Article
Psychiatry
Fangfang Shangguan, Ziwei Chen, Yue Lv, Xiang-Yang Zhang
Summary: In this study, cortisol and interleukins were found to be associated with clinical presentation in a relatively large sample size of schizophrenia patients. Patients with schizophrenia had significantly higher levels of cortisol and IL-2 compared to healthy controls. Additionally, higher levels of IL-6 were observed in patients in remission compared to non-remitting patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Immunology
Feride Eren, Lilly Schwieler, Funda Orhan, Anna Malmqvist, Fredrik Piehl, Simon Cervenka, Carl M. Sellgren, Helena Fatouros-Bergman, Goran Engberg, Sophie Erhardt
Summary: In this study, immune aberrations in schizophrenia were investigated by analyzing a large number of immune-related proteins. It was found that several inflammatory proteins were significantly elevated in the plasma of both first-episode psychosis patients and schizophrenia patients, and these elevations were associated with disease severity. However, only CD5 showed a difference in cerebrospinal fluid.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Psychiatry
Milica M. Borovcanin, Slavica Minic Janicijevic, Natasa R. Mijailovic, Ivan P. Jovanovic, Nebojsa N. Arsenijevic, Katarina Vesic
Summary: This study suggests a potential association between uric acid levels and inflammatory responses in different phases of schizophrenia. However, the exact mechanism underlying the involvement of uric acid in the pathogenesis of schizophrenia remains uncertain.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychiatry
Evgeny A. Ermakov, Mark M. Melamud, Valentina N. Buneva, Svetlana A. Ivanova
Summary: The immune system abnormalities are associated with the pathogenesis of schizophrenia, and immune parameters may help identify subgroups with signs of inflammation. Gaps in knowledge about immune abnormalities in schizophrenia have been identified.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Immunology
Andrea Francesca Salvador, Kalil Alves de Lima, Jonathan Kipnis
Summary: Interactions between the immune system and the nervous system play a crucial role in shaping host behavior and nervous system function. These interactions may have evolved to maximize an organism's ability to respond to environmental threats. The immune system relays information to the nervous system through cytokine signaling, and the brain may be hardwired to process information from the immune system in a specific way.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Rheumatology
Aurelie Najm, Iain B. McInnes
Summary: IL-23, a pro-inflammatory cytokine secreted by dendritic cells and macrophages, plays a key role in the pathogenesis of rheumatic diseases by promoting T cell differentiation into Th17 cells. Therapeutic strategies targeting IL-23 have shown efficiency in PsA but not yet in RA.
Article
Psychiatry
Gabriela Hjell, Jaroslav Rokicki, Attila Szabo, Rene Holst, Natalia Tesli, Christina Bell, Thomas Fischer-Vieler, Maren Caroline Frogner Werner, Synve Hoffart Lunding, Monica Bettina Elkjaer Greenwood Ormerod, Ingrid Torp Johansen, Srdjan Djurovic, Thor Ueland, Ole Andreas Andreassen, Ingrid Melle, Trine Vik Lagerberg, Lynn Morch-Johnsen, Nils Eiel Steen, Unn Kristin Haukvik
Summary: This study found that impulsivity in patients with severe mental disorders is associated with specific diagnoses, with a stronger association in bipolar disorder and depression. However, there is no significant association between impulsivity and circulating immune markers. Among patients, impulsivity is negatively associated with lithium treatment and positively associated with antidepressant treatment.
Review
Medicine, General & Internal
Piotr Marcinowicz, Magdalena Wiedlocha, Natalia Zborowska, Weronika Debowska, Piotr Podwalski, Blazej Misiak, Ernest Tyburski, Agata Szulc
Summary: The study shows that antipsychotic treatment leads to decreased concentrations of certain pro-inflammatory and anti-inflammatory cytokines in FEP patients, while leaving levels of other cytokines unaffected. Comparing with other meta-analyses involving schizophrenic subjects, the results are consistent in some cytokines but indicate a decrease in anti-inflammatory IL-10 in FEP patients after antipsychotic treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Jingqi He, Yisen Wei, Jinguang Li, Ying Tang, Junyu Liu, Zhangyin He, Risheng Zhou, Xingtao He, Honghong Ren, Yanhui Liao, Lin Gu, Ning Yuan, Xiaogang Chen, Jinsong Tang
Summary: This study compared serum IL-6 levels between TRS and PRS patients and explored potential sex differences in the association between TRS and IL-6 levels. The results showed that TRS patients had higher serum IL-6 levels, especially in females. The findings suggest that the inflammatory response system may play a role in the pathogenesis of TRS in a sex-dependent manner.
Article
Psychiatry
Arafat Hussein Al-Dujaili, Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Michael Maes
Summary: The study found significantly higher levels of HMGB1, DKK1, IL-6, and CCL11 in SCZ patients. NRTT patients had significantly higher levels of IL-6 and DDKI compared to PRTT and controls, with IL-10 being higher in NRTT than in controls. HMGB1, IL-6, and CCL11 explained a large part of the variance in PHEMN symptoms and formal thought disorders, while most neurocognitive functions were predicted by HMGB1, DDKI, and CCL11.
SCHIZOPHRENIA BULLETIN
(2021)
Review
Biochemistry & Molecular Biology
Magdalena Grazul, Pawel Kwiatkowski, Kacper Hartman, Anna Kilanowicz, Monika Sienkiewicz
Summary: Efficient functionality of the immune system is crucial in fighting against infectious diseases and modern common diseases connected with inflammation. Essential oils possess valuable properties such as antimicrobial, antioxidant, anti-inflammatory, and immunostimulating effects. Some constituents of essential oils can stimulate the proliferation of immune cells, and the interaction between essential oil components and recommended drugs should be explored for medical use.
Review
Psychiatry
Connor Dunleavy, Richard J. Elsworthy, Rachel Upthegrove, Stephen J. Wood, Sarah Aldred
Summary: This study provides a comprehensive analysis of cytokine perturbations in antipsychotic-naive first-episode psychosis (FEP) populations. The results suggest a significant elevation in proinflammatory cytokine concentrations in these patients. The relationship between cytokines and negative symptoms varies, with some cytokines showing moderate positive correlations, while others show negative or positive correlations. Future studies should focus on longitudinal research to investigate how cytokine fluctuations may impact symptom exacerbation.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Review
Neurosciences
Yu Huang, Xin Zhang, Na Zhou
Summary: This article reviewed a series of studies and found a close association between interleukin-2 (IL-2) and schizophrenia. It discussed the changes of IL-2 in the onset, progression, and treatment of schizophrenia, as well as the possible mechanisms by which IL-2 affects schizophrenia.
Article
Biochemistry & Molecular Biology
Flavia S. Mueller, Joseph Scarborough, Sina M. Schalbetter, Juliet Richetto, Eugene Kim, Amalie Couch, Yohan Yee, Jason P. Lerch, Anthony C. Vernon, Ulrike Weber-Stadlbauer, Urs Meyer
Summary: Research has shown that offspring exposed to the same MIA can be divided into different subgroups with significant differences in behavior, transcription, brain networks, and immune spectra. Offspring with a high innate inflammatory cytokine status displayed impairments in social approach and sensorimotor gating in adulthood.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Zhiqing Li, Xiaosu Chen, Junyan Dan, Tianju Hu, Ye Hu, Shuxun Liu, Yangyang Chai, Yansong Shi, Jian Wu, Hailai Ni, Jiaqi Zhu, Yanfeng Wu, Nan Li, Yizhi Yu, Zhongfang Wang, Jincun Zhao, Nanshan Zhong, Xianwen Ren, Zhongyang Shen, Xuetao Cao
Summary: This study investigates the innate immune landscape of human Omicron infection and finds that IL-1 beta or IFN responsiveness of myeloid cells may indicate the severity of the disease. This information could help understand the immune response to Omicron variant and its impact on COVID-19 outcomes.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Psychiatry
Leilei Wang, Yi Yin, Yanfang Zhou, Junchao Huang, Ping Zhang, Song Chen, Hongzhen Fan, Yimin Cui, Xingguang Luo, Shuping Tan, Zhiren Wang, Chiang-Shan R. Li, Baopeng Tian, Li Tian, L. Elliot Hong, Yunlong Tan
Summary: The study found that patients with first-episode schizophrenia experienced more severe childhood trauma and had lower serum brain-derived neurotrophic factor levels compared to healthy controls. Emotional abuse, emotional neglect, and Childhood Trauma Questionnaire total score were positively associated with positive, general psychopathological subscores, and total scores in patients, while emotional neglect was positively associated with positive symptoms. Additionally, emotional neglect and Childhood Trauma Questionnaire total score were negatively correlated with serum brain-derived neurotrophic factor levels.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
Junchao Huang, Ping Zhang, Yanfang Zhou, Jinghui Tong, Yimin Cui, Shuping Tan, Zhiren Wang, Fude Yang, Peter Kochunov, Baopeng Tian, Li Tian, L. Elliot Hong, Yunlong Tan
Summary: The study revealed differences in TRP pathway metabolites between patients with TRS and NTRS, with the 5-HT/TRP ratio being associated with clinical symptoms and cognitive performance in TRS patients. This suggests a potential link between an upregulated 5-HT biosynthetic pathway and treatment-resistant schizophrenia, potentially leading to new pharmacological approaches for TRS.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Editorial Material
Neurosciences
Marie-Eve Tremblay, Charlotte Madore, Li Tian, Alexei Verkhratsky
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Leilei Wang, Yi Yin, Wei Feng, Yanfang Zhou, Junchao Huang, Ping Zhang, Song Chen, Hongzhen Fan, Yimin Cui, Xingguang Luo, Shuping Tan, Zhiren Wang, Baopeng Tian, Li Tian, Chiang-Shan R. Li, Yunlong Tan
Summary: The study found that childhood trauma in patients with first-episode schizophrenia is associated with smaller left OFC H-shaped sulci volumes and worse cognitive function. This suggests that childhood trauma may contribute to cognitive deficits in these patients by affecting OFC structure.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Neurosciences
Shujuan Pan, Yanfang Zhou, Ling Yan, Fangling Xuan, Jinghui Tong, Yanli Li, Junchao Huang, Wei Feng, Song Chen, Yimin Cui, Fude Yang, Shuping Tan, Zhiren Wang, Baopeng Tian, L. Elliot Hong, Yun-Long Tan, Li Tian
Summary: This study investigated the role of the cytokine TGF-beta 1 in patients with schizophrenia and found that higher levels of TGF-beta 1 were associated with abnormalities in brain structure and cognitive function.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Neurosciences
Na Li, Yanli Li, Junchao Huang, Ping Zhang, Jinghui Tong, Song Chen, Yimin Cui, Shuping Tan, Zhiren Wang, Fude Yang, Elliot Hong, Chiang-Shan R. Li, Li Tian, Yunlong Tan
Summary: This study found that the disturbance of the TLR4 signaling pathway in schizophrenia patients may be related to tardive dyskinesia and cognitive deficits.
NEUROSCIENCE LETTERS
(2022)
Article
Clinical Neurology
Shuang-Jiang Zhou, Lei-Lei Wang, Ting-Ting Wang, Jing-Qi Wang, Jing-Xu Chen
Summary: This study examines the occurrence of aggression, sleep disturbances, and suicide risk among Chinese adolescents, and reveals the relationships between these factors. The findings indicate that experiencing aggression is associated with an increased suicide risk, and insomnia, nightmare distress, and fatigue mediate this relationship.
Article
Immunology
Song Chen, Fengmei Fan, Fang-Ling Xuan, Ling Yan, Meihong Xiu, Hongzhen Fan, Yimin Cui, Ping Zhang, Ting Yu, Fude Yang, Baopeng Tian, L. Elliot Hong, Yunlong Tan, Li Tian
Summary: This study aimed to investigate the role of monocytic subsets and their specific signature genes in regulating cerebral cortical thickness and cognitive functions in first-episode schizophrenia patients. The study found significant changes in expressions of monocytic signature genes, particularly for intermediate and nonclassical subsets. The findings also showed reduced cortical thicknesses and weaker intra-relationships between monocytic genes and cortices in patients, compared to healthy controls. Interestingly, the study revealed a reversed association between monocytic genes and cortical thicknesses and cognition in patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychiatry
Hongna Li, Wenjin Chen, Mengzhuang Gou, Wei Li, Jinghui Tong, Yanfang Zhou, Ting Xie, Ting Yu, Wei Feng, Yanli Li, Song Chen, Baopeng Tian, Shuping Tan, Zhiren Wang, Shujuan Pan, Na Li, Xingguang Luo, Ping Zhang, Junchao Huang, Li Tian, Chiang-Shan R. Li, Yunlong Tan
Summary: This study reveals the association between altered TLR4 signaling pathway activity and deficits in cognition and white matter integrity in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Cell Biology
Keerthana Chithanathan, Kelli Somelar, Monika Jurgenson, Tamara Zarkovskaja, Kapilraj Periyasamy, Ling Yan, Nathaniel Magilnick, Mark P. Boldin, Ana Rebane, Li Tian, Alexander Zharkovsky
Summary: This study found that miR-146b is abundantly expressed in neuronal cells and miR-146a is mainly expressed in microglia and astroglia. miR-146b deficiency leads to anxiety-like behaviors and enhanced cognition, as well as an increase in the number of neurons and a decrease in the abundance of astroglia. Furthermore, it was discovered that the deficiency of miR-146b is associated with elevated expression of the gene Gdnf in the hippocampus.
Article
Biology
Keerthana Chithanathan, Fang-Ling Xuan, Miriam Ann Hickey, Li Tian
Summary: Compared to wildtype mice, 5 x FAD mice exhibited enhanced anxiety as early as 2 months old and showed increased pro-inflammatory cytokines in the olfactory bulb. The microglial activation and morphological changes were more prominent in the olfactory bulb of 2-month-old 5 x FAD mice. In the frontal cortex, pro-inflammatory cytokines were upregulated at a later stage (5-6 months old).
Article
Clinical Neurology
Tian-He Song, Ting-Ting Wang, Yun-Yue Zhuang, Hua Zhang, Jun-Hui Feng, Tang-Ren Luo, Shuang-Jiang Zhou, Jing-Xu Chen
Summary: Adolescents with major depressive disorder (MDD) are more likely to experience frequent nightmares and nightmare distress, which may increase their suicide risk. Female gender, junior grade, recurrent depressive episode, severe nightmare distress, and severe depressive symptoms are independently and significantly associated with suicide risk.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Clinical Neurology
Marine Tessier, Marta Saez Garcia, Emmanuelle Goubert, Edith Blasco, Amandine Consumi, Benoit Dehapiot, Li Tian, Florence Molinari, Jerome Laurin, Francois Guillemot, Christian A. Huebner, Christophe Pellegrino, Claudio Rivera
Summary: The study reveals a novel mechanism of action for the Na-K-Cl cotransporter (NKCC1) inhibitor bumetanide in neurological disorders. It shows that bumetanide accelerates microglial activation dynamics, resulting in an increase in parvalbumin interneuron survival through increased microglial BDNF expression and contact with interneurons.
Article
Psychiatry
Mengzhuang Gou, Wenjin Chen, Yanli Li, Song Chen, Wei Feng, Shujuan Pan, Xingguang Luo, Shuping Tan, Baopeng Tian, Wei Li, Jinghui Tong, Yanfang Zhou, Hongna Li, Ting Yu, Zhiren Wang, Ping Zhang, Junchao Huang, Peter Kochunov, Li Tian, Chiang-Shan R. Li, L. Elliot Hong, Yunlong Tan
Summary: This study aimed to investigate the association between altered immune-inflammatory response system (IRS) and compensatory immune-regulatory reflex system (IRS/CIRS) dynamics with reduced white matter integrity in patients with schizophrenia. The results showed that the IRS/CIRS ratio was significantly higher in patients with schizophrenia compared to healthy controls, and the reduced white matter integrity was mainly observed in the genu of corpus callosum (GCC). The white matter integrity of GCC was positively associated with IRS/CIRS ratio and negatively associated with negative symptom scores.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Linlin Sun, Nan Li, Ligang Zhang, Jingxu Chen
Summary: This study aimed to evaluate the role of Elastography point quantification (ElastPQ) in the quantitative assessment of fatty liver disease in mental disorder patients and provide a noninvasive detection method for non-alcoholic fatty liver (NAFLD) caused by atypical antipsychotics drugs (AAPDs). A total of 168 mental disorder patients treated with AAPDs and 58 healthy volunteers were included in the study. All subjects underwent ultrasound and ElastPQ tests, and the basic data of the patients were analyzed. The results showed that BMI, liver function, and ElastPQ value were significantly higher in the patient group compared to the healthy volunteers. The value of ElastPQ increased with treatment prolongation, and Olanzapine had a considerable influence on liver stiffness.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
