xiaohui Liu, Qingtao Wang, Chongdong Liu, Yuling Chen, Haiteng Deng
Summary: High expression of CD38 leads to degradation of DHFR and increased susceptibility to ferroptosis. BMDMs from aged mice with high CD38 expression are more susceptible to ferroptosis, but this susceptibility can be reversed by NMN replenishment.
CELL DEATH & DISEASE
(2022)
Article
Psychiatry
M. van Verseveld, R. J. T. Mocking, D. Scheepens, F. ten Doesschate, M. Westra, R. A. Schoevers, A. H. Schene, G. A. van Wingen, J. A. van Waarde, H. G. Ruhe
Summary: This study provides the first indication that polyunsaturated fatty acids (PUFAs) are associated with the efficacy of electroconvulsive therapy (ECT). The results suggest that PUFAs may affect ECT outcomes by influencing neuronal electrochemical properties and neurogenesis. PUFAs could potentially serve as a modifiable factor predicting ECT outcomes and further investigation is warranted in other ECT cohorts.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Wade T. Johnson, Nicholas C. Dorn, Dora A. Ogbonna, Nunzio Bottini, Nisarg J. Shah
Summary: Lipids are a diverse class of molecular regulators with ubiquitous physiological roles in sustaining life. They can be used directly as structural cellular building blocks or as a substrate for generating signaling mediators to regulate cell behavior, playing a key role in immune activation and suppression.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Applied
Azemina Bajramova, Peter Spegel
Summary: This study compares the nutritional value of the fatty acid profiles of superfruits (goji berry, white mulberry, and cranberry) and common fruits (banana, apple, and strawberry). The findings suggest that cranberries and apples have the most beneficial lipid profiles, while superfruits do not show a common and beneficial lipid profile.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Pharmacology & Pharmacy
Jaewang Lee, Daiha Shin, Jong-Lyel Roh
Summary: Cancer disrupts lipid metabolism, leading to altered metabolism intermediates and contributing to abnormal growth and metastasis. The shift in lipid metabolism towards an increased presence of polyunsaturated fatty acids (PUFAs) in membrane phospholipids (PLs) also causes resistance to cancer therapy. The vulnerability of cancer cells to lipid peroxidation (LPO) and subsequent ferroptosis, a new form of regulated cell death, depends on adaptive lipidome remodeling, LPO patterns, and LPO scavenging ability. Understanding the molecular basis of altered lipid metabolism in cancer may offer new opportunities for overcoming cancer resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaping Shao, Zhenfa Fu, Yanfeng Wang, Zhaofei Yang, Yushan Lin, Song Li, Cheng Cheng, Min Wei, Zheyi Liu, Guowang Xu, Weidong Le
Summary: By using metabolomics and lipidomics analysis, this study investigated the effects of fasting on brain metabolism in mice. The results showed that fasting induced triacylglycerol degradation and lipolysis to meet energy demands, and led to changes in amino acid profiles that may play crucial roles in energy metabolism, neurotransmitter signaling, and anti-inflammatory and antioxidant responses. Additionally, the study reported a significant elevation of neuroprotective lipids called N-acylethanolamines in the brain and liver during fasting. These findings provide novel insights into the molecular basis and mechanisms of calorie restriction and offer a comprehensive resource for further investigation.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Biology
Ji-Yoon Lee, Won Kon Kim, Kwang-Hee Bae, Sang Chul Lee, Eun-Woo Lee
Summary: Ferroptosis is a type of iron-dependent regulated necrosis induced by lipid peroxidation in cellular membranes. Polyunsaturated fatty acids associated with specific phospholipids are responsible for ferroptosis-inducing lipid peroxidation. Cells take up essential fatty acids from blood to produce PUFAs, which undergo lipid peroxidation through various pathways tightly regulated by metabolic and signaling pathways.
Review
Nutrition & Dietetics
Alice Cartoni Mancinelli, Simona Mattioli, Cornelia Twining, Alessandro Dal Bosco, Ann M. Donoghue, Komala Arsi, Elisa Angelucci, Diletta Chiattelli, Cesare Castellini
Summary: This study provides an overview of the main strategies for enriching and preserving n-3 LC-PUFA in poultry products, which include dietary supplementation and improving rearing conditions. Additionally, factors such as genotype, rearing system, transport, and cooking processes can impact the content of this fatty acid in poultry products.
Article
Oncology
Jenna K. Minami, Danielle Morrow, Nicholas A. Bayley, Elizabeth G. Fernandez, Jennifer J. Salinas, Christopher Tse, Henan Zhu, Baolong Su, Rhea Plawat, Anthony Jones, Alessandro Sammarco, Linda M. Liau, Thomas G. Graeber, Kevin J. Williams, Timothy F. Cloughesy, Scott J. Dixon, Steven J. Bensinger, David A. Nathanson
Summary: Malignant tumors exhibit heterogeneous metabolic reprogramming, hindering the identification of vulnerabilities for metabolism-targeted therapy. Through analysis of lipidomic, transcriptomic, and genomic data, this study identifies CDKN2A deletion as a molecular alteration that remodels the lipidome in glioblastoma (GBM), leading to higher lipid peroxidation and selective vulnerability to ferroptosis. This research provides a resource for understanding the molecular and lipidomic characteristics of GBM, and reveals a potential therapeutic target related to altered lipid metabolism.
Review
Nutrition & Dietetics
Karla MacDonald-Ramos, Alejandra Martinez-Ibarra, Adriana Monroy, Juan Miranda-Rios, Marco Cerbon
Summary: Dietary fatty acids play crucial roles in metabolic diseases and inflammation, with diverse effects on miRNA expression. Recent studies have shown that high fat ketogenic diets do not increase saturated fat content in the serum and are not associated with increased inflammation. Further research is needed to explore the complex interactions and potential therapeutic applications of DFAs.
Review
Biochemistry & Molecular Biology
Silvio Bellino, Paola Bozzatello, Cristina Badino, Emanuela Mantelli, Paola Rocca
Summary: Investigations into the effects of long-chain n-3 and long-chain n-6 polyunsaturated fatty acids (LC n-3 PUFAs; LC n-6 PUFAs) on psychiatric symptoms are gaining increasing interest, with evidence suggesting potential positive impacts on impulsivity and aggression by modulating levels of these compounds in plasma and blood cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Harsh B. Jadhav, Uday Annapure
Summary: Designer lipid is a chemically or enzymatically modified lipid with superior physicochemical properties and nutritional benefits, widely used in the food and pharmaceutical industries. Its demand has been increasing due to its unique properties and health benefits.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Cell Biology
Takeshi Harayama, Bruno Antonny
Summary: The number of double bonds in membrane lipid acyl chains varies greatly across different levels of life. This article reviews different approaches used to understand the variability in acyl chain composition. It suggests that a comprehensive understanding of lipid unsaturation is limited not only by technical difficulties, but also by the subtle effects of the position of double bonds on various properties of membrane lipids.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2023)
Article
Geriatrics & Gerontology
Natalia Mota-Martorell, Pol Andres-Benito, Meritxell Martin-Gari, Jose Daniel Galo-Licona, Joaquim Sol, Anna Fernandez-Bernal, Manuel Portero-Otin, Isidro Ferrer, Mariona Jove, Reinald Pamplona
Summary: The fatty acid profiles of different regions in the human central nervous system show general traits in terms of chain length, monounsaturated and polyunsaturated fatty acid content. Overall, most adult brain regions exhibit sustained and well-preserved lipid profiles with minor changes, while specific regions associated with memory domains are greatly affected by aging.
Review
Endocrinology & Metabolism
Jori Aalders, Giesje Nefs, Esther Hartman, Linh A. Nguyen, Per Winterdijk, Edgar van Mil, Henk-Jan Aanstoot, Frans Pouwer
Summary: This study aims to evaluate the psychometric properties of instruments assessing the division of care responsibilities between parents and children with type 1 diabetes. Thirteen questionnaires were identified, with the Diabetes Family Responsibility Questionnaire (DFRQ) being the most frequently used. However, there were variations in instructions, content and number of tasks, response options, and scoring methods among the questionnaires. Overall, the reporting and quality of psychometric properties were suboptimal.
CURRENT DIABETES REVIEWS
(2023)
Review
Endocrinology & Metabolism
Marzia Mohseni, Nanna Lindekilde, Genevieve Forget, Rachel J. Burns, Frans Pouwer, Norbert Schmitz, Sonya S. Deschenes
Summary: A systematic review found a positive association between high levels of trait anger/hostility and an increased risk of incident type 2 diabetes. However, there is insufficient evidence to confirm the association between anger/hostility and diabetes-related complications. Further longitudinal studies are needed to investigate this relationship.
CURRENT DIABETES REVIEWS
(2023)
Article
Endocrinology & Metabolism
Hannah Chatwin, Melanie Broadley, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie A. Amiel, Bastiaan de Galan, Rory J. McCrimmon, Ulrik Pedersen-Bjergaard, Frans Pouwer, Jane Speight
Summary: Hypoglycemia has a negative impact on various domains of quality of life for adults with type 1 diabetes, including leisure activities, physical health, ability to keep fit and be active, sleep, emotional well-being, spontaneity, independence, work/studies, and dietary freedom. Psychological factors play a larger role in explaining this negative impact than hypoglycemia frequency and awareness.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Clinical Neurology
D. A. van Dijk, M. L. Deen, Th M. van den Boogaard, H. G. Ruhe, J. Spijker, F. P. M. L. Peeters
Summary: This study aimed to determine the prevalence of and risk factors for treatment dropout in a large outpatient sample. The analysis of data from 2235 outpatients with MDD revealed that 14.5% of patients dropped out of treatment. Results showed that higher scores on the Measure for Quantification of Treatment Resistance in Depression were associated with lower dropout odds.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Jill Carlton, Philip Powell, Donna Rowen, Melanie Broadley, Frans Pouwer, Jane Speight, Simon Heller, Mari-Anne Gall, Myriam Rosilio, Christopher J. Child, Jonathan Comins, Rory J. McCrimmon, Bastiaan de Galan, John Brazier
Summary: This study aims to develop a new hypoglycaemia-specific PROM to assess the impact of hypoglycaemia on quality of life in patients with diabetes. The study uses a mixed-methods, three-stage design, collecting information through qualitative interviews and validating it through psychometric testing, ultimately generating a hypoglycaemia-specific PROM and preference-based measure.
Article
Clinical Neurology
D. A. van Dijk, R. M. Meijer, Th. M. van den Boogaard, J. Spijker, H. G. Ruhe, F. P. M. L. Peeters
Summary: This study retrospectively analyzed data from 715 outpatient depression patients and found that a longer waiting time was associated with a less favorable treatment outcome. The results suggest that reducing waiting time can improve treatment outcomes for depression patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Amanda M. Legemaat, Marcella A. S. Haagedoorn, Huibert Burger, Damiaan Denys, Claudi L. Bockting, Gert J. Geurtsen
Summary: This study aimed to assess the proportion of Major Depressive Disorder (MDD) patients with demonstrated valid performance and determine their cognitive functioning. The analysis showed that around 94% of MDD patients had valid neuropsychological test performance in studies using Performance Validity Tests (PVT's). However, there is limited information regarding the cognitive functioning of these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Editorial Material
Multidisciplinary Sciences
Claudi Bockting, Eva A. M. van Dis, Johan Bollen, Robert van Rooij, Willem L. Zuidema
Summary: Conversational AI is a transformative change for the field of science, and it requires a thoughtful response.
Article
Public, Environmental & Occupational Health
Ragnhild B. Strandberg, Roy M. Nilsen, Frans Pouwer, Jannicke Igland, Rachel B. Forster, Anne Karen Jenum, Esben S. Buhl, Marjolein M. Iversen
Summary: This study assessed the proportion of diabetes educational program participation among adults with type 2 diabetes mellitus (T2DM) in Norway, and its associations with place of residence, education, and immigrant background. The results showed that overall participation rate was 18%, with variations among different Norwegian counties. Individuals with immigrant background and lower education level were less likely to participate. Therefore, more efforts are needed to promote diabetes educational programs among patients with T2DM.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Psychiatry
M. van Verseveld, R. J. T. Mocking, D. Scheepens, F. ten Doesschate, M. Westra, R. A. Schoevers, A. H. Schene, G. A. van Wingen, J. A. van Waarde, H. G. Ruhe
Summary: This study provides the first indication that polyunsaturated fatty acids (PUFAs) are associated with the efficacy of electroconvulsive therapy (ECT). The results suggest that PUFAs may affect ECT outcomes by influencing neuronal electrochemical properties and neurogenesis. PUFAs could potentially serve as a modifiable factor predicting ECT outcomes and further investigation is warranted in other ECT cohorts.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Uffe Soholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Jill K. Carlton, Julia Mader, Petra Martina Baumann, Mikel Gomes, Gilberte J. Martine-Edith, Daniel Pollard, Dajana Rath, Simon Heller, Ulrik J. Pedersen-Bjergaard, Rory McCrimmon, Eric Renard, Mark Evans, Bastiaan de Galan, Thomas A. Forkmann, Stephanie Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans Pouwer
Summary: The aim of this study was to determine the acceptability and psychometric properties of the Hypo-METRICS app, which is designed to assess the impact of hypoglycemia on daily functioning in people with insulin-treated diabetes. Participants completed daily check-ins for 10 weeks using the app and answered questions about their subjective daily functioning. The results showed high completion rates, satisfactory psychometric properties, and demonstrated that the app is acceptable and reliable for exploring the daily impact of hypoglycemia.
Article
Biology
Saige Rutherford, Pieter Barkema, Ivy F. Tso, Chandra Sripada, Christian F. Beckmann, Henricus G. Ruhe, Andre F. Marquand, Chris Baker
Summary: In this study, we extended the normative model repository introduced in Rutherford et al., 2022a to include normative models for lifespan trajectories of structural surface area and brain functional connectivity. We used two resting-state network atlases (Yeo-17 and Smith-10) and an updated online platform to transfer these models to new data sources. Through benchmarking tasks, we demonstrated the value of normative modeling features compared to raw data features, especially in group difference testing and classification tasks. These accessible resources are intended to promote the broader adoption of normative modeling in the neuroimaging community.
Article
Neurosciences
Sonsoles Alonso, Anna Tyborowska, Nessa Ikani, Roel J. T. Mocking, Caroline A. Figueroa, Aart H. Schene, Gustavo Deco, Morten L. Kringelbach, Joana Cabral, Henricus G. Ruhe
Summary: 《Dynamic Changes in Brain Network Connectivity during Recurrence of Major Depressive Disorder》This study investigated the dynamic changes in brain connectivity during the transition from remission to recurrence in major depressive disorder (MDD) patients. The findings showed that during recurrence, there was increased activity in the basal ganglia-anterior cingulate cortex and visuo-attentional networks, as well as a longer duration of activation in the default mode network. Additionally, the synchrony between the reward network and the rest of the brain was significantly reduced during recurrence. These results provide initial evidence of altered dynamical exploration of functional networks during a recurrent depressive episode.
HUMAN BRAIN MAPPING
(2023)
Article
Endocrinology & Metabolism
Kevin P. Marks, Frans Pouwer, Morten B. Jensen, Else H. Ibfelt, Lene J. Kristensen, Mikael Thastum, Niels H. Birkebaek
Summary: This study aimed to determine whether caregiver responses to the Strengths and Difficulties Questionnaire (SDQ) can predict HbA1c trajectory membership in children and adolescents with type 1 diabetes. The results showed that higher SDQ total difficulties scores and specific subscale scores were associated with different types of HbA1c trajectories. Additionally, single-parent family and low caregiver education level were also found to be associated with HbA1c trajectories.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Review
Endocrinology & Metabolism
Frans Pouwer, Byron Perrin, Andy Lavender, Bijan Najafi, Khalida Ismail, Loretta Vileikyte
Summary: Diabetic foot ulceration is a common and recurrent condition that negatively affects individuals' quality of life. Adhering to foot self-care recommendations is crucial for DFU prevention, and psychological factors such as depression can hinder treatment and ulcer healing. However, the role of psychological and social factors in DFU management is still limited. This narrative overview suggests that a stronger focus on psychological factors could improve care for high-risk DFU patients.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)